Review
Medicine, General & Internal
Ruben Aquino-Martinez, Scarlette Hernandez-Vigueras
Summary: Periodontal bacteria dissemination into the lower respiratory tract may increase the risk of severe COVID-19 lung infection in older patients, as bacterial infection can cause permanent damage and senescence in cells, which in turn facilitates SARS-CoV-2 replication.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Jose Miguel Rivera-Caravaca, Ivan J. Nunez-Gil, Gregory Y. H. Lip, Aitor Uribarri, Maria C. Viana-Llamas, Adelina Gonzalez, Alex F. Castro-Mejia, Berta Alonso Gonzalez, Emilio Alfonso, Juan Fortunato Garcia Prieto, Chiara Cavallino, Bernardo Cortese, Gisela Feltes, Inmaculada Fernandez-Rozas, Jaime Signes-Costa, Jia Huang, Marcos Garcia Aguado, Martino Pepe, Rodolfo Romero, Enrico Cerrato, Victor Manuel Becerra-Munoz, Sergio Raposeiras Roubin, Francesco Santoro, Rodrigo Bagur, Luciano Sposato, Ibrahim El-Battrawy, Alvaro Lopez Masjuan, Antonio Fernandez-Ortiz, Vicente Estrada, Carlos Macaya, Francisco Marin
Summary: This study compared the clinical outcomes and short-term prognosis of hospitalized COVID-19 patients with and without prior oral anticoagulation (OAC) therapy. The study found that patients on prior OAC therapy had a higher risk of mortality and worse clinical outcomes compared to those without prior OAC therapy, but there were no differences in outcomes between patients previously taking different types of OAC.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2022)
Article
Medicine, General & Internal
Johannes Rueckel, Nicola Fink, Sophia Kaestle, Theresa Stuber, Vincent Schwarze, Eva Gresser, Boj F. Hoppe, Jan Rudolph, Wolfgang G. Kunz, Jens Ricke, Bastian O. Sabel
Summary: Radiologists showed higher sensitivity and specificity in diagnosing COVID-19 compared to influenza based on CT imaging analysis, indicating the potential of CT for expedited patient management during the upcoming influenza season.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Engineering, Multidisciplinary
Marina Kljakovic-Gaspic Batinjan, Tea Petrovic, Frano Vuckovic, Irzal Hadzibegovic, Barbara Radovani, Ivana Jurin, Lovorka Derek, Eva Huljev, Alemka Markotic, Ivica Luksic, Irena Trbojevic-Akmacic, Gordan Lauc, Ivan Gudelj, Rok Civljak
Summary: This study analyzed and compared the IgG glycosylation characteristics of patients with influenza, COVID-19, and healthy controls. The results showed significant decreases in IgG galactosylation, sialylation, and bisecting GlcNAc in deceased COVID-19 patients, while IgG fucosylation increased. Influenza patients and COVID-19 survivors had stable IgG glycosylation. The similarities in IgG glycosylation changes between COVID-19 survivors and influenza patients may indicate different immune responses to enveloped viruses.
Article
Public, Environmental & Occupational Health
David M. Morens, Jeffery K. Taubenberger, Anthony S. Fauci
Summary: The 1918 influenza pandemic and the 2019-2021 COVID-19 pandemic share similarities in clinical, pathological, and epidemiological features, as well as public health responses and research efforts. Both pandemics had lasting psychosocial effects related to loss and hardship. Reflection on lessons learned from these two deadly pandemics is crucial in addressing the challenges of COVID-19.
AMERICAN JOURNAL OF PUBLIC HEALTH
(2021)
Review
Immunology
Jennifer Summers, Amanda Kvalsvig, Lucy Telfar Barnard, Julie Bennett, Matire Harwood, Nick Wilson, Michael G. Baker
Summary: Exploring the COVID-19 response in New Zealand and comparing it to the 1918-19 influenza pandemic reveals significant improvements in terms of strategic direction, elimination strategy, border restrictions, vaccination rollout, and central government support. However, the lessons from 1918-19 regarding the prevention of inequities among social groups were not fully learned, as demonstrated by the ongoing unequal health outcomes in New Zealand.
