Article
Fisheries
Xiaomeng Ren, Han Zhang, Xiaolong Yan, Yuena Sun, Tianjun Xu
Summary: The study found that NOP56 acts as a negative regulator of the MyD88-mediated NF-KB signaling pathway by inhibiting MyD88 protein expression, providing new insights into the regulatory mechanism in teleost fish.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yuchun Liu, Yang Chen, Cong Ding, Xiangzhan Zhu, Xiaorui Song, Yanhong Ren, Qionglin Wang, Yaodong Zhang, Xiaomin Sun
Summary: TRIM56 plays a positive role in TNF alpha-induced NF-kappa B signaling by enhancing the ubiquitination of TAK1, providing new insights into the complex mechanisms of inflammation and immune response.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Jionghuang Chen, Kexiong Qiao, Chaolei Zhang, Xinyang Zhou, Qian Du, Yuezhen Deng, Liping Cao
Summary: NF-KB signaling is active in pancreatic cancer and plays a crucial role in its progression. This study demonstrates that VRK2 regulates TNFa/NF-KB signaling by interacting with IKKss and activating the pathway. VRK2 overexpression promotes the growth of pancreatic cancer cells and organoids. Inhibition of IKKss abolishes the promotive effect of VRK2. These findings suggest that VRK2 may serve as a potential therapeutic target for pancreatic cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Aleksandra Kusiak, Gareth Brady
Summary: The human innate immune response can be activated by various stimuli, such as PAMPs and DAMPs. These stimuli trigger intracellular signaling pathways that activate transcription factors from the NF-kappa B and IRF families, which play crucial roles in inflammation and antiviral response.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Takahisa Kouwaki, Tasuku Nishimura, Guanming Wang, Reiko Nakagawa, Hiroyuki Oshiumi
Summary: Post-translational modification of LGP2 fine-tunes antiviral innate immune responses by promoting late-phase expression of type I interferons, while attenuating other antiviral proteins.
Article
Virology
Guolei Wang, Zhiqiang Li, Mingfu Tian, Xianghua Cui, Jun'e Ma, Siyu Liu, Chenglin Ye, Li Yuan, Muhammad Suhaib Qudus, Uzair Afaq, Kailang Wu, Xinghui Liu, Chengliang Zhu
Summary: Several studies have demonstrated that beta-glucan can induce trained immunity in innate immune cells to defend against bacterial and fungal infections, but its role in antiviral infection remains unclear. This study investigated the role of trained immunity induced by Candida albicans and beta-glucan in antiviral innate immunity. It showed that C. albicans and beta-glucan promoted the expression of IFN-beta and IL-6 in mouse macrophages triggered by viral infection. Mechanistically, beta-glucan could promote the phosphorylation and ubiquitination of TBK1, a key protein of the innate immune pathway. These findings suggest that beta-glucan can enhance innate antiviral immunity and may serve as a potential therapeutic target for antiviral treatment.
Article
Biochemistry & Molecular Biology
Xiaomin Guo, Pengcheng Ma, Yuwei Li, Yanan Yang, Chaoming Wang, Tao Xu, Huishan Wang, Chaocui Li, Bingyu Mao, Xiaopeng Qi
Summary: The study demonstrated that ubiquitination of STAT1 by the E3 ligase RNF220 plays a significant role in STAT1 activation and innate immune responses. Deficiency in Rnf220 gene leads to downregulation of IFN signaling and decreased expression of ISGs, making RNF220 a potential therapeutic target against bacterial and viral infection and inflammatory diseases.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Virology
Thomas Phelan, Clara Lawler, Andreas Pichlmair, Mark A. A. Little, Andrew G. G. Bowie, Gareth Brady
Summary: Molluscum contagiosum virus (MCV) is a poxvirus that causes a common and persistent infection in humans. It encodes immunosuppressive proteins that inhibit antiviral immunity, particularly through the NF-kappa B signaling pathway. A specific MCV protein, MC008, has been identified to target and inhibit NF-kappa B by disrupting its activation through interaction with NEMO. This finding highlights the evolutionary pressure for MCV to disable key signaling proteins in multiple ways.
JOURNAL OF VIROLOGY
(2023)
Article
Multidisciplinary Sciences
Kishu Ranjan, Matija Hedl, Clara Abraham
Summary: The study found that macrophages from IBD-risk carriers in the RNF186 region showed reduced cytokines upon stimulation through multiple pattern recognition receptors (PRRs). RNF186 was found to be crucial for PRR-initiated signaling complex assembly, downstream signaling, and antimicrobial pathways. Cells transfected with the rare RNF186-A64T IBD-risk variant demonstrated a reduction in RNF186-dependent outcomes, indicating a loss of function in PRR-initiated outcomes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Fei Qin, Baoshan Cai, Peng Wang, Runyu Cao, Yuling Zhang, Hongling Wen, Yi Zheng, Wei Zhao, Chengjiang Gao, Bingyu Liu
Summary: This study reveals the role of the ESCRT system in regulating RLR-mediated antiviral responses and identifies LTN1 as a negative regulator of RLR-mediated antiviral innate immunity. This research provides new targets for intervention in viral infections.
