Article
Medicine, Research & Experimental
Jade Jaffar, Ian Glaspole, Karen Symons, Glen Westall
Summary: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with poor prognosis, and the transcription factor NF-ΚB is suggested as a potential therapeutic target. ACT001, an NF-ΚB inhibitor, showed inhibitory effects on fibroblast activity in primary lung fibroblasts from patients with and without IPF, indicating its potential as a therapeutic agent for IPF.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
David W. Waters, Michael Schuliga, Prabuddha S. Pathinayake, Lan Wei, Hui-Ying Tan, Kaj E. C. Blokland, Jade Jaffar, Glen P. Westall, Janette K. Burgess, Cecilia M. Prele, Steven E. Mutsaers, Christopher L. Grainge, Darryl A. Knight
Summary: The study demonstrates that the phenomenon of senescence-induced senescence can occur in vitro in primary cultures of human lung fibroblasts, providing a possible explanation for the abnormal abundance of senescent cells in the lungs of IPF patients.
Article
Chemistry, Multidisciplinary
Xuan Zhang, Ying Dong, Wan-chen Li, Bi-xi Tang, Jia Li, Yi Zang
Summary: This study investigated the potential of roxithromycin in treating pulmonary fibrosis by targeting senescent cells. Results showed that roxithromycin could selectively kill senescent cells, inhibit senescent cell-induced lung fibroblast activation, attenuate lung injury, inflammation, and fibrosis, and achieve these effects by inhibiting the NOX4 pathway.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Cell Biology
Theresa A. Kant, Manja Newe, Luise Winter, Maximilian Hoffmann, Susanne Kaemmerer, Erik Klapproth, Karolina Kuenzel, Mark P. Kuehnel, Lavinia Neubert, Ali El-Armouche, Stephan R. Kunzel
Summary: Pulmonary fibrosis is a chronic progressive disease with limited treatment options, highlighting the need for models to develop effective therapies. Downregulation of PLK2 in human pulmonary fibrosis and the phenotype of PLK2 KO mice suggest a potential genetic predisposition towards pulmonary fibrosis, warranting further investigation into the role of PLK2 in this condition.
Article
Environmental Sciences
Jiali Yuan, Ping Li, Honghong Pan, Qi Xu, Tiantian Xu, Yan Li, Dong Wei, Yiqun Mo, Qunwei Zhang, Jingyu Chen, Chunhui Ni
Summary: This study found that miR-770-5p is downregulated in silica-induced pulmonary fibrosis and exerts an anti-fibrotic effect by targeting TGFBR1. Experimental evidence showed that miR-770-5p can reduce fibrotic lesions and control the activation of pulmonary fibroblasts.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
David C. Yang, Shenwen Gu, Ji-Min Li, Ssu-Wei Hsu, Szu-Jung Chen, Wen-Hsin Chang, Ching-Hsien Chen
Summary: Tobacco smoking can induce highly proliferative and invasive activities in lung fibroblasts, leading to fibrotic lung lesions in mice. Genetic suppression of AXL in smoke-exposed fibroblasts inhibits AXL downstream pathways and aggressive phenotypes. Pharmacological inhibition of AXL may be a potential therapeutic strategy in treating tobacco smoking-related pulmonary fibrosis.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Review
Biology
Pataje G. S. Prasanna, Molykutty Aryankalayil, Deborah E. Citrin, C. Norman Coleman
Summary: This article investigates the mechanisms and potential biomarkers of radiation-induced pulmonary fibrosis (RIPF), as well as the roles of microRNAs (miRNA) and therapy-induced senescence (TIS) in the pathogenesis of RIPF.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2023)
Article
Immunology
Xiaohe Li, Ling Ma, Yuli Wei, Jinying Gu, Jingjing Liang, Shimeng Li, Yunyao Cui, Rui Liu, Hui Huang, Cheng Yang, Honggang Zhou
Summary: Cabozantinib shows potential as a treatment for acute lung injury and pulmonary fibrosis by improving pathological state, reducing inflammation, inhibiting fibrosis, and regulating key signaling pathways such as TLR4/NF-kappa B/NLRP3 and TGF-131/Smad3.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Engineering, Biomedical
Ting Zhao, Bokai Gong, Shiqin Luo, Rongping Zhang, Ling Zhang, Yuan Huang, Huile Gao, Tao Gong
Summary: A fibroblastic foci-targeting and hypoxia-cleavable drug delivery system (Fn-Azo-BSA@PEG) was developed to reprogram the fibrosis in idiopathic pulmonary fibrosis (IPF). The system utilized modified peptides to target fibroblastic foci and allowed for efficient drug diffusion through hypoxia-responsive azobenzene groups. The nanoparticles showed promising results in inhibiting activated fibroblasts and reducing fibrosis-related protein secretion, as well as accumulating in pulmonary tissue and prolonging survival in a mouse model.
