Article
Medicine, General & Internal
Jeremy M. Jacobs, Lea Baider, Gil Goldzweig, Eli Sapir, Yakir Rottenberg
Summary: Late life depression is a significant barrier to long-term healthy aging. Current treatment methods have a low success rate, and a wider perspective that includes frailty, resilience, intrinsic capacity, and social determinants is suggested for a better understanding and treatment of depression in older people.
FRONTIERS IN MEDICINE
(2023)
Article
Multidisciplinary Sciences
Lauren L. Schmitz, Valentina Duque
Summary: Research on maternal-fetal epigenetic programming suggests that adverse exposures in the womb can have long-term effects on adult health. However, causal research on epigenetic programming in humans is rare and often unable to distinguish between intrauterine effects and postnatal conditions. In this study, a quasi-natural experiment was conducted using economic shocks during the Great Depression to examine the impact of early life environmental exposures on aging-related epigenetic changes in later life. The findings indicate that exposure to economic conditions in the 1930s had lasting effects on epigenetic aging, specifically during the intrauterine period.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Behavioral Sciences
Ana Paula Mendes-Silva, Erica Leandro Marciano Vieira, Gabriela Xavier, Lucelia Scarabeli Silva Barroso, Laiss Bertola, Efrem Augusto Ribeiro Martins, Elisa Macedo Brietzke, Sintia Iole Nogueira Belangero, Breno Satler Diniz
Summary: The study found that older adults with late-life depression have shorter telomeres compared to healthy controls, especially those with more severe depressive symptoms. There was a negative correlation between telomere length and the severity of depressive symptoms and medical burden, but no significant correlation with cognitive performance.
BRAIN AND BEHAVIOR
(2021)
Article
Geriatrics & Gerontology
David Bickford, Ruth T. Morin, Cara Woodworth, Elizabeth Verduzco, Maryam Khan, Emily Burns, J. Craig Nelson, R. Scott Mackin
Summary: The study revealed that in Late Life Depression (LLD), frailty and functional disability are significantly associated with higher levels of suicidal ideation, independent of depression symptom severity.
AGING & MENTAL HEALTH
(2021)
Article
Geriatrics & Gerontology
Kitty J. E. Kokkeler, Richard C. Oude Voshaar, Didi Rhebergen, Rob H. S. van den Brink, Jan Spijker, Radboud M. Marijnissen
Summary: Frailty is more pronounced in late-life depression with more severe immuno-metabolic dysregulation. However, the trajectories of frailty measures over time do not differ significantly between subgroups, suggesting that the differences may have originated in midlife. Future studies should consider the relevance of geriatric assessment at earlier ages in specialized mental health care.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2022)
Article
Medicine, General & Internal
Ivet Bayes Marin, Daniel Fernandez, Jose Luis Ayuso-Mateos, Matilde Leonardi, Beata Tobiasz-Adamczyk, Seppo Koskinen, Albert Sanchez-Niubo, Paula Cristobal-Narvaez
Summary: This study examined the differences between older migrants and non-migrants in terms of socioeconomic status, depression, multimorbidity, healthy aging, and lifestyle behaviors. The results showed that migrants had a higher prevalence of health conditions and depression, and worse healthy aging was associated with a higher risk of depressive symptoms in migrants.
