Article
Biophysics
Zhaorui Song, Yongkuan Suo, Shuang Duan, Shanshan Zhang, Lifu Liu, Botong Chen, Zhen Cheng
Summary: Fluorescent lateral flow immunoassay (LFA) based on rare earth doped nanoparticles (RENPs) emitting in the second near-infrared (NIR-II) window is a common analytical platform for point-of-care testing (POCT) that enables easy and early screening of biomarkers. This platform shows high sensitivity, low cost, and has potential for early diagnosis of tumor biomarkers.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Analytical
Sulieman Ibraheem Shelash Al-Hawary, Raed H. Althomali, Botir Boltayevich Elov, Manar Hussn, Rasha Fadhel Obaid, Hijran Sanaan Jabbar, Rosario Mireya Romero-Parra, Sajad Ali Zearah, Zeid Fadel Albahash, I. B. Sapaev
Summary: Smartphone-based devices are revolutionizing patient care and management in healthcare, with the potential to become the main biomedical diagnosis tool. However, there are important issues regarding the reliability of the fabricated probes that need to be addressed. This review focuses on the applications, performance, and technology gaps of smartphone-based lateral flow assay devices, highlighting the need for improved signal transducing techniques and more sensitive lens for accurate results in whole blood media.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Analytical
Xianxian Zhao, Ye Yuan, Xiaoya Liu, Fajiang Mao, Ge Xu, Qingzhong Liu
Summary: The development of a versatile and sensitive analytical biomarker detection platform is crucial for early disease diagnosis and treatment. In this study, a novel fluorescence-based, ultrasensitive, and label-free biomarker detection platform is proposed. This platform demonstrates high sensitivity and specificity, and shows great potential in clinical diagnosis and anticancer drug development.
ANALYTICAL CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Wenbin Hao, Yan Huang, Lei Wang, Jing Liang, ShuangShuang Yang, Lei Su, Xueji Zhang
Summary: Developing a rapid antibody-based detection method is crucial for preventing and controlling the spread of COVID-19. A ReSe2 nanosheet was used as a label in a photothermal LFIA for highly sensitive detection of SARS-CoV-2 Spike protein IgG antibodies. An integrated device including a photothermal LFIA, portable laser, and smartphone with a thermal imager was introduced for rapid and on-site detection of COVID-19. The integrated device exhibited great potential for rapid and home self-testing diagnosis of COVID-19.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Analytical
Xin Wang, Haiyang Wang, Xinyu Wan, Meijin Li, Dianping Tang
Summary: The study presents a portable photoelectrochemical (PEC) immunoassay platform for rapid and low-cost detection of carcinoembryonic antigen (CEA) using a smartphone. The system utilizes disposable screen-printed carbon electrodes and a S-scheme heterojunction BiOCl/CuBi2O4 to achieve efficient electron transfer and excellent photocurrent response. The proposed immunoassay demonstrates good linearity within the concentration range of 0.01-40 ng mL-1 and a detection limit of 3.5 pg mL-1 (S/N = 3).
ANALYTICA CHIMICA ACTA
(2023)
Review
Chemistry, Multidisciplinary
Siew Suan Ng, Hooi Ling Lee, Pandian Bothi Raja, Ruey-an Doong
Summary: This review focuses on the application of optical biosensors for carcinoembryonic antigen (CEA) detection. Many nanomaterial-based biosensors have been developed as alternatives to traditional methods, but they have certain drawbacks. The advantages of optical biosensors, such as sensitivity and being free from interference, are discussed. The roles of nanomaterials in each application are summarized, and the challenges and future prospects are highlighted.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Medicine, General & Internal
Wen-Yeh Hsieh, Cheng-Han Lin, Tzu-Ching Lin, Chao-Hsu Lin, Hui-Fang Chang, Chin-Hung Tsai, Hsi-Tien Wu, Chih-Sheng Lin
Summary: The COVID-19 pandemic, caused by SARS-CoV-2, poses a significant challenge to the global healthcare system. Early detection and treatment of infected cases are crucial, with rapid and cost-effective immunoassays like LFIA being utilized for quick and large-scale testing.
Article
Chemistry, Analytical
Ziting Ma, Jinnian Guo, Lu Jiang, Suqing Zhao
Summary: Dengue is a common and deadly mosquito-borne infectious disease globally. Early detection of dengue virus is crucial for preventing disease spread and providing timely response. Lateral flow immunoassay (LFIA) systems are low-cost, rapid, sensitive, and simple detection methods suitable for point-of-care testing in dengue-affected areas. However, current commercial LFIA kits fail to fully meet the requirements for sensitivity, specificity, serotype differentiation, and multiplex detection. Various strategies have been applied to optimize LFIA for dengue detection.
