Article
Psychology, Multidisciplinary
Sarah M. Tashjian, Virginia Fedrigo, Tanaz Molapour, Dean Mobbs, Colin F. Camerer
Summary: This study reveals the significance of social dynamics (friends vs. strangers) on tonic arousal and the impact of subjective fear and threat predictability on phasic arousal.
PSYCHOLOGICAL SCIENCE
(2022)
Article
Psychology, Multidisciplinary
Fan Xuan Chen, Xinyu Zhang, Lasse Laustsen, Joey T. Cheng
Summary: The study reveals that dominant leaders can promote group cooperation by assuming the role of threatening punishment. This influence is not only evident when leaders are assigned to groups, but also seen when followers are evoked with impressions of leader dominance through personality, attitude, or physical appearance.
PSYCHOLOGICAL SCIENCE
(2021)
Article
Psychology, Clinical
Sara D. McMullin, Grant S. Shields, George M. Slavich, Tony W. Buchanan
Summary: The study found that lifetime stress exposure is associated with impulsivity and addiction, but these effects vary depending on the addiction outcome and timing of stress exposure.
JOURNAL OF HEALTH PSYCHOLOGY
(2021)
Article
Psychology, Multidisciplinary
Jurgen Schneider, Tom Rosman, Augustin Kelava, Samuel Merk
Summary: In three experimental studies, we investigated the potential impact of badges for open-science practices on trust in scientists and topic-specific epistemic beliefs. We found that badges influenced trust as expected, with the exception of the public sample. We also found evidence for the relationship between badges, epistemic beliefs, and trust, and no moderation by epistemic beliefs.
PSYCHOLOGICAL SCIENCE
(2022)
Article
Psychiatry
Christopher S. Stauffer, Tyler E. Morrison, Nathan K. Meinzer, David Leung, Jessica Buffington, Evan G. Sheh, Thomas C. Neylan, Aoife O'Donovan, Joshua D. Woolley
Summary: Co-occurring PTSD and AUD is common and treatment options are limited. Intranasal oxytocin administration may be effective in reducing symptoms, but dosage is important. This study found that oxytocin 20 IU had no effect on startle reactivity in co-occurring patients, while oxytocin 40 IU increased startle reactivity.
PSYCHIATRY RESEARCH
(2022)
Article
Psychology, Multidisciplinary
Cory J. Clark, Maja Graso, Ilana Redstone, Philip E. Tetlock
Summary: Two preregistered studies with representative U.S. adult samples tested the harm-hypervigilance hypothesis in risk assessments of controversial behavioral science. The findings showed that people consistently overestimated harmful reactions and underestimated helpful ones, even when incentivized for accuracy. The study also found associations between harm overestimations and support for censoring science, offense towards scientific findings, and conservative ideology.
PSYCHOLOGICAL SCIENCE
(2023)
Article
Environmental Sciences
Barbara Urban-Malinga, Magdalena Jakubowska, Anna Hallmann, Agnieszka Dabrowska
Summary: The study found limited toxic effects of graphene on the marine polychaete Hediste diversicolor, with the activation of defense mechanisms observed at the early stage of exposure. Significant inter-individual variability in the activities of certain biomarkers was found at the end of the long-term experiment, and the polychaetes buried deeper in sediments containing graphene exhibited escape and avoidance behavior.
Article
Psychology, Multidisciplinary
Sofia Carozza, Joni Holmes, Duncan E. Astle
Summary: Despite evidence supporting the harmful effects of childhood adversity, there is still controversy over its nature and underlying mechanisms. This study analyzed data from the ALSPAC and found that deprivation and threat are separate dimensions of adversity. Early experiences of deprivation were found to be associated with later measures of cognition and emotional functioning, with this association varying based on age of exposure. The study did not find a specific association between threat and emotional functioning.
PSYCHOLOGICAL SCIENCE
(2022)
Article
Multidisciplinary Sciences
Nadine Hamieh, Alexis Descatha, Marie Zins, Marcel Goldberg, Sebastien Czernichow, Nicolas Hoertel, Marie Plessz, Yves Roquelaure, Frederic Limosin, Cedric Lemogne, Joane Matta, Guillaume Airagnes
Summary: This study examined the potential association between physical exertion at work and subsequent tobacco, cannabis, alcohol, and sugar and fat consumption. The results showed that high levels of physical exertion at work were associated with increased tobacco and cannabis use, as well as a diet rich in sugar and fat. Therefore, the impact of physical exertion at work on substance use and dietary habits should be addressed and preventive strategies should be implemented.
