Article
Engineering, Biomedical
Yong Tang, Keyu Luo, Yin Chen, Yueqi Chen, Rui Zhou, Can Chen, Jiulin Tan, Moyuan Deng, Qijie Dai, Xueke Yu, Jian Liu, Chengmin Zhang, Wenjie Wu, Jianzhong Xu, Shiwu Dong, Fei Luo
Summary: The phosphorylation state of PTP1B Y152 plays a central role in initiating the departure of cells from their niches during bone regeneration. A peptide called 152RM was found to promote cell migration via integrin avp3, enhance MSCs osteogenic differentiation by inhibiting ATF3, and induce type H vessels formation by activating Notch signaling. In vivo studies showed that DBM-MSN/152RM scaffolds were effective in inducing bone formation and type H vessels expansion.
BIOACTIVE MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Evangelia Papadimitriou, Vasiliki K. Kanellopoulou
Summary: Protein tyrosine phosphatase receptor zeta 1 (PTPRZ1) is highly expressed during embryonic development but limited in adulthood. It plays a role in oligodendrocytes' survival and maturation in the central nervous system. In gliomas, PTPRZ1 is significantly upregulated and studied as a potential cancer driver and therapy target. However, its functional significance and tumor-suppressor role in other cancer types need further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Pei-Jie Chen, Yun-Tian Zhang
Summary: Tyrosine phosphorylation is a reversible process regulated by protein tyrosine kinases and phosphatases. Abnormalities in these proteins, such as PTP1B, can contribute to the development of diseases including cancer. Recent studies have shown that PTP1B plays an important role in cancer initiation and progression, making it a potential target for cancer therapies. This review focuses on the functions and pharmacological effects of PTP1B in different types of cancer.
CURRENT CANCER DRUG TARGETS
(2022)
Article
Biochemistry & Molecular Biology
Ming-Fo Hsu, Yoshihiro Ito, Jai Prakash Singh, Shu-Fang Hsu, Alan Wells, Kuang-Yu Jen, Tzu-Ching Meng, Fawaz G. Haj
Summary: This study identified alpha-actinin4 as a novel substrate of PTP1B in podocytes and demonstrated their interaction in regulating podocyte function. Targeting PTP1B and alpha-actinin4 could be a potential therapeutic approach for podocyte injury.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Panae Noomuna, John M. Hausman, Ruhani Sansoya, Theodosia Kalfa, Mary Risinger, Philip S. Low
Summary: Proteolysis of the major erythrocyte tyrosine phosphatase PTP1B leads to increased tyrosine phosphorylation in sickle cells, which weakens the erythrocyte membrane and causes release of membrane vesicles and cell free hemoglobin, contributing to the symptoms of sickle cell disease.
Article
Oncology
Shahenda S. Abdelsalam, Mazhar Pasha, Heba El-Gamal, Maram Hasan, Mohamed A. Elrayess, Asad Zeidan, Hesham M. Korashy, Abdelali Agouni
Summary: Inhibiting PTP1B can prevent ER stress-induced endothelial dysfunction and impaired angiogenesis. PTP1B blockade reduced ER stress-induced apoptosis and cell cycle arrest, possibly through decreased expression levels of caspase-12 and PARP1.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Sonia Rocha, Mariana Lucas, Vera L. M. Silva, Pedro M. O. Gomes, Artur M. S. Silva, Alberto N. Araujo, Natalia Aniceto, Rita C. Guedes, M. Luisa Corvo, Eduarda Fernandes, Marisa Freitas
Summary: This study evaluated a library of 22 pyrazole compounds against human PTP1B activity, identifying two potent inhibitors and highlighting the importance of additional benzene rings in enhancing PTP1B inhibition. The most active compounds showed selectivity over TCPTP and molecular docking analyses revealed key residue contacts. This study represents a significant step in the design of novel PTP1B inhibitors.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Analytical
Ke Xiao, Rong Zhu, Cuicui Du, Hejie Zheng, Xiaohua Zhang, Jinhua Chen
Summary: A self-powered photoelectrochemical (PEC) sensor using zinc-air batteries as a power source was developed for activity assay of protein tyrosine phosphatase 1B (PTP1B). The sensor showed superior performance with a broad linear response range and low detection limit, indicating great potential in the diagnosis of protein phosphatase-related diseases and the development of targeted drugs.
