期刊
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
卷 15, 期 6, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dsx.2021.102324
关键词
Vitamin C; Ascorbic acid; L-ascorbate; Coronavirus; COVID 19; COVID penumonia; SARS-CoV-2
Vitamin C supplementation did not show significant benefits in reducing mortality, ICU or hospital length of stay, and need for invasive mechanical ventilation in COVID-19 patients. Sub-group analyses did not reveal any observable advantages. More well-designed RCTs are needed in this aspect.
Background and aims: Vitamin C has been used as an anti-oxidant in various diseases including viral illnesses like coronavirus disease (COVID-19). Methods: Meta-analysis of randomized controlled trials (RCT) investigating the role of vitamin C supplementation in COVID-19 was carried out. Results: Total 6 RCTs including n = 572 patients were included. Vitamin C treatment didn't reduce mortality (RR 0.73, 95% CI 0.42 to 1.27; I-2 = 0%; P = 0.27), ICU length of stay [SMD 0.29, 95% CI -0.05 to 0.63; I-2 = 0%; P = 0.09), hospital length of stay (SMD -0.23, 95% CI -1.04 to 0.58; I-2 = 92%; P = 0.57) and need for invasive mechanical ventilation (Risk Ratio 0.93, 95% CI 0.61 to 1.44; I-2 = 0%; P = 0.76). Further sub-group analysis based on severity of illness (severe vs. non-severe), route of administration (IV vs. oral) and dose (high vs. low) failed to show any observable benefits. Conclusion: No significant benefit noted with vitamin C administration in COVID-19. Well-designed RCTs with standardized control group needed on this aspect. (C) 2021 Diabetes India. Published by Elsevier Ltd. All rights reserved.
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