Review
Immunology
Haijiao Jing, Xiaoming Wu, Mengqi Xiang, Langjiao Liu, Valerie A. Novakovic, Jialan Shi
Summary: This review investigates the crosstalk between inflammation and thrombosis in COVID-19 patients, focusing on the contributions of inflammation to thrombosis pathogenesis and proposing combined use of anti-inflammatory and anticoagulant therapies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Ophthalmology
Aniruddha Kishandutt Agarwal, Sridharan Sudharshan, Padmamalini Mahendradas, Kalpana Babu, Pratik Shenoy, Mohit Dogra, Reema Bansal, Manisha Agarwal, Jyotirmay Biswas, S. Balamurugan, Rupesh Agrawal, Vishali Gupta
Summary: During the COVID-19 pandemic, uveitis specialists may reduce ongoing systemic IMT or opt for less aggressive treatment strategies for NIU, which may put these patients at a higher risk of uveitis relapse.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Review
Nutrition & Dietetics
Chengyu Liu, Wanyao Yan, Jiajian Shi, Shun Wang, Anlin Peng, Yuchen Chen, Kun Huang
Summary: Individuals with obesity have shown worse prognosis and higher mortality in the COVID-19 pandemic. Dyslipidemia, a common condition in obese individuals, plays a major role in the severity of COVID-19. The use of statins, lipid-regulating drugs, has been associated with a reduced risk of progressing to severe illness and in-hospital death in COVID-19 patients. However, caution should be taken due to potential side effects and concerns about interference with COVID-19 vaccines. Further clinical trials are needed to fully understand the benefits, harms, and mechanisms of statin use in the context of COVID-19.
FRONTIERS IN NUTRITION
(2022)
Review
Pharmacology & Pharmacy
Dongling Liu, Xiang Zeng, Zufeng Ding, Fenghua Lv, Jawahar L. Mehta, Xianwei Wang
Summary: COVID-19 infection has a high mortality rate in patients with preexisting cardiovascular diseases, and those with cardiovascular comorbidities have a higher risk of death. Drugs used to treat COVID-19 can have adverse effects on the heart.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Xue Cao, Wenjuan Li, Ting Wang, Dongzhi Ran, Veronica Davalos, Laura Planas-Serra, Aurora Pujol, Manel Esteller, Xiaolin Wang, Huichuan Yu
Summary: Epigenetic aging is associated with the risk of SARS-CoV-2 infection and developing severe COVID-19. The accumulation of epigenetic aging from COVID-19 may contribute to the post-COVID-19 syndrome among survivors.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Roberta Eduarda Grolli, Maiqueli Eduarda Dama Mingoti, Amanda Gollo Bertollo, Adriana Remiao Luzardo, Joao Quevedo, Gislaine Zilli Reus, Zuleide Maria Ignacio
Summary: During the pandemic, social isolation and concerns about COVID-19 may harm the mental health of the elderly. Immunosenescence and pandemic stress increase the risk of psychiatric disorders among the elderly. Stress and disorders may exacerbate inflammation and COVID-19 symptoms in the elderly.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Alessandra Vergori, Alessandro Cozzi Lepri, Stefania Cicalini, Giulia Matusali, Veronica Bordoni, Simone Lanini, Silvia Meschi, Roberta Iannazzo, Valentina Mazzotta, Francesca Colavita, Ilaria Mastrorosa, Eleonora Cimini, Davide Mariotti, Lydia De Pascale, Alessandra Marani, Paola Galli, AnnaRosa Garbuglia, Concetta Castilletti, Vincenzo Puro, Chiara Agrati, Enrico Girardi, Francesco Vaia, Andrea Antinori
Summary: HIV-infected individuals showed a strong humoral response after the third dose of a SARS-CoV-2 vaccine, while their cell-mediated immunity remained stable. This study highlights the usefulness of a third vaccine dose in people living with HIV who are on suppressive antiretroviral therapy.