Review
Immunology
Luiz Pedro Souza-Costa, Josiane Teixeira Andrade-Chaves, Juvana Moreira Andrade, Vivian Vasconcelos Costa, Luis Henrique Franco
Summary: Innate immunity is the body's first line of defense against infections, but uncontrolled or aberrant inflammatory responses can lead to tissue damage and chronic inflammatory diseases. This review focuses on the importance of ubiquitination in regulating innate immune signaling and inflammation, highlighting the role of the protein Smurf1 and its potential as a therapeutic target for infectious and inflammatory conditions.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Zhenzhen Yan, Haifeng Wu, Hansen Liu, Guimin Zhao, Honghai Zhang, Wanxin Zhuang, Feng Liu, Yi Zheng, Bingyu Liu, Lei Zhang, Chengjiang Gao
Summary: PRMT1 is an essential regulator of TBK1 activation, promoting its oligomerization and subsequent interferon production through asymmetric methylation. Mice with myeloid-specific Prmt1 knockout are more susceptible to infection with DNA and RNA viruses.
Review
Biochemistry & Molecular Biology
Mohammad Reza Zinatizadeh, Bettina Schock, Ghanbar Mahmoodi Chalbatani, Peyman Kheirandish Zarandi, Seyed Amir Jalali, Seyed Rouhollah Miri
Summary: The NF-kB transcription factor family plays a critical role in controlling important regulatory gene expression in the cellular environment, impacting processes such as immunity, inflammation, cell death, and proliferation. Understanding NF-kB function can help in the development of treatments for rare and widespread diseases.
Article
Immunology
Caixia Qiao, Fan Huang, Jiuyi He, Qiuyu Wu, Zhijin Zheng, Tingting Zhang, Ying Miao, Yukang Yuan, Xiangjie Chen, Qian Du, Yang Xu, Depei Wu, Zhengyuan Yu, Hui Zheng
Summary: Skp2 plays multiple roles in malignant tumors, including negatively regulating IFN-I-mediated antiviral activity. It interacts with IFNAR2 and promotes its degradation, leading to inhibition of IFN-I signaling and antiviral activity. Ceftazidime, an antibiotic, was found to repress Skp2 and enhance IFNAR2 stability and antiviral activity.
Article
Hematology
Nicola Ferrari, George Ward, Christina Gewinner, Matthew P. Davis, Simone Jueliger, Harpreet Saini, Joanne Munck, Tomoko Smyth, Roberta Ferraldeschi, Harold Keer, John Lyons, Martin J. Sims
Summary: Tolinapant is a potent immunomodulatory molecule capable of inducing complete tumor regression in a TCL model, activating both adaptive and innate immune responses through the induction of immunogenic cell death.
Review
Biochemistry & Molecular Biology
Laurence Dubrez
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Correction
Cell Biology
Valerie Glorian, Jennifer Allegre, Jean Berthelet, Baptiste Dumetier, Pierre-Marie Boutanquoi, Nathalie Droin, Cemile Kayaci, Jessy Cartier, Simon Gemble, Guillaume Marcion, Daniel Gonzalez, Romain Boidot, Carmen Garrido, Olivier Micheau, Eric Solary, Laurence Dubrez
CELL DEATH & DISEASE
(2018)
Article
Multidisciplinary Sciences
Jennifer Allegre, Jessy Cartier, Valerie Glorian, Nathalie Droin, Baptiste Dumetier, Cemile Kayaci, Jean Berthelet, Simon Gemble, Celine Vuillier, Laurent Maillet, Carmen Garrido, Laurence Dubrez
Article
Biochemistry & Molecular Biology
Sebastien Z. Causse, Guillaume Marcion, Gaetan Chanteloup, Burhan Uyanik, Christophe Boudesco, Bogdan B. Grigorash, Romain Douhard, Alexandre M. M. Dias, Baptiste Dumetier, Lucile Dondaine, Gustavo J. Gozzi, Etienne Moussay, Jerome Paggetti, Celine Mirjolet, Aurelie de Thonel, Laurence Dubrez, Oleg N. Demidov, Jessica Gobbo, Carmen Garrido
Article
Genetics & Heredity
Laurence Duplomb, Julie Riviere, Gaetan Jego, Romain Da Costa, Arlette Hammann, Jessica Racine, Alain Schmitt, Nathalie Droin, Claude Capron, Marie-Anne Gougerot-Pocidalo, Laurence Dubrez, Bernard Aral, Arnaud Lafon, Patrick Edery, Jamal Ghoumid, Edward Blair, Salima El Chehadeh-Djebbar, Virginie Carmignac, Julien Thevenon, Julien Guy, Francois Girodon, Jean-Noel Bastie, Laurent Delva, Laurence Faivre, Christel Thauvin-Robinet, Eric Solary
JOURNAL OF MOLECULAR MEDICINE-JMM
