Review
Chemistry, Multidisciplinary
Antonio Jose Guillot, Miquel Martinez-Navarrete, Teresa M. Garrigues, Ana Melero
Summary: Lipid vesicles offer cost-effective improvement in skin drug absorption when the production process is optimized. Designing the ideal vesicle is a significant challenge as their properties are interrelated. Size, deformability degree, and drug loading are the key features that determine transdermal drug absorption. Interest in this technology is growing exponentially, although commercialization has been limited by preservation and scalability issues, which can be overcome with freeze-drying and modern escalation methods. This predicts wider use of these technologies in the market and clinical practice.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Chemistry, Multidisciplinary
Tania Limongi, Francesca Susa, Monica Marini, Marco Allione, Bruno Torre, Roberto Pisano, Enzo di Fabrizio
Summary: In designing a new drug, consideration should be given to the preferred route of administration and ensuring the pharmacokinetics of the active molecules match the drug profile and tolerability requirements. Over the past 20 years, nanotechnologies have provided alternative solutions for effective drug delivery, with lipid nano vesicular carriers successfully overcoming various challenges.
Article
Pharmacology & Pharmacy
Antonio Jose Guillot, Pablo Merino-Gutierrez, Andrea Bocchino, Conor O'Mahony, Rosa Maria Giner, Maria Carmen Recio, Teresa Maria Garrigues, Ana Melero
Summary: Vitamin B12 deficiency is a common condition that can be treated by oral or transdermal supplementation. This study aimed to enhance transdermal delivery of cyanocobalamin using ultraflexible lipid vesicles. The results showed that ultraflexible vesicles had better transdermal fluxes compared to a drug solution. The pre-treatment of the skin with a solid microneedle array also increased the potential systemic circulation of the drug.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Review
Chemistry, Multidisciplinary
Ana Claudia Paiva-Santos, Ana Luisa Silva, Catarina Guerra, Diana Peixoto, Miguel Pereira-Silva, Mahdi Zeinali, Filipa Mascarenhas-Melo, Ricardo Castro, Francisco Veiga
Summary: The use of nanotechnology in developing efficient drug delivery systems, such as ethosomes, which contain a high concentration of ethanol, has unique advantages in enhancing drug permeation across the skin. Ethosomes show promise as an alternative to traditional liposomes for delivering therapeutic agents for various skin pathologies, with potential applications in acne, psoriasis, alopecia, skin infections, hormonal deficiencies, among others. Further research is needed to fully explore the potential of ethosomal-based formulations in skin delivery of active ingredients.
PHARMACEUTICAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Aneta Kalvodova, Kristyna Dvorakova, Eliska Petrova, Bozena B. B. Michniak-Kohn, Jarmila Zbytovska
Summary: Due to the complex pathophysiology of skin diseases, a complex approach is required for their treatment. Topical corticosteroids, which are conventionally used, have low effectiveness and often lead to local or systemic side effects. Nanoformulation of potent anti-inflammatory drugs has been chosen as an optimal strategy for enhancing the topical delivery of corticosteroids. In this study, we formulated hydrocortisone (HC) and hydrocortisone-17-butyrate (HCB) into three different systems - lipid nanocapsules (LNC), polymeric nanoparticles (PNP), and ethosomes (ETZ). These systems were characterized and tested for their efficiency in delivering HC and HCB to ex vivo skin samples. The results showed that ETZ was the most effective delivery system for both transdermal and dermal drug targeting, but also had a profound effect on the skin barrier with limited restoration. LNC and PNP had significant effects in dermal delivery with minimal transdermal penetration, especially in the case of HCB.
Article
Pharmacology & Pharmacy
Ali M. Nasr, Fayrouz Moftah, Mohammed A. S. Abourehab, Shadeed Gad
Summary: This study successfully formulated valsartan ethosomes for sustained release transdermal gel dosage form. The optimized VLT-ETHs showed nanometric size, negative surface charge, and high drug encapsulation, resulting in enhanced bioavailability. In vivo studies demonstrated sustained release of VLT from the ethosomal gel in rats.
