Review
Cell Biology
Aleksandra Dabrowska, Juhi Kumar, Charalampos Rallis
Summary: Cellular and animal models have played a crucial role in understanding the relationship between diet, nutrient-response signaling pathways, and lifespan regulation. Recent advancements in drug treatments, mutagenesis, and high-throughput screens have provided valuable insights into cellular metabolism, development, and aging. Scientists are now focusing on characterizing growth and stress pathways to identify interventions for healthy aging and age-related diseases.
Article
Multidisciplinary Sciences
Shengjie Fan, Yingxuan Yan, Ying Xia, Zhenyu Zhou, Lingling Luo, Mengnan Zhu, Yongli Han, Deqiang Yao, Lijun Zhang, Minglv Fang, Lina Peng, Jing Yu, Ying Liu, Xiaoyan Gao, Huida Guan, Hongli Li, Changhong Wang, Xiaojun Wu, Huanhu Zhu, Yu Cao, Cheng Huang
Summary: Using C. elegans as a model, researchers found that nomilin, a compound found in citrus fruit, significantly extended the lifespan, healthspan, and toxin resistance of the nematodes. This anti-aging effect was dependent on specific pathways and nuclear hormone receptors. Additionally, nomilin was identified to directly bind with the human pregnane X receptor (hPXR). In animal studies, dietary supplementation of nomilin improved healthspan and lifespan, and induced a gene signature associated with longevity.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Samuel F. Kingsley, Yonghak Seo, Calista Allen, Krishna S. Ghanta, Steven Finkel, Heidi A. Tissenbaum
Summary: The long-term exposure to glucose alters the intestine microbial E. coli, leading to a decrease in the lifespan and healthspan of the host, Caenorhabditis elegans. The critical role of detoxification genes in maintaining health during a chronic high-sugar diet is highlighted in this study.
SCIENTIFIC REPORTS
(2021)
Article
Geriatrics & Gerontology
Lixin Wang, Ping Qiao, Zhuoer Ouyang, Danyang Li, Jingtong Zheng, Guoqiang Wang, Fang Wang
Summary: This study characterized the chemical composition of ginseng volatile oil (GVO) using gas chromatography-mass spectrometry (GC-MS), and found 73 volatile components in GVO. The study investigated the effects of GVO on the lifespan and healthspan of Caenorhabditis elegans and found that GVO significantly extended the lifespan and promoted the health of the nematodes. GVO also increased the antioxidant capacity and survival rate of nematodes after heat shock. Additionally, the study revealed that GVO up-regulated autophagy-related genes and increased the expression of superoxide dismutase 1 (sod-1), which are associated with aging.
Article
Biology
Javier Huayta, Joseph P. Crapster, Adriana San-Miguel
Summary: Dietary restriction (DR) activates the DAF-16 transcription factor in C. elegans, leading to lifespan extension. However, the extent of this activation and its impact on lifespan has not been quantitatively determined. In this study, we used CRISPR/Cas9-enabled fluorescent tagging, quantitative image analysis, and machine learning to assess the endogenous activity of DAF-16 under different DR regimes. Our results show strong endogenous DAF-16 activity induced by DR, with the activity being less responsive in aged individuals. DAF-16 activity is a robust predictor of lifespan, accounting for 78% of its variability under DR.
COMMUNICATIONS BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Masaharu Uno, Yuri Tani, Masanori Nono, Emiko Okabe, Saya Kishimoto, Chika Takahashi, Ryoji Abe, Takuya Kurihara, Eisuke Nishida
Summary: The study highlights the importance of communication between neuronal DAF-16 and intestinal DAF-16 in regulating organismal lifespan.
Article
Multidisciplinary Sciences
Lucas R. Mergan, Brecht R. Driesschaert, Liesbet R. Temmerman
Summary: Axenic dietary restriction (ADR), where animals feed on (semi-)defined culture medium in the absence of any other lifeform, is a peculiar but potent means of achieving longevity. ADR has been shown to more than double the lifespan of Caenorhabditis elegans, but the underlying mechanism remains unclear and seems distinct from other forms of dietary restriction. Our study focuses on the role of the protein CUP-4 and the coelomocytes, suggesting their involvement in ADR-mediated longevity. However, further investigation is needed to understand the immune function and endocytosis-related processes of the coelomocytes in the context of longevity.
Article
Cell Biology
Katharina Papsdorf, Jason W. Miklas, Amir Hosseini, Matias Cabruja, Christopher S. Morrow, Marzia Savini, Yong Yu, Carlos G. Silva-Garcia, Nicole R. Haseley, Luke Meraz Murphy, Pallas Yao, Elisa de Launoit, Scott J. Dixon, Michael P. Snyder, Meng C. Wang, William B. Mair, Anne Brunet
Summary: A study found that dietary mono-unsaturated fatty acids (MUFAs) are linked to longevity in several species. The mechanisms by which MUFAs extend lifespan involve an organelle network involving lipid droplets and peroxisomes. MUFAs increase the number of lipid droplets and peroxisomes, and this regulation of organelle abundance is critical for MUFA-induced longevity.