ANALYTICAL CHEMISTRY
(2022)
Review
Biology
Meiling Zhang, Chenglin Liu, Long Zhao, Xuejiao Zhang, Ying Su
Summary: Maintaining normal cellular behavior is crucial for organism survival, and protein phosphorylation is a key mechanism to control cellular behavior. Protein phosphorylation is reversible and regulated by protein kinases and phosphatases. While protein kinases have been well recognized for their roles in cellular processes, recent research highlights the active and specific functions of protein phosphatases in various cellular processes, especially in organ regeneration. This review provides an overview of protein phosphatase classification and their functions in representative developmental processes, and summarizes the recent research on the function and underlying mechanism of protein phosphatases in organ regeneration of vertebrates, including liver, bone, neuron, and heart.
Article
Cell Biology
Stephanie M. Stanford, Meghan Collins, Michael A. Diaz, Zachary J. Holmes, Paul Gries, Matthew R. Bliss, Alessia Lodi, Vida Zhang, Stefano Tiziani, Nunzio Bottini
Summary: LMPTP plays a key role in adipocyte differentiation by regulating PDGFRα signaling and affecting multiple pathways involved in fat cell growth, differentiation, and glucose utilization in adipose tissue.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Dongyan Song, Jose M. Adrover, Christy Felice, Lisa N. Christensen, Xue-Yan He, Joseph R. Merrill, John E. Wilkinson, Tobias Janowitz, Scott K. Lyons, Mikala Egeblad, Nicholas K. Tonks
Summary: PTP1B inhibitors have shown potential in preventing acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). These inhibitors can attenuate aberrant neutrophil function, inhibit neutrophil migration, and promote an aged-neutrophil phenotype by reducing signaling through the CXCR4 chemokine receptor. Additionally, PTP1B inhibitors have therapeutic effects in sepsis models.
Article
Chemistry, Analytical
Ke Xiao, Rong Zhu, Cuicui Du, Hejie Zheng, Xiaohua Zhang, Jinhua Chen
Summary: Self-powered sensors have great potential in the field of early disease diagnosis. In this study, a self-powered photoelectrochemical sensor with zinc-air batteries was developed for activity assay of protein tyrosine phosphatase 1B (PTP1B), showing superior performance.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Yi-Chun Chen, Yu-Show Fu, Shang-Wen Tsai, Po-Kuei Wu, Chao-Ming Chen, Wei-Ming Chen, Cheng-Fong Chen
Summary: MSCs derived from bone marrow, adipose tissue, and Wharton's jelly have the potential to promote angiogenesis in tissue regeneration. This study compares the angiogenic effects of secretomes from different sources of MSCs and identifies IL-1b as a key factor in angiogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Tapan Behl, Amit Gupta, Aayush Sehgal, Ali Albarrati, Mohammed Albratty, Abdulkarim M. Meraya, Asim Najmi, Saurabh Bhatia, Simona Bungau
Summary: Type 2 diabetes is a widely spread metabolic disorder with limitations in conventional therapies. Protein tyrosine phosphatase is a promising therapeutic target, and various inhibitors have shown effectiveness in managing diabetes.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Immunology
Liang Ren, Daonan Shen, Chengcheng Liu, Yi Ding
Summary: The oral cavity contains a wide range of microbial species, and imbalanced microbiota-host interactions are responsible for various oral diseases. Recent studies have shown that bacterial protein phosphorylation plays a crucial role in oral bacterial dysbiosis and bacteria-host interactions, and ongoing research aims to uncover the underlying mechanisms.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Neurosciences
Fei Luo, Ting Wang, Jun-yong Deng, Xiao-dan Luo
Summary: Orexin, a neuropeptide synthesized in the hypothalamus, modulates brain activity and is involved in psychiatric disorders. This study found that orexin enhances GABAergic transmission onto mPFC pyramidal neurons by inhibiting inward rectifier K+ channels on Sst interneurons, further depolarizing the interneurons and increasing Ca2+ influx through T-type Ca2+ channels.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Engineering, Multidisciplinary
Yujie Guo, Maodong Pan, Xiaohui Wei, Fei Luo, Fangbin Sun, Martin Ruess
Summary: This research extends the previous work on nonlinear stability analysis to dynamic buckling analysis, prediction of complex snap-through and mode-jumping behavior. A modified generalized-alpha time integration scheme combined with a nonlinear isogeometric Kirchhoff-Love shell element is used for accuracy and controllable high-frequency dissipation. Weak enforcement of boundary conditions and a least-squares B-spline surface fitting approach are proposed to model geometric imperfections. The proposed method outperforms established developments in terms of solution quality and robustness.