SCIENTIFIC REPORTS
(2022)
Review
Psychiatry
Julija Gecaite-Stonciene, Maria G. G. Rossetti, Paolo Brambilla, Brian M. M. Hughes, Narseta Mickuviene, Marcella Bellani
Summary: This study systematically reviews the existing research on psychophysiological response during laboratory-induced stress and its relationship with neural correlates in mental disorders. The evidence from studies exploring the interplay between stress psychophysiology and neural correlates in mental disorders is limited and heterogeneous. Further studies are warranted to better understand the mechanisms of how psychophysiological stress markers interplay with neural correlates in the manifestation and progression of psychiatric illnesses.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Neurosciences
Smilla Weisser, Madeleine Mueller, Jonas Rauh, Roland Esser, Johannes Fuss, Beat Lutz, Jan Haaker
Summary: This study found that the levels of circulating eCBs increase during the acquisition of threat responses. The elevated eCB levels are associated with physiological and neural responses during threat learning.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Neurosciences
Aida Helana Binti Affandi, Alexandra C. Pike, Oliver Joe Robinson
Summary: Anxiety and stress are adaptive responses to threat that can promote both active and passive harm avoidance behaviors. While threat of shock may lead individuals to engage in passive avoidance, it may not necessarily increase active avoidance behavior. One potential explanation is that anxiety favors passive harm avoidance strategies to conserve energy.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Public, Environmental & Occupational Health
Brian Shiner, Krista Huybrechts, Jiang Gui, Luke Rozema, Jenna Forehand, Bradley Watts, Tammy Jiang, Jessica E. Hoyt, Jack Esteves, Paula P. Schnurr, Kristen Ray, Jaimie L. Gradus
Summary: A recent exploratory study found that direct-acting antivirals (DAAs) used for hepatitis C virus (HCV) infection may improve symptoms of posttraumatic stress disorder (PTSD). Among the evaluated DAAs, glecaprevir/pibrentasvir (GLE/PIB) showed better improvement in PTSD symptoms compared to ledipasvir/sofosbuvir (LDV/SOF), suggesting that GLE/PIB may be a potential treatment for PTSD.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Heather C. Brenhouse
Summary: Lifelong maladaptive behavior or illness often originates from early physiological aberrations, especially in cases of early life adversity. Exposure to adversity can lead to atypical sensitivity and responsivity to threats, which may be adaptive in preparing individuals for lifelong danger. However, it can also result in difficulties with emotion regulation and social relationships. Understanding the early development of physiological and immune systems is crucial for preventing and managing maladaptive threat sensitivity.
MOLECULAR PSYCHIATRY
(2023)
Article
Psychiatry
Qimeng Sun, Qingsong Qin, Maria Basta, Baixin Chen, Yun Li
Summary: Our study revealed that during the COVID-19 outbreak, adults with mental health disorders experienced significantly increased rates of anxiety, depression, and insomnia compared to the period before the pandemic. These individuals also had higher odds of developing COVID-19-related stress and worsening mental health symptoms. Factors such as prior levels of anxiety, depression, and insomnia, as well as COVID-19-related stress, were predictors for the exacerbation of symptoms in this population.
Article
Clinical Neurology
Jack M. Shireman, Fatemeh Atashi, Gina Lee, Eunus S. Ali, Miranda R. Saathoff, Cheol H. Park, Sol Savchuk, Shivani Baisiwala, Jason Miska, Maciej S. Lesniak, C. David James, Roger Stupp, Priya Kumthekar, Craig M. Horbinski, Issam Ben-Sahra, Atique U. Ahmed
Summary: Glioblastoma is a primary brain cancer with a near 100% recurrence rate. A molecular circuit involving the interaction between ARL13B and IMPDH2 has been identified, which affects the efficacy of chemotherapy.
Article
Psychology, Biological
Lauren M. Papp, Chrystyna D. Kouros, Hannah K. Witt, John J. Curtin, Shari M. Blumenstock, Alexandra Barringer
Summary: This study examined the relationship between young adults' momentary mood, mental health symptoms, and prescription drug misuse. It found that higher than usual negative mood was linked to a greater likelihood of misuse, but contrary to expectations, misuse was also more likely following elevated positive mood. Prescription misuse was associated with higher levels of negative mood and lower levels of positive mood.
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
(2022)
Article
Clinical Neurology
Dana Mitchell, Jack M. Shireman, Mahua Dey
NEUROLOGIC CLINICS
(2022)
Article
Psychology, Multidisciplinary
Sarah E. Victor, Jessica L. Schleider, Brooke A. Ammerman, Daniel E. Bradford, Andrew R. Devendorf, June Gruber, Lisa A. Gunaydin, Lauren S. Hallion, Erin A. Kaufman, Stephen P. Lewis, Dese'Rae L. Stage
Summary: This commentary leverages the perspectives of authors and signatories with personal experiences of psychopathology to improve inclusivity in psychological fields, by fostering discussion, research, and inclusion efforts. Concrete recommendations for personal and systemic changes are provided to improve recognition and acceptance of psychopathology experiences among psychologists.