NATURE CELL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jiahao Zhu, Yumei Jia, Cong Wang, Wangting Zhou, Yifan Shu, Kaixin Zhang, Xiaoxiong Zeng, Renpeng Guo
Summary: This study investigated the anti-aging activities of Lonicera japonica polysaccharides (LJPs) and revealed their mechanism of action. LJPs were found to prolong the lifespan of Caenorhabditis elegans, improve its fitness, reduce lipofuscin accumulation, and activate stress-related genes and antioxidant system. These effects were mediated by the DAF-16 pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Cell Biology
Zhimin Qi, Huihui Ji, Monika Le, Hanmei Li, Angela Wieland, Sonja Bauer, Li Liu, Michael Wink, Ingrid Herr
Summary: Sulforaphane extends the lifespan of C. elegans by modulating the insulin/IGF-1 signaling pathway, promoting healthspan by increasing mobility and appetite while reducing lipofuscin accumulation.
Article
Engineering, Environmental
Xin Hua, Dayong Wang
Summary: N- (1,3-Dimethylbutyl)-N '-phenyl-p-phenylenediamine (6-PPD), a common additive in rubber, enters the environment through tire wear particles. Its derivative 6-PPDQ has been identified in water samples and has toxic effects on coho salmon. This study found that environmentally relevant concentrations of 6-PPDQ can reduce lifespan and healthspan in Caenorhabditis elegans, with dysregulation in the insulin signaling pathway as the underlying mechanism.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Biology
Abigail R. R. Guillermo, Karolina Chocian, Gavriil Gavriilidis, Julien Vandamme, Anna Elisabetta Salcini, Jane Mellor, Alison Woollard
Summary: This study identifies chromatin modifiers as key regulators of longevity, with interactions between different factors such as expression levels and tissue specificity influencing lifespan outcomes. When considering molecular and tissue-specific effects, the heterochromatin loss model of ageing may be too simplistic to fully explain organismal ageing.
Article
Biochemistry & Molecular Biology
Lei Zhou, Jin Liu, Lan-Lan Bu, Duan-Fang Liao, Shao-Wu Cheng, Xi-Long Zheng
Summary: The novel compound curcumin acetylsalicylate (CA) was found to extend the lifespan of Caenorhabditis elegans in a dose-dependent manner, decrease oxidative stress, and increase the expression of antioxidative genes. Activation of the DAF-16 transcription factor by CA may contribute to delaying aging in C. elegans.
Article
Biochemistry & Molecular Biology
Jing Yao, Jiangying Zeng, Huinan Tang, Qianwen Shi, Xiangyu Li, Jingjing Tan, Yirui Cheng, Tianyuan Li, Jiyuan He, Yongjun Zhang
Summary: This research improved the extraction process of Auricularia auricula crude polysaccharides and obtained purified polysaccharides. The purified polysaccharides showed significant effects on lifespan, antioxidant system, and cell apoptosis through the up-regulation of gene expression.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Multidisciplinary Sciences
Tong-Hong Wang, Wei-Che Tseng, Yann-Lii Leu, Chi-Yuan Chen, Wen-Chih Lee, Ying-Chih Chi, Shu-Fang Cheng, Chun-Yu Lai, Chen-Hsin Kuo, Shu-Ling Yang, Sien-Hung Yang, Jiann-Jong Shen, Chun-Hao Feng, Chih-Ching Wu, Tsong-Long Hwang, Chia-Jen Wang, Shu-Huei Wang, Chin-Chuan Chen
Summary: The flavonoid corylin, isolated from Psoralea corylifolia, has been found to exhibit longevity properties in yeast, human cells, and mice. Traditional Chinese medicine has long been believed to increase lifespan, but identifying the specific molecules responsible for this effect has been challenging. Through screening traditional Chinese medicines and isolating compounds, researchers identified corylin as a key molecule in Psoralea corylifolia that extends lifespan in various organisms.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Anjar P. P. Asmara, Anchalee Prasansuklab, Tewin Tencomnao, Alison T. T. Ung
Summary: This study investigated the bioactive phytochemicals of Acacia saligna in Australia through sequential polarity-based extraction. The methanolic extracts from barks, leaves, and flowers showed the highest activity and no toxicity against adipocytes. Compound isolation led to the identification of two novel natural products and several known natural products. The identified compounds displayed strong antioxidant and alpha-glucosidase inhibitory activities. This research highlights the potential of Australian A. saligna as a source of bioactive compounds for drug development targeting type 2 diabetes.
Article
Plant Sciences
Kamonwan Chaikhong, Sawarin Chumpolphant, Panthakarn Rangsinth, Chanin Sillapachaiyaporn, Siriporn Chuchawankul, Tewin Tencomnao, Anchalee Prasansuklab
Summary: This study screened 16 Thai medicinal plant species and identified potential anti-skin aging properties. The leaves of A. occidentale and G. zeylanicum exhibited strong antioxidants and inhibition against elastase and tyrosinase. Other potential plants include S. alata leaf and A. catechu fruit, with relatively high anti-elastase and anti-tyrosinase activities, respectively. These findings suggest that these plants and their derived compounds could be developed as promising and effective agents for skin aging therapy.