ACTA BIOMATERIALIA
(2023)
Article
Cell Biology
Jiawen Zhou, Haiyun Chen, Qiuyi Wang, Sihan Chen, Rong Wang, Ziyang Wang, Cuicui Yang, Ao Chen, Jingyu Zhao, Zihao Zhou, Zhiyuan Mao, Guoping Zuo, Dengshun Miao, Jianliang Jin
Summary: This study determined the mechanism of senescence-associated pulmonary fibrosis and revealed the roles of Sirt1 and vitamin D in this process. Sirt1 improved lung function and prevented pulmonary fibrosis by modulating the TGF-beta 1/IL-11/MEK/ERK signaling pathway. This research is of great importance for designing treatments for chronic lung diseases.
Article
Biotechnology & Applied Microbiology
Ji-Min Li, David C. Yang, Justin Oldham, Angela Linderholm, Jun Zhang, Jun Liu, Nicholas J. Kenyon, Ching-Hsien Chen
Summary: The study reveals that decreased levels of ASS1 in IPF patients are correlated with fibrotic status. Inhibition of ASS1 function in fibroblasts activates the Met receptor, which in turn triggers the Src-STAT3 signaling pathway. Additionally, targeting ASS1 deficiency may provide a promising therapeutic strategy against pulmonary fibrosis.
Review
Cell Biology
Shenghui Zhou, Jiaojiao Zhu, Ping-Kun Zhou, Yongqing Gu
Summary: This review summarizes the mechanism and functions of type 2 alveolar epithelial cell senescence in radiation-induced pulmonary fibrosis (RIPF) and discusses the prospects of clinical treatment by targeting senescent AT2 cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Environmental Sciences
Ya-Qian Li, Xu-Liang An, Fu-Yu Jin, Yi-Fei Bai, Tian Li, Xin-Yu Yang, Shu-Peng Liu, Xue-Min Gao, Na Mao, Hong Xu, Wen-Chen Cai, Fang Yang
Summary: The effects of integrated stress response inhibitor (ISRIB) on cellular senescence and pulmonary fibrosis in silicosis were evaluated. ISRIB significantly reduced the degree of pulmonary fibrosis and reversed the expression of senescence-related factors in mice with silicosis. These findings suggest that ISRIB may alleviate pulmonary fibrosis in silicosis by inhibiting cellular senescence.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Review
Biochemistry & Molecular Biology
Jose Miguel Osorio, Claudio Espinoza-Perez, Constanza Rimassa-Tare, Victor Machuca, Juan Ortega Bustos, Matias Vallejos, Hector Vargas, Guillermo Diaz-Araya
Summary: Cardiac fibroblasts play a central role in the development of cardiac fibrosis and can become senescent, leading to organ dysfunction. Early senescence in cardiac fibroblasts after myocardial infarction seems to be protective, but in non-infarcted models, it can be deleterious. New drugs called senolytics and senostatics have emerged as potential therapeutical strategies for treating aging-related cardiac pathologies, but more research is needed to determine their effectiveness in different pathological contexts and timings of intervention.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Oncology
Geri Traver, Konjeti R. Sekhar, Peter A. Crooks, Diane S. Keeney, Michael L. Freeman
Summary: Nucleophosmin1 (NPM1) is over-expressed in NSCLC, promoting tumor growth and correlating with lower survival probability. YTR107, a small molecule radiation sensitizer, inhibits SUMOylated NPM1 from associating with RAD51, enhancing radiation-induced cell lethality. The data suggest that YTR107 represents a potential therapeutic target for NSCLC control.