NATURE COMMUNICATIONS
(2022)
Letter
Medicine, General & Internal
David Fisher, Stephen Malnick
Summary: The researchers administered convalescent plasma to high-risk outpatients within 1 week after the onset of symptoms of Covid-19, which differs from previous studies with shorter time frames.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Qunfeng Luo, Yunxi Zheng, Jin Zhang
Summary: This review summarizes the progress of combination therapies targeting SARS-CoV-2, which involve at least one small molecule in order to block the viral life cycle and alleviate host complications. It provides significant inspiration for further development of treatment strategies against SARS-CoV-2, particularly its mutant variants.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Review
Endocrinology & Metabolism
Hugo Rodrigues Alves, Guilherme Schittine Bezerra Lomba, Cassiano Felippe Goncalves-de-Albuquerque, Patricia Burth
Summary: Irisin produced during exercise plays a crucial role in improving metabolism, preventing inflammation-related diseases, and potentially combating conditions like COVID-19.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Stefano Bruscoli, Pier Giorgio Puzzovio, Maria Zaimi, Katerina Tiligada, Francesca Levi-Schaffer, Carlo Riccardi
Summary: COVID-19 presents a significant health and economic challenge globally, with glucocorticoids (GCs) being widely used for treatment due to their anti-inflammatory and immunosuppressive effects. However, there is controversy surrounding the use of GCs for early treatment of non-hospitalized patients with COVID-19.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Medicine, General & Internal
Patricia O. Guimaraes, Daniel Quirk, Remo H. Furtado, Lilia N. Maia, Jose F. Saraiva, Murillo O. Antunes, Roberto Kalil Filho, Vagner M. Junior, Alexandre M. Soeiro, Alexandre P. Tognon, Viviane C. Veiga, Priscilla A. Martins, Diogo D. F. Moia, Bruna S. Sampaio, Silvia R. L. Assis, Ronaldo V. P. Soares, Luciana P. A. Piano, Kleber Castilho, Roberta G. R. A. P. Momesso, Frederico Monfardini, Helio P. Guimaraes, Dario Ponce de Leon, Majori Dulcine, Marcia R. T. Pinheiro, Levent M. Gunay, J. Jasper Deuring, Luiz V. Rizzo, Tamas Koncz, Otavio Berwanger
Summary: Among patients hospitalized with Covid-19 pneumonia, tofacitinib led to a lower risk of death or respiratory failure through day 28 than placebo. The mortality rate was lower in the tofacitinib group within 28 days. However, the rate of serious adverse events was similar in both groups.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Microbiology
Ido-David Dechtman, Ran Ankory, Keren Sokolinsky, Esther Krasner, Libby Weiss, Yoav Gal
Summary: The COVID-19 pandemic caused by SARS-CoV-2 has resulted in a large number of cases and deaths worldwide. Vaccines are the best strategy for prevention, but there are still many severely ill individuals from at-risk populations. Pharmacological treatments are important despite vaccination efforts. This review evaluates drugs under clinical evaluation for COVID-19 with broad spectrum activity, including antiviral agents and host-directed therapies, which may be relevant for future coping with biological warfare agents and respiratory infections.
Editorial Material
Immunology
Brahm Coler, Kristina Adams Waldorf
Summary: It is currently unclear whether COVID-19 during pregnancy affects the health of children. Data suggests that maternal SARS-CoV-2 infection may indirectly affect the fetal immune response even when the virus does not infect the fetus.
Article
Immunology
Martijn Zoodsma, Aline H. de Nooijer, Inge Grondman, Manoj Kumar Gupta, Agnes Bonifacius, Valerie A. C. M. Koeken, Emma Kooistra, Gizem Kilic, Ozlem Bulut, Nina Goedecke, Nico Janssen, Matthijs Kox, Jorge Dominguez-Andres, Adriaan J. van Gammeren, Anton A. M. Ermens, Andre J. A. M. van der Ven, Peter Pickkers, Rainer Blasczyk, Georg M. N. Behrens, Frank L. van de Veerdonk, Leo A. B. Joosten, Cheng-Jian Xu, Britta Eiz-Vesper, Mihai G. Netea, Yang Li
Summary: This study utilized the Olink platform to perform targeted proteomics and investigated protein concentrations in different groups of individuals, including hospitalized COVID-19 patients, post-COVID-19 individuals, and healthy individuals. The results showed that SARS-CoV-2 infection causes acute inflammation and has a lasting impact on the circulating proteome. Furthermore, the circulating proteome can differentiate between different disease severities and is associated with the time after infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Letter
Rheumatology
Pedro M. Machado, Martin Schaefer, Anja Strangfeld, Laure Gossec, Milena Gianfrancesco, Saskia Lawson-Tovey, Elsa F. Mateus, Loreto Carmona, Kimme L. Hyrich, Philip C. Robinson, Jinoos Yazdany
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Mikhail Protopopov, Fabian Proft, Stephanie Wichuk, Pedro M. Machado, Robert G. Lambert, Ulrich Weber, Susanne Juhl Pedersen, Mikkel Ostergaard, Joachim Sieper, Martin Rudwaleit, Xenofon Baraliakos, Walter P. Maksymowych, Denis Poddubnyy
Summary: This study compares the ability of MRI and conventional radiography to detect structural lesions indicative of axSpA.