Article
Virology
Drishya Prakashan, Narlawar S. Shrikrishna, Manisha Byakodi, K. Nagamani, Sonu Gandhi
Summary: The COVID-19 pandemic has highlighted the need for a rapid diagnostic device. Lateral flow immunoassays (LFIA) have the advantage of providing quick results, being easy to handle, and cost-effective. This study developed an LFIA using antibody-labeled gold nanoparticles for the detection of the Receptor-Binding Domain (RBD) of SARS-CoV-2. The optimized LFIA strips showed a limit of detection of 1ng/ml and high sensitivity and specificity when compared to the gold standard. The developed LFIA can be used as a portable and cost-effective diagnostic device for rapid detection of SARS-CoV-2.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Chemistry, Analytical
Yi Gu, Yang Guo, Yang Deng, Haipeng Song, Rui Nian, Wenshuai Liu
Summary: A novel pentameric nanobodies-based immunoassay (PNIA) demonstrated superior sensitivity and high specificity for detecting CEACAM-5 antigen. The use of bispecific or multivalent nanobody design provided new insights into the development of immunoassays for clinical diagnosis.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Mostafa Mahmoud, Christoph Ruppert, Simone Rentschler, Stefan Laufer, Hans-Peter Deigner
Summary: This study presents a novel method for quantifying biomarkers using fluorescent quantum dots as labels, read using a 3D printed smartphone imager, successfully achieving simultaneous quantification of interleukin-6 and thrombin. The method performs well in complex samples and effectively reduces turnaround time.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Wanghong He, Minli You, Zedong Li, Lei Cao, Feng Xu, Fei Li, Ang Li
Summary: The study developed a lateral flow immunoassay strip platform for simultaneous detection of three periodontitis biomarkers using upconversion nanoparticles, achieving successful results in clinical samples. The platform demonstrated high sensitivity and detection specificity, as well as rapid detection capabilities.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Multidisciplinary
Chaoqun Wang, Ziqiang Deng, Hu Zhang, Rui Liu, Yi Lv
Summary: Magnetic particles (MPs) are widely used in various biological applications, and this study discovered a novel function of commercialized MPs-internal standard for accurate quantification of biomolecules. The proposed MPs-based immunoassay greatly improves the accuracy and precision by eliminating potential MPs loss and intensity fluctuations during magnetic separation.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Jin-Ho Park, Eung-Kyu Park, Young Kwan Cho, Ik-Soo Shin, Hakho Lee
Summary: This study describes a method that transforms ubiquitous smartphones into robust lateral flow assay readers by utilizing optical calibration. The method corrects shape distortion, illumination brightness, and color imbalances through image processing, enabling consistent optical signals for quantitative molecular analysis under different illumination conditions.
Article
Nanoscience & Nanotechnology
Lingting Huang, Yongyi Zeng, Xiaolong Liu, Dianping Tang
Summary: An enhanced pressure-based immunoassay with a versatile electronic sensor has been developed for sensitive biological analysis. This system utilizes a sandwich-type immune complex to generate a strong electrical signal through a triple-step signal amplification strategy. Compared to traditional systems, this synergistic system with two physical quantities offers a lower limit of detection and a wider detection range.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Medicine, Research & Experimental
Shaho Ghahremani Dehbokri, Nazila Alizadeh, Alireza Isazadeh, Amir Baghbanzadeh, Soheil Abbaspour-Ravasjani, Khalil Hajiasgharzadeh, Behzad Baradaran
Summary: Breast cancer is a prevalent and deadly disease, and its incidence rate is increasing globally. Conventional treatment approaches, such as surgery, radiation therapy, and chemotherapy, often yield unsatisfactory outcomes. Therefore, developing innovative strategies, such as immunotherapy, is crucial for effective breast cancer therapy. The blockade of immune checkpoints, particularly cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), has shown promising results in cancer immunotherapy. The use of anti-CTLA-4 antibodies alone or in combination with other therapeutic agents enhances the tumor-suppressive effects of the immune system and improves cancer prognosis. Immune checkpoint inhibitors hold great potential for breast cancer treatment. This review discusses the role of CTLA-4 and its therapeutic potential in breast cancer therapeutics.
CURRENT MOLECULAR MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Monireh Khordadmehr, Hamed Ezzati, Amirali Shahbazfar, Farinaz Jigari-Asl, Behzad Baradaran, Elham Baghbani, Saeed Noorolyai
Summary: The overexpression of miR-451a can enhance the chemosensitivity of breast cancer cells to carboplatin therapy, which may provide a beneficial strategy for future cancer therapy.
PHARMACEUTICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Fahimeh Zahednezhad, Parvin Zakeri-Milani, Javid Shahbazi Mojarrad, Muhammad Sarfraz, Mohammad Mahmoudian, Behzad Baradaran, Hadi Valizadeh
Summary: This study investigates the cellular uptake and cytotoxicity of surface-modified cisplatin (CisP) loaded liposomes in macrophage and cancer cells. Modified/un-modified liposomes were prepared and characterized for various properties. The results show that the modified liposomes demonstrate higher cellular uptake and increased cytotoxicity in the studied cells. Acetyl carnitine modification of CisP-liposomes can be considered an effective approach for increasing cellular uptake and cytotoxicity in cancer and macrophage cells.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Oncology
Samane Abbasi, Milad Asghari Totmaj, Masoumeh Abbasi, Saba Hajazimian, Pouya Goleij, Javad Behroozi, Behrouz Shademan, Alireza Isazadeh, Behzad Baradaran
Summary: Over the last decade, novel therapeutic approaches like CAR-T-cell immunotherapy have transformed the treatment perspective of human malignancies. However, this therapy is associated with side effects and faces challenges in manufacturing, engineering, applications, and toxicities. Further studies are needed to enhance efficacy and minimize adverse events.
Review
Oncology
Zanyar HajiEsmailpoor, Peyman Tabnak, Behzad Baradaran, Fariba Pashazadeh, Leili Aghebati-Maleki
Summary: The purpose of this study was to evaluate the diagnostic performance of computed tomography (CT) scan-based radiomics in predicting lymph node metastasis (LNM) in gastric cancer (GC) patients. The results showed that there were differences in sensitivity, specificity, diagnostic odds ratio (DOR), and area under the curve (AUC) between radiomics models and combined models. Subgroup analysis also found that different CT scan phases, regions of interest (ROIs), and segmentation methods had an impact on diagnostic accuracy. In conclusion, CT scan-based radiomics approach has the potential to predict LNM in GC patients preoperatively as a non-invasive diagnostic tool.
FRONTIERS IN ONCOLOGY
(2023)
Review
Multidisciplinary Sciences
Omid Rahbar Farzam, Niloofar Mehran, Farzaneh Bilan, Ehsan Aghajani, Reza Dabbaghipour, Ghazale Asemani Shahgoli, Behzad Baradaran
Summary: Colorectal cancer, a common malignancy with high mortality, can be effectively treated using imaging-guided photothermal therapy combined with nanotechnology. This approach minimizes side effects and improves treatment outcomes, making it significant for colorectal cancer treatment.
Article
Rheumatology
Roghayeh Tofigh, Mohammadali Hosseinpourfeizi, Reza Safaralizadeh, Sepideh Ghoddusifar, Behzad Baradaran
Summary: This study identifies NEAT1, GAS5, and GAPLINC as promising serological biomarkers in rheumatoid arthritis (RA). The reduced expression of NEAT1 and GAS5 suggests their potential roles as diagnostic and prognostic markers, while the significantly elevated average expression of GAPLINC in RA patients' serum samples indicates its potential as a biomarker candidate for disease stratification. TMEVPG1, on the other hand, displayed unaltered expression levels in RA samples.
CURRENT RHEUMATOLOGY REVIEWS
(2023)
Article
Biology
Rozhin Dabbaghi, Reza Safaralizadeh, Shima Rahmani, Nesa Barpour, Mohammadali Hosseinpourfeizi, Ali Rajabi, Behzad Baradaran
Summary: This study investigates the role of T-bet, IFN-gamma, and MEG3 in the pathogenesis of multiple sclerosis (MS) and their potential as diagnostic and therapeutic targets. The results show that T-bet expression is elevated in treatment-naive relapsing-remitting MS (RRMS) patients compared to healthy individuals. RRMS patients treated with different disease modifying therapies (DMTs) exhibit downregulated T-bet and MEG3 expression levels, with more pronounced effects in females. The correlation between T-bet and MEG3 and between IFN-gamma and T-bet is observed in healthy individuals, while a strong positive correlation is found between MEG3 and IFN-gamma in RRMS patients treated with Glatiramer Acetate (GA). Remarkably, RRMS patients treated with Dimethyl Fumarate (DMF) show a significant positive correlation between T-bet and MEG3. These findings suggest the diagnostic potential of T-bet in RRMS and indicate the need for further exploration of the interplay between MEG3, T-bet, and IFN-gamma in RRMS patients.