Article
Pharmacology & Pharmacy
Andleeb Nikhat, Nazeer Hasan, Zeenat Iqbal, Prashant Kesharwani, Sushama Talegaonkar
Summary: A lutein-loaded ethosomal gel formulation was developed and optimized using QbD software. The formulation showed good dermal deposition and antioxidant effect, as confirmed by various characterization tests.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Lijuan Ye, Weibin Chen, Yuan Chen, Yuqin Qiu, Jun Yi, Xiaofang Li, Qiuxiao Lin, Bohong Guo
Summary: A hybrid nanocarrier was developed to facilitate transdermal delivery of drugs. The f-MWCNTs-KP-ES preparation showed sustained release effect and faster skin penetration rate compared to commercial gel. Fluorescence microscopy and in vivo pharmacokinetic experiments confirmed the faster and deeper penetration of f-MWCNTs-RB-ES. The overall data demonstrate the promising transdermal drug delivery system of f-MWCNTs composite ethosomes formulation.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Akila Kesavan, U. Chandrasekhar Reddy, Jais Kurian, Kannoth M. Muraleedharan
Summary: In this study, a new derivative with a fluorescent tag was designed and synthesized as a drug delivery system for anticancer drugs. The results showed that the new lipid-based carriers had small particle size, stable formulations, and efficient distribution in the cytosol of cells. The uptake rate was high, and the nanocarriers exhibited good safety profile.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Samruddhi Kulkarni, Bala Prabhakar, Pravin Shende
Summary: Aquasomes are a promising nanocarrier with multiple potential applications in the treatment of diseases such as hemophilia A, cancer, and hepatitis. They can enter target cells by modifying surface chemistry and provide prolonged drug release. With a larger surface area, volume, and mass ratio, aquasomes allow drugs to penetrate cells and exhibit a prolonged drug release profile.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Biochemistry & Molecular Biology
Chengdian He, Xiong He, Yi Zhang, Xiaofeng Han, Yujun Yang, Yong Shen, Teng Wang, Qing Wu, Yukun Yang, Wei Xu, Jin Bai, Zhenyu Wang
Summary: This study presents an ultrasound-controlled monodisperse lipid vesicles (U-CMLVs) hydrogel dressing that combines with ultrasound to form a transdermal drug delivery system (TDDS). Utilizing microfluidic technology, size controllable U-CMLVs with high drug encapsulation efficiency and quantitative encapsulation of ultrasonic response materials are prepared and mixed with hydrogel to create the desired thickness of dressings. The use of high and low frequency ultrasound controls the movement and rupture of U-CMLVs, enabling the drugs to penetrate the epidermis and dermis, achieving deep, controllable, efficient, and safe drug delivery through TDDS.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Yu Li, Fei Xu, Xiang Li, Si-Ying Chen, Lin-Yu Huang, Yao-Yao Bian, Jia Wang, Ye-Ting Shu, Guo-Jun Yan, Jie Dong, Shao-Ping Yin, Wei Gu, Jun Chen
Summary: This study formulated curcumin-loaded ethosomes with different phospholipid compositions and found a significant interaction between unsaturated PC and saturated HPC. The composite phospholipid ethosomes with a PC/HPC ratio of 1:1 showed the best vesicle stability and flexibility, leading to reduced uptake by skin cells and increased transdermal efficiency.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Yousef A. Bin Jardan, Abdul Ahad, Mohammad Raish, Fahad I. Al-Jenoobi
Summary: Sinapic acid (SA) is a bioactive phenolic acid with diverse properties such as anti-inflammatory, antioxidant, anticancer, and antibacterial activities. This study aimed to enhance the water solubility of SA through the formulation of SA-transethosomes and evaluate their efficacy. The optimized formulation showed high entrapment efficacy, appropriate vesicle size, and smooth surface morphology, as well as enhanced antioxidant activity and penetration ability.
Review
Chemistry, Multidisciplinary
Suliman Khan, Anwarul Hasan, Farnoosh Attar, Mohammad Mahdi Nejadi Babadaei, Hojjat Alizadeh Zeinabad, Majid Salehi, Morteza Alizadeh, Mahbub Hassan, Hossein Derakhshankhah, Michael R. Hamblin, Qian Bai, Majid Sharifi, Mojtaba Falahati, Timo L. M. ten Hagen
Summary: Microneedle arrays have attracted attention as cancer detection and treatment platforms, delivering active molecules through the skin and improving patient health. They enable controlled release of multiple drugs, optimizing treatment and preventing drug interactions.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Pharmacology & Pharmacy
Marwa H. Abdallah, Amr S. Abu Lila, Rahamat Unissa, Heba S. Elsewedy, Hanaa A. Elghamry, Mahmoud S. Soliman
Summary: The study focused on designing, optimizing, and evaluating an ethosomal gel containing Brucine for enhanced anti-inflammatory effects. The developed gel showed good physical properties, extended drug release, and significantly higher skin permeation compared to other formulations. In a rat model, the Brucine ethosomal gel demonstrated potent anti-inflammatory activity by reducing paw inflammation after 24 hours.