Article
Engineering, Environmental
Xu Li, Huijie Lu, Kun Yang, Lizhong Zhu
Summary: The use of nanoscale zero-valent iron (NZVI) can effectively degrade tetracyclines (TCs) and reduce the potential risks of antibiotic resistance genes (ARGs) by decreasing horizontal gene transfer. NZVI's biotic degradation contributes significantly to the removal of TCs and is attributed to reduced toxicity and increased microbial biomass and enzyme activities.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Chemistry, Physical
Long Su, Fei Lu, Xu Liu, Chunting Wang, Yanan Gao, Stefano Passerini, Liqiang Zheng, Xinpei Gao
Summary: Localized high-concentration electrolytes (LHCEs) with unique microstructures enable the hopping diffusion of Li+ through anion ligand layers, resulting in high transference number and fast diffusion of Li+. The anion coordinated with multiple Li+ undergoes defluorination reactions and contributes to the formation of a stable and robust LiF-rich solid electrolyte interphase (SEI) layer, enhancing cycling stability. These insights highlight the correlation between electrolyte microstructure and properties, providing guidance for the design of improved electrolytes.
JOURNAL OF POWER SOURCES
(2023)
Article
Materials Science, Biomaterials
Yanan Gao, Jingyu Xiao, Zijian Chen, Yutao Ma, Xiaoya Liu, Dishuang Yang, Hwa Liang Leo, Hanry Yu, Jian Kong, Qiongyu Guo
Summary: Developing a three-dimensional in vitro tumor model with vasculature systems for testing endovascular interventional therapies is challenging. Here, an orthotopic liver tumor spheroid model is developed to evaluate transcatheter arterial chemoembolization (TACE) treatment. The model resembles the unique tumor microenvironment and can efficiently assess various diagnostic and therapeutic strategies.
BIOMATERIALS SCIENCE
(2023)
Article
Oncology
Jinsong Yang, Ai Huang, Kunyu Yang, Ke Jiang
Summary: This study aims to investigate whether the addition of immunotherapy to neoadjuvant chemoradiotherapy can improve the pathologic complete response rate in esophageal carcinoma. Patients will receive neoadjuvant chemoradiotherapy followed by surgery. The primary endpoint is the pathologic complete response rate after neoadjuvant chemoradiotherapy plus immunotherapy.
Article
Meteorology & Atmospheric Sciences
Yanyi He, Kun Yang, Yanghang Ren, Mijun Zou, Xu Yuan, Wenjun Tang
BULLETIN OF THE AMERICAN METEOROLOGICAL SOCIETY
(2023)
Article
Engineering, Electrical & Electronic
Da Lu, Rui Duan, Kunde Yang
Summary: This paper presents a constrained CPD-based algorithm for DOA estimation using a highly structured uniform linear AVSA. The algorithm incorporates prior structured information to improve the accuracy of DOA estimation. Numerical simulations verify the effectiveness and superior performance of the algorithm.
CIRCUITS SYSTEMS AND SIGNAL PROCESSING
(2023)
Article
Genetics & Heredity
Zihao Liang, Xudong Zheng, Yuan Wang, Kai Chu, Yanan Gao
Summary: This study used bioinformatics and systems biology to identify potential medications for treating COVID-19, IAV, and COPD, as well as potential target genes. The study also identified transcription factor-gene connections, protein-drug interactions, and gene-microRNA coregulatory networks associated with these genes.
FUNCTIONAL & INTEGRATIVE GENOMICS
(2023)
Article
Gastroenterology & Hepatology
Maojun You, Yanan Gao, Junliang Fu, Runze Xie, Zhenyu Zhu, Zhixian Hong, Lingzhan Meng, Shunda Du, Junliang Liu, Fu-Sheng Wang, Pengyuan Yang, Liang Chen
Summary: This study investigates the epigenomic programs that regulate the differentiation and generation of HBV-related T cells in response to viral infection and HBV + HCC unique immune exhaustion. The study also highlights the correlation between HBV-related tumor-infiltrating regulatory T cells and increased viral titer and poor prognosis in patients.