(2019)
Article
Biochemistry & Molecular Biology
Gustavo J. Gozzi, Daniel Gonzalez, Christophe Boudesco, Alexandre M. M. Dias, Guillaume Gotthard, Burhan Uyanik, Lucile Dondaine, Guillaume Marcion, Francois Hermetet, Camille Denis, Laurianne Hardy, Peggy Suzanne, Romain Douhard, Gaetan Jego, Laurence Dubrez, Oleg N. Demidov, Fabrice Neiers, Loic Briand, Jana Sopkova-de Oliveira Santos, Anne-Sophie Voisin-Chiret, Carmen Garrido
CELL DEATH AND DIFFERENTIATION
(2020)
Editorial Material
Medicine, Research & Experimental
Baptiste Dumetier, Valerie Glorian, Jennifer Allegre, Laurence Dubrez
M S-MEDECINE SCIENCES
(2019)
Review
Biochemistry & Molecular Biology
Laurence Dubrez, Sebastien Causse, Natalia Borges Bonan, Baptiste Dumetier, Carmen Garrido
Review
Cell Biology
Baptiste Dumetier, Aymeric Zadoroznyj, Laurence Dubrez
Review
Immunology
Thibault Roudaire, Marie-Claire Heloir, David Wendehenne, Aymeric Zadoroznyj, Laurence Dubrez, Benoit Poinssot
Summary: Both plants and animals possess sophisticated innate immune systems equipped with receptors to detect danger signals and initiate antimicrobial defenses through regulated cell death signaling pathways.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Microbiology
Evelyne Kohli, Sebastien Causse, Valentin Baverel, Laurence Dubrez, Natalia Borges-Bonan, Oleg Demidov, Carmen Garrido
Summary: During viral infection, ER chaperones play crucial roles in the folding and quality control of viral proteins, particularly viral glycoproteins. Viruses hijack ER chaperones at various stages of their infection cycle and to evade immune responses and prevent apoptosis. The development of broad-spectrum antiviral drugs may target these chaperones for therapeutic intervention.
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Gabriel Ichim, Benjamin Gibert, Sahil Adriouch, Catherine Brenner, Nathalie Davoust, Solange Desagher, David Devos, Svetlana Dokudovskaya, Laurence Dubrez, Jerome Estaquier, Germain Gillet, Isabelle Guenal, Philippe P. Juin, Guido Kroemer, Patrick Legembre, Romain Levayer, Stephen Manon, Patrick Mehlen, Olivier Meurette, Olivier Micheau, Bernar Mignotte, Florence Nguyen-Khac, Nikolay Popgeorgiev, Jean-Lu Poyet, Muriel Priault, Jean-Ehrlan Ricci, Franck B. Riquet, Santos A. Susin, Magal Suzanne, Pierre Vacher, Ludivine Walter, Bertran Mollereau
Summary: Since the Nobel Prize was awarded more than twenty years ago for discovering the core apoptotic pathway in C. elegans, researchers around the world have conducted extensive research on apoptosis and various other forms of regulated cell death. Although there are still many aspects of regulated cell death that need to be clarified in specific cell subtypes and disease conditions, the last decade has seen the description of multiple cell death modalities, some of which have been successfully used in clinical therapy. To keep research into cell death alive, francophone researchers from several institutions in France and Belgium established the French Cell Death Research Network (FCDRN), which is at the forefront of emerging topics in cell death research. These research efforts will enhance our mechanistic knowledge of regulated cell death and its therapeutic applications in the coming years.
Article
Biochemistry & Molecular Biology
Baptiste Dumetier, Aymeric Zadoroznyj, Jean Berthelet, Sebastien Causse, Jennifer Allegre, Pauline Bourgeois, Florine Cattin, Cindy Racoeur, Catherine Paul, Carmen Garrido, Laurence Dubrez
Summary: Cellular inhibitor of apoptosis-1 (cIAP1) is a signaling regulator involved in the regulation of multiple signaling pathways and has oncogenic properties. It interacts with the molecular adaptor TRAF2 to form signaling complexes and promotes tumor growth through the activation of the JAK/STAT3 pathway.
Article
Biochemistry & Molecular Biology
Celine Vuillier, Steven Lohard, Aurelie Fetiveau, Jennifer Allegre, Cemile Kayaci, Louise E. King, Frederique Braun, Sophie Barille-Nion, Fabien Gautier, Laurence Dubrez, Andrew P. Gilmore, Philippe P. Juin, Laurent Maillet