期刊
FRONTIERS IN MOLECULAR BIOSCIENCES
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmolb.2021.745649
关键词
TGFBI; pan-cancer; immune subtype; tumor microenvironment; prognoses; drug responses
资金
- National Natural Science Foundation of China [81773339, 81800788]
- Science and Technology Department of Hunan Province, China [2017WK2041, 2018SK52511]
- Open Sharing Fund for the Large-scale Instruments and Equipment of Central South University
The study conducted a pan-cancer analysis of TGFBI mRNA and protein expression, prognosis of various cancer types, and their associations with tumor microenvironment components, immune cell infiltration, tumor mutational burden, microsatellite instability, and genetic alterations. The results showed that TGFBI expression varied among different cancer types and had correlations with prognosis, TME components, TMB, MSI, immune cell infiltration, and immunoinhibitory and immunostimulatory gene subsets. These findings suggest that TGFBI plays a role in immune responses and may serve as a prognostic marker in various cancers.
Transforming growth factor-beta-induced (TGFBI) protein has important roles in tumor growth, metastasis, and immunity. However, there is currently no pan-cancer evidence regarding TGFBI. In this study, we conducted a pan-cancer analysis of TGFBI mRNA and protein expression and prognoses of various cancer types using public databases. We also investigated the associations of TGFBI expression with tumor microenvironment (TME) components, immune cell infiltration, tumor mutational burden (TMB), and microsatellite instability (MSI), along with the TGFBI genetic alteration types. The results showed that TGFBI expression varied among different cancer types, and it was positively or negatively related to prognosis in various cancers. TGFBI expression was also significantly correlated with TME components, TMB, MSI, immune cell infiltration, and immunoinhibitory and immunostimulatory gene subsets. These findings indicate that TGFBI participates in various immune responses and it may function as a prognostic marker in various cancers. The findings may be useful for developing immunotherapies that target TGFBI.
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