FRONTIERS IN MEDICINE
(2022)
Article
Geriatrics & Gerontology
Astrid Lugtenburg, Marij Zuidersma, Klaas J. Wardenaar, Ivan Aprahamian, Didi Rhebergen, Robert A. Schoevers, Richard C. Oude Voshaar
Summary: This study aimed to identify late-life-related subtypes of depression based on measures of depressive symptom dimensions, cognitive performance, and physical frailty. The results showed that patients could be subtyped by specific combinations of age-related clinical features, which may have prospective relevance. Subtyping according to cognitive profile and physical frailty could be relevant for treatment studies on the effectiveness of antidepressants, psychotherapy, and geriatric rehabilitation.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Geriatrics & Gerontology
Emma Mastrobattista, Eric J. Lenze, Charles F. Reynolds, Benoit H. Mulsant, Julie Wetherell, Gregory F. Wu, Daniel M. Blumberger, Jordan F. Karp, Meryl A. Butters, Ana Paula Mendes-Silva, Erica L. Vieira, George Tseng, Breno S. Diniz
Summary: This study assessed the levels of GDF-15 in 393 older adults, including 308 with major depressive disorder (MDD) and 85 non-depressed individuals. The results showed that older adults with MDD had significantly higher levels of GDF-15, which were associated with physical comorbidity burden, cognitive decline, and late-onset depression.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Geriatrics & Gerontology
Ina S. Almdahl, Ingrid Agartz, Kenneth Hugdahl, Maria S. Korsnes
Summary: Understanding the biological changes that occur prior to onset of late-life depression (LLD) is key to its prevention. This study investigated predictors of LLD and found that baseline cortical amyloid burden, cerebrospinal fluid (CSF) amyloid beta levels, and white matter hyperintensity volume (WMH) were significant predictors of incident depression. Cognitive scores declined in the incident depression group compared to the never-depressed group, and hippocampal volume was reduced following depression.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Article
Cell Biology
Fangyu Liu, Thomas R. Austin, Jennifer A. Schrack, Jingsha Chen, Jeremy Walston, Rasika A. Mathias, Morgan Grams, Michelle C. Odden, Anne Newman, Bruce M. Psaty, Diego Ramonfaur, Amil M. Shah, B. Gwen Windham, Josef Coresh, Keenan A. Walker
Summary: Proteomic approaches have unique advantages in identifying biological pathways influencing physical frailty. By studying plasma proteins, this research discovered proteins associated with prefrailty, frailty, and incident frailty. The findings provide insights into frailty etiology and intervention targets.
Article
Public, Environmental & Occupational Health
Anna Rajtar-Zembaty, Jakub Rajtar-Zembaty, Katarzyna Olszewska, Roksana Epa, Adrian Andrzej Chrobak, Barbara Starowicz-Filip, Anna Betkowska-Korpala
Summary: This study aimed to evaluate cognitive functions in late-life depression (LLD) patients and investigate their relationship with depressive symptoms. The results revealed that executive functions were the most impaired in LLD patients, and there was a correlation between executive dysfunction and the severity of depression in LLD.
PSYCHOLOGY HEALTH & MEDICINE
(2022)
Review
Psychology, Multidisciplinary
Nancy A. Pachana, Roy F. Baumeister
Summary: The quest for meaning in life takes new challenges and directions during late life, with key themes such as limited remaining time, concern with legacy, self-continuity and integration, challenges to self-worth, and prioritization of positivity emerging as important factors.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Psychology, Clinical
Jo Anne Sirey, Nili Solomonov, Arielle Guillod, Paula Zanotti, Jihui Lee, Mohamed Soliman, George S. Alexopoulos
Summary: The study found that the PROTECT psychotherapy for depression among elder abuse victims is feasible, acceptable, and effective. Most victims reported experiencing two or more types of abuse. The PROTECT therapy group showed greater reduction in depression severity compared to the Usual Care group, while both groups had similar improvements in quality of life.
INTERNATIONAL PSYCHOGERIATRICS
(2021)
Article
Geriatrics & Gerontology
Maria Chiara Fastame
Summary: This study found that life satisfaction in late adulthood is influenced by factors such as satisfaction with family ties, perceived physical health, negative mood, and education. Perceived emotional connection with family members and a physically active lifestyle are the most significant protective factors in boosting life satisfaction in late adulthood.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Clinical Neurology
Melis Orhan, Sigfried Schouws, Patricia van Oppen, Max Stek, Paul Naarding, Didi Rhebergen, Annemieke Dols, Nicole Korten
Summary: This study found that both older age bipolar disorder (OABD) and late life depression (LLD) are associated with cognitive dysfunction. OABD patients showed more severe cognitive dysfunction compared to LLD patients, regardless of the severity of depressive symptoms. These findings suggest that other disease characteristics may contribute to the differences in cognitive functioning between OABD and LLD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Anna Butjosa, Judith Usall, Regina Vila-Badia, Gisela Mezquida, Manuel J. Cuesta, Elisa Rodriguez-Toscano, Silvia Amoretti, Antonio Lobo, Ana Gonzalez-Pinto, Ana Espliego, Iluminada Corripio, Eduard Vieta, Inmaculada Baeza, Dani Berge, Miguel Bernardo
Summary: This study explored traumatic life events (TLEs) in first-episode psychosis (FEP) patients and healthy controls (HC), finding that FEP patients had a higher number of TLEs and a significantly higher proportion of individuals with multiple TLEs. There were no gender or age differences observed. Overall, the number and cumulative TLEs should be taken into account in the detection, epidemiology, and recovery processes of FEP.
