Review
Microbiology
Evgeniya V. Prazdnova, Andrey V. Gorovtsov, Nikita G. Vasilchenko, Maxim P. Kulikov, Varvara N. Statsenko, Anna A. Bogdanova, Alexandr G. Refeld, Yaroslav A. Brislavskiy, Vladimir A. Chistyakov, Michael L. Chikindas
Summary: This review focuses on the mechanisms of quorum-sensing suppression by Gram-positive microorganisms and its practical applications in food fermentation, probiotics, and biotechnology. It also discusses the possible evolutionary role of quorum-quenching mechanisms during the development of interspecies interactions of bacteria.
Review
Biochemistry & Molecular Biology
Victor Markus, Abraham Abbey Paul, Kerem Terali, Nazmi Ozer, Robert S. Marks, Karina Golberg, Ariel Kushmaro
Summary: An imbalance in gut microbiota, called dysbiosis, can affect host health and lead to diseases like inflammatory bowel disease, cancer, obesity, depression, and autism. The inhibition of bacterial quorum sensing (QS) by artificial sweeteners has been found to contribute to this dysbiosis. QS is a communication system mediated by small molecules, called autoinducers (AIs), which enable bacteria to interact and coordinate their gene expression. AIs play a role in maintaining the equilibrium of gut microbiota and interference in QS can disrupt this balance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Food Science & Technology
Yucheng Zhang, Ning Ma, Peng Tan, Xi Ma
Summary: This review provides an overview of how gut bacteria use quorum sensing (QS) to communicate and coordinate their activities, and the role of QS in the interaction between the gut host and microbiota. Understanding the communication network of gut microbiota is crucial for developing strategies against bacterial illnesses and improving gut health.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Microbiology
Sarika Suresh, Prathiksha Prabhakara Alva, Ramya Premanath
Summary: Quorum sensing is a method of inter-cellular communication in bacteria that affects gene expression and pathogenicity, with carbohydrates in the nutritional environment playing an important role in this process. Pathogenic bacteria can rapidly regulate their QS-linked virulence gene expression based on changing nutrient levels to thrive in diverse niches.
ARCHIVES OF MICROBIOLOGY
(2021)
Review
Microbiology
Esmeralda Escobar-Mucino, Margarita M. P. Arenas-Hernandez, M. Lorena Luna-Guevara
Summary: Quorum sensing is a cell-cell communication process in bacteria that can be controlled by inhibitor molecules to regulate the expression of virulence genes and combat infectious pathogens. These inhibitors also have negative regulatory activity on genes related to bacterial biofilm formation.
Article
Immunology
Sathursha Gunaratnam, Mathieu Millette, Lynne McFarland, Herbert L. DuPont, Monique Lacroix
Summary: This paper discusses the potential of opportunistic pathogenic bacteria to cause disease when disrupting the normal microbiome, and current therapeutic strategies for Clostridioides difficile, including disrupting virulence factor production through interfering with quorum sensing systems. Probiotics and other QS inhibitors targeting QS systems may represent important new directions for the treatment and prevention of C. difficile infections.
MICROBIAL PATHOGENESIS
(2021)
Review
Microbiology
Leon M. T. Dicks
Summary: The human gut contains almost 3000 microbial species, primarily bacteria, which produce quorum sensing molecules that influence the gut microbiome and communicate with the host. These molecules have a significant effect on our physiological and mental health.
Review
Chemistry, Medicinal
Zhendong Niu, Peng Lei, Yuxi Wang, Jiaxing Wang, Jinlin Yang, Jifa Zhang
Summary: LpxC is a key enzyme in the synthesis of outer membrane lipid A in gram-negative bacteria, and inhibitors of this enzyme have shown promising broad-spectrum antibiotic activity.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Engineering, Environmental
Chunxiao Dai, Yuanyuan Qu, Weize Wu, Shuzhen Li, Zhuo Chen, Shengyang Lian, Jiawei Jing
Summary: This study established a QS-related protein database and an automatic annotation pipeline for rapid and accurate annotation and classification of QS-related sequences in aquatic environments. It provides a useful tool for understanding bacterial communication in water environments.
Article
Biochemistry & Molecular Biology
Simona Cavalu, Samar S. Elbaramawi, Ahmed G. Eissa, Mohamed F. Radwan, Tarek S. Ibrahim, El-Sayed Khafagy, Bruno Silvester Lopes, Mohamed A. M. Ali, Wael A. H. Hegazy, Mahmoud A. Elfaky
Summary: The development of bacterial resistance to antibiotics is a growing public health concern exacerbated by the formation of biofilms. The study aimed to evaluate the anti-quorum sensing (QS), anti-biofilm, and anti-virulence activities of the beta-adrenoreceptor blocker atenolol against Gram-negative bacteria. In silico studies showed that atenolol had a significant binding affinity to the QS receptors of the tested bacteria. In vitro and in vivo experiments demonstrated that atenolol effectively competed with QS proteins, downregulated the expression of QS- and virulence-encoding genes, and reduced bacterial biofilm formation, virulence enzyme production, and motility. It also protected mice from bacterial infection. These findings suggest that atenolol has potential as an adjuvant in the treatment of aggressive bacterial infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Rohit Ruhal, Rashmi Kataria
Summary: Biofilms formed by Gram-positive and Gram-negative bacteria are the root cause of industrial biofouling and antimicrobial resistance during infections. To understand the mechanisms of biofilm formation better, it is essential to study common components and genetic regulations that are shared among the two types of bacteria.
