Article
Biochemistry & Molecular Biology
Souheyla Benfrid, Kyu-Ho Park, Mariano Dellarole, James E. Voss, Carole Tamietti, Gerard Pehau-Arnaudet, Bertrand Raynal, Sebastien Brule, Patrick England, Xiaokang Zhang, Anastassia Mikhailova, Milena Hasan, Marie-Noelle Ungeheuer, Stephane Petres, Scott B. Biering, Eva Harris, Anavaj Sakuntabhai, Philippe Buchy, Veasna Duong, Philippe Dussart, Fasseli Coulibaly, Francois Bontems, Felix A. Rey, Marie Flamand
Summary: The NS1 protein of the dengue virus forms a high-affinity complex with human high-density lipoproteins (HDL), leading to inflammation and accumulation in plasma of dengue patients.
Review
Biochemistry & Molecular Biology
Zihang Liu, Panpan Deng, Shengnan Liu, Yiying Bian, Yuanyuan Xu, Qiang Zhang, Huihui Wang, Jingbo Pi
Summary: Cytokine storm refers to a state of the immune system characterized by excessive release of cytokines, leading to inflammation, organ failure, and disease outcomes. NRF2, a transcription factor involved in cellular redox homeostasis, has emerged as a potential therapeutic target in preventing and treating cytokine storms. This review summarizes the causes of cytokine storms and the rationale for targeting NRF2 as a therapeutic intervention.
Review
Pharmacology & Pharmacy
Xue-Ling Wang, Michael Schnoor, Lei-Miao Yin
Summary: MT-2 was initially discovered to be involved in zinc homeostasis and cadmium detoxification, but it has recently gained attention for its altered expression in diseases such as asthma and cancers. Pharmacological strategies have been developed to target MT-2, indicating its potential as a drug target for various diseases. This review highlights recent advances in understanding the protein structure, regulation, binding partners, and new functions of MT-2 in inflammatory diseases and cancers.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Pharmacology & Pharmacy
Shengqiang Li, Zhen Lei, Meng Zhao, Yonghao Hou, Di Wang, Xingli Xu, Xiaowen Lin, Jingxin Li, Shuhai Tang, Jingui Yu, Tao Meng
Summary: Propofol can reduce myocardial I/R injury by activating PKC/NRF2 pathway, leading to increased antioxidant enzyme expression and decreased levels of lactate dehydrogenase and creatine kinase-MB.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Jianhua Rao, Jiannan Qiu, Ming Ni, Hao Wang, Peng Wang, Lei Zhang, Zeng Wang, Mu Liu, Feng Cheng, Xuehao Wang, Ling Lu
Summary: The study revealed the crucial role of macrophage Nrf2 in liver ischemia/reperfusion injury, attenuating inflammation by binding to Timp3 and inhibiting the RhoA/ROCK pathway, providing a potential therapeutic target for organ ischemia/reperfusion injury.
Article
Medicine, Research & Experimental
Justin Fortune Creeden, Ali Sajid Imami, Hunter M. Eby, Cassidy Gillman, Kathryn N. Becker, Jim Reigle, Elissar Andari, Zhixing K. Pan, Sinead M. O'Donovan, Robert E. McCullumsmith, Cheryl B. McCullumsmith
Summary: The study suggests that the antidepressant fluoxetine may act as a potential therapy for hyperinflammatory states such as asthma, sepsis, and COVID-19 by targeting IL6ST and NF-kappaB Subunit 1 (NFKB1).
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Gastroenterology & Hepatology
Dan-Dan Zhu, Xue-Mei Tan, Li-Qing Lu, Si-Jia Yu, Ru-Li Jian, Xin-Fang Liang, Yi-Xuan Liao, Wei Fan, Luciia Barbier-Torres, Austin Yang, He-Ping Yang, Ting Liu
Summary: COVID-19 caused by SARS-CoV-2 is a global pandemic that not only affects respiratory system but also leads to systemic inflammation and liver damage. NRF2 plays a crucial role in regulating antioxidant proteins in the context of COVID-19-induced inflammation and liver injury.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Immunology
Heike C. Hawerkamp, Adam H. Dyer, Neha D. Patil, Matt McElheron, Niamh O'Dowd, Laura O'Doherty, Aisling Ui Mhaonaigh, Angel M. George, Aisling M. O'Halloran, Conor Reddy, Rose Anne Kenny, Mark A. Little, Ignacio Martin-Loeches, Colm Bergin, Sean P. Kennelly, Seamas C. Donnelly, Nollaig M. Bourke, Aideen Long, Jacklyn Sui, Derek G. Doherty, Niall Conlon, Cliona Ni Cheallaigh, Padraic G. Fallon