EMERGING INFECTIOUS DISEASES
(2023)
Article
Virology
Jianguo Zhang, Daoyin Ding, Xing Huang, Jinhui Zhang, Deyu Chen, Peiwen Fu, Yinghong Shi, Wenrong Xu, Zhimin Tao
Summary: In this study, clinical characteristics of COVID-19 and influenza patients were compared, showing differences in demographic data, medical history, laboratory findings, and radiological characteristics between the two infectious diseases. COVID-19 cohort displayed more diversity in CT features compared to the influenza cohort, providing valuable insights for differential diagnosis.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sherief H. Garrana, Avik Som, Gabrielle S. Ndakwah, Tristan Yeung, Jennifer Febbo, Allen P. Heeger, Min Lang, Shaunagh McDermott, Dexter P. Mendoza, Eric W. Zhang, Amita Sharma, Anand K. Narayan, Brent P. Little
Summary: The study compared the chest CT features of COVID-19, influenza, and noninfectious organizing pneumonia (OP), showing substantial overlap in CT findings among the three conditions. Radiologists had low diagnostic accuracy in distinguishing between these pneumonia types, highlighting the challenges in diagnosing COVID-19 by CT, particularly in the presence of other potential causes of OP.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2021)
Article
Microbiology
Jennifer M. Farrell, Conan Y. Zhao, Keiko M. Tarquinio, Sam P. Brown
Summary: The COVID-19 literature suggests that bacterial infections are more common in fatal cases than in recovered cases, but it is unclear if they significantly contribute to mortality. More data is needed to determine the relative importance of bacterial infections in COVID-19 mortality. Additionally, potential long-term consequences of SARS-CoV-2 infection are also summarized.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Nutrition & Dietetics
Giancarlo Ceccarelli, Cristian Borrazzo, Claudia Pinacchio, Letizia Santinelli, Giuseppe Pietro Innocenti, Eugenio Nelson Cavallari, Luigi Celani, Massimiliano Marazzato, Francesco Alessandri, Franco Ruberto, Francesco Pugliese, Mario Venditti, Claudio M. Mastroianni, Gabriella D'Ettorre
Summary: Through comparing patients with severe COVID-19 pneumonia who received the best available therapy (BAT) with those who received BAT and supplemented with oral bacteriotherapy, it was found that oral bacteriotherapy can reduce the mortality rate of COVID-19 patients, potentially playing a role in the management of COVID-19 pneumonia patients.
FRONTIERS IN NUTRITION
(2021)
Article
Endocrinology & Metabolism
G. Dipalma, A. D. Inchingolo, A. Mancini, M. E. Maggiore, G. M. Tartaglia, G. Malcangi, E. Ferrara, F. Lorusso, A. Scarano, I. R. Bordea, I Tesoro, C. Sforza, C. Maspero, M. Farronato, M. G. Cagetti, V Lanteri, A. Patano, S. Ceci, G. Marinelli, A. Corriere, A. Gnoni, S. Scacco, L. Nucci, K. Ferati, A. Bexheti-Ferati, B. Rapone, A. M. Inchingolo, F. Inchingolo
Summary: SARS-CoV-2 infection can lead to immune system damage, and maintaining periodontal health can reduce susceptibility to COVID-19 and prevent disease aggravation. There is a connection between periodontal diseases and the development and course of respiratory illnesses. Good oral and systemic health, as well as quitting smoking, may be beneficial in preventing and managing COVID-19 infections.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Multidisciplinary Sciences
Pablo Jose Antunez Muinos, Diego Lopez Otero, Ignacio J. Amat-Santos, Javier Lopez Pais, Alvaro Aparisi, Carla E. Cacho Antonio, Pablo Catala, Teba Gonzalez Ferrero, Gonzalo Cabezon, Oscar Otero Garcia, Jose Francisco Gil, Marta Perez Poza, Jordi Candela, Gino Rojas, Victor Jimenez Ramos, Carlos Veras, J. Alberto San Roman, Jose R. Gonzalez-Juanatey
Summary: The study aimed to establish laboratory predictors of mortality in COVID-19 disease in order to identify high-risk patients. By analyzing various laboratory biomarkers, a Covid-19 Lab score was created to predict mortality, with different risk groups identified based on the score. The score was found to be a simple and dynamic tool that could effectively predict mortality in patients with SARS-CoV2 infection.
SCIENTIFIC REPORTS
(2021)
Article
Virology
Vu L. Ngo, Andrew T. Gewirtz
Summary: The article discusses how the composition of a host's microbiome may influence outcomes following encounters with respiratory viral pathogens, particularly SARS-CoV-2. It suggests possible approaches to manipulate microbiota to ameliorate disease induced by respiratory viral pathogens.
