Article
Microbiology
Mon-Chien Lee, Yu-Tsai Tu, Chia-Chia Lee, Shiow-Chwen Tsai, Han-Yin Hsu, Tsung-Yu Tsai, Te-Hua Liu, San-Land Young, Jin-Seng Lin, Chi-Chang Huang
Summary: The study investigated the effects of supplementation with Lactobacillus plantarum TWK10 on muscle mass and functional performance in elderly individuals, revealing that consecutive supplementation for more than six weeks effectively improved muscle strength and endurance, reducing sarcopenia and physical fragility.
Review
Cell Biology
Ting Zhang, Jin-ke Cheng, Yao-min Hu
Summary: Sarcopenia, a progressive loss of skeletal muscle mass and function with aging, has been shown to be closely related to gut microbiota. Strategies such as probiotics and fecal microbiota transplantation have shown potential in ameliorating muscle loss.
AGEING RESEARCH REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Kippeum Lee, Jisoo Kim, Soo-Dong Park, Jae-Jung Shim, Jung-Lyoul Lee
Summary: Sarcopenia, the loss of muscle mass and function in elderly individuals, is a common issue affecting quality of life. Recent studies have shown that certain lactic acid bacteria may help improve muscle function. L. plantarum HY7715 promotes myoblast differentiation and mitochondrial biogenesis, inhibiting the sarcopenic process in skeletal muscle.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Geriatrics & Gerontology
Chaoran Liu, Wing-Hoi Cheung, Jie Li, Simon Kwoon-Ho Chow, Jun Yu, Sunny Hei Wong, Margaret Ip, Joseph Jao Yiu Sung, Ronald Man Yeung Wong
Summary: This systematic review analyzed the evidence on the effects of gut microbiota on muscle/sarcopenia, showing that altering the gut microbiota can directly affect muscle phenotypes. Probiotics, prebiotics, short-chain fatty acids, and bacterial products are potential novel therapies to enhance muscle mass and physical performance. The potential mechanisms of microbiome modulating muscle include protein, energy, lipid, and glucose metabolism, inflammation level, neuromuscular junction, and mitochondrial function.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Medicine, Research & Experimental
Zhibo Zeng, Zonghao Huang, Wen Yue, Shah Nawaz, Xinzhu Chen, Jing Liu
Summary: The administration of Lactobacillus plantarum has significant immunoenhancing effects in immunosuppressed mice, restoring specific immune markers in the spleen and increasing the number of goblet cells in the intestine. Microbial taxonomic analysis showed changes in the gut microbiota composition, with a decrease in Firmicutes and an increase in Verrucomicrobia and Actinobacteria. Additionally, treatment with Lactobacillus plantarum restored mRNA expression of inflammatory cytokines.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Food Science & Technology
Yuhan Xu, Qiaoling Xie, Wei Zhang, Meizhen Zhu, Xiaoxuan Chen, Dongbei Guo, Lili Pan, Junru Li, Hui Lan, Hongwei Li
Summary: The effects of probiotics Lp662 and Lp299v on severe inflammatory bowel disease induced by dextran sodium sulfate were evaluated. The results showed that these probiotics can reduce weight loss caused by colitis, decrease tissue injury, and lower inflammatory factor levels. Additionally, probiotics can also increase bone density. Therefore, probiotics have the potential to be a treatment option for inflammatory bowel disease.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Food Science & Technology
Jing Yu, Yongjun Xia, Guangqiang Wang, Zhiqiang Xiong, Hui Zhang, Phoency F-H Lai, Xin Song, Lianzhong Ai
Summary: The study found that the strain AR495 of Lactobacillus plantarum significantly inhibited osteoporosis and improved intestinal health in ovx mice. AR495 modulated bone resorption and intestinal inflammatory responses, as well as enhanced intestinal microbial stability and short-chain fatty acid production in ovx mice.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Review
Nutrition & Dietetics
Matthew D. Watson, Brett L. Cross, Gregory J. Grosicki
Summary: Globally, the population aged 65 and older is growing rapidly, facing issues such as changes in body composition, declines in cardiorespiratory fitness, and reductions in muscle size and function. Decreased muscle protein synthesis in response to anabolic stimuli plays a key role in the development of sarcopenia in aging individuals. Recent studies suggest a bidirectional gut-muscle axis affecting aging muscle health, with lifestyle habits potentially impacting changes in the microbiome.
