Review
Pharmacology & Pharmacy
Huiqun Huang, Ronghui Liu, Jie Yang, Jing Dai, Shuhao Fan, Jiang Pi, Yubo Wei, Xinrong Guo
Summary: Cancer immunotherapy is a novel approach to enhance the immune system's ability to detect and eliminate cancer cells. Gold nanoparticles (AuNPs) have been explored as drug carriers in immunotherapy due to their stability, surface versatility, and optical properties. This review summarizes the synthesis routes and utilization of AuNPs as drug carriers, focusing on drug loading, targeting strategies, and drug release mechanisms in AuNP-based immunotherapy. The application and therapeutic efficacy of AuNPs in combination with cancer immunotherapy are also briefly discussed.
Article
Materials Science, Biomaterials
Quan-Bing Chen, Mei-Hua Shen, Xiao-He Ren, Shuai Zhu, Jin-Ting Shang, Wei Liu, Zhao-Wei Zhang, Zhi-Jun Dong, Hua-Zhi Gu, Xian-Zheng Zhang, Qiong Yuan, Tao Zou
Summary: This study utilizes tumor-triggered targeting ammonium bicarbonate liposomes for fluorescence and photothermal imaging-guided chemo/photothermal/photodynamic multimodal therapy, which effectively treats tumors without significant side effects.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Materials Science, Biomaterials
Jeffrey Watchorn, Samantha Stuart, Aaron J. Clasky, Matthew H. Oliveira, Darcy C. Burns, Frank X. Gu
Summary: Nanoparticle-based drug delivery systems have gained popularity for enhancing the effectiveness of active pharmaceutical ingredients and targeting alternative routes of drug administration. By understanding the binding behavior of polymers on nanoparticle surfaces, it is possible to optimize nanoparticle formulations and guide mucoadhesion.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Materials Science, Biomaterials
Jeffrey Watchorn, Samantha Stuart, Aaron J. Clasky, Matthew H. Oliveira, Darcy C. Burns, Frank X. Gu
Summary: Nanoparticle-based drug delivery systems have gained popularity as they improve the effectiveness of pharmaceutical ingredients and enhance absorption through mucosal drug delivery. However, the binding behavior of polymer-coated nanoparticles to mucin proteins can differ from that of polymer in solution, and the nanoparticle core influences the binding fate of polymer materials.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Kristen N. Sikora, Laura J. Castellanos-Garcia, Joseph M. Hardie, Yuanchang Liu, Michelle E. Farkas, Vincent M. Rotello, Richard W. Vachet
Summary: A dual-mode mass spectrometry imaging method was used to evaluate the distributions and biochemical effects of anti-TNF-alpha nanoparticle stabilized capsules in mice, revealing that most anticipated biochemical changes occur in sub-organ regions separate from where the nanomaterials accumulate. The study demonstrates the power of matrix-assisted laser desorption/ionization mass spectrometry imaging in evaluating both expected and unexpected outcomes associated with complex therapeutic delivery systems.
Article
Chemistry, Multidisciplinary
Mingming Zhao, Xiaoxi Song, Jiahui Lu, Siwen Liu, Xuan Sha, Qi Wang, Xu Cao, Kai Xu, Jingjing Li
Summary: In this study, a glutathione and adenosine-5'-triphosphate dual-sensitive nanoplatform was fabricated for controlled drug release and activatable MRI of tumors. The nanoplatform, based on DNA aptamer and manganese dioxide nanosheets, allowed targeted drug delivery to tumor cells and on-demand drug release through the co-effect of ATP aptamer and GSH reduction. The combination of MRI and chemodynamic therapy improved the inhibition of tumor growth and imaging.
Article
Biophysics
Ali Mahmoudi, Prashant Kesharwani, Muhammed Majeed, Yong Teng, Amirhossein Sahebkar
Summary: Curcumin is a natural compound with promising therapeutic benefits, but it suffers from low solubility and bioavailability. Incorporating curcumin into gold nanoparticles can improve its properties and enhance its anticancer and antioxidant capacities. Additionally, the combination of nanogold and curcumin can be utilized in various therapeutic methods.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Medicine, Research & Experimental
M. A. Sanzhakov, V. A. Kudinov, K. K. Baskaev, G. E. Morozevich, D. S. Stepanova, T. I. Torkhovskaya, Yu. A. Tereshkina, E. I. Korotkevich, E. G. Tikhonova
Summary: The study focused on constructing composite phospholipid-gold nanoparticles using soy phosphatidylcholine and a targeted ligand to enhance specific delivery into tumor cells and visualization of malignant neoplasms. In vitro and in vivo experiments demonstrated a significant increase in accumulation of the nanoparticles with a targeted fragment, showing promising potential for early diagnosis and treatment of various types of tumors.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Multidisciplinary
Gabriel Perli, Diego L. Bertuzzi, Denio E. P. Souto, Miguel D. Ramos, Carolyne B. Braga, Samile B. Aguiar, Catia Ornelas
Summary: Dendronized gold nanoparticles with charged peripheral groups were successfully synthesized and characterized. The results showed that these nanoparticles have stability and functionalization potential, which could be used as weapons against multi-drug resistant bacterial infections.