Review
Rheumatology
Penelope Esther Palominos, Daniel G. Fernandez-Avila, Laura C. Coates, Adewale Adebajo, Adrien Nzeusseu Toukap, Ahmed Abogamal, Ari Polachek, Arno W. R. van Kuijk, Francesco Caso, Gabriele de Marco, Gurjit S. Kaeley, Ingrid Steinkoenig, Jeffrey Chau, Marie Feletar, Marijn Vis, Ori Elkayam, Philipp Sewerin, Salvatore d'Angelo, Sibel Zehra Aydin, Waleed Alshehhi, Philip S. Helliwell
Summary: This literature review aimed to identify the most efficacious current interventions for dactylitis and provide up-to-date scientific evidence to support the 2021 GRAPPA recommendations on the management of psoriatic arthritis. The analysis of original articles revealed a lack of consensus regarding dactylitis assessment and the paucity of data concerning the effect of certain medications.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Health Care Sciences & Services
Helena Santos, Ana Rita Henriques, Jaime Branco, Pedro M. Machado, Helena Canhao, Fernando M. Pimentel-Santos, Ana Maria Rodrigues
Summary: The study found that both spondyloarthritis and chronic low back pain have similar impacts on health-related quality of life (HRQoL), including mental, physical, and social domains. Patients with spondyloarthritis and chronic low back pain reported significantly lower HRQoL compared to those without rheumatic diseases. Modifiable factors such as multimorbidity, active disease, obesity, and regular physical exercise were associated with HRQoL in these conditions.
QUALITY OF LIFE RESEARCH
(2023)
Article
Rheumatology
Julien Duquesne, Vincent Bouget, Paul Henry Cournede, Bruno Fautrel, Francis Guillemin, Pascal H. P. de Jong, Judith W. Heutz, Marloes Verstappen, Annette H. M. van der Helm-van Mil, Xavier Mariette, Samuel Bitoun
Summary: The study aims to use routine clinical and biological data to build machine learning models for predicting EULAR inadequate response to MTX and identifying simple predictive biomarkers. The results show that the algorithm can accurately predict whether patients have an inadequate response to MTX and can guide new therapeutic strategies.
Article
Rheumatology
Alen Zabotti, Gabriele De Marco, Laure Gossec, Xenofon Baraliakos, Daniel Aletaha, Annamaria Iagnocco, Paolo Gisondi, Peter Balint, Heidi Bertheussen, Wolf-Henning Boehncke, Nemanja S. Damjanov, Maarten de Wit, Enzo Errichetti, Helena Marzo-Ortega, Mikhail Protopopov, Lluis Puig, Ruben Queiro, Piero Ruscitti, Laura Savage, Georg Schett, Stefan Siebert, Tanja A. Stamm, Paul Studenic, Ilaria Tinazzi, Filip E. Van den Bosch, Annette van der Helm-van Mil, Abdulla Watad, Josef S. Smolen, Dennis G. McGonagle
Summary: This study proposes EULAR guidelines for the early diagnosis of psoriatic arthritis (PsA) by conducting research on multiple patients. It also establishes standardized operating procedures for clinical practice and trials, providing guidance and consensus in the field of prevention and interception of PsA for psoriasis patients.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Rheumatology
Evelyn Hsieh, Dzifa Dey, Rebecca Grainger, Mengtao Li, Pedro M. Machado, Manuel F. Ugarte-Gil, Jinoos Yazdany
Summary: Although the public health emergency associated with the COVID-19 pandemic has ended, challenges remain for individuals with rheumatic diseases. Disruptions in healthcare and medication supply shortages have impacted the health and mental well-being of these individuals. Telemedicine and changes in healthcare utilization have also affected rheumatology practices globally. Efforts are needed to improve healthcare access, stabilize rheumatology drug supplies, and implement evidence-based vaccination practices to reduce COVID-19 morbidity and mortality among individuals with rheumatic diseases.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Gaetane Nocturne, Xavier Mariette
Summary: The management of Sjogren's disease is challenging due to the heterogeneous clinical presentations and lack of validated treatment. However, international experts have been working on establishing recommendations for management. With active research in this field, we expect the development of effective treatments in the near future, benefiting patients.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
Maxime Beydon, Raphaele Seror, Veronique Le Guern, Pascale Chretien, Xavier Mariette, Gaetane Nocturne
Summary: This study compared disease characteristics between primary Sjogren's syndrome (pSS) patients of African ancestry and Caucasian ancestry. The results showed that patients of African ancestry had younger age at diagnosis, higher titre of gammaglobulins, higher rates of positive anti-SSA and anti-RNP antibodies, and more frequent systemic complications. Factors associated with disease activity were sub-Saharan African ancestry, rheumatoid factor, and anti-RNP positivity. In conclusion, patients of African ancestry displayed higher disease activity with increased B-cell activation.