INTERNATIONAL JOURNAL OF SOCIAL PSYCHIATRY
(2023)
Article
Psychology, Clinical
Ana Catalan, Claudia Aymerich, Amaia Bilbao, Borja Pedruzo, Jose Luis Perez, Nerea Aranguren, Gonzalo Salazar de Pablo, Emily Hedges, Patxi Gil, Rafael Segarra, Ana Gonzalez-Pinto, Aranzazu Fernandez-Rivas, Lucia Inchausti, Philip McGuire, Paolo Fusar-Poli, Miguel Angel Gonzalez-Torres
Summary: COVID-19-related mortality and hospitalization rates were higher for patients with pre-existing psychotic disorders, while patients with affective disorders had lower rates.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Alex G. Segura, Gisela Mezquida, Albert Martinez-Pinteno, Patricia Gasso, Natalia Rodriguez, Lucia Moreno-Izco, Silvia Amoretti, Miquel Bioque, Antonio Lobo, Ana Gonzalez-Pinto, Alicia Garcia-Alcon, Alexandra Roldan-Bejarano, Eduard Vieta, Elena de la Serna, Alba Toll, Manuel J. Cuesta, Sergi Mas, Miquel Bernardo
Summary: Early intervention is crucial for preventing the progression of psychotic disorders. This study found that genetic susceptibility related to cognitive performance is associated with an increased risk of first-episode psychosis (FEP) and its clinical and cognitive progression. Additionally, genetic susceptibility for depression is associated with a worsening trajectory of executive function and general cognitive status.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Immunology
Naiara Parraza-Diez, Cristina Bermudez-Ampudia, Raquel Cobos-Campos, Ines Garmendia, Estibalitz Orruno, Elena Ojeda, Ignacio Garitano, Maria Robledo, Jose Joaquin Portu, Antxon Apinaniz
Summary: This study analyzed the willingness, knowledge, and risk perception of patients and healthcare workers (HCWs) to get the vaccines against SARS-CoV-2. The results showed that the majority of patients and HCWs had a positive attitude towards vaccination, and HCWs had better knowledge and risk perception of COVID-19 compared to the surveyed patients. However, some HCWs expressed hesitancy towards the effectiveness of the new vaccines and the scientific evidence.
Article
Critical Care Medicine
S. Iribarren-Diarasarri, C. Bermudez-Ampudia, R. Barreira-Mendez, A. Vallejo-Delacueva, I. Bediaga-Diazdecerio, S. Martinez-Alutiz, L. Ruilope-Alvaro, C. Vinuesa-Lozano, N. Aretxabala-Cortajarena, A. San Sebastian-Hurtado, M. Martin-Martinez, I Arce-Gomez
Summary: The incidence of post-intensive care syndrome is high in COVID-19 patients who have been admitted to the critical care units. Delirium and the need for tracheostomy are associated with the occurrence of post-intensive care syndrome.
MEDICINA INTENSIVA
(2023)
Article
Clinical Neurology
Daniel J. Tozer, Robin B. Brown, Jessica Walsh, Young T. Hong, Guy B. Williams, John T. O'Brien, Franklin I. Aigbirhio, Tim D. Fryer, Hugh S. Markus
Summary: Recent studies have found evidence of increased microglial activation, indicating inflammation, in cerebral small vessel disease. However, it is unclear whether these areas of neuroinflammation progress to tissue damage. This study showed that white matter destined to become white matter hyperintensities already exhibited signs of altered inflammation at baseline.
Article
Psychology, Clinical
Monica Martinez-Cengotitabengoa, Cassie L. Jackson, Eleanor J. Pugh, Daniel Long-Martinez, Andoni Sanchez-Martinez, Monike Sanchez-Martinez, Cristina Bermudez-Ampudia, Maria-Teresa Martinez-Cengotitabengoa
Summary: This study found that children with FASD who have sentinel facial features have poorer cognitive outcomes and lower IQ scores. In children without sentinel facial features, stronger executive functioning is related to significantly stronger conceptual, social, and practical adaptive behaviors.
AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE
(2023)
Letter
Psychiatry
Maria Irigoyen-Otinano, Carla Albert-Porcar, Cecilia Borras, Margarita Puigdevall-Ruestes, Ana Gonzalez-Pinto
EUROPEAN JOURNAL OF PSYCHIATRY
(2023)
Letter
Pharmacology & Pharmacy
Raquel Cobos-Campos, Arantza Saez de Lafuente-Morinigo, Jose Aurelio Cordero-Guevara, Cristina Bermudez-Ampudia, Antxon Apinaniz, Julene Argaluza, Naiara Parraza
AMERICAN JOURNAL OF THERAPEUTICS
(2023)
Article
Geriatrics & Gerontology
Anne D. Kershenbaum, Annabel C. Price, Rudolf N. Cardinal, Shanquan Chen, James M. Fitzgerald, Jonathan Lewis, Sinead Moylett, John T. O'Brien
Summary: Previous studies have shown reduced survival in Lewy body dementia (LBD) compared to Alzheimer's disease (AD), but the reasons for this are not known. This study aimed to identify cause of death categories accounting for the reduced survival in LBD. The findings indicated that PDD and DLB patients had higher hazard ratios for death compared to AD patients.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Clinical Neurology
Maria Martzoukou, Anastasia Nousia, Grigorios Nasios
Summary: Previous studies found that commonly used tests for aphasia identification cannot detect the subtle language deficits of LHBD individuals. Similarly, individuals with RHBD often have undetected language disorders due to the lack of specialized tests for evaluating their language processing skills. This study aimed to evaluate the language deficits of 80 stroke survivors with LHBD or RHBD who were initially diagnosed as having no aphasia or language deficits. Results showed that both groups performed significantly worse compared to a healthy control group, highlighting the need for an effective battery of language tests to evaluate and treat patients' language abilities.
APPLIED NEUROPSYCHOLOGY-ADULT
(2023)
Article
Medicine, Research & Experimental
Raquel Cobos-Campos, Jose Aurelio Cordero-Guevara, Antxon Apinaniz, Arantza Saez de Lafuente, Cristina Bermudez Ampudia, Julene Argaluza Escudero, Iraida Perez Llanos, Naiara Parraza Diez
Summary: Smartphones have become useful tools in medicine, allowing for healthcare to be brought to inaccessible areas and improving patients' quality of life. However, the quality and effectiveness of health apps need to be assessed to provide valuable tools.
INTERACTIVE JOURNAL OF MEDICAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Leonidas Chouliaras, John T. O'Brien
Summary: Dementia is a major cause of disability and death worldwide, with no disease modifying treatment available for common types such as Alzheimer's disease, Vascular dementia, Lewy Body Dementia, and Frontotemporal dementia. Early and accurate diagnosis of dementia subtype is crucial for improving clinical care and developing better treatments. Structural and molecular imaging methods, particularly multimodal magnetic resonance imaging (MRI) and positron emission tomography imaging (PET), have provided insight into the pathophysiology of neurodegenerative dementias and are increasingly being used for early and accurate diagnosis. However, there are still gaps in imaging tracers for certain protein abnormalities, and more extensive diagnostic imaging studies are needed.
MOLECULAR PSYCHIATRY
(2023)
Article
Clinical Neurology
Laura M. Wright, Paul C. Donaghy, David J. Burn, John -Paul Taylor, John T. O'Brien, Alison J. Yarnall, Fiona E. Matthews, Michael J. Firbank, Alan J. Thomas, Rachael A. Lawson
Summary: There is a limited longitudinal relationship between neuropsychiatric symptoms (NPS) and cognitive decline in prodromal Lewy body dementias (LBD). Core neuropsychiatric symptoms are not strongly associated with cognition, suggesting different underlying neuropathological mechanisms.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Weijie Huang, Jianmin Zeng, Lina Jia, Dajiang Zhu, John O'Brien, Craig Ritchie, Ni Shu, Li Su
Summary: Genetic risk factors such as APOE ε4 and MAPT A allele are associated with changes in amyloid and tau pathways and cortical morphology in young healthy adults. Machine learning models showed that using all cortical features could accurately classify individuals with genetic risks of dementia. APOE ε4 carriers exhibited a more convoluted and thinner cortex across the cerebral cortex, while MAPT A allele carriers showed similar patterns in regions vulnerable to early tau pathology. There was a synergetic effect between APOE ε4 and MAPT A allele, with carriers of both risk factors showing the most deviation from the typical cortical pattern.
BRAIN COMMUNICATIONS
(2023)
