Article
Rheumatology
Amanthi Nadira Arumahandi de Silva, Leonie Maria Frommert, Fredrik N. Albach, Jens Klotsche, Veronika Scholz, Lara Maria Jeworowski, Tatjana Schwarz, Alexander ten Hagen, Jan Zernicke, Victor Max Corman, Christian Drosten, Gerd-Ruediger Burmester, Robert Biesen
Summary: This study found that methotrexate (MTX) reduces the humoral immune response to COVID-19 vaccination in patients with autoimmune rheumatic diseases (AIRD), and discontinuing MTX for at least 10 days significantly improves antibody response in patients over 60 years old.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Immunology
Grant Sprow, Mohsen Afarideh, Joshua Dan, Rui Feng, Emily Keyes, Madison Grinnell, Josef Concha, Victoria P. Werth
Summary: The study found that fully vaccinated dermatomyositis patients were more likely to report exacerbation of autoimmune signs and symptoms after vaccination compared to fully vaccinated lupus erythematosus patients. However, given the risks of COVID-19, clinicians should still promote vaccination in most patients with autoimmune skin disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Rheumatology
Jack Arnold, Kevin Winthrop, Paul Emery
Summary: This article discusses the impact of immunosuppressive therapy on COVID-19 vaccination, proposing a suggestion to temporarily suspend treatment to improve vaccine effectiveness, and urging decisions on withholding immunosuppressive therapy to be made in advance without sufficient data support.
Review
Immunology
Han Zheng, Ting Zhang, Yiyao Xu, Xin Lu, Xinting Sang
Summary: Cases of autoimmune hepatitis (AIH) after COVID-19 vaccination have been reported, suggesting a potential autoimmune reaction. This study summarizes 27 cases of AIH, providing emerging evidence of such autoimmune phenomena in response to COVID-19 vaccines. Factors such as molecular mimicry, adjuvants, epitope spreading, and bystander activation may contribute to the development of AIH. Corticosteroids appear to be effective in treating post-vaccination AIH, but further research is needed to determine the exact mechanism and causality.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Gastroenterology & Hepatology
Sotaro Ozaka, Takashi Kobayashi, Kazuhiro Mizukami, Kazunari Murakami
Summary: This article reviews the efficacy, safety, and liver injury following COVID-19 vaccination in patients with chronic liver diseases. It emphasizes the urgency and importance of vaccination in this population.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Immunology
Yair Zlotnik, Avi Gadoth, Ibrahim Abu-Salameh, Anat Horev, Rosa Novoa, Gal Ifergane
Summary: This article describes a case of a 48-year-old man who developed rapidly progressive cognitive decline and hyponatremia shortly after receiving the second dose of the mRNA COVID-19 vaccine. The patient was diagnosed with anti-LGI1 autoimmune encephalitis (AE) and showed a favorable response to high dose steroid therapy. This case highlights the need for increased awareness of rare autoimmune reactions, particularly anti-LGI1 AE, following the COVID-19 vaccination.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Azam Safary, Kamal Esalatmanesh, Amir Taher Eftekharsadat, Mohammad -Reza Jafari Nakjavani, Alireza Khabbazi
Summary: Vaccination against COVID-19 is important for achieving herd immunity and controlling the pandemic. However, a small number of people may develop autoimmune rheumatic diseases (ARDs) as a rare adverse reaction to the vaccines. This study identifies individuals who developed de-novo ARDs after COVID-19 vaccination, with a higher prevalence among those who received the AstraZeneca vaccine. Prompt diagnosis and treatment can prevent irreversible organ damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Rheumatology
Parikshit Sen, Naveen Ravichandran, Arvind Nune, James B. Lilleker, Vishwesh Agarwal, Sinan Kardes, Minchul Kim, Jessica Day, Marcin Milchert, Tamer Gheita, Babur Salim, Tsvetelina Velikova, Abraham Edgar Gracia-Ramos, Ioannis Parodis, Albert Selva O'Callaghan, Elena Nikiphorou, Tulika Chatterjee, Ai Lyn Tan, Lorenzo Cavagna, Miguel A. Saavedra, Samuel Katsuyuki Shinjo, Nelly Ziade, Johannes Knitza, Masataka Kuwana, Oliver Distler, Hector Chinoy, Vikas Agarwal, Rohit Aggarwal, Latika Gupta
Summary: This study assessed the safety of COVID-19 vaccines in patients with SAIDs compared to healthy controls. The results showed that SAID patients had a slightly higher risk of minor adverse events compared to the control group, but the absolute risk of major adverse events was small. There were minor differences in adverse events between vaccine types in SAID patients.
