Article
Gastroenterology & Hepatology
Abigail Raffner Basson, Jeffry Katz, Sargun Singh, Fabiano Celio, Fabio Cominelli, Alexander Rodriguez-Palacios
Summary: Although artificial sweeteners are considered safe, they can contribute to gastrointestinal inflammation. In this study, IBD patients were found to consume artificial sweeteners and low calorie foods/drinks more frequently compared to control participants. Consumption of artificial sweeteners correlated with healthy habits among IBD patients.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Chemistry, Medicinal
Mengfan Liao, Songyi Wei, Xianmin Hu, Juan Liu, Jun Wang
Summary: This study investigates the protective effect and mechanisms of Eckol, a seaweed-derived bioactive phlorotannin, on chronic ulcerative colitis in mice. The results show that Eckol can reduce disease activity indexes, improve colon length shortening and colonic tissue damage, decrease inflammatory cytokine levels, and regulate immune cell levels and signaling pathways.
Article
Gastroenterology & Hepatology
Julien Kirchgesner, Rishi J. Desai, Maria C. Schneeweiss, Laurent Beaugerie, Sebastian Schneeweiss, Seoyoung C. Kim
Summary: Combination therapy with vedolizumab and thiopurines is associated with a lower risk of treatment failure compared to vedolizumab monotherapy in patients with CD, but the effect is less pronounced in UC.
Review
Immunology
Giovanni Monteleone, Eleonora Franze, Edoardo Troncone, Claudia Maresca, Irene Marafini
Summary: Interleukin-34 (IL-34) plays a crucial role in chronic inflammatory bowel diseases (IBD) by promoting interactions between immune cells and stromal cells, leading to increased mucosal inflammation and production of fibrogenic molecules.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Food Science & Technology
Andrea Nieto-Veloza, Zhihong Wang, Qixin Zhong, Doris D'Souza, Hari B. Krishnan, Vermont P. Dia
Summary: This study assessed the in vivo anti-inflammatory properties of Lunasin protease inhibitor concentrate (LPIC). In vitro tests showed that LPIC induced the production of nitric oxide and maintained cytokine levels. In vivo experiments demonstrated that LPIC significantly attenuated tissue damage in ulcerative colitis.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Review
Nutrition & Dietetics
Erik Oudman, Jan W. Wijnia, Misha J. Oey, Mirjam van Dam, Albert Postma
Summary: Crohn's disease and ulcerative colitis patients are at risk of developing Wernicke's encephalopathy due to thiamine depletion, rapid and high-dose thiamine treatment can effectively alleviate symptoms and save lives.
Review
Immunology
Reza Yarani, Ali Shojaeian, Oana Palasca, Nadezhda T. Doncheva, Lars Juhl Jensen, Jan Gorodkin, Flemming Pociot
Summary: This review discusses the differential regulation of miRNAs in inflammatory bowel disease (IBD) and their potential diagnostic and therapeutic applications. Through literature curation and computational analysis, a consensus set of differentially expressed miRNAs in mucosal tissues was obtained. The role of these miRNAs and their potential targets in IBD are highlighted.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Tatsuki Noguchi, Soichiro Ishihara, Motoi Uchino, Hiroki Ikeuchi, Koji Okabayashi, Kitaro Futami, Shinji Tanaka, Hiroki Ohge, Hisashi Nagahara, Kazuhiro Watanabe, Michio Itabashi, Kinya Okamoto, Yoshiki Okita, Tsunekazu Mizushima, Yusuke Mizuuchi, Kazutaka Yamada, Yoshifumi Shimada, Yu Sato, Hideaki Kimura, Kenichi Takahashi, Koya Hida, Yusuke Kinugasa, Junji Okuda, Koji Daito, Fumikazu Koyama, Hideki Ueno, Takayuki Yamamoto, Tsunekazu Hanai, Atsuo Maemoto, Koji Oba, Yoichi Ajioka, Kenichi Sugihara
Summary: Patients with longstanding inflammatory bowel disease, such as ulcerative colitis and Crohn's disease, are at high risk of developing intestinal cancers. This study found significant differences between intestinal cancers associated with ulcerative colitis and Crohn's disease. Crohn's disease-associated cancers were diagnosed at more advanced stages, detected less frequently by surveillance, and had a poorer prognosis compared to those associated with ulcerative colitis.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Cell Biology
Faezeh Niazi Shahraki, Saeideh Momtaz, Maryam Baeeri, Danial Khayatan, Naser-Aldin Lashgari, Nazanin Momeni Roudsari, Ali Reza Abdollahi, Ahmad Reza Dehpour, Amir Hossein Abdolghaffari
Summary: This study evaluated the anti-inflammatory effects of Licofelone in a rat model of acetic acid-induced colitis. The results showed that Licofelone attenuated colitis, increased superoxide dismutase activity, and significantly reduced colonic levels of inflammatory factors. Additionally, the concurrent use of nitric oxide synthase inhibitors with Licofelone reversed the observed positive effects, demonstrating the role of nitric oxide in the pathogenesis of inflammatory bowel disease and the mechanism of action of Licofelone in colitis healing.
