Article
Oncology
Roberta Giordo, Zena Wehbe, Panagiotis Paliogiannis, Ali H. Eid, Arduino A. Mangoni, Gianfranco Pintus
Summary: Tumor growth and progression are dependent on adequate blood supply. Tumor cells drive the formation of new blood vessels through the release of pro-angiogenic molecules. The processes involved in tumor angiogenesis are similar to normal vascular development, but with less control mechanisms. Targeting tumor blood vessels has been a focus of research, and nanomedicine offers advantages in specific drug delivery. This review comprehensively assesses key modulators of tumor vascular biology, promising nano-strategies, and future directions.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Nele Warmke, Fiona Platt, Alexander F. Bruns, Claire H. Ozber, Natalie J. Haywood, Yilizila Abudushalamu, Charles Slater, Victoria Palin, Piruthivi Sukumar, Stephen B. Wheatcroft, Nadira Y. Yuldasheva, Mark T. Kearney, Kathryn J. Griffin, Richard M. Cubbon
Summary: In this study, pericyte insulin signaling was found to promote angiopoietin-1 secretion and endothelial Tie2 signaling. Disruption of this pathway led to excessive vascular sprouting and venous plexus abnormalities, mimicking diabetic retinopathy characteristics. Future research should focus on evaluating the role of pericyte insulin signaling in this disease.
Article
Endocrinology & Metabolism
Nele Warmke, Fiona Platt, Alexander F. Bruns, Claire H. Ozber, Natalie J. Haywood, Yilizila Abudushalamu, Charles Slater, Victoria Palin, Piruthivi Sukumar, Stephen B. Wheatcroft, Nadira Y. Yuldasheva, Mark T. Kearney, Kathryn J. Griffin, Richard M. Cubbon
Summary: Pericytes play a crucial role in regulating vascular development and stability, with dysfunction potentially contributing to diabetic retinopathy. Knockout of insulin receptors in pericytes resulted in abnormal vascular development, indicating the importance of insulin signaling in promoting angiopoietin-1 secretion and endothelial Tie2 signaling.
Article
Pharmacology & Pharmacy
Valeria Mastrullo, Daan R. van der Veen, Priyanka Gupta, Rolando S. Matos, Jonathan D. Johnston, John H. McVey, Paolo Madeddu, Eirini G. Velliou, Paola Campagnolo
Summary: Pericytes play a critical role in regulating circadian rhythms in endothelial cells and silencing this system disproportionately affects their pro-angiogenic function. Considering the effect of circadian rhythms is important for the development of mature vascular structures and to obtain the maximal reparative effect in tissue engineering and regenerative medicine.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell & Tissue Engineering
Elana M. Meijer, Christian G. M. van Dijk, Rafael Kramann, Marianne C. Verhaar, Caroline Cheng
Summary: Graft (pre)vascularization is crucial for the survival and integration of complex large-sized tissue-engineered organ constructs, ensuring medium or blood supply by mimicking the morphology and functionality of the microcapillary bed. Pericytes play a crucial role in microvascular function, blood vessel stability, and maintenance of specific functions in different organs, making them the preferred cell type for application in TE grafts. Utilizing tissue-specific pericytes that match the TE organ may benefit organ function.
TISSUE ENGINEERING PART B-REVIEWS
(2022)
Article
Biochemical Research Methods
Lili Zhang, Yuanyuan Han, Qixin Chen, Waruna Lakmal Dissanayaka
Summary: The study elucidates the important role of Sema4D-plexin-B1 signaling in the interaction between endothelial cells and SHED, facilitating the recruitment of SHED as mural cells.
Review
Anatomy & Morphology
Roya Fattahi, Fariba Mohebichamkhorami, Mohammad Mehdi Khani, Masoud Soleimani, Simzar Hosseinzadeh
Summary: This paper discusses the self-regeneration and repair of bone tissue under the right physiological conditions, and recommends using tissue engineering to treat bone defects. Aspirin, a non-steroidal anti-inflammatory drug, not only has anticoagulant effects but also promotes bone regeneration and angiogenesis.