Article
Endocrinology & Metabolism
Alexander Gorshtein, Adi Turjeman, Hadar Duskin-Bitan, Leonard Leibovici, Eyal Robenshtok
Summary: This study analyzed data from the largest healthcare organization in Israel and found no association between COVID-19 vaccination and the incidence of GD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Pharmacology & Pharmacy
Consolato M. Sergi
Summary: Autoimmune hepatitis (AIH) is liver inflammation characterized by autoimmunity to hepatocytes. mRNA vaccines have been useful in tackling the COVID-19 pandemic but have been associated with side effects such as myocarditis and AIH. A comparison between titin protein and myocarditis suggests the relevance of autoimmune phenomena following mRNA technology-based vaccination. The co-existence of myasthenia gravis and AIH and the presence of anti-titin antibodies highlight the potential for autoimmune reactions. Balancing the pros and cons of booster shots is crucial.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Dermatology
Hyun Jeong Ju, Ju Yeong Lee, Ju Hee Han, Ji Hae Lee, Jung Min Bae, Solam Lee
Summary: This nationwide population-based study conducted in South Korea investigated the incidence and risk of autoimmune connective tissue disorders following mRNA-based COVID-19 vaccination. The results suggest that the risk of most autoimmune connective tissue disorders is not significantly increased in vaccinated individuals compared to controls. However, caution is necessary when interpreting the results for rare outcomes.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Rheumatology
Georgina Nakafero, Matthew J. Grainge, Tim Card, Christian D. Mallen, Jonathan S. Nguyen Van-Tam, Hywel C. Williams, Abhishek Abhishek
Summary: This study investigated the association between COVID-19 vaccination and flare-ups of autoimmune rheumatic disease (AIRD). The results showed that COVID-19 vaccination was associated with a reduced risk of AIRD flares, regardless of prior COVID-19 infection, AIRD type, and mRNA or DNA vaccination technology.
Article
Virology
Jerzy Swierkot, Marta Madej, Magdalena Szmyrka, Lucyna Korman, Renata Sokolik, Iga Andrasiak, Ewa Morgiel, Agata Sebastian
Summary: This study evaluated the prevalence of autoimmune antibodies before and after SARS-CoV-2 mRNA vaccination in healthcare professionals. The findings showed no significant increase in the prevalence of certain antibodies or autoimmune diseases after vaccination. However, there was an association between the severity of vaccine adverse events and ANA titre.
Review
Immunology
Yue Chen, Zhiwei Xu, Peng Wang, Xiao-Mei Li, Zong-Wen Shuai, Dong-Qing Ye, Hai-Feng Pan
Summary: Autoimmune manifestations have been reported in response to certain COVID-19 vaccines, but it is still unclear whether there is a causal relationship. These reports can help guide the clinical assessment and management of autoimmune manifestations after vaccination.
Article
Immunology
Denise Fiorelli, Vincenza Caruso, Riccardo Belardi, Sergio Bernardini, Marzia Nuccetelli
Summary: This study aims to evaluate the impact of mRNA vaccine on the development of possible positive autoantibody profile in healthcare workers. The results suggest no autoreactive response changes over time in healthy subjects after vaccination, indicating no correlation between the administration of the vaccine and the possible onset of autoimmune disorders.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Krzysztof Lukaszuk, Grzegorz Jakiel, Izabela Woclawek Potocka, Jolanta Kiewisz, Jolanta Olszewska, Wlodzimierz Sieg, Amira Podolak, Ewa Pastuszek, Artur Wdowiak
Summary: ICSI is a commonly used treatment for oocyte fertilization, and the quality of sperm selection depends on accurate visualization of morphology. We emphasize the importance of optical system's resolution in observing sperm and provide specific microscope system setup recommendations. Furthermore, a lack of standardization in microscopy techniques for both ICSI and IMSI may contribute to mixed research results.
