Article
Endocrinology & Metabolism
Alexi Vasbinder, Elizabeth Anderson, Husam Shadid, Hanna Berlin, Michael Pan, Tariq U. Azam, Ibrahim Khaleel, Kishan Padalia, Chelsea Meloche, Patrick O'Hayer, Erinleigh Michaud, Tonimarie Catalan, Rafey Feroze, Pennelope Blakely, Christopher Launius, Yiyuan Huang, Lili Zhao, Lynn Ang, Monica Mikhael, Kara Mizokami-Stout, Subramaniam Pennathur, Matthias Kretzler, Sven H. Loosen, Athanasios Chalkias, Frank Tacke, Evangelos J. Giamarellos-Bourboulis, Jochen Reiser, Jesper Eugen-Olsen, Eva L. Feldman, Rodica Pop-Busui, Salim S. Hayek
Summary: Diabetes mellitus is a major risk factor for severe COVID-19, and the association between diabetes and COVID-19 outcomes may be largely mediated by inflammation as assessed by suPAR levels. Hyperglycemia, independent of inflammation, also plays a role in COVID-19 outcomes.
Review
Biochemistry & Molecular Biology
Luc Rochette, Geoffrey Dogon, Marianne Zeller, Yves Cottin, Catherine Vergely
Summary: GDF15, a member of the TGF-beta superfamily, is induced by injury and aging, and plays a role in inflammation and the pathogenesis of cardiovascular diseases, metabolic disorders, and neurodegenerative processes. It functions as a heart-derived endocrine hormone with cardioprotective properties, and may serve as a therapeutic target in cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Urology & Nephrology
Yashwanth Reddy Sudhini, Changli Wei, Jochen Reiser
Summary: suPAR is the soluble form of uPAR, associated with inflammation and immune activation. It has become a unique factor for kidney diseases and is related to COVID-19 infection as well as lung and kidney dysfunction. suPAR plays an important role in glomerular kidney diseases, the connection between acute kidney injury and chronic kidney disease, and may serve as a therapeutic target.
Article
Clinical Neurology
Simon Frerich, Rainer Malik, Marios K. Georgakis, Moritz F. Sinner, Steven J. Kittner, Braxton D. Mitchell, Martin Dichgans
Summary: This study used genetic data to assess the associations between cardiac traits and stroke risk, finding that cardiac traits have limited effects on stroke risk beyond known clinical risk factors.
Review
Biochemistry & Molecular Biology
Qi Long, Bingjie Lv, Shijiu Jiang, Jibin Lin
Summary: Cardiovascular disease (CVD) is the leading cause of death globally. Recent studies have discovered the important roles of circular RNAs (circRNAs) in CVD, providing a new theoretical basis for diagnosing and treating CVD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Changli Wei, Ryan Spear, Eunsil Hahm, Jochen Reiser
Summary: This mini-review discusses suPAR as a key circulating molecule mediating kidney disease with a particular focus on differently spliced isoforms.
FRONTIERS IN MEDICINE
(2021)
Review
Chemistry, Multidisciplinary
Brigitte Sipos, Peter Jirak, Vera Paar, Richard Rezar, Moritz Mirna, Kristen Kopp, Uta C. Hoppe, Alexander E. Berezin, Michael Lichtenauer
Summary: Cardiovascular diseases are a leading cause of death globally, and in recent years, various biomarkers have been studied with some showing diagnostic and predictive value. This review focuses on four promising biomarkers, providing an overview of their current status and potential use in estimating cardiovascular risk in certain patient populations. Further research is needed to determine the clinical relevance and optimal utilization of these biomarkers in routine practice.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Timothy E. O'Toole, Xiaohong Li, Daniel W. Riggs, David J. Hoetker, Shahid P. Baba, Aruni Bhatnagar
Summary: The study found significant associations between nonconjugated carnosine and cardiovascular risk factors like hypertension and heart failure, while carnosine conjugates were significantly associated with diabetes and HDL levels. This suggests that carnosine and its conjugates may be informative biomarkers for assessing CVD risk, especially in relation to diabetes and skeletal muscle injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Dorota Rozanski, Stanislaw Szlufik, Ryszard Tomasiuk, Lukasz Milanowski, Monika Figura, Kamila Saramak, Piotr Myrcha, Dariusz Koziorowski
Summary: This study found that suPAR, an inflammatory biomarker elevated in cardiovascular diseases, is also elevated in patients with ischemic stroke. SuPAR levels correlate positively with other inflammatory biomarkers and with disabilities or dependence in daily activities 2 years after a stroke.
