Article
Biophysics
Miaomiao Zhang, Shixin Xu, Chen Du, Ruoying Wang, Cuicui Han, Yongan Che, Wei Feng, Chengwei Wang, Shan Gao, Wen Zhao
Summary: In this study, a novel bilayer wound dressing made of poly(L-lactate-caprolactone) copolymer (PLCL) nanofibrous and keratin hydrogel loaded with fibroblast growth factor (FGF-2) was prepared using the low-pressure filtration-assisted method. The bilayer dressing was found to mimic the dermis and epidermis. It exhibited good porosity, maximum water absorption, and tight bond at the interface. In vitro and in vivo studies demonstrated the biocompatibility, biodegradability, and ability to promote skin healing of the bilayer dressing, making it a promising biomedical wound dressing for skin tissue engineering applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Review
Polymer Science
Chang Huang, Xizi Xu, Junhao Fu, Deng-Guang Yu, Yanbo Liu
Summary: Bleeding control is crucial in healthcare, which has led to advancements in wound dressing research and development. Electrospun polyacrylonitrile nanofibers offer excellent properties for wound dressings, showing great potential in manufacturing.
Article
Biochemistry & Molecular Biology
Fahimeh Kazeminava, Siamak Javanbakht, Mohammad Nouri, Khosro Adibkia, Khudaverdi Ganbarov, Mehdi Yousefi, Majid Ahmadi, Pourya Gholizadeh, Hossein Samadi Kafil
Summary: In this study, citric acid-based quantum dots were used as a crosslinked agent to synthesize carboxymethyl cellulose/polyvinyl alcohol nanofibers. The resulting nanofibers demonstrated good cytocompatibility and antibacterial efficacy, making them potential wound healing scaffolds.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Materials Science, Biomaterials
Trinh Thi-Phuong Ho, Vinh Khanh Doan, Nam Minh-Phuong Tran, Linh Kim-Khanh Nguyen, An Nguyen-My Le, Minh Hieu Ho, Trinh Nhu-Thuy, Toi Van Vo, Lam Dai Tran, Thi-Hiep Nguyen
Summary: This study fabricated an electrospun polycaprolactone (EsPCL) membrane coated with various densities of chitosan oligomers (COS) as a bioactive wound dressing. Results showed that increasing COS density led to enhanced antibacterial activities, faster hemostasis, and affected re-epithelialization and wound healing in mice. The membrane and chitosan oligomers were suggested for further studies in wound dressing applications.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Materials Science, Multidisciplinary
Quanhong Hu, Xingyi Wan, Shaobo Wang, Tian Huang, Xinyang Zhao, Chuyu Tang, Minjia Zheng, Xueyu Wang, Linlin Li
Summary: This study successfully constructed a Janus nanofiber dressing with comprehensive functions of bacterial killing, piezoelectric stimulation to promote fibroblast migration, and unidirectional liquid delivery for wound exudate removal. The Janus dressing, fabricated through layer-by-layer electrostatic spinning technology, exhibits ultrathin, flexible, breathable, and piezoelectric characteristics. Experimental results indicate that the Janus dressing not only drains excess wound exudate and kills local bacteria, but also generates dynamic piezopotential to accelerate wound healing on mice through fibroblast proliferation and migration, collagen deposition, angiogenesis, and re-epithelialization.
SCIENCE CHINA-MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Erika Maria Tottoli, Enrica Chiesa, Gabriele Ceccarelli, Silvia Pisani, Giovanna Bruni, Ida Genta, Bice Conti, Rossella Dorati
Summary: Biofiber is a new generation bandage with patented fiber technology that is highly absorbent and textured. It is designed to treat complex injuries like burns and can adapt to any part of the body. The prototypes of textured bandages developed with PLA-PCL-based fibers showed good stability and demonstrated enhanced protein shielding and compatibility with cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Materials Science, Multidisciplinary
Yufan Zhu, Wei Zhou, Jieyu Xiang, Minhao Wu, Zhe Chen, Zhiqiang Yang, Renxiong Wei, Lin Cai
Summary: In this study, a Janus bilayer electrospun dressing was developed using modified electro-spinning technologies. The dressing consists of a hydrophilic outer layer loaded with deferoxamine (DFO) and a hydrophobic inner layer with mesh-like structure. The Janus dressing showed good biocompatibility and facilitated biofluid drainage, while promoting angiogenesis.