Review
Biochemistry & Molecular Biology
Aneta Slabuszewska-Jozwiak, Aron Lukaszuk, Marta Janicka-Kosnik, Artur Wdowiak, Grzegorz Jakiel
Summary: Obesity is strongly associated with the development of endometrial cancer, and adipokines such as adiponectin and leptin may play a role in this process. Understanding the signaling pathway of these cytokines in endometrial cancerogenesis could potentially lead to targeted therapies and fertility-sparing treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Tomasz Maciag, Dorota M. Krzyzanowska, Lukasz Rabalski, Sylwia Jafra, Robert Czajkowski
MOLECULAR PLANT-MICROBE INTERACTIONS
(2022)
Article
Cell Biology
Amira Podolak, Izabela Woclawek-Potocka, Krzysztof Lukaszuk
Summary: Mitochondria, known as 'the powerhouses of the cell', play a crucial role in cellular energy production and are essential for successful fertilisation and embryo development. Mitochondrial DNA, which is inherited from the mother, is important for providing sufficient energy for the developing embryo. Mutations or deletions in mitochondrial DNA may affect human fertility and early embryogenesis. The field of mitochondrial research has great potential for clinical application, but there are still many questions and uncertainties in assessing and improving DNA quantity and function in reproductive medicine.
Article
Immunology
Krzysztof Lukaszuk, Amira Podolak, Paulina Malinowska, Jakub Lukaszuk, Grzegorz Jakiel
Summary: Media reports have affected confidence in the AstraZeneca COVID-19 vaccine, leading many previously vaccinated individuals to refuse further doses. However, there is a shortage of mRNA vaccines due to increased demand, and there have been cases of individuals receiving the AstraZeneca vaccine after the first dose of the Pfizer/BioNTech vaccine. Only 10% of people in low-income countries have received at least one dose of the COVID-19 vaccine.
Article
Reproductive Biology
Milena Traut, Ilona Kowalczyk-Zieba, Dorota Boruszewska, Joanna Jaworska, Krzysztof Lukaszuk, Izabela Woclawek-Potocka
Summary: This study evaluated the differences in mitochondrial DNA content, oxidative stress, and developmental competence in blastocysts derived from pre-pubertal and pubertal heifers in the cattle-breeding industry. The findings indicated higher mitochondrial DNA copy numbers in blastocysts from pre-pubertal heifers, which correlated with alterations in gene markers for developmental competence and lower quality of the blastocysts compared to those derived from pubertal heifers.
Review
Environmental Sciences
Jacek K. Szymanski, Aneta Slabuszewska-Jozwiak, Grzegorz Jakiel
Summary: Millions of women worldwide suffer from overactive bladder and urinary retention, including those of reproductive age. Sacral neuromodulation (SNM) has been an effective therapy for treatment-resistant hyperactive bladder and idiopathic urinary retention for 25 years. This paper presents a case of a pregnant woman who had a positive response to SNM for her overactive bladder and successfully gave birth by cesarean section. Although current recommendations suggest deactivating SNM during pregnancy, further studies with long-term follow-up are needed to accurately determine the effects of SNM therapy on the fetus and pregnancy course.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Agriculture, Dairy & Animal Science
Joanna Jaworska, Amanda M. M. de Mestre, Joanna Wisniewska, Bettina Wagner, Arkadiusz Nowicki, Ilona Kowalczyk-Zieba, Izabela Woclawek-Potocka
Summary: This study identified the presence of regulatory T cells and NK cells in the endometrium of non-pregnant cycling mares. The percentage of these cells showed large fluctuations between individual mares. Both Tregs and NK cells may play important roles in preparing the endometrium for semen deposition and pregnancy, but further research is needed.