Review
Cell Biology
Paul Philipp Heinisch, Corina Bello, Maximilian Y. Emmert, Thierry Carrel, Martina Dressen, Juergen Hoerer, Bernhard Winkler, Markus M. Luedi
Summary: Endothelial progenitor cells (EPC) have the potential to influence the integrity and stability of the vascular endothelium, but their role and applicability as biomarkers in clinical settings are still uncertain. Evaluating endothelial dysfunction remains a major challenge, largely due to the heterogeneity of this cell population. To use EPC levels as biomarkers for vascular function and cardiovascular risk, defining their phenotype accurately and updating current isolation methods are urgent priorities.
Article
Chemistry, Multidisciplinary
Peter Jirak, Franz Haertel, Moritz Mirna, Richard Rezar, Michael Lichtenauer, Vera Paar, Lukas J. Motloch, Albert Topf, Atilla Yilmaz, Uta C. Hoppe, P. Christian Schulze, Sebastian Nuding, Karl Werdan, Daniel Kretzschmar, Rudin Pistulli, Henning Ebelt
Summary: This study conducted a comparative analysis of biomarker levels in patients with ischemic cardiovascular diseases and sepsis, finding significantly elevated levels of all tested novel cardiac biomarkers in sepsis patients. The study suggests that novel biomarkers, particularly those related to cardiovascular components, offer a promising tool for assessing sepsis patients.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Meyer Elbaz, Julien Faccini, Clemence Laperche, Marie-Helene Grazide, Jean-Bernard Ruidavets, Cecile Vindis
Summary: Circulating miR-223 and miR-186 are promising predictive biomarkers for long-term mortality after MI.
Review
Cell Biology
Xue Sun, Gebang Wang, Wenting Luo, Hui Gu, Wei Ma, Xiaowei Wei, Dan Liu, Shanshan Jia, Songying Cao, Yu Wang, Zhengwei Yuan
Summary: Cardiovascular diseases are the leading cause of death worldwide, and studies have shown that non-coding RNAs play a significant role in their development. Small nucleolar RNAs are a novel species of ncRNAs that may regulate different illnesses, including CVDs. Understanding the molecular processes and signaling pathways of snoRNAs in relation to CVDs is essential for further research and potential clinical applications.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Medicine, General & Internal
Helena Enocsson, Cornelia Idoff, Annette Gustafsson, Melissa Govender, Francis Hopkins, Marie Larsson, Asa Nilsdotter-Augustinsson, Johanna Sjowall
Summary: Admission levels of suPAR were higher in patients with severe/critical COVID-19 and correlated with length of hospital stay. Additionally, suPAR functioned as an independent predictor of COVID-19 disease severity.
FRONTIERS IN MEDICINE
(2021)
Article
Surgery
Christian Morath, Salim S. Hayek, Bernd Doehler, Christian Nusshag, Claudia Sommerer, Martin Zeier, Jochen Reiser, Caner Suesal
Summary: High levels of soluble urokinase plasminogen activator receptor (suPAR) are associated with increased risk of all-cause and cardiovascular mortality in kidney transplant recipients, independent of kidney function.
TRANSPLANT INTERNATIONAL
(2022)
Article
Surgery
Eleni Laou, Nikolaos Papagiannakis, Aikaterini Tsiaka, Stamatina Tsapournioti, Konstantinos Chatzikallinikidis, Georgios Mantzaflaras, Ioannis Karadontas, Jesper Eugen-Olsen, Athanasios Chalkias
Summary: This study investigated the impact of general anesthesia and major surgery on perioperative levels of soluble urokinase plasminogen activator receptor (suPAR) and C-reactive protein (CRP). The results showed no significant difference in suPAR levels before and after surgery, while CRP levels increased significantly during surgery. There was no correlation between CRP and suPAR levels. In conclusion, despite the activation of systemic inflammatory response, general anesthesia and operative trauma did not affect perioperative suPAR levels.
EUROPEAN SURGICAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Jens Christian Laursen, Ida Kirstine Bull Rasmussen, Emilie Hein Zobel, Philip Hasbak, Lene Holmvang, Christian Stevns Hansen, Bernt Johan von Scholten, Marie Frimodt-Moller, Peter Rossing, Tine Willum Hansen, Andreas Kjaer, Rasmus Sejersten Ripa
Summary: Cardiac angiogenesis assessed by Ga-68-RGD PET was similar in type 2 diabetes and non-diabetic controls, and was not associated with kidney function or other risk factors.