Review
Chemistry, Multidisciplinary
Amir Mohammad Maadani, Erfan Salahinejad
Summary: Bioceramics, particularly calcium phosphates, bioactive glasses, and crystalline silicates, are widely used biomaterials for tissue regeneration and therapeutic delivery. Polymeric coatings, such as polylactic acid (PLA) and poly(lactic-co-glycolic acid) (PLGA), have been extensively researched for enhancing the properties of ceramic tissue engineering scaffolds. Both PLA and PLGA can improve the mechanical behaviors of the scaffolds, but PLA has a greater influence on their biodegradability, bioactivity, and delivery kinetics. However, the biocompatibility response to this surface treatment is dependent on the specific conditions and needs further experimentation for accurate determination.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Multidisciplinary
Kathleen Cullion, Laura C. Petishnok, Hyunji Koo, Brendan Harty, Juan M. Melero-Martin, Daniel S. Kohane
Summary: Targeted nanoparticle drug delivery systems have the potential to enhance drug accumulation within bioengineered human vascular networks, demonstrating significantly increased drug levels compared to off-target sites without targeting. This approach has the potential to greatly improve drug delivery to vascular anomalies.
Review
Cell Biology
Yoshimichi Sato, Jaime Falcone-Juengert, Teiji Tominaga, Hua Su, Jialing Liu
Summary: The neurovascular unit (NVU) depicts the relationship between brain cells and the vascular structure, regulating cerebral blood flow and maintaining brain homeostasis. Dysregulation of the NVU is a key pathological feature underlying neurological disorders. Understanding NVU dysfunction and remodeling is crucial for targeted therapy design and relevant research progress.
Review
Materials Science, Multidisciplinary
Jung-Hwan Lee, Prakash Parthiban, Guang-Zhen Jin, Jonathan C. Knowles, Hae-Won Kim
Summary: This article discusses the importance of proangiogenic efforts in tissue repair and regeneration, focusing on the pivotal roles of engineered matrices in stimulating angiogenesis processes. The design and tuning of matrices for the proper presentation of growth factors and the sustained release of angiogenic molecules are crucial for tissue repair therapies.
PROGRESS IN MATERIALS SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Sebastian Blatt, Daniel G. E. Thiem, Andreas Pabst, Bilal Al-Nawas, Peer W. Kaemmerer
Summary: The combination of bone substitute materials (BSMs) with platelet-rich fibrin (PRF) showed significant positive pro-angiogenic effects, particularly with alloplastic and xenogeneic materials, leading to increased vessel formation in vivo. This demonstrates the enhanced angiogenetic potential of BSMs when combined with PRF, suggesting potential for bony regeneration in clinical applications.
Article
Cell Biology
Michael R. Williamson, Cathleen Joy A. Fuertes, Andrew K. Dunn, Michael R. Drew, Theresa A. Jones
Summary: This study demonstrates that reactive astrocytes play a crucial role in vascular repair and remodeling after ischemic stroke in mice, by activating transcriptional programs related to vascular remodeling. Ablation of reactive astrocytes significantly impairs vascular and extracellular matrix remodeling, leading to prolonged blood flow deficits, exacerbated vascular permeability, ongoing cell death, and worsened motor recovery. These findings highlight the critical role of reactive astrocytes as cellular mediators of vascular remodeling during neural repair.
Article
Cardiac & Cardiovascular Systems
William Cathery, Ashton Faulkner, Eva Jover, Iker Rodriguez-Arabaolaza, Anita C. Thomas, Elisa Avolio, Massimo Caputo, Paolo Madeddu
Summary: The study demonstrates that pericytes isolated from umbilical cords of newborns can be used in vascular engineering, and these cells can improve the elasticity and rupture strain of grafts when cultured under dynamic flow conditions.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Engineering, Biomedical
Pengzhen Cheng, Tianqing Cao, Xueyi Zhao, Weiguang Lu, Sheng Miao, Fenru Ning, Dong Wang, Yi Gao, Long Wang, Guoxian Pei, Liu Yang
Summary: This study identifies the intracellular binding target of EV-NID1 and further elucidates a novel approach and mechanism, thereby providing a cell-free construction strategy with precise targets for the development of vascularized tissue engineering products.
BIOACTIVE MATERIALS
(2022)