Article
Microbiology
Chia-Chia Lee, Yi-Chu Liao, Mon-Chien Lee, Yi-Chen Cheng, Shiou-Yun Chiou, Jin-Seng Lin, Chi-Chang Huang, Koichi Watanabe
Summary: This study found that viable and heat-killed forms of Lactiplantibacillus plantarum TWK10 have similar effects in improving exercise performance and attenuating exercise-induced inflammatory responses, but viable TWK10 has a better effect in regulating body composition. The differences in efficacy between the two forms may be due to their differential impacts on shaping gut microbiota.
Article
Agriculture, Multidisciplinary
Wan Wang, Fei Liu, Cong Xu, Zhijing Liu, Jiage Ma, Liya Gu, Zhanmei Jiang, Juncai Hou
Summary: The study showed that the combination of L. plantarum 69-2 and GOS could significantly improve liver function, antioxidant capacity, and inflammation by regulating gut microbiota and activating the hepatic AMPK/SIRT1 signaling pathway. By targeting the gut microbiota through the gut-liver axis, it provided new insights for alleviating aging.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Food Science & Technology
Xiaofeng Jiang, Xiaojun Qi, Chao Xie
Summary: This study investigated the potential effects of the probiotic strain Lactobacillus plantarum LP45 on glucocorticoid-induced osteoporosis (GIO) in rats. The results showed that oral administration of LP45 dose-dependently improved bone defects, increased bone mineral density and biomechanics, and restored molecular changes related to bone metabolism in GIO rats. These findings suggest that LP45 has the potential to be a dietary supplement with beneficial effects against osteoporosis.
FOOD & NUTRITION RESEARCH
(2023)
Article
Food Science & Technology
Yuxiao Liao, Xiaolei Zhou, Zhao Peng, Dan Li, Zitong Meng, Shiyin Xu, Xuefeng Yang, Liegang Liu, Wei Yang
Summary: This study found that yeast protein supplementation can improve muscle conditions in elderly mice by promoting muscle protein synthesis and regeneration. These improvements are closely related to changes in gut microbiota.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Food Science & Technology
Yunting Li, Anfei Liu, Lixuan Chen, Yang Xiang, Dingbang Huang, Wanwen Huang, Zhenhui Chen, Hongying Fan, Xiaojing Meng
Summary: The study found that Lactobacillus plantarum WSJ-06 can improve neurological disorders induced by lead exposure, alleviate memory dysfunction, and achieve this effect by modulating gut microbiota and serum metabolites.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Geriatrics & Gerontology
Chul-Hyun Park, Eun-Ju Lee, Hyung-Lae Kim, Yong-Taek Lee, Kyung Jae Yoon, Han-Na Kim
Summary: This study reveals the sex-specific differences in gut microbiota diversity, composition, and metabolic pathways related to skeletal muscle mass. Men with higher muscle mass have higher diversity and certain abundant species in gut microbiota. No significant differences in gut microbiota were observed among different muscle mass groups in women. Functional analysis suggests that the gut microbiota of individuals with lower muscle mass is enriched with genes related to amino acid biosynthesis and energy generation. This study expands our understanding of the relationship between skeletal muscle mass and gut microbiota.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Food Science & Technology
Yunting Li, Anfei Liu, Lixuan Chen, Yang Xiang, Dingbang Huang, Wanwen Huang, Zhenhui Chen, Hongying Fan, Xiaojing Meng
Summary: Lactobacillus plantarum WSJ-06 alleviates neuroinflammation and memory impairment caused by chronic lead exposure by modulating gut microbiota and serum metabolites.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Microbiology
Shih-Ting Lin, Li-Ting Wang, Hsing-Min Wang, Tomohiko Tamura, Koji Mori, Lina Huang, Koichi Watanabe
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2020)
Article
Microbiology
Chien-Hsun Huang, Chun-Lin Wang, Jong-Shian Liou, Ai-Yun Lee, Jochen Blom, Lina Huang, Koichi Watanabe
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2019)