Article
Endocrinology & Metabolism
Viktor Rotbain Curovic, Niels Jongs, Marjolein Y. A. M. Kroonen, Emilie H. Zobel, Tine W. Hansen, Taha Sen, Gozewijn D. Laverman, Adriaan Kooy, Frederik Persson, Peter Rossing, Hiddo J. L. Heerspink
Summary: This randomized crossover trial found significant variation in participants' responses to different drug classes in terms of urinary albumin to creatinine ratio (UACR) reduction. The results suggest that systematic rotation through different drug classes can overcome resistance to RAS inhibitors.
Review
Peripheral Vascular Disease
Kei Asayama, Katarzyna Stolarz-Skrzypek, Wen-Yi Yang, Tine W. Hansen, Jana Brguljan-Hitij, Augustine N. Odili, Yan Li, Jan A. Staessen
Summary: The International Databases on Ambulatory (IDACO) and Home (IDHOCO) Blood Pressure in Relation to Cardiovascular Outcome conducted a meta-analysis which found that 24-hour and nighttime blood pressure levels are the best predictors of adverse health outcomes. They also established corresponding thresholds for home and ambulatory blood pressure. The study emphasized the importance of out-of-office blood pressure monitoring in tackling the hypertension pandemic.
HYPERTENSION RESEARCH
(2023)
Article
Social Sciences, Biomedical
Trine Schifter Larsen, Jesper Eugen-Olsen, Ove Andersen, Jeanette Wassar Kirk
Summary: This article examines the development of a biomarker called suPAR in an emergency department of a hospital in Copenhagen, Denmark. The study finds that suPAR, while seen as a promising triage strategy, faces challenges due to diagnostic practices and the desire for experience-based scripts in clinical practice. The non-specificity and prognostic nature of suPAR make it problematic in clinical practices, as it cannot rule out specific diagnoses and may lead to the notion of secure clinical actions. Specific diagnostic criteria versus prognostic interpretation and non-specificity risk profiling present challenges for healthcare workers in the emergency department. The article reflects on how the becoming of suPAR is strengthened through specificity enactments and engagement in triage strategies, while also highlighting the need to accommodate diagnostic ambiguity.
Article
Endocrinology & Metabolism
Niels Sondergaard Heinrich, Rune Ploegstra Pedersen, Mark Bitsch Vestergaard, Ulrich Lindberg, Ulrik Bjorn Andersen, Bryan Haddock, Tine Willum Hansen, Alessia Fornoni, Henrik Bo Wiberg Larsson, Peter Rossing
Summary: This study investigated the effects of ezetimibe on the urine albumin creatinine ratio (UACR) and kidney parenchyma fat content (kidney-PF) in individuals with type 2 diabetes and early chronic kidney disease. The results showed that ezetimibe did not significantly reduce UACR or kidney-PF overall, but it did reduce kidney-PF in participants with high baseline levels.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Viktor Rotbain Curovic, Nete Tofte, Morten Lindhardt, Katarina Adamova, Stephan J. L. Bakker, Joachim Beige, Joline W. J. Beulens, Andreas L. Birkenfeld, Gemma Currie, Christian Delles, Ingo Dimos, Lidmila Francova, Marie Frimodt-Moller, Peter Girman, Ruediger Goeke, Tine W. Hansen, Tereza Havrdova, Adriaan Kooy, Gozewijnw D. Laverman, Harald Mischak, Gerjan Navis, Giel Nijpels, Marina Noutsou, Alberto Ortiz, Aneliya Parvanova, Frederik Persson, John R. Petrie, Piero L. Ruggenenti, Femke Rutters, Ivan Rychlik, Justyna Siwy, Goce Spasovski, Marijn Speeckaert, Matias Trillini, Petra Zuerbig, Heiko von der Leyen, Peter Rossing
Summary: This study examines the relationship between baseline diabetic retinopathy (DR) and the risk of developing microalbuminuria, kidney function decline, and cardiovascular events (CVEs) in type 2 diabetes patients. The results show that the presence of DR is associated with an increased risk of developing microalbuminuria and CVEs, but not kidney function decline.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2023)
Article
Endocrinology & Metabolism
Jens Christian Laursen, Christian Stevns Hansen, Marco Bordino, Marie Frimodt-Moller, Tine Willum Hansen, Luciano Bernardi, Per-Henrik Groop, Peter Rossing
Summary: This study explored the association between baroreflex sensivity and blood oxygen saturation (SpO2) in type 1 diabetes and various degrees of microvascular disease. It was found that higher baroreflex sensitivity was associated with higher SpO2 in type 1 diabetes. Compared with non-diabetic controls, type 1 diabetes patients had lower baroreflex sensitivity and lower SpO2. Therefore, hypoxia could be a therapeutic target in type 1 diabetes.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2023)
Article
Multidisciplinary Sciences
Christina Gjerlev W. Poulsen, Daniel G. K. Rasmussen, Federica Genovese, Tine Hansen, Signe Holm K. Nielsen, Henrik Reinhard, Bernt Johan von Scholten, Peter Jacobsen, Hans-Henrik Parving, Morten Asser Karsdal, Peter Rossing, Marie Frimodt-Moller
Summary: This study investigated whether C3M, a degradation product of collagen type III, is a risk marker for the progression of chronic kidney disease (CKD) in individuals with type 2 diabetes and microalbuminuria. The results showed that higher levels of sC3M were associated with CKD progression in these patients.
