4.7 Article

BCNet: A Novel Network for Blood Cell Classification

期刊

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2021.813996

关键词

blood cells; convolutional neural network; randomized neural network; ResNet-18; transfer learning

资金

  1. Royal Society International Exchanges Cost Share Award [RP202G0230]
  2. Medical Research Council Confidence in Concept Award, United Kingdom [MC_PC_17171]
  3. Hope Foundation for Cancer Research, United Kingdom [RM60G0680]
  4. British Heart Foundation Accelerator Award, United Kingdom [AA/18/3/34220]
  5. Sino-United Kingdom Industrial Fund, United Kingdom [RP202G0289]
  6. Global Challenges Research Fund (GCRF), United Kingdom [P202PF11]
  7. Guangxi Key Laboratory of Trusted Software [kx201901]

向作者/读者索取更多资源

In this study, seven models for the automatic classification of blood cells are proposed, and the results indicate that the BCNet model outperforms other methods.
Aims: Most blood diseases, such as chronic anemia, leukemia (commonly known as blood cancer), and hematopoietic dysfunction, are caused by environmental pollution, substandard decoration materials, radiation exposure, and long-term use certain drugs. Thus, it is imperative to classify the blood cell images. Most cell classification is based on the manual feature, machine learning classifier or the deep convolution network neural model. However, manual feature extraction is a very tedious process, and the results are usually unsatisfactory. On the other hand, the deep convolution neural network is usually composed of massive layers, and each layer has many parameters. Therefore, each deep convolution neural network needs a lot of time to get the results. Another problem is that medical data sets are relatively small, which may lead to overfitting problems.Methods: To address these problems, we propose seven models for the automatic classification of blood cells: BCARENet, BCR5RENet, BCMV2RENet, BCRRNet, BCRENet, BCRSNet, and BCNet. The BCNet model is the best model among the seven proposed models. The backbone model in our method is selected as the ResNet-18, which is pre-trained on the ImageNet set. To improve the performance of the proposed model, we replace the last four layers of the trained transferred ResNet-18 model with the three randomized neural networks (RNNs), which are RVFL, ELM, and SNN. The final outputs of our BCNet are generated by the ensemble of the predictions from the three randomized neural networks by the majority voting. We use four multi-classification indexes for the evaluation of our model.Results: The accuracy, average precision, average F1-score, and average recall are 96.78, 97.07, 96.78, and 96.77%, respectively.Conclusion: We offer the comparison of our model with state-of-the-art methods. The results of the proposed BCNet model are much better than other state-of-the-art methods.

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