MATERIALS & DESIGN
(2023)
Article
Materials Science, Multidisciplinary
Wencheng Liang, Mingli Jiang, Junyong Zhang, Xiaoming Dou, Yan Zhou, Yun Jiang, Li Zhao, Meidong Lang
Summary: In this study, novel antibacterial composite scaffolds were prepared with improved water absorption rate, water retention rate, and mechanical strength compared to traditional scaffolds. The addition of hyaluronic acid enhanced the biocompatibility of the scaffolds, and the positive charge in the scaffolds contributed to their antibacterial activity. The scaffolds showed potential for wound healing and could be used as wound dressings.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2021)
Review
Polymer Science
Xiaotong Zhang, Yanxin Wang, Zhiyuan Gao, Xinhui Mao, Jiaxuan Cheng, Linjun Huang, Jianguo Tang
Summary: This article reviews the recent advancements in the application of electrospinning nanofibers for bioactive wound healing. It provides an overview of the wound healing process and electrospinning methods, discusses the advantages and disadvantages of different synthetic and natural polymers used in wound dressings, explores the blending of polymers, and examines the incorporation of functional additives for better wound healing.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Claudia Mouro, Ana P. Gomes, Merja Ahonen, Raul Fangueiro, Isabel C. Gouveia
Summary: This study successfully incorporated Chelidonium majus extract into nanofibrous meshes using a needleless emulsion electrospinning technique, demonstrating promising healing support properties for wound infections.
Review
Chemistry, Physical
Jiahao Yang, Lan Xu
Summary: Electrospun nanofiber membranes (NFMs) with high porosity and large specific surface area provide a suitable environment for wound healing and a large number of carrying sites for wound healing factors. The design of nanofiber structure can imitate the structure of human dermis and promote hemostasis, anti-inflammatory, and wound healing. Therefore, it has been widely studied in wound dressing.
Article
Biophysics
Shokoh Parham, Anousheh Zargar Kharazi
Summary: This study develops a flexible cellulosic textile nanocomposite with clove herbal medicine and demonstrates its potential applications in antimicrobial activity and wound healing. The nano emulsion containing clove herbal medicine was confirmed to contain eugenol and had a mean size between 100 and 300 nm. The wound dressing showed high antimicrobial activity and significant improvement in in vivo wound healing and in vitro cellular compatibility.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Materials Science, Multidisciplinary
Shokoh Parham, Anousheh Zargar Kharazi, Hamid Reza Bakhsheshi-Rad, Mahshid Kharaziha, Ahmad Fauzi Ismail, Safian Sharif, Mahmood Razzaghi, Seeram RamaKrishna, Filippo Berto
Summary: Wound dressings have evolved from using natural materials to customizable electrospun polymers that contain active compounds for wound healing and infection prevention. Electrospun polymeric nanofibers are considered promising for enhancing skin regeneration and controlling wound infection.