MICROBIOLOGICAL RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Mahmoud A. A. Elfaky, Samar S. S. Elbaramawi, Ahmed G. G. Eissa, Tarek S. S. Ibrahim, El-Sayed Khafagy, Mohamed A. M. Ali, Wael A. H. Hegazy
Summary: This study demonstrates that doxazosin, an alpha-adrenoreceptor blocker, possesses anti-bacterial virulence and anti-quorum sensing (QS) activities against Pseudomonas aeruginosa and Proteus mirabilis. It significantly reduces biofilm formation and the release of QS-controlled pigment and virulence factors in both bacteria as well as downregulating QS encoding genes in P. aeruginosa. However, further toxicological and pharmacological investigations are necessary to evaluate the clinical potential of doxazosin as a novel anti-virulence agent.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Environmental Sciences
Dai Chunxiao, Fang Ma, Weize Wu, Shuzhen Li, Jing Yang, Zhuo Chen, Shengyang Lian, Yuanyuan Qu
Summary: Indole is found to have an influence on the microbial communities in biological wastewater treatments. It enriched indole degrader Burkholderiales and inhibited pathogens at different concentrations. Indole also affected the abundance and distribution of genes in signaling transduction mechanisms pathway and quorum-sensing signaling acceptors. Moreover, it increased the abundance of antibiotic resistance genes, especially aminoglycoside, multidrug, tetracycline, and sulfonamide.
ENVIRONMENTAL RESEARCH
(2023)
Article
Engineering, Environmental
Huizhi Hu, Feng Luo, Yirong Liu, Xiangguo Zeng
Summary: Quorum sensing plays a crucial role in regulating bacterial ecological relations and physiological behaviors, particularly in the formation of biofilm and granular sludge. Understanding bacterial QS in engineered reactors is essential for improving wastewater treatment efficiency.
WATER SCIENCE AND TECHNOLOGY
(2021)
Review
Gastroenterology & Hepatology
Garance Coquant, Doriane Aguanno, Sandrine Pham, Nathan Grellier, Sophie Thenet, Veronique Carriere, Jean-Pierre Grill, Philippe Seksik
Summary: Bacteria communicate and regulate activities through quorum sensing, impacting gut health. Various QS systems may play a crucial role in intestinal disorders. Understanding the role of bacterial social networks in gut physiology can lead to the development of new therapeutic strategies.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Chemistry, Physical
Shanshan Cheng, Xu Chen, Meng Wang, Gaoqiang Li, Xiaofeng Qi, Yongtao Tian, Mochen Jia, Yanbing Han, Di Wu, Xinjian Li, Zhifeng Shi
Summary: In this study, two-dimensional MXene nanosheets were used as high-efficiency co-catalysts to construct Cs2AgBiBr6/Ti3C2Tx Schottky heterostructures by in-situ growth of Cs2AgBiBr6 perovskite nanocrystals on Ti(3)C(2)Tx nanosheets via thermal injection method. The optimized Cs2AgBiBr6/Ti3C2Tx nanocomposites showed significantly enhanced organic dye degradation rate, about 4.7 times higher than that of the pristine Cs2AgBiBr6 nanocrystals. The outstanding photocatalytic activity of Cs2AgBiBr6/Ti3C2Tx nanocomposites was attributed to the strong interaction between Cs2AgBiBr6 nanocrystals and highly conductive 2D Ti(3)C(2)Tx nanosheets, a large interface contact area, and favorable Fermi level alignment, which promoted charge transfer and separation efficiency while suppressing electron-hole recombination. Moreover, the Cs2AgBiBr6/ MXenes-based photocatalysts exhibited good repeatability and long-term stability. This work will guide the construction of high-efficiency and stable photocatalytic materials for environmental purification.
APPLIED SURFACE SCIENCE
(2023)
Article
Marine & Freshwater Biology
Xiao-Hong Liu, Xu Pang, Li Jin, De-Yong Pu, Zhi-Jian Wang, Yao-Guang Zhang
Summary: This study aimed to investigate the effects of cadmium on lipid metabolism in freshwater fish using rare minnows (Gobiocypris rarus) as the model species. The results showed that exposure to high concentrations of cadmium led to severe damage in the form of lipid droplet accumulation, abnormal rough endoplasmic reticulum lamellae, and hepatocyte necrosis. Furthermore, hepatic and serum lipids were significantly increased, while the mRNA transcripts of certain genes related to lipid oxidation, synthesis, and transport were altered. These findings suggest that disrupted lipid transport may play a key role in the accumulation of hepatic lipid droplets.
