期刊
ANTIOXIDANTS
卷 10, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/antiox10111744
关键词
Blumea laciniata; antioxidant ability; anti-ageing effect; Caenorhabditis elegans
Blumea laciniata polyphenol extract (EBL) demonstrates potent antioxidant and anti-ageing abilities, improving survival under thermal stress, reducing reactive oxygen species levels, increasing antioxidant enzyme activities, and extending lifespan in Caenorhabditis elegans. The insulin/IGF-1 signaling pathway is involved in EBL's effects on antioxidant and anti-ageing properties.
Blumea laciniata is widely used as a folk medicine in Asia, but relevant literature on it is rarely reported. We confirmed that polyphenol extract (containing chlorogenic acid, rutin, and luteolin-4-O-glucoside) from B. laciniata (EBL) showed strong antioxidant ability in vitro. Hence, in this work, we applied Caenorhabditis elegans to further investigate the antioxidant and anti-ageing abilities of EBL in vivo. The results showed that EBL enhanced the survival of C. elegans under thermal stress by 12.62% and sharply reduced the reactive oxygen species level as well as the content of malonaldehyde. Moreover, EBL increased the activities of antioxidant enzymes such as catalase and superoxide dismutase. Additionally, EBL promoted DAF-16, a transcription factor, into the nucleus. Besides, EBL extended the lifespan of C. elegans by 17.39%, showing an anti-ageing effect. Different mutants indicated that the insulin/IGF-1 signaling pathway participated in the antioxidant and anti-ageing effect of EBL on C. elegans.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据