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Junwei Zhang, Fei Luo, Haocheng Sun, Jian Wang, Wenjing Duan, Yueming Yan
Summary: In this study, the effects of Glu-A1a encoded 1Ax1 subunit on gluten physicochemical properties, molecular structures, and breadmaking quality were comprehensively investigated. The presence of the 1Ax1 subunit significantly improved gluten content, dough rheological properties, and other physicochemical properties. The 1Ax1 subunit also enhanced gluten microstructure and altered its secondary structure, resulting in improved breadmaking quality.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Toxicology
Jie-Fang Gao, Liu Tang, Fei Luo, Lu Chen, Yi-Yuan Zhang, Hong Ding
Summary: Atopic dermatitis (AD) is a chronic inflammatory skin disorder. Obesity is associated with a higher prevalence and severity of AD, but the reasons are not well understood. Myricetin, a dietary flavonoid, has anti-inflammatory effects, but its role in AD is unclear. This study investigated the effects of obesity on AD and the potential benefits of myricetin in obese AD.
TOXICOLOGICAL SCIENCES
(2023)
Article
Mining & Mineral Processing
Di Yu, Enlong Liu, Bo Xiang, Yunyong He, Fei Luo, Chuan He
Summary: This paper proposes a three-scale binary medium-based constitutive model to describe the elasto-plastic behavior of mudstone samples. The model considers the meso structures and micro components and adopts different homogenization methods to obtain their respective mechanical properties. The extended self-consistent scheme is improved to be adaptable to composites with varying meso components. The micro-meso-macro constitutive model for mudstone samples is proposed based on the mean-field method and the critical mechanical connections between different scales.
INTERNATIONAL JOURNAL OF MINING SCIENCE AND TECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Yinghu Song, Jialiang Li, Guojun Song, Lina Zhang, Zhen Liu, Xianhui Jing, Fei Luo, Yingda Zhang, Yuhan Zhang, Xiaoru Li
Summary: A multifunctional linear polyurethane supramolecular elastomer with excellent self-healing ability, improved mechanical properties, and high ductility was successfully prepared. The elastomer displayed high tensile strength, elongation, toughness, and repair efficiency. The combination of quadruple hydrogen bonds and thermo-reversible Diels-Alder bonds contributed to the outstanding mechanical, self-healing, shape recovery, and reprocessing properties of the polyurethane elastomer. It has potential applications as a substrate for flexible conductive materials or conductive composite material, enhancing material lifespan through multiple self-repair cycles.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Engineering, Civil
Chunjie Zhai, Chuqiao Chen, Xinlei Zheng, Zhimin Han, Yuhan Gao, Chenggang Yan, Fei Luo, Jianmin Xu
Summary: In this paper, an eco-CACC strategy is proposed for heterogeneous platoons with time delays and input saturations to achieve platoon stability, fuel economy, riding comfort, and driving efficiency.
IEEE TRANSACTIONS ON INTELLIGENT TRANSPORTATION SYSTEMS
(2023)
Article
Orthopedics
Can Chen, Sen Yang, Yong Tang, Chengmin Zhang, Xueke Yu, Kai Li, Chunhua Chen, Wei Dai, Zhigang Rong, Fei Luo
Summary: This study aimed to explore the relationship between trunk muscle function and spinal-pelvic parameters in degenerative spinal deformity (DSD) patients and provide new insights into the mechanism of DSD. The results showed that trunk extensor strength was significantly lower in DSD patients, which may be closely related to the deformity and reflect the overall trunk imbalance. This study is of great importance for further understanding the pathological mechanism of DSD.
