期刊
INTERNATIONAL JOURNAL OF NEUROSCIENCE
卷 127, 期 8, 页码 726-734出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/00207454.2016.1236382
关键词
circular RNAs; non-coding RNAs; microRNA sponge; microRNA; neurological diseases
资金
- National Natural Science Foundation of China [81301119]
- Ministry of Science and Technology of China [2013BAI09B03]
- Beijing Municipal Administration of Hospitals' Youth Programme [QML20160504]
Circular RNAs (circRNAs) are novel endogenous non-coding RNAs characterized by the presence of a covalent bond linking the 3' and 5' ends generated by backsplicing. In this review, we summarize a number of the latest theories regarding the biogenesis, properties and functions of circRNAs. Specifically, we focus on the advancing characteristics and functions of circRNAs in the brain and neurological diseases. CircRNAs exhibit the characteristics of species conservation, abundance and tissue/developmental-stage-specific expression in the brain. We also describe the relationship between circRNAs and several neurological diseases and highlight their functions in neurological diseases.
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