Letter
Endocrinology & Metabolism
Jens Christian Laursen, Viktor Rotbain Curovic, Marjolein Y. A. M. Kroonen, Niels Jongs, Emilie H. Zobel, Tine W. Hansen, Marie Frimodt-Moller, Gozewijn D. Laverman, Adriaan Kooy, Frederik Persson, Hiddo J. L. Heerspink, Christian Stevns Hansen, Peter Rossing
DIABETES OBESITY & METABOLISM
(2023)
Article
Peripheral Vascular Disease
De-Wei An, Tine W. Hansen, Lucas S. Aparicio, Babangida Chori, Qi-Fang Huang, Fang-Fei Wei, Yi-Bang Cheng, Yu-Ling Yu, Chang-Sheng Sheng, Natasza Gilis-Malinowska, Jose Boggia, Wiktoria Wojciechowska, Teemu J. Niiranen, Valerie Tikhonoff, Edoardo Casiglia, Krzysztof Narkiewicz, Katarzyna Stolarz-Skrzypek, Kalina Kawecka-Jaszcz, Antti M. Jula, Wen-Yi Yang, Angela J. Woodiwiss, Jan Filipovsky, Ji-Guang Wang, Marek W. Rajzer, Peter Verhamme, Tim S. Nawrot, Jan A. Staessen, Yan Li
Summary: This study found and validated a PWV threshold for cardiovascular events and total mortality through an individual-participant meta-analysis. The results showed that a PWV threshold of 9 m/s can effectively predict cardiovascular events and total mortality.
Article
Endocrinology & Metabolism
Ninna Hahn Tougaard, Tine Willum Hansen, Peter Rossing
Summary: Vitamin D deficiency may be a risk marker for cardiovascular events and heart failure in both type 1 and type 2 diabetes, but not for microvascular complications or all-cause mortality.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Asger Wretlind, Viktor Rotbain Curovic, Andressa de Zawadzki, Tommi Suvitaival, Jin Xu, Emilie Hein Zobel, Bernt Johan von Scholten, Rasmus Sejersten Ripa, Andreas Kjaer, Tine Willum Hansen, Tina Vilsboll, Henrik Vestergaard, Peter Rossing, Cristina Legido-Quigley
Summary: Treatment with liraglutide can reduce the levels of C16 ceramide and C24:1 ceramide, which are associated with cardiovascular disease (CVD) risk.
LIPIDS IN HEALTH AND DISEASE
(2023)
Article
Neurosciences
Mark B. Vestergaard, Jens Christian Laursen, Niels Sondergaard Heinrich, Peter Rossing, Tine Willum Hansen, Henrik B. W. Larsson
Summary: This study found brain alterations and atrophy in patients with T1D, possibly due to complications of diabetes affecting cerebral vascular and glycolytic functions.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Alexandra Louise Moller, Ninna Hahn Tougaard, Daniel Guldager Kring Rasmussen, Federica Genovese, Pernille Falberg Ronn, Tine Willum Hansen, Morten Asser Karsdal, Peter Rossing
Summary: The pro-fibrotic molecule endotrophin, generated during collagen type VI formation, has been identified as a potential risk marker for complications in type 1 diabetes. Higher levels of serum endotrophin were associated with kidney complications and increased mortality in type 1 diabetes patients. However, there was no significant association between serum endotrophin and cardiovascular events or diabetic eye disease. Urinary endotrophin was not found to be associated with any outcomes.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