Article
Multidisciplinary Sciences
Daryna Sokolova, Anna Smolarska, Przemyslaw Bartnik, Lukasz Rabalski, Maciej Kosinski, Magdalena Narajczyk, Dorota M. Krzyzanowska, Magdalena Rajewska, Inez Mruk, Paulina Czaplewska, Sylwia Jafra, Robert Czajkowski
Summary: This study identified two D. solani IPO 2222 mutants, DsR34 and DsR207, that showed reduced ability to macerate potato tuber tissues compared to the wildtype strain. Genome sequencing revealed altered genes encoding secretion protein HlyD and elongation factor Tu, which impacted the proteomes of the mutants.
SCIENTIFIC REPORTS
(2023)
Article
Infectious Diseases
Lukasz Rabalski, Aleksandra Milewska, Anne Pohlmann, Karolina Gackowskal, Tomasz Lepionka, Klaudiusz Szczepaniak, Agnieszka Swiatalska, Izabela Sieminska, Zbigniew Arent, Martin Beer, Marion Koopmanse, Maciej Grzybek, Krzysztof Pyrc
Summary: A fatal disease outbreak in cats occurred in Poland in June 2023. Most cases tested were positive for highly pathogenic avian influenza A (H5N1) virus, with genetic analyses revealing initial adaptations to mammalian hosts. The cat viral sequences were highly similar, indicating a potential common infection source. Investigation of possible infection routes led to the detection of HPAI H5N1 virus in poultry meat samples from affected households.
Article
Biochemistry & Molecular Biology
Katarzyna Skuza, Pawel Rutyna, Lukasz Krzowski, Lukasz Rabalski, Tomasz Lepionka
Summary: This study conducted surveillance and sequencing of SARS-CoV-2 variants among Polish military personnel, identifying multiple lineages and demonstrating the effectiveness of pre-departure and post-mission screening and isolation in preventing the spread of variants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Mariusz J. Kujawa, Dominik Swieton, Jolanta Wierzba, Malgorzata Grzywinska, Oskar Budzilo, Monika Limanowka, Karolina Pierzynowska, Lidia Gaffke, Lukasz Grabowski, Zuzanna Cyske, Estera Rintz, Lukasz Rabalski, Maciej Kosinski, Grzegorz Wegrzyn, Arkadiusz Manski, Paulina Anikiej-Wiczenbach, Lakshminarayan Ranganath, Maciej Piskunowicz
Summary: Until now, few studies have focused on the early symptoms of alkaptonuria (AKU) in children. This comprehensive study evaluated 13 pediatric patients with AKU over multiple visits. The study included clinical evaluations, imaging tests, cognitive assessments, and genetic analyses. The most common symptoms observed were dark urine, joint pain, and dark ear wax. Cognitive deficits and adaptive abilities were found in almost half of the children. Various HGD gene variants were identified, including a potentially pathogenic mutation.
JOURNAL OF INHERITED METABOLIC DISEASE
(2023)
Article
Virology
Laurensius Kevin Lie, Aleksandra Synowiec, Jedrzej Mazur, Lukasz Rabalski, Krzysztof Pyrc
Summary: The lack of suitable in vitro culture model has hindered research on wild-type human coronaviruses. In this study, a stable A549 cell line was developed that is permissive to HCoV-229E virus, providing a platform for further studies on HCoV-229E infectiology.
Article
Virology
Lukasz Rabalski, Maciej Kosinski, Piotr Cybulski, Tomasz Stadejek, Krzysztof Lepek
Summary: Influenza A viruses remain a significant concern for public health and veterinary services due to their ability to generate diverse and potentially deadly strains. This study investigated the genetic diversity of swine influenza viruses from Polish farms and found consistency with evolutionary trends in Europe.
Correction
Immunology
L. Rabalski
EMERGING INFECTIOUS DISEASES
(2022)