Article
Chemistry, Medicinal
Ibrahim M. Abdulbaqi, Yusrida Darwis, Reem Abou Assi, Nurzalina Abdul Karim Khan
DRUG DESIGN DEVELOPMENT AND THERAPY
(2018)
Article
Nanoscience & Nanotechnology
Arshad Ali Khan, Ibrahim M. Abdulbaqi, Reem Abou Assi, Vikneswaran Murugaiyah, Yusrida Darwis
NANOSCALE RESEARCH LETTERS
(2018)
Article
Pharmacology & Pharmacy
Arshad Ali Khan, Jahanzeb Mudassir, Safia Akhtar, Vikneswaran Murugaiyah, Yusrida Darwis
Article
Nanoscience & Nanotechnology
Jahanzeb Mudassir, Yusrida Darwis, Suriani Muhamad, Arshad Ali Khan
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2019)
Review
Oncology
S. Aishah A. Razak, Amirah Mohd Gazzali, Faisalina Ahmad Fisol, Ibrahim M. Abdulbaqi, Thaigarajan Parumasivam, Noratiqah Mohtar, Habibah A. Wahab
Summary: Lung cancer, with the highest incidence rate among all types of cancer, presents challenges in treatment. Utilizing nanotechnology to improve drug delivery methods can enhance efficacy and reduce side effects.
Review
Chemistry, Medicinal
Reem Abou Assi, Ibrahim M. Abdulbaqi, Chan Siok Yee
Summary: Research indicates that the next silent epidemic may be linked to chronic liver diseases, specifically metabolic-associated fatty liver disease (MAFLD). Current treatment options for MAFLD focus on lifestyle improvements and pharmacotherapy, while surgery is ineffective without managing the disease's comorbidities. Nanotechnology is seen as an emerging approach in addressing MAFLD, with nanoformulations aimed at improving drug safety, stability, and liver-targeting properties.
Article
Environmental Sciences
Reem Abou Assi, Theam Foo Ng, Jing Rui Tang, Mohd Sayuti Hassan, Siok Yee Chan
Summary: This study highlights significant differences in knowledge, behavior, and opinion between laboratory users of distilled and non-distilled water. Laboratory users scored higher in all four variables.
Review
Chemistry, Medicinal
Ibrahim M. Abdulbaqi, Reem Abou Assi, Anan Yaghmur, Yusrida Darwis, Noratiqah Mohtar, Thaigarajan Parumasivam, Fadi G. Saqallah, Habibah A. Wahab
Summary: Lung cancer is a leading cause of cancer-related deaths, and systemic therapeutics have limitations due to adverse effects. Pulmonary delivery of anticancer drugs offers advantages, but faces physiological barriers and technological challenges that lipid-based nanocarriers may help to overcome.
Article
Multidisciplinary Sciences
Ibrahim M. M. Abdulbaqi, Yusrida Darwis, Siok-Yee Chan, Nasir Hayat Khan, Nafiu Aminu
Summary: This study aimed to develop a simple, rapid, stability-indicating HPLC-UV method for the quantitative determination of anthocyanin in H.S. plant extract and nutraceutical products.
Review
Pharmacology & Pharmacy
Siew Mei Tan, Xin Yi Teoh, Jia Le Hwang, Zhao Peng Khong, Rana Sejare, Abdulsalam Q. Almashhadani, Reem Abou Assi, Siok Yee Chan
Summary: Electrospinning is a versatile technique for generating fibrous structures with potential applications in tissue engineering, wound dressings, and controlled drug delivery. However, there are limited pharmaceutical products manufactured using this technique, possibly due to the inherent instability of solid dispersion and the gap between lab-scale and industrial-scale production.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Reem Abou Assi, Ibrahim M. Abdulbaqi, Toh Seok Ming, Chan Siok Yee, Habibah A. Wahab, Shaik Mohammed Asif, Yusrida Darwis