ADVANCED ENGINEERING MATERIALS
(2022)
Article
Biophysics
Na Yi, Mengyue Wang, Li Song, Fan Feng, Jiwei Li, Ruyi Xie, Zhihui Zhao, Weichao Chen
Summary: In this study, a high-performance calcium alginate/carbon polymer dots/forsythin (CA/CPDs/FT) composite nanofibrous membrane was developed for the preparation of biological dressings with antibacterial and antioxidant properties. The addition of carbon polymer dots improved the nanofiber morphology and mechanical strength of the membrane. The CA/CPDs/FT membrane exhibited satisfactory antibacterial and antioxidant properties due to the natural characteristics of forsythin. Furthermore, the composite membrane had excellent hygroscopicity exceeding 700%. In vitro and in vivo experiments demonstrated that the CA/CPDs/FT nanofibrous membrane effectively prevented bacterial invasion, scavenged free radicals, and promoted wound healing. Its good hygroscopicity and antioxidation characteristics are beneficial for the clinical application of high-exudate wounds.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Engineering, Multidisciplinary
Seyede Mahtab Hosseini, Majid Abdouss, Saeedeh Mazinani, Azim Soltanabadi, Mohammadreza Kalaee
Summary: This study prepared polyvinyl alcohol (PVA) nanofibers containing chitosan nanoparticles and drug-loaded graphene oxide-magnetite nanocomposites for smart wound dressing. The nanofiber membranes showed high water absorption, low degradability, controlled drug release, good antimicrobial properties against gram-positive and gram-negative bacteria, and high compatibility with cells.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Engineering, Aerospace
Haiqiang Liu, Meibao Yao, Xueming Xiao, Hutao Cui
Summary: Semantic segmentation of Martian terrain is crucial for rover route planning and navigation on Mars. Existing methods perform poorly in the unstructured Martian environment. Therefore, a novel hybrid attention semantic segmentation (HASS) network is proposed, which includes a global intra-class attention branch, a local inter-class attention branch, and a representation merging module. In addition, a panorama semantic segmentation dataset named MarsScapes is established, providing fine-grained annotations for eight semantic categories. Extensive experiments on MarsScapes and the public AI4Mars datasets demonstrate the superiority of the proposed method.
Article
Chemistry, Multidisciplinary
Deng-Guang Yu, Qiang Li, Wenliang Song, Lin Xu, Kaihui Zhang, Tao Zhou
Summary: The essence of higher education is to cultivate innovative talents for society. Higher education institutions need to respond to social needs and government policies while improving teaching to enhance education effectiveness. This paper presents examples of combined education in HEIs on safety education and innovation education, encouraging students to innovate during their laboratory experiments on electrospinning.
JOURNAL OF CHEMICAL EDUCATION
(2023)
Review
Chemistry, Multidisciplinary
Chao Li, Junjun Yang, Wenjun He, Mengyuan Xiong, Xinsheng Niu, Xiaoyan Li, Deng-Guang Yu
Summary: This review summarizes the types of micro-nano array structures and analyzes fabrication methods based on top-down and bottom-up construction, including templating, etching, self-assembly, and electrospinning/electrospraying. It focuses on the shape reconfiguration of surface micro-nano array structures under physical stimuli and the changes in material surface properties during the reconfiguration process. Additionally, the applications of biomimetic micro-nano array composite surfaces in droplet transport, adhesion properties, sensors, and soft robotics are discussed, along with the current challenges and prospects in this field.
ADVANCED MATERIALS INTERFACES
(2023)
Review
Biochemistry & Molecular Biology
Hang Liu, Yubin Bai, Chang Huang, Ying Wang, Yuexin Ji, Yutong Du, Lin Xu, Deng-Guang Yu, Sim Wan Annie Bligh
Summary: Herbal medicine has been proven to be effective in medical treatment with low toxicity, minimal side effects, and good biocompatibility, but its bioavailability is hindered by low water solubility. Electrospinning technology provides a solution by creating electrospun fibers with high specific surface area, porosity, strength, and flexibility. This paper reviews the development of electrospinning technology and the incorporation of herbal medicine into electrospun nanofibers using various polymers. It also discusses the recent progress and future prospects of using these herbal medicine nanofibers in biomedical and food applications.
Article
Psychology, Multidisciplinary
Deng-Guang Yu, Yutong Du, Jiahua Chen, Wenliang Song, Tao Zhou
Summary: Students' behaviors are closely related to their learning efficiencies, particularly in terms of professional knowledge. Different types of behaviors have different influences. Disclosing the special relationship between undergraduate students' conscious safety behaviors in laboratory experiments and their learning efficiencies is important for fostering them into professional talents.