BMC RESEARCH NOTES
(2023)
Article
Engineering, Aerospace
S. A. H. Hosseini, O. Rahmani, V. Refaeinejad, H. Golmohammadi, M. Montazeripour
Summary: This paper investigates the effect of deepness on the in-plane free vibration behavior of a curved functionally graded nanobeam based on nonlocal elasticity theory. Differential equations and boundary conditions are developed using Hamilton's principle, and nonlocal theory is adopted to study the size effect. Material properties vary in the radial direction. The natural frequencies are obtained using the Navier solution technique. Furthermore, the influence of the deepness effect on vibrations is considered by examining the thickness to radius ratio and the differences percentage between cases with and without deepness effect is studied. The results show that the arc angle and power law exponent parameters have the most significant impact on the differences percentage.
ADVANCES IN AIRCRAFT AND SPACECRAFT SCIENCE
(2023)
Article
Immunology
Ali Sayadmanesh, Vahid Yekehfallah, Amir Valizadeh, Ali Abedelahi, Hajar Shafaei, Dariush Shanehbandi, Mohsen Basiri, Behzad Baradaran
Summary: CAR T cell therapy has shown promising efficacy in patients with hematologic malignancies, but it also presents potential toxicity and adverse effects. This study focuses on the unexpected side effects of targeting normal host tissues and discusses recent safety strategies.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Farid Mostafaei, Somayeh Mahdinloo, Hadi Valizadeh, Salar Hemmati, Mahdieh Abdi, Muhammad Sarfraz, Behzad Baradaran, Parvin Zakeri-Milani
Summary: Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer, usually diagnosed in advanced stages. Chemotherapy is commonly used to treat advanced liver cancer but faces challenges that reduce its effectiveness. This review discusses the prevalence, staging, and treatment methods for liver cancer. It also explores recent studies on smart drug- and gene-delivery systems designed specifically for HCC, aiming to improve treatment efficacy.
Review
Oncology
Najibeh Shekari, Dariush Shanehbandi, Tohid Kazemi, Habib Zarredar, Behzad Baradaran, Seyed Amir Jalali
Summary: This article summarizes current evidence on V-domain immunoglobulin suppressor of T cell activation (VISTA), its related ligands, their interactions and effects, as well as preclinical and clinical targeting agents. Investigating VISTA ligands helps understand their functions and roles, and may facilitate the discovery of alternative therapeutic approaches targeting the VISTA pathway.
CANCER CELL INTERNATIONAL
(2023)
Article
Genetics & Heredity
Masoumeh Hajizadeh, Farnaz Hajizadeh, Sevil Ghaffarei, Mohammad Amin Doustvandi, Khadijeh Hajizadeh, Seyyed Mohammad Yaghoubi, Fateme Mohammadnejad, Nadia Allahyarzadeh Khiabani, Pegah Mousavi, Behzad Baradaran
Summary: This review summarizes the role and potential efficacy of miRNAs in promoting and inhibiting cell proliferation and apoptosis in HCC, as well as the role of miRNAs in therapy resistance in HCC.
Article
Materials Science, Multidisciplinary
Zeinab Asghari Adib, Amir Reza Sharifi, Mohammad Ali Kiani, Hossein Yousefi, Daniel Horak, Uliana Kostiv, Ali Nabavi-Rad, Abbas Yadegar, Mohammad Yaghoubi-Avini, Hamed Golmohammadi
Summary: A biocompatible nanosensor has been developed for diagnosing Helicobacter pylori (H. pylori) infection, utilizing changes in pH-dependent fluorescence/color profile caused by the enzymatic reaction of H. pylori urease enzyme with urea. A portable 3D-printed smartphone-based imaging platform was fabricated for monitoring the nanosensor. This smart nanosensor shows potential for non-invasive diagnosis of H. pylori infection and offers insights for the development of innovative ingestible/swallowable sensors for non-invasive gastrointestinal diagnostics.
MATERIALS ADVANCES
(2023)
Article
Medicine, Research & Experimental
Maryam Tohidast, Neda Memari, Mohammad Amini, Seyed Samad Hosseini, Asiyeh Jebelli, Mohammad Amin Doustvandi, Behzad Baradaran, Ahad Mokhtarzadeh
Summary: This study demonstrates that the combination of miR-145 and paclitaxel can inhibit cell proliferation and migration in prostate cancer cells, and enhance chemosensitivity. This combination therapy may be a promising approach for the treatment of prostate cancer.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2023)
