期刊
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
卷 306, 期 1, 页码 20-28出版社
ELSEVIER GMBH
DOI: 10.1016/j.ijmm.2015.11.001
关键词
Pseudomonas aeruginosa; Lung injury; Inflammation
资金
- Fundaccao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Programa Estrategico de Apoio a Pesquisa em Saude (PAPES) FIOCRUZ
- Programa de Fomento a Pesquisa da Universidade Federal Fluminense (FOPESQ/UFF)
- European Community's Seventh Framework Programme (FP7) [HEALTH-F4-2011-282095]
Pseudomonas aeruginosa is an opportunistic bacterium causing lung injury in immunocompromised patients correlated with high morbidity and mortality. Many bacteria, including P. aeruginosa, use extra-cellular signals to synchronize group behaviors, a process known as quorum sensing (QS). In the P. aeruginosa complex QS system controls expression of over 300 genes, including many involved in host colonization and disease. P. aeruginosa infection elicits a complex immune response due to a large number of immunogenic factors present in the bacteria or released during infection. Here, we focused on the mechanisms by which P. aeruginosa triggers lung injury and inflammation, debating the possible ways that P. aeruginosa evades the host immune system, which leads to immune suppression and resistance. (C) 2015 Elsevier GmbH. All rights reserved.
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