BEHAVIORAL SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Jianfeng Zhou, Pu Wang, Deng-Guang Yu, Yuanjie Zhu
Summary: This review summarizes the recent developments in electrospinning and its application in biphasic drug release. Various electrospun nanostructures and their roles in facilitating biphasic release are analyzed.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Article
Chemistry, Analytical
Yutong Du, Zili Yang, Shixiong Kang, Deng-Guang Yu, Xiren Chen, Jun Shao
Summary: This study demonstrates the fabrication of a glucose biosensor using electrospun core-sheath nanofibers. Two types of films were created, one solely composed of core-sheath nanofibers and the other a double-layer hybrid film. The hybrid film showed higher degradation efficiency of beta-D-glucose and colorimetric sensing capability. The study highlights the flexibility of electrospinning for creating bio-cascade reaction structures and the potential of the double-layer hybrid film for developing sensing nanomaterials.
Review
Polymer Science
Pu Wang, He Lv, Xianyang Cao, Yanan Liu, Deng-Guang Yu
Summary: This paper provides an overview of the common polymers, preparation, and applications of electrospun porous nanofibers. The polymers commonly used to construct porous structures and the main pore-forming methods in porous nanofibers by electrospinning are introduced. Recent applications of electrospun porous nanofibers in various fields are reviewed, and the challenges and possible research directions for future study are discussed.
Review
Chemistry, Analytical
Yutong Du, Deng-Guang Yu, Tao Yi
Summary: Electrospun nanofibers have unique properties that make them beneficial in various scientific fields. Multiple-fluid electrospinning allows for the creation of nanostructures in a straightforward and efficient manner, holding promise for large-scale production.
Editorial Material
Chemistry, Medicinal
Deng-Guang Yu, Jianfeng Zhou
Summary: The past two decades have seen the success and progress of electrospinning, particularly in its applications in pharmaceutics. Four hot regions for further development in pharmaceutics using electrospinning are identified. The potential for electrospinning to provide better services to the field of pharmaceutics is highlighted.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Lin Xu, Hua He, Yutong Du, Shengwei Zhang, Deng-Guang Yu, Ping Liu
Summary: Smart drug delivery is a highly desired technology in pharmaceutics, which delivers drug molecules according to the requests of human biological rhythms or by maximizing drug therapeutic effects. In this study, a modified coaxial electrospraying process was used to fabricate core-shell nanoparticles using cellulose acetate and polyvinylpyrrolidone. The nanoparticles exhibited pulsatile release of ATP and sustained release of 90% loaded ATP.
Editorial Material
Biochemistry & Molecular Biology
Deng-Guang Yu, Chang Huang
Article
Biochemistry & Molecular Biology
Jianfeng Zhou, Liangzhe Wang, Wenjian Gong, Bo Wang, Deng-Guang Yu, Yuanjie Zhu
Summary: In this study, advanced micro-nanomanufacturing technologies and composite micro-nanostructures were used to develop a new type of pharmaceutical formulation with rapid hemostasis, pain relief, and antimicrobial properties. A novel beaded nanofiber structure (BNS) was fabricated using electrohydrodynamic atomization (EHDA) technique and reversed-phase solvent. The integration of Chinese herbs and Western medicine in this study provides valuable insights for the development of novel multiscale functional micro-/nano-composite materials and pioneers the developments of new types of medicines.
Article
Polymer Science
Yuexin Ji, Hua Zhao, Hui Liu, Ping Zhao, Deng-Guang Yu
Summary: A modified coaxial electrospraying process was developed to coat a hydrophobic lipid on composites composed of an anticancer drug and insoluble polymeric matrix. The coated hybrid microparticles were able to provide an improved sustained-release profile compared to the uncoated composite microparticles.
Article
Materials Science, Multidisciplinary
Shu Chen, Jianfeng Zhou, Boya Fang, Yue Ying, Deng-Guang Yu, Hua He
Summary: This study utilized three types of electrohydrodynamic atomization processes (electrospraying, electrospinning, and coaxial electrospinning) to create ultra-thin products based on hydroxypropyl methylcellulose (HPMC) for the fast dissolution of a poorly water-soluble drug, ketoprofen (KET). The results showed that the electrospun nanofibers, electrosprayed microparticles, and core-shell nanofibers had the expected morphology and inner structure, with KET mainly in an amorphous state. In vitro dissolution tests demonstrated that the core-shell nanofibers (E3) had the best rapid release performance. EHDA nanostructures can support the development of nano drug delivery systems by tailoring the spatial distribution of drug molecules within the nano products.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2023)