JOURNAL OF BACK AND MUSCULOSKELETAL REHABILITATION
(2023)
Article
Plant Sciences
Fei Luo, Dong Zhu, Haocheng Sun, Rong Zou, Wenjing Duan, Junxian Liu, Yueming Yan
Summary: In this study, the mechanisms of wheat selenium-binding protein-A (TaSBP-A) in response to Cd stress were investigated. Overexpression of TaSBP-A enhanced Cd tolerance in yeast, Arabidopsis and wheat. Transgenic Arabidopsis exhibited reduced oxidative stress and improved photosynthesis efficiency under Cd stress, while transgenic wheat showed increased Cd content in the root and decreased Cd content in the leaf. The unique CXXC motif in TaSBP was identified as a major Cd-binding site. Overall, TaSBP-A can enhance Cd sequestration in roots and inhibit Cd transfer to leaves, thus improving plant Cd tolerance.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Biotechnology & Applied Microbiology
Yueqi Chen, Chuan Yang, Qijie Dai, Jiulin Tan, Ce Dou, Fei Luo
Summary: In this study, it was found that gold nanospheres (GNS) significantly prevented ovariectomy-induced osteoporosis in a gut microbiota-dependent manner. The gold nanospheres altered the gut microbial diversity and composition, reducing the abundance of TMAO-related metabolites. Lower TMAO levels alleviated bone loss by reducing inflammation response. The gold nanospheres also inhibited the release of pro-osteoclastogenic or proinflammatory cytokines. Overall, these results demonstrate the protective effects of gold nanospheres on osteoporosis as a gut microbiota modulator.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Review
Physiology
Jieqing Zeng, Junhao Guo, Si Huang, Yisen Cheng, Fei Luo, Xusan Xu, Riling Chen, Guoda Ma, Yajun Wang
Summary: Ferroptosis is a novel form of regulated cell death driven by iron-dependent lipid peroxidation, which plays vital roles in various diseases. Sirtuins, which have broad functional significance, have been found to participate in the occurrence of ferroptosis through influencing redox balance, iron metabolism, and lipid metabolism. This article reviewed the roles of sirtuins in ferroptosis and the related molecular mechanisms, providing valuable targets for the prevention and treatment of ferroptosis-associated diseases.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Pinzhen Chen, Zhou Zhou, Li Sun, Xueke Yu, Kai Li, Jin Li, Min He, Xiaoyue Zhou, Fei Luo, Jun Zhao, Wei Chen
Summary: This study investigated the sex differences in age-related back extensor muscle degeneration using Dixon MRI and analyzed the relationship between quantitative muscle parameters and back muscle strength in healthy adults. The results showed that the fat fraction of multifidus muscle and erector spinae significantly increased with age in both genders. In females, the total erector spinae functional cross-sectional area and relative functional cross-sectional area correlated with age. In males, all muscle size parameters, except total multifidus muscle cross-sectional area, correlated with age. Back extension muscle strength correlated with muscle fat fraction, cross-sectional area, and functional cross-sectional area. The study concluded that functional cross-sectional area had the highest association with back muscle strength compared to fat fraction and cross-sectional area.
EUROPEAN RADIOLOGY
(2023)
Article
Geochemistry & Geophysics
Fei Luo, Eliane Bodanese, Salabat Khan, Kaishun Wu
Summary: In this article, we proposed a spectro-temporal network (STnet) that integrates a temporal convolutional network (TCN) and a convolutional neural network (CNN) for human activity recognition from radar signals. Experimental results showed that the proposed method achieved 99.64% overall accuracy (OA) in testing, outperforming the other three networks.
IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING
(2023)
Article
Computer Science, Information Systems
Fei Luo, Yongqiong Zhu, Yanping Fu, Huajian Zhou, Zezheng Chen, Chunxia Xiao
Summary: In this study, a voxel-based modeling pipeline is proposed to reconstruct single objects with complex backgrounds using sparse RGB-D images, avoiding geometric post-processing operations on background removal. Experimental results validate the effectiveness and flexibility of the proposed pipeline.
VISUAL INFORMATICS
(2023)
Article
Computer Science, Information Systems
Fei Luo, Salabat Khan, Yandao Huang, Kaishun Wu
Summary: A wide range of sensors is used in human activity recognition, generating large amounts of data during monitoring. Server-based and cloud-based computing require uploading all sensor data, leading to increased costs and latency. However, the development of edge computing addresses this problem by moving computation and data storage closer to the sensors instead of relying on central servers/clouds.
IEEE TRANSACTIONS ON MOBILE COMPUTING
(2023)
Article
Engineering, Biomedical
Jianqiu Yang, Zhenzhen Huang, Jiang Tan, Jingye Pan, Shixuan Chen, Wenbing Wan
Summary: By functionalizing a decellularized pomelo peel with an adhesive hydrogel and antibacterial materials, the hybrid wound dressing can effectively inhibit bacterial infection, promote granulation tissue formation and angiogenesis, and reduce scar formation during wound healing.
BIOACTIVE MATERIALS
(2024)
Article
Engineering, Biomedical
Yong Mei, Xiaohua Qin, Zhenyu Yang, Shiyao Song, Xiaoting Liu, Chong Wu, Jieying Qian, Xiaowan Huang, Yunjiao Zhang, Weiling He
Summary: This article presents a novel nanoparticle for treating KRAS-TP53 co-mutation in gastrointestinal cancers. The nanoparticle can degrade mutant p53 proteins (mutp53) and deliver the drug AMG510 to inhibit mutant KRAS and mutp53 signaling pathways. The results show that the nanoparticle can effectively reduce cell proliferation and migration, and demonstrate remarkable therapeutic efficacy in a tumor-bearing mouse model.
BIOACTIVE MATERIALS
(2024)