PERSPECTIVES ON PSYCHOLOGICAL SCIENCE
(2022)
Article
Psychology, Clinical
Daniel E. E. Bradford, Angelica DeFalco, Emily R. R. Perkins, Ivan Carbajal, Jasmine Kwasa, Fallon R. R. Goodman, Felicia Jackson, Lietsel N. S. Richardson, Nina Woodley, Lindsay Neuberger, Jennifer A. A. Sandoval, Helen J. J. Huang, Keanan J. J. Joyner
Summary: Research using psychophysiological methods has potential for improving clinical assessment, identifying risk factors, and informing treatment. However, the unique methodological features of existing approaches limit inclusive research participation and result in exclusion of Black participants. Reflection and input from a wider range of affected individuals are needed to develop and refine new technologies.
CLINICAL PSYCHOLOGICAL SCIENCE
(2022)
Article
Cell Biology
Jack M. Shireman, Nikita Gonugunta, Lei Zhao, Akshita Pattnaik, Emily Distler, Skyler Her, Xiaohu Wang, Rahul Das, Jaques Galipeau, Mahua Dey
Summary: Age-related immune dysfunctions have close connections with pathologies like cancers and lack of vaccine efficacy among the elderly. An engineered fusokine, GIFT-7, has the potential to reverse aging-related lymphoid organ atrophy. In experiments using aged mouse models of glioblastoma, peripheral vaccination with GIFT-7TVax resulted in thymic regeneration, long-term antitumor immunity, increased pro-inflammatory cytokines, enhanced T-cell trafficking to the brain, and robust T-cell formation.
Review
Psychology, Biological
Michael W. Lewis, Daniel E. Bradford, Edward F. Pace-Schott, Scott L. Rauch, Isabelle M. Rosso
Summary: Persistent fear is a major symptom of PTSD, and deficient fear extinction retention is considered to be a mechanism of the illness and a target of therapy. However, the evidence for deficient fear extinction in PTSD using laboratory paradigms is inconclusive, possibly due to methodological variations across studies. This study reviewed the literature to identify these methodological differences and conducted a Multiverse Analysis to measure their impact on statistical findings. The findings revealed inconsistent results for fear extinction retention in PTSD, but consistently elevated skin conductance response to a danger cue was found. The study discusses the methodological parameters contributing to inconsistent findings and their implications for future research.
Article
Multidisciplinary Sciences
Ella N. Perrault, Jack M. Shireman, Eunus S. Ali, Peiyu Lin, Isabelle Preddy, Cheol Park, Shreya Budhiraja, Shivani Baisiwala, Karan Dixit, C. David James, Dieter H. Heiland, Issam Ben-Sahra, Sebastian Pott, Anindita Basu, Jason Miska, Atique U. Ahmed
Summary: This study investigates the cellular plasticity-induced adaptation during temozolomide (TMZ) therapy in glioblastoma (GBM) using single-cell RNA sequencing. The increased expression of RRM2, which regulates dNTP production vital for DNA damage response, was observed. Analysis of patients' tissues revealed strong correlations between RRM2 and dNTPs. Treatment with RRM2 inhibitor 3-AP enhances the efficacy of TMZ therapy in PDX models, providing new insights into chemoresistance through RRM2-mediated nucleotide production.
Letter
Neurosciences
Daniel E. Bradford, Amelia S. Dev, Angelica DeFalco, Freya Whittaker, Kiara R. Timpano
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Psychology, Biological
Michael W. Lewis, Daniel E. Bradford, Eylul Akman, Kevin Frederiks, Scott L. Rauch, Isabelle M. Rosso
Summary: Unconditioned responding (UCR) to an aversive stimulus is associated with defensive responding during fear acquisition, but its relationships with extinction training, PTSD symptom severity, and fearful traits are unknown. This study found that UCR, particularly unconditioned startle, is positively associated with defensive responding and fearful traits, but not with PTSD symptom severity.
Review
Oncology
Jack M. Shireman, Simon Ammanuel, Jens C. Eickhoff, Mahua Dey
Summary: This study reveals significant differences in immunobiology between males and females, which also affect the overall response to immunotherapy in GBM treatment.
NEURO-ONCOLOGY ADVANCES
(2022)