Summary: Clinical outcomes of SARS-CoV-2 infection show a wide range, from asymptomatic cases to severe pneumonia and death. This variability is influenced by differences in the immune response to the virus. A study measured inflammatory markers in patients with acute COVID-19 and found that most pro-inflammatory markers were significantly elevated, and specific markers were associated with disease severity.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Virology
Muhammad Suhaib Qudus, Mingfu Tian, Summan Sirajuddin, Siyu Liu, Uzair Afaq, Muneeba Wali, Jinbiao Liu, Pan Pan, Zhen Luo, Qiwei Zhang, Ge Yang, Pin Wan, Yongkui Li, Jianguo Wu
Summary: In severe cases of COVID-19, a cytokine storm, characterized by excessive release of pro-inflammatory cytokines, can lead to acute respiratory distress syndrome (ARDS), multiple organ dysfunction syndrome (MODS), and even death. Key pro-inflammatory cytokines such as interleukin-1 (IL-1), IL-2, IL-6, tumor necrosis factor-alpha, interferon (IFN)-gamma, and IL-10 have been found in severe COVID-19, and they play a role in amplifying pro-inflammatory responses through complex inflammatory networks. Understanding the involvement of these cytokines in SARS-CoV-2 infection and their role in triggering or regulating cytokine storm can provide insight into the pathogenesis of severe COVID-19. Currently, there are limited effective therapeutic strategies for cytokine storm, with glucocorticoids being used but also causing fatal side effects. Identifying key cytokines and developing targeted interventions, such as neutralizing antibodies or inhibitors of inflammatory signal pathways, may help improve treatment options.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hong-Yi Zheng, Xiao-Yan He, Wei Li, Tian-Zhang Song, Jian-Bao Han, Xiang Yang, Feng-Liang Liu, Rong-Hua Luo, Ren-Rong Tian, Xiao-Li Feng, Yu-Hua Ma, Chao Liu, Ming-Hua Li, Yong-Tang Zheng
Summary: The study revealed that in old rhesus macaques, SARS-CoV-2 infection induced elevated levels of apoptosis, autophagy, NF-kappa B activation, and increased IFN-α and IL-6-secreting cells in lung tissue. This pathological pattern, possibly related to an age-related pro-inflammatory microenvironment in lungs and spleens, was significantly correlated with the systemic accumulation of CXCR3+ cells in lungs, spleens, and peripheral blood.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Plant Sciences
Isadora de Fatima Braga Magalhaes, Ana Leticia Marinho Figueiredo, Elizeu Mendes da Silva, Adryan Adam Batalha de Miranda, Claudia Quintino da Rocha, Katia da Silva Calabrese, Fernando Almeida-Souza, Ana Lucia Abreu-Silva
Summary: A study focuses on the anti-inflammatory potential of Passovia ovata extract, which contains high levels of flavonoids. The results demonstrate significant reduction in inflammatory markers both in cell experiments and animal models. This study indicates the potential of Passovia ovata extract as a new agent for suppressing inflammatory responses.
Article
Biochemistry & Molecular Biology
Aakanksha Jha, Joseph Larkin III, Erika Moore
Summary: This study introduces a PEGDA hydrogel platform to investigate the utilization of SOCS1-KIR as a macrophage phenotype manipulating peptide. Results from immunocytochemistry, cytokine secretion assays, and gene expression analysis demonstrate a reduction in M1 activation due to SOCS1-KIR treatment. The retention of SOCS1-KIR in the hydrogel and the unaffected swelling ratio of the hydrogel are also demonstrated.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Critical Care Medicine
Taylor E. Wallen, Matthew R. Baucom, Lisa G. England, Rebecca M. Schuster, Timothy A. Pritts, Michael D. Goodman
Summary: The study found that whole blood resuscitation can reduce the acute postinjury neuroinflammatory response after combined TBI/shock compared with HTS. The addition of either propranolol or TXA may modulate the postinjury systemic and cerebral inflammatory response with more improvements noted after propranolol administration. Multimodal treatment with resuscitation and pharmacologic therapy after TBI and hemorrhagic shock may mitigate the inflammatory response to these injuries to improve recovery.
