Neuroprotective Effects of a Small Mitochondrially-Targeted Tetrapeptide Elamipretide in Neurodegeneration

Elamipretide (SS-31) Improves Functional Connectivity in Hippocampus and Other Related Regions Following Prolonged Neuroinflammation Induced by Lipopolysaccharide in Aged Rats

(2021) Yang Liu et al.   Frontiers in Aging Neuroscience

Neuronal Mitochondria Modulation of LPS-Induced Neuroinflammation

(2020) Micah Harland et al.   JOURNAL OF NEUROSCIENCE

In search of an anti-inflammatory drug for Alzheimer disease

(2020) Erika Gyengesi et al.   Nature Reviews Neurology

Regulation of BDNF-TrkB Signaling and Potential Therapeutic Strategies for Parkinson’s Disease

(2020) Jin   Journal of Clinical Medicine

Restoring mitochondrial superoxide levels with elamipretide (MTP-131) protects db/db mice against progression of diabetic kidney disease

(2020) Satoshi Miyamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial protein interaction landscape of SS-31

(2020) Juan D. Chavez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Abnormal Mitochondrial Quality Control in Neurodegenerative Diseases

(2020) Xu Yan et al.   Frontiers in Cellular Neuroscience

Elamipretide Attenuates Pyroptosis and Perioperative Neurocognitive Disorders in Aged Mice

(2020) Youmei Zuo et al.   Frontiers in Cellular Neuroscience

Lipopolysaccharide-Induced Neuroinflammation as a Bridge to Understand Neurodegeneration

(2019) Carla Ribeiro Alvares Batista et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuroinflammation — a common thread in neurological disorders

(2019) Nils Erik Gilhus et al.   Nature Reviews Neurology

Neuroprotective Effects of Ginseng Phytochemicals: Recent Perspectives

(2019) Xing Huang et al.   MOLECULES

SS-31 reduces inflammation and oxidative stress through the inhibition of Fis1 expression in lipopolysaccharide-stimulated microglia

(2019) Yunan Mo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The endotoxin hypothesis of neurodegeneration

(2019) Guy C. Brown   Journal of Neuroinflammation

Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice

(2019) Weixing Zhao et al.   Journal of Neuroinflammation

The biomedical challenge of neurodegenerative disorders: an opportunity for cannabinoid-based therapies to improve on the poor current therapeutic outcomes

(2018) Javier Fernández-Ruiz   BRITISH JOURNAL OF PHARMACOLOGY

Synergistic Protective Effects of Mitochondrial Division Inhibitor 1 and Mitochondria-Targeted Small Peptide SS31 in Alzheimer’s Disease

(2018) P. Hemachandra Reddy et al.   JOURNAL OF ALZHEIMERS DISEASE

Mechanisms of Cell Damage in Neurological Diseases and Putative Neuroprotective Strategies

(2018) Perla D. Maldonado et al.   Oxidative Medicine and Cellular Longevity

Hypertension and Diagnosis of Parkinson’s Disease: A Meta-Analysis of Cohort Studies

(2018) Liyan Hou et al.   Frontiers in Neurology

Global, regional, and national burden of Alzheimer's disease and other dementias, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2018) Emma Nichols et al.   LANCET NEUROLOGY

Global, regional, and national burden of Parkinson's disease, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2018) E. Ray Dorsey et al.   LANCET NEUROLOGY

Neuroinflammatory Cytokines Induce Amyloid Beta Neurotoxicity through Modulating Amyloid Precursor Protein Levels/Metabolism

(2018) Fawaz Alasmari et al.   Biomed Research International

Intraneuronal protein aggregation as a trigger for inflammation and neurodegeneration in the aging brain

(2017) Antonio Currais et al.   FASEB JOURNAL

Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity

(2017) Vincenzo Sorrentino et al.   NATURE

Elamipretide (SS-31) Ameliorates Isoflurane-Induced Long-Term Impairments of Mitochondrial Morphogenesis and Cognition in Developing Rats