Article
Genetics & Heredity
Dasa Jevsinek Skok, Nina Hauptman, Miha Jerala, Nina Zidar
Summary: Ulcerative colitis (UC) and Crohn's disease (CD) involve imbalance in cytokine levels, with INSL5, LEFTY1, and BMP8B identified as potential key genes that may play a role in both diseases and require further investigation for diagnostic potential.
Article
Gastroenterology & Hepatology
Marina Liso, Giulio Verna, Elisabetta Cavalcanti, Stefania De Santis, Raffaele Armentano, Angela Tafaro, Antonio Lippolis, Pietro Campiglia, Antonio Gasbarrini, Mauro Mastronardi, Theresa Torres Pizarro, Fabio Cominelli, Loris Riccardo Lopetuso, Marcello Chieppa
Summary: This study provides new insights and alternative approaches to treat ulcerative colitis (UC) patients. It suggests that anti-interleukin (IL)1 strategies, such as anakinra, may be a more effective therapeutic option for primary nonresponders to anti-tumor necrosis factor (TNF) therapy.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Biochemical Research Methods
Florent Clerc, Karli R. Reiding, Noortje de Haan, Carolien A. M. Koeleman, Agnes L. Hipgrave Ederveen, Natalia Manetti, Viktoria Dotz, Vito Annese, Manfred Wuhrer
Summary: This study investigates the associations of immunoglobulin A1 and A2 glycosylation with inflammatory bowel diseases (IBD). Differences in IgA O- and N-glycosylation between patient groups were found to be associated with the diseases, and a statistical model was constructed to predict the disease group of the patients. These findings contribute to the development of noninvasive biomarkers for IBD and improvement in patient care.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Giorgos Bamias, Theresa T. Pizarro, Fabio Cominelli
Summary: This review describes the cellular and molecular immunological mechanisms of intestinal fibrosis in IBD, with a particular focus on animal models of intestinal fibrosis. Based on this research, potential future targets for antifibrotic therapies for IBD patients can be identified.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Medical Informatics
Marco Chierici, Nicolae Puica, Matteo Pozzi, Antonello Capistrano, Marcello Dorian Donzella, Antonio Colangelo, Venet Osmani, Giuseppe Jurman
Summary: The SI-CURA project aims to develop artificial intelligence solutions for discriminating different pathologies, including inflammatory bowel disease, based on endoscopic imaging. The deep learning prototype developed in this study achieves high performance in identifying disease patterns and shows potential as a decision support tool for endoscopy-based diagnosis.
BMC MEDICAL INFORMATICS AND DECISION MAKING
(2022)
Article
Gastroenterology & Hepatology
Amy L. Lightner, Sarah Vogler, John McMichael, Xue Jia, Miguel Regueiro, Taha Qazi, Scott R. Steele
Summary: While UC patients were more likely to have neoplasia detected during colonoscopy, the rates of progression from LGD and HGD to adenocarcinoma were equivalent in UC and CD, suggesting consistent endoscopic surveillance strategies for all IBD patients.
JOURNAL OF CROHNS & COLITIS
(2021)