Article
Immunology
Tom Houben, Tulasi Yadati, Robbin de Kruijf, Marion J. J. Gijbels, Joost J. F. P. Luiken, Marc van Zandvoort, Dimitris Kapsokalyvas, Dieter Luetjohann, Marit Westerterp, Jogchum Plat, David Leake, Ronit Shiri-Sverdlov
Summary: 2-hydroxypropyl-beta-cyclodextrin is considered a novel pharmacological compound with the potential to decrease cellular cholesterol levels, but recent studies have shown that its use may lead to inflammatory responses, which are dependent on exposure time.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Xiuhua Yang, Yingying Tian, Linlin Zheng, Thanh Luu, Joanne Kwak-Kim
Summary: Recurrent pregnancy losses (RPL) is a common reproductive disorder with various underlying etiologies. Recent research has shown that the immune response, particularly the imbalance of cytokines in the maternal-fetal interface, plays a crucial role in RPL. The increased NK1/NK2 ratio in decidual NK (dNK) cells of RPL patients contributes to a pro-inflammatory cytokine milieu and increased NK cell cytotoxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Peng-jie Yang, Wei-xin Yuan, Jia Liu, Jin-ying Li, Bing Tan, Chen Qiu, Xiao-long Zhu, Cong Qiu, Dong-mei Lai, Li-he Guo, Lu-yang Yu
ACTA PHARMACOLOGICA SINICA
(2018)
Article
Environmental Sciences
Jing Liu, Xiaoqing Ye, Dapeng Ji, Xiaofei Zhou, Cong Qiu, Weiping Liu, Luyang Yu
ENVIRONMENTAL POLLUTION
(2018)
Article
Physiology
Jiqin Zhang, Chaofei Chen, Li Li, Huanjiao J. Zhou, Fenghe Li, Haifeng Zhang, Luyang Yu, Yuxin Chen, Wang Min
FRONTIERS IN PHYSIOLOGY
(2018)
Article
Cell & Tissue Engineering
Jinying Li, Chen Qiu, Zheng Zhang, Weixin Yuan, Zhen Ge, Bing Tan, Pengjie Yang, Jia Liu, Xiaolong Zhu, Cong Qiu, Dongmei Lai, Lihe Guo, Luyang Yu
CELL TRANSPLANTATION
(2018)
Article
Cell & Tissue Engineering
Bing Tan, Weixin Yuan, Jinying Li, Pengjie Yang, Zhen Ge, Jia Liu, Chen Qiu, Xiaolong Zhu, Cong Qiu, Dongmei Lai, Lihe Guo, Liang Wang, Luyang Yu
Article
Biochemistry & Molecular Biology
Jie Zhang, Jiaqi Huang, Tongyun Qi, Yizhou Huang, Yuting Lu, Tianwei Zhan, Hui Gong, Zhengyi Zhu, Yueli Shi, Jianhong Zhou, Luyang Yu, Xue Zhang, Hongqiang Cheng, Yuehai Ke
Article
Cell Biology
Wencao Zhao, Le Cao, Hanru Ying, Wenjuan Zhang, Dantong Li, Xiaolong Zhu, Wenzhi Xue, Shuang Wu, Mengye Cao, Cong Fu, Haonan Qi, Yimei Hao, Yun-Chi Tang, Jun Qin, Tao P. Zhong, Xiaoxi Lin, Luyang Yu, Xuri Li, Lin Li, Dianqing Wu, Weijun Pan
Article
Cell Biology
Lu Gong, Qinghe Zhang, Xiao Pan, Shuming Chen, Lina Yang, Bin Liu, Weijun Yang, Luyang Yu, Zhi-Xiong Xiao, Xin-Hua Feng, Haihe Wang, Zhi-Min Yuan, Jinrong Peng, Wei-Qiang Tan, Jun Chen
Review
Biochemistry & Molecular Biology
Chen Qiu, Zhen Ge, Wenyu Cui, Luyang Yu, Jinying Li
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Multidisciplinary Sciences
Xinyi Wan, Filipe Pinto, Luyang Yu, Baojun Wang
NATURE COMMUNICATIONS
(2020)
Article
Biotechnology & Applied Microbiology
Xinyi Wan, Behide Saltepe, Luyang Yu, Baojun Wang
Summary: Synthetic biology has provided new tools and capabilities for engineering cells, especially in the field of microbial sensors. Despite successful proof-of-concept demonstrations in the laboratory, real-world applications are limited by technical and societal constraints, which can be addressed through new technological developments in synthetic biology.
MICROBIAL BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jinying Li, Chen Qiu, Jiayi Zhou, Yang Wei, Weixin Yuan, Jia Liu, Wenyu Cui, Jianan Huang, Cong Qiu, Lihe Guo, Luyang Yu, Zhen Ge
Summary: The study found that human amniotic epithelial stem cells may be a potential source of functional photoreceptor cells and has great potential in the treatment of retinal degeneration diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Chen Qiu, Yuan Sun, Jinying Li, Yuchen Xu, Jiayi Zhou, Cong Qiu, Shaomin Zhang, Yong He, Luyang Yu
Summary: Spinal cord injury leads to loss of motor and sensory function, and current therapies are ineffective. This study demonstrates the potential of inducing human amniotic epithelial cells into neural-like cells and using them in a 3D-printed biomimetic spinal cord scaffold to partially restore neural circuits and locomotion in a rat model of SCI.
BIOENGINEERING-BASEL
(2022)
Article
Cell & Tissue Engineering
Xuechai Bai, Jia Liu, Weixin Yuan, Yang Liu, Wei Li, Siyu Cao, Luyang Yu, Liang Wang
CELL TRANSPLANTATION
(2020)
Article
Pharmacology & Pharmacy
Lin Song, Sha Ding, Zhen Ge, Xiaolong Zhu, Cong Qiu, Yuewen Wang, Enyin Lai, Weijun Yang, Yi Sun, Samson A. Chow, Luyang Yu
BRITISH JOURNAL OF PHARMACOLOGY
(2018)