Article
Cell Biology
Guojie Xu, Lei Zhao, Qingling Hua, Lanqing Wang, Hongli Liu, Zhenyu Lin, Min Jin, Jing Wang, Pengfei Zhou, Kunyu Yang, Gang Wu, Dandan Yu, Dejun Zhang, Tao Zhang
Summary: In this study, it was found that CEMIP interacts with GRAF1, and the combination of high CEMIP and low GRAF1 predicts poor survival of patients. It was also revealed that CEMIP promotes CRC metastasis by negatively regulating the stability of GRAF1 and by bridging MIB1 and GRAF1. Furthermore, it was demonstrated that CEMIP activates the CDC42/MAPK pathway-regulated EMT, which is essential for CEMIP-mediated migration and invasion of CRC cells. It was concluded that CDC42 inhibitor could be a potential therapeutic strategy for CEMIP-mediated CRC metastasis.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Qi Zhang, Jinglei Li, Zihan Chen, Ke Jiang, Kunyu Yang, Fang Huang, Ai Huang, Xiaodong Zhang, Jinxiang Zhang, Hui Wang
Summary: In this study, it was found that the deubiquitinase OTUD1 is downregulated in lung adenocarcinoma (LUAD) and inhibits the progression of LUAD by deubiquitinating and stabilizing FHL1. Furthermore, the drug VE-822 was identified as a candidate agonist for OTUD1 and showed inhibitory effects on the proliferation of LUAD both in vitro and in vivo.
Article
Food Science & Technology
Xue Yang, Xue Li, Yanan Gao, Jiaqi Wang, Nan Zheng
Summary: Aflatoxin B1 (AFB1) and aflatoxin M1 (AFM1) are environmental pollutants that pose a carcinogenic risk to humans. This study found that AFB1 and AFM1 affect intestinal resistance to pollutants and cause lipid metabolism disorders, which may be the main mechanism of their enterotoxicity.
Article
Energy & Fuels
Yanan Gao, Donghao Lan, Cunbao Li, Liyuan Yu, Guangkai Zhang
Summary: A novel 3D Hoek-Brown strength criterion and associated constitutive model is developed based on mechanical tests and finite deformation theory under disturbance stress paths. The nonlinear behavior of rock under loading, represented by the stress-strain relationship and deformation field, is studied using the finite deformation theory. A damage variable (DV) based on mean rotation angle (O) is then proposed to establish a novel strength criterion (NSC). The NSC is validated to have better agreement with experimental data compared to other strength criteria, and an associated elasto-plastic constitutive model is developed.
GEOMECHANICS FOR ENERGY AND THE ENVIRONMENT
(2023)
Article
Public, Environmental & Occupational Health
Ze Luan, Zhiru Zhang, Yanan Gao, Shiyuan Du, Nan Wu, Yulu Chen, Xin Peng
Summary: This study conducted a bibliometric analysis on the application of electronic health records in the nursing field from 2000 to 2020. The results showed an increasing trend in the quantity of publications and research hotspots. The analysis of author collaboration networks and research topics provided a reference for the effective use of electronic health records in nursing.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Biology
Mengjin Liu, Yu Lan, Yuhan Qin, Yanan Gao, Yulin Deng, Nuomin Li, Chen Zhang, Hong Ma
Summary: By simulating the space radiation environment, we found that astrocytes have a protective effect on neuronal cells, and neuronal cells influence the activation of astrocytes in oxidative and inflammatory damage in the central nervous system. Exosomes play an essential role in this interaction.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Xiaojuan Liu, Feng Gao, Tiantian Jin, Ke Ma, Haijiang Shi, Ming Wang, Yanan Gao, Wenjuan Xue, Jing Zhao, Songtao Xiao, Yinggen Ouyang, Guoan Ye
Summary: Covalent organic frameworks (COFs) are used to selectively capture Th(IV), and the design of Py-TFImI-25 COF and Py-TFIm-25 COF provides insights into the role of different N sites in the selective capture. Both COFs exhibit high uptake capacity and adsorption rate for thorium, and the mechanism of selective coordination is investigated. This research contributes to the design of novel adsorbents for thorium separation.
NATURE COMMUNICATIONS
(2023)