(2017) Jing Wu et al.   Frontiers in Cellular Neuroscience

Evidence of Oxidative Stress and Secondary Mitochondrial Dysfunction in Metabolic and Non-Metabolic Disorders

(2017) Karolina M. Stepien et al.   Journal of Clinical Medicine

Mitochondria-Targeted Antioxidants Protect Against Amyloid-β Toxicity in Alzheimer's Disease Neurons

(2017) Maria Manczak et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer’s disease: experimental models and reality

(2016) Eleanor Drummond et al.   ACTA NEUROPATHOLOGICA

BDNF pathway is involved in the protective effects of SS-31 on isoflurane-induced cognitive deficits in aging mice

(2016) Jing Wu et al.   BEHAVIOURAL BRAIN RESEARCH

Mitochondria-targeted molecules MitoQ and SS31 reduce mutant huntingtin-induced mitochondrial toxicity and synaptic damage in Huntington's disease

(2016) Xiangling Yin et al.   HUMAN MOLECULAR GENETICS

Mitochondrial dynamics and quality control in Huntington's disease

(2016) Pedro Guedes-Dias et al.   NEUROBIOLOGY OF DISEASE

SS31 Ameliorates age-related activation of NF-κB signaling in senile mice model, SAMP8

(2016) Zhi-Hua Hao et al.   Oncotarget

Potential neuroprotective properties of epigallocatechin-3-gallate (EGCG)

(2015) Neha Atulkumar Singh et al.   Nutrition Journal

Interrelation of Oxidative Stress and Inflammation in Neurodegenerative Disease: Role of TNF

(2015) Roman Fischer et al.   Oxidative Medicine and Cellular Longevity

A Mitochondrion-Targeted Antioxidant Ameliorates Isoflurane-Induced Cognitive Deficits in Aging Mice

(2015) Jing Wu et al.   PLoS One

Serendipity and the Discovery of Novel Compounds That Restore Mitochondrial Plasticity

(2014) H H Szeto et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Mitochondria-Targeted Peptide Reverses Mitochondrial Dysfunction and Cognitive Deficits in Sepsis-Associated Encephalopathy

(2014) Jing Wu et al.   MOLECULAR NEUROBIOLOGY

Energy Failure

(2013) Divya Pathak et al.   ANNALS OF NEUROLOGY

First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics

(2013) Hazel H Szeto   BRITISH JOURNAL OF PHARMACOLOGY

Mitochondrial Alterations near Amyloid Plaques in an Alzheimer's Disease Mouse Model

(2013) Hong Xie et al.   JOURNAL OF NEUROSCIENCE

El estrés oxidativo en las enfermedades neurológicas: ¿causa o consecuencia?

(2013) M.L. Díaz-Hung et al.   NEUROLOGIA

Neuroinflammation: The role and consequences

(2013) Monty Lyman et al.   NEUROSCIENCE RESEARCH

Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease

(2011) M. J. Calkins et al.   HUMAN MOLECULAR GENETICS

The Mitochondria-Targeted Antioxidant MitoQ Prevents Loss of Spatial Memory Retention and Early Neuropathology in a Transgenic Mouse Model of Alzheimer's Disease

(2011) M. J. McManus et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial Approaches for Neuroprotection

(2010) Rajnish K. Chaturvedi et al.   Annals of the New York Academy of Sciences

Neuroprotection by a mitochondria-targeted drug in a Parkinson's disease model

(2010) Anamitra Ghosh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Basic mechanisms of neurodegeneration: a critical update

(2010) Kurt A. Jellinger   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease

(2010) Barry J. Snow et al.   MOVEMENT DISORDERS

Mitochondria Targeted Peptides Protect Against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Neurotoxicity

(2009) Lichuan Yang et al.   ANTIOXIDANTS & REDOX SIGNALING