Article
Microbiology
Yen-Chi Wu, Shih-Ting Lin, Jia-Rong Guu, Tomohiko Tamura, Koji Mori, Li-Ting Wang, Lina Huang, Koichi Watanabe
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2020)
Article
Microbiology
Shih-Ting Lin, Li-Ting Wang, Yen-Chi Wu, Jia-Rong Jeremy Guu, Tomohiko Tamura, Koji Mori, Lina Huang, Koichi Watanabe
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2020)
Article
Microbiology
Chien-Hsun Huang, Chih-Chieh Chen, Jong-Shian Liou, Ai-Yun Lee, Jochen Blom, Yu-Chun Lin, Lina Huang, Koichi Watanabe
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2020)
Article
Microbiology
Jinshui Zheng, Stijn Wittouck, Elisa Salvetti, Charles M. A. P. Franz, Hugh M. B. Harris, Paola Mattarelli, Paul W. O'Toole, Bruno Pot, Peter Vandamme, Jens Walter, Koichi Watanabe, Sander Wuyts, Giovanna E. Felis, Michael G. Ganzle, Sarah Lebeer
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2020)
Article
Microbiology
Jong-Shian Liou, Chien-Hsun Huang, Nao Ikeyama, Ai-Yun Lee, I-Ching Chen, Jochen Blom, Chih-Chieh Chen, Chia-Hsuan Chen, Yu-Chun Lin, Sung-Yuan Hsieh, Lina Huang, Moriya Ohkuma, Koichi Watanabe, Mitsuo Sakamoto
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2020)
Article
Microbiology
Monica Modesto, Maria Satti, Koichi Watanabe, Chien-Hsun Huang, Jong-Shian Liou, Tomohiko Tamura, Satomi Saito, Koji Mori, Lina Huang, Camillo Sandri, Caterina Spiezio, Barbara Sgorbati, Donatella Scarafile, Cesare Camma, Massimo Ancora, Claudio Patavino, Masanori Arita, Paola Mattarelli
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2020)
Article
Biotechnology & Applied Microbiology
Monica Modesto, Maria Satti, Koichi Watanabe, Donatella Scarafile, Chien-Hsun Huang, Jong-Shian Liou, Tomohiko Tamura, Satomi Saito, Mizuki Watanabe, Koji Mori, Lina Huang, Camillo Sandri, Caterina Spiezio, Masanori Arita, Paola Mattarelli
SYSTEMATIC AND APPLIED MICROBIOLOGY
(2020)
Article
Microbiology
Chien-Hsun Huang, Chih-Chieh Chen, Shih-Hau Chiu, Jong-Shian Liou, Yu-Chun Lin, Jin-Seng Lin, Lina Huang, Koichi Watanabe
Article
Microbiology
Shih-Ting Lin, Jia-Rong Guu, Hsing-Min Wang, Tomohiko Tamura, Koji Mori, Lina Huang, Koichi Watanabe
Summary: Five strains belonging to the genus Fructobacillus were isolated from paper mulberry in Taiwan. Phylogenetic analysis based on gene sequences showed that these strains represented four novel species. The proposed names for these species are Fructobacillus papyriferae sp. nov., Fructobacillus papyrifericola sp. nov., Fructobacillus broussonetiae sp. nov., and Fructobacillus parabroussonetiae sp. nov.
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2022)
Article
Microbiology
Han-Yin Hsu, Yi-Chu Liao, Shih-Hsuan Lin, Jin-Seng Lin, Chia-Chia Lee, Koichi Watanabe
Summary: In this study, the safety of TWK10 was comprehensively assessed both in vivo and in vitro. The results showed that TWK10 did not cause genetic mutations, chromosomal abnormalities, red blood cell abnormalities, or subacute toxicity. Additionally, TWK10 was susceptible to all antibiotics tested, except kanamycin, and no antimicrobial resistance genes, virulence factors, or genes involved in biogenic amine synthesis were found in its genome.
Article
Microbiology
Sheng-Yao Wang, Yen-Po Chen, Ren-Feng Huang, Yi-Lu Wu, Shang-Tse Ho, Kuan-Yi Li, Koichi Watanabe, Ming-Ju Chen
Summary: HL1 and M1 strains were identified as L. kefiranofaciens subsp. kefirgranum, showing specific genes related to polysaccharide synthesis and other functionalities. The findings provide potential insights for probiotic screening and functionality predictions.
Article
Physiology
Yi-Chen Cheng, Chia-Chia Lee, Mon-Chien Lee, Han-Yin Hsu, Jin-Seng Lin, Chi-Chang Huang, Koichi Watanabe
Summary: The heat-killed Lactiplantibacillus plantarum TWK10 (TWK10-HK) demonstrated the ability to improve exercise endurance performance, increase muscle weight and strength, and regulate body composition in a double-blind, placebo-controlled clinical trial.
PHYSIOLOGICAL REPORTS
(2023)