CURRENT OPINION IN VIROLOGY
(2021)
Article
Immunology
Zhongwei Jia, Xiangyu Yan, Liwei Gao, Shenggang Ding, Yan Bai, Yuejie Zheng, Yuxia Cui, Xianfeng Wang, Jingfeng Li, Gen Lu, Yi Xu, Xiangyu Zhang, Junhua Li, Ning Chen, Yunxiao Shang, Mingfeng Han, Jun Liu, Hourong Zhou, Cen Li, Wanqiu Lu, Jun Liu, Lina Wang, Qihong Fan, Jiang Wu, Hanling Shen, Rong Jiao, Chunxi Chen, Xiaoling Gao, Maoqiang Tian, Wei Lu, Yonghong Yang, Gary Wing-Kin Wong, Tianyou Wang, Runming Jin, Adong Shen, Baoping Xu, Kunling Shen
Summary: Majority clinical characteristics of pediatric COVID-19 pneumonia patients were milder than non-COVID-19 patients. However, lymphocytopenia remained a prominent feature of COVID-19 pediatric pneumonia.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Medicine, Research & Experimental
Karan Varshney, Preshon Pillay, Ashmit Daiyan Mustafa, Dennis Shen, Jenna Renee Adalbert, Malik Quasir Mahmood
Summary: COVID-19 and influenza are two serious respiratory infections that impact populations worldwide, but little is known about the clinical aspects of co-infection. This study conducted a systematic review of the clinical characteristics, treatments, and outcomes for patients co-infected with influenza and COVID-19. The analysis included 64 studies with a total of 6086 co-infected patients. Co-infected patients showed similar symptoms to mono-infected individuals, but had a higher risk of poor outcomes. Screening for influenza in high-risk COVID-19 patients and improving treatment, testing, and vaccination rates are recommended to enhance patient outcomes.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Kenichi Imai, Yorimasa Ogata
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Ryo Koike, Marni E. Cueno, Keiko Nodomi, Muneaki Tamura, Noriaki Kamio, Hajime Tanaka, Ai Kotani, Kenichi Imai
Article
Medicine, General & Internal
Norihisa Watanabe, Sho Yokoe, Yorimasa Ogata, Shuichi Sato, Kenichi Imai
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Chihiro Miya, Marni E. Cueno, Ryuta Suzuki, Shuichiro Maruoka, Yasuhiro Gon, Tadayoshi Kaneko, Yoshiyuki Yonehara, Kenichi Imai
Summary: The study found that Porphyromonas gingivalis gingipains may be the primary virulence factor influencing both MUC5AC gene expression and protein levels, while lipopolysaccharide or FimA fimbriae have no effect on this.
Article
Biochemistry & Molecular Biology
Yuwa Takahashi, Norihisa Watanabe, Noriaki Kamio, Sho Yokoe, Ryuta Suzuki, Shuichi Sato, Toshimitsu Iinuma, Kenichi Imai
Summary: Periodontitis may be a risk factor for exacerbating COVID-19, promoting SARS-CoV-2 infection and worsening inflammation in the lower respiratory tract.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Noriaki Kamio, Mayumi Hayata, Muneaki Tamura, Hajime Tanaka, Kenichi Imai
Summary: Chronic periodontitis is a risk factor for pneumonia, and periodontopathic bacteria enhance pneumococcal adhesion to human alveoli by inducing PAFR expression. Among the virulence factors of Porphyromonas gingivalis, gingipains play a key role in this process.
Review
Biochemistry & Molecular Biology
Kenichi Imai, Hajime Tanaka
Summary: The oral cavity has gained attention in the context of COVID-19 as a potential route for SARS-CoV-2 transmission and replication. Saliva, containing infective viral loads, is crucial in viral spread, while oral bacteria may complicate COVID-19 progression. Oral health management not only prevents comorbidities but also has a potential impact on COVID-19 advancement.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Infectious Diseases
Yu Kono, Muneaki Tamura, Marni E. Cueno, Morio Tonogi, Kenichi Imai
Summary: The study showed that ions released from the S-PRG filler can suppress the growth and pathogenicity of oral bacterial flora, potentially preventing diseases inside and outside the oral cavity.
Article
Biochemistry & Molecular Biology
Sho Yokoe, Akira Hasuike, Norihisa Watanabe, Hideki Tanaka, Hiroyuki Karahashi, Shin Wakuda, Osamu Takeichi, Takayuki Kawato, Hideki Takai, Yorimasa Ogata, Shuichi Sato, Kenichi Imai
Summary: Periodontitis is a common inflammatory condition that affects the supporting tissues of teeth. The role of Epstein-Barr virus (EBV) in the etiology of periodontitis is not well understood. This study found that inactivated EBV induces high levels of interleukin (IL)-6 and IL-8 in human gingival fibroblasts (HGFs), leading to inflammation and osteoclast differentiation, suggesting that EBV may contribute to the onset and progression of periodontitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ryuta Suzuki, Noriaki Kamio, Tadayoshi Kaneko, Yoshiyuki Yonehara, Kenichi Imai
Summary: Fusobacterium nucleatum may play a role in exacerbation of chronic obstructive pulmonary disease (COPD), causing inflammatory responses and exacerbating disease progression.
Review
Virology
Masami Takei, Noboru Kitamura, Yosuke Nagasawa, Hiroshi Tsuzuki, Mitsuhiro Iwata, Yasuko Nagatsuka, Hideki Nakamura, Kenichi Imai, Shigeyoshi Fujiwara
Summary: It is believed that viral infections can trigger autoimmune diseases, with EBV potentially playing a crucial role in the pathogenesis of rheumatoid arthritis.