Article
Rheumatology
Xavier Mariette
Summary: Long COVID refers to a syndrome characterized by persistent symptoms for more than 3 months after acute benign COVID-19, with a prevalence ranging from 10% to 80%. The symptoms closely resemble fibromyalgia. Research suggests that the prevalence of long COVID was significantly higher after the first wave of the pandemic, which may be associated with the stress and lockdown measures during that period. However, objective biological abnormalities to explain long COVID have not been replicated. Therefore, the term "long COVID" is inappropriate and should be replaced by "fibromyalgia-like post-COVID syndrome", with research encouraged to understand the psychosomatic and somatic mechanisms involved.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Alexandra Kachaner, Elisabeth Berge, Frederic Desmoulins, Christine Le Pajolec, Antoine Rousseau, Marc Labetoulle, Gaetane Nocturne, Xavier Mariette, Raphaele Seror
Summary: This study describes primary Sjogren's disease patients who do not have or have a low level of dryness, and compares them with Sjogren's disease patients who have oral or ocular dryness features.
Letter
Rheumatology
Gaetane Nocturne, Oriane Marmontel, Mathilde di Filippo, Pascale Chretien, Roman Krzysiek, Francois Lifermann, Nawal Rahal, Rakiba Belkhir, Philippe Moulin, Xavier Mariette
Article
Rheumatology
Pedro M. Machado, Martin Schaefer, Satveer K. Mahil, Jean Liew, Laure Gossec, Nick Dand, Alexander Pfeil, Anja Strangfeld, Anne Constanze Regierer, Bruno Fautrel, Carla Gimena Alonso, Carla G. S. Saad, Christopher E. M. Griffiths, Claudia Lomater, Corinne Miceli-Richard, Daniel Wendling, Deshire Alpizar Rodriguez, Dieter Wiek, Elsa F. Mateus, Emily Sirotich, Enrique R. Soriano, Francinne Machado Ribeiro, Felipe Omura, Frederico Rajao Martins, Helena Santos, Jonathan Dau, Jonathan N. Barker, Jonathan Hausmann, Kimme L. Hyrich, Lianne Gensler, Ligia Silva, Lindsay Jacobsohn, Loreto Carmona, Marcelo M. Pinheiro, Marcos David Zelaya, Maria de los Angeles Severina, Mark Yates, Maureen Dubreuil, Monique Gore-Massy, Nicoletta Romeo, Nigil Haroon, Paul Sufka, Rebecca Grainger, Rebecca Hasseli, Saskia Lawson-Tovey, Suleman Bhana, Thao Pham, Tor Olofsson, Wilson Bautista-Molano, Zachary S. Wallace, Zenas Z. N. Yiu, Jinoos Yazdany, Philip C. Robinson, Catherine H. Smith
Summary: This study investigated factors associated with severe COVID-19 in patients with psoriasis, psoriatic arthritis, and axial spondyloarthritis. The study found that age, sex, comorbidities, disease activity, and glucocorticoid use were associated with the severity of COVID-19. Additionally, later pandemic time periods, psoriasis, and the use of TNFi, IL17i, and IL-23i/IL-12+23i were associated with a reduced risk of severe COVID-19.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Letter
Rheumatology
Mathilde Pezot, Gaetane Nocturne, Rakiba Belkhir, Julien Henry, Stephan Pavy, Raphaele Seror, Xavier Mariette, Samuel Bitoun
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Letter
Rheumatology
Zachary S. Wallace, Jeffrey A. Sparks, Philip C. Robinson, Pedro M. Machado, Jinoos Yazdany
ANNALS OF THE RHEUMATIC DISEASES
(2023)