Review
Biochemistry & Molecular Biology
Alison T. Ung, Anjar P. Asmara
Summary: Acacia saligna is a fast-growing plant that has been introduced to various parts of the world due to its adaptability to drought and saline and alkaline soils. Studies have been conducted on the bioactivities and phytochemicals of the plant extracts, but there is still a lack of comprehensive information linking these bioactivities to the identified compounds.
Article
Biochemistry & Molecular Biology
Anjar P. Asmara, Anchalee Prasansuklab, Anchalee Chiabchalard, Hui Chen, Alison T. Ung
Summary: Methanolic extracts from various parts of Acacia saligna showed significant antioxidant activities. These extracts and isolated compounds were able to reduce cellular reactive oxygen species (ROS) levels and maintain mitochondrial function in 3T3-L1 adipocytes. They also activated the AMPK signaling pathway and enhanced glucose uptake.
Article
Biochemistry & Molecular Biology
Anjar P. Asmara, Hui Chen, Alison T. Ung
Summary: Secondary metabolites of Acacia saligna show potential in treating type 2 diabetes mellitus and its related conditions. They can reduce lipid levels, promote mitochondrial biogenesis, and decrease pro-inflammatory cytokines. This study provides important evidence for further exploring the pharmacological mechanisms of these compounds.
Article
Nutrition & Dietetics
Nattaporn Pattarachotanant, Panthakarn Rangsinth, Watis Warayanon, George Pak-Heng Leung, Siriporn Chuchawankul, Anchalee Prasansuklab, Tewin Tencomnao
Summary: In this study, the neuroprotective and xenobiotic detoxification effects of ethanolic extract of Aquilaria crassna leaves (ACEE) were investigated. The results showed that ACEE had neuroprotective effects and could ameliorate the negative effects of high benzo[a]pyrene induction. The active compound clionasterol was identified as a potential key constituent.
Article
Food Science & Technology
Ansella Amanda Epifani Widoyanti, Kamonwan Chaikong, Panthakarn Rangsinth, Patcharaporn Saengratwatchara, George Pak-Heng Leung, Anchalee Prasansuklab
Summary: Nam Wah banana byproducts were investigated for their phytochemicals, antioxidant and anti-inflammatory activities, and toxicity. The results showed that the byproducts contain antioxidant and anti-inflammatory compounds, suggesting potential therapeutic applications.
Review
Food Science & Technology
Panthakarn Rangsinth, Rajasekharan Sharika, Nattaporn Pattarachotanant, Chatrawee Duangjan, Chamaiphron Wongwan, Chanin Sillapachaiyaporn, Sunita Nilkhet, Nichaporn Wongsirojkul, Anchalee Prasansuklab, Tewin Tencomnao, George Pak-Heng Leung, Siriporn Chuchawankul
Summary: Ergosterol, a sterol found in edible mushrooms, is not only a precursor to vitamin D2 but also exhibits various pharmacological effects, such as antimicrobial, antioxidant, anticancer, antidiabetic, and anti-neurodegenerative activities. This review provides an overview of the pharmacological effects of ergosterol, its underlying mechanisms, and potential applications.
Article
Pharmacology & Pharmacy
Polly Ho-Ting Shiu, Chengwen Zheng, Panthakarn Rangsinth, Wen Wang, Jingjing Li, Renkai Li, George Pak-Heng Leung
Summary: The study evaluated the antioxidant and anti-inflammatory effects of gallic acid, a natural triphenolic compound, on HaCaT keratinocytes and investigated its mechanisms of action. The results showed that gallic acid at concentrations below 30 μM was not toxic to HaCaT cells, reduced intracellular reactive oxygen species, and suppressed the release of interleukin-8 and monocyte chemoattractant protein-1 in stimulated HaCaT keratinocytes. Furthermore, gallic acid decreased NF-KB expression and inhibited the phosphorylation of ERK1/2, p38 MAPK, and Akt in stimulated HaCaT keratinocytes. In conclusion, gallic acid exhibited antioxidant and anti-inflammatory effects on keratinocytes, potentially through the inhibition of MAPK-, NF-KB-, and Akt-dependent signaling pathways.
BANGLADESH JOURNAL OF PHARMACOLOGY
(2023)
Article
Chemistry, Applied
Bishwajit Bokshi, Hui Chen, Alison T. Ung
Summary: The chlorophyll-free fractions of Andrographis paniculata have been found to significantly enhance glucose uptake and reduce lipid accumulation. The acid, basic, and neutral fractions all showed improved glucose uptake, and the presence of chemicals with antidiabetic activities was detected. These findings support the use of A. paniculata in treating type 2 diabetes.
NATURAL PRODUCT RESEARCH
(2023)