Article
Oncology
Noor Essa, Fiona O'Connell, Adriele Prina-Mello, Jacintha O'Sullivan, Simone Marcone
Summary: The relationship between obesity and cancer has been well characterized, but the biological mechanisms in obese cancer patients are still unclear. The obese tumor microenvironment provides additional benefits to tumor cells against anticancer therapies by altering the extracellular matrix composition and immune cell profile, while nanotechnology, particularly gold nanoparticles, is being researched for cancer treatment due to their sensitizing abilities for cancer cells and enhancement of drug delivery.
Article
Pharmacology & Pharmacy
Gaetano Giammona, Salvatore Emanuele Drago, Giovanna Calabrese, Paola Varvara, Maria Giovanna Rizzo, Nicolo Mauro, Giuseppe Nicotra, Sabrina Conoci, Giovanna Pitarresi
Summary: In this paper, a rational design of a hybrid nanosystem capable of locally delivering anticancer drugs and heat is proposed. By combining gold nanorods with a specially designed galactosylated amphiphilic graft copolymer, the nanosystem can recognize and target hepatic cells overexpressing specific receptors. The drug-loaded nanoparticles demonstrated efficient near infrared-triggered chemo-phototherapy in vitro, making them promising candidates for dual-mode therapy of hepatocarcinoma.
Article
Biochemistry & Molecular Biology
Chiara Tramontano, Bruno Miranda, Giovanna Chianese, Luca De Stefano, Carlo Forestiere, Marinella Pirozzi, Ilaria Rea
Summary: This study combined inorganic diatomite nanoparticles with gelatin-stabilized gold nanoparticles to develop an optical platform for drug delivery. By increasing the thickness of the gelatin shells, the drug loading capacity was improved. Optical modeling was used to monitor drug release processes and proved to be an efficient tool for designing polymer-coated nanocarriers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Inorganic & Nuclear
Manoj Kumar Sarangi, Sasmita Padhi, Goutam Rath, Sitansu Sekhar Nanda, Dong Kee Yi
Summary: The emergence of nanobiotechnology offers a unique opportunity for advancements in disease diagnosis and treatment. Gold nanoparticles (AuNPs) with functionalized surfaces have gained significant attention due to their unique properties, such as optical, electrical, magnetic, and catalytical properties. AuNPs have shown great potential in various biomedical applications including sensing, targeted drug delivery, bio-imaging, immunotherapy, vaccines, cancers, and infectious diseases, thanks to their key features such as electronic, optical, surface plasmon resonance, physicochemical, and immunomodulatory effects. Additionally, the low toxicity, biocompatibility, tunability, and stability of AuNPs make them promising candidates for diagnostic and therapeutic applications.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Christine M. Hamadani, Indika Chandrasiri, Mahesh Loku Yaddehige, Gaya S. Dasanayake, Iyanuoluwani Owolabi, Alex Flynt, Mehjabeen Hossain, Lucy Liberman, Timothy P. Lodge, Thomas A. Werfel, Davita L. Watkins, Eden E. L. Tanner
Summary: Researchers have discovered that ionic liquids based on choline carboxylic acid can form stable and biocompatible nano-assemblies with linear-dendritic block copolymers (LDBCs). These nano-assemblies have the ability to hitchhike on red blood cells and exhibit different cellular uptake behavior compared to other nanoparticles.
Review
Pharmacology & Pharmacy
Jia-shuai He, Shi-jin Liu, Yi-ran Zhang, Xiao-dong Chu, Zheng-bin Lin, Zhan Zhao, Sheng-hui Qiu, Yan-guan Guo, Hui Ding, Yun-long Pan, Jing-hua Pan
Summary: Immunotherapy is a crucial anti-tumor strategy that activates the immune system to recognize and destroy cancer cells. Gold nanoparticles (AuNPs) can be used for anticancer treatment and delivering antitumor drugs or combining other treatment strategies. AuNPs, acting as immune regulators and drug carriers, have the potential to enhance the efficiency and safety of cancer immunotherapy.
FRONTIERS IN PHARMACOLOGY
(2021)