AQUATIC TOXICOLOGY
(2023)
Article
Cell Biology
Yanping Li, Jingyuan Xu, Weiting Chen, Xingxing Wang, Zhibo Zhao, Yuqi Li, Linkun Zhang, Junkui Jiao, Qin Yang, Qiuying Ding, Ping Yang, Li Wei, Yao Chen, Yaxi Chen, Xiong Z. Ruan, Lei Zhao
Summary: Macrophagy/autophagy is protective in sepsis-induced liver injury. CD36, a member of class B scavenger receptors, plays important roles in various disorders. In sepsis, CD36 expression is increased in hepatocytes, accompanied by impaired autophagy flux. CD36 knockout improves liver injury and autophagosome-lysosome fusion impairment in septic mice. Mechanistically, CD36 acts as a bridge molecule between UBQLN1 and SNARE proteins, promoting the proteasomal degradation of SNARE proteins and fusion impairment. Targeting CD36 in hepatocytes may be a promising strategy for treating septic liver injury.
Article
Agricultural Engineering
Yijing Gao, Teng Cai, Jian Yin, Huan Li, Xinyu Liu, Xueqin Lu, Hongxia Tang, Weijie Hu, Guangyin Zhen
Summary: In-situ bioelectrocatalysis (BE) was integrated into the up-flow anaerobic sludge bed (UASB) reactor to enhance the re-granulation process and alter microbial metabolic behaviors, solving the challenges of granular sludge disintegration and washing out.
BIORESOURCE TECHNOLOGY
(2023)
Article
Oncology
Shuangshuang Deng, Qiping Zhu, Hongyan Chen, Tianyu Xiao, Yinshen Zhu, Jinli Gao, Qing Li, Yong Gao
Summary: The study aims to accurately screen potential immune cells that can predict the survival of colorectal cancer (CRC) patients and identify related prognostic predictors. Sample data of CRC patients were collected from the GEO and TCGA databases to establish a prognosis-scoring model and validate prognostic-related immune cells. Clinical samples from CRC diagnosed patients were also analyzed to further screen prognostic predictors.
Article
Infectious Diseases
Qiuyi Xu, Hejiang Wei, Simin Wen, Jiamin Chen, Yuxuan Lei, Yanhui Cheng, Weijuan Huang, Dayan Wang, Yuelong Shu
Summary: This study aimed to explore factors related to the immune response to influenza vaccines. The results showed that the immune response was associated with age group, vaccination history, chronic conditions, frequency of colds, and region. Age, vaccination history, frequency of colds, and chronic conditions had varying degrees of impact on the efficacy of the influenza vaccine. Therefore, it is necessary to develop optimized vaccination strategies for vulnerable groups to improve the effectiveness of influenza vaccines.
BMC INFECTIOUS DISEASES
(2023)
Article
Chemistry, Physical
Yiman Lu, Xiaoning Zhao, Ya Lin, Peng Li, Ye Tao, Zhongqiang Wang, Jiangang Ma, Haiyang Xu, Yichun Liu
Summary: In this study, we developed lightweight electromagnetic interference shielding materials with temperature resistant and compressible performance. The MXene/carbon composite foam exhibited excellent electromagnetic interference shielding effectiveness in the X-band, Ku-band, and K-band, with a low MXene loading and a low density. Additionally, the foam demonstrated stable performance after exposure to air for a year and maintained high shielding effectiveness after compressing-releasing cycles.
Article
Cell & Tissue Engineering
Carlos A. Pinzon-Arteaga, Yinjuan Wang, Yulei Wei, Ana E. Ribeiro Orsi, Leijie Li, Giovanna Scatolin, Lizhong Liu, Masahiro Sakurai, Jianfeng Ye, Hao Ming, Leqian Yu, Bo Li, Zongliang Jiang, Jun Wu
Summary: We developed an efficient method to generate bovine blastocyst-like structures (blastoids) by assembling bovine trophoblast stem cells and expanded potential stem cells. Bovine blastoids resemble blastocysts in morphology, cell composition, single-cell transcriptomes, in vitro growth, and the ability to elicit maternal recognition of pregnancy following transfer to recipient cows. Bovine blastoids serve as an accessible in vitro model for studying embryogenesis and improving reproductive efficiency in livestock species.
Article
Chemistry, Physical
Chengli He, Zixiang Hao, Linrui Wang, Dong Qiu, Mingyan Wang, Yang Chen, Xiaoli Cui
Summary: Mechanical force-induced N-2 fixation is a promising strategy for ammonia synthesis at room temperature and atmospheric pressure. This study demonstrates a simple and rapid approach to synthesize NH3 in the N-2+H-2+H2O system and elucidates the reaction mechanism through theoretical calculations. The NH3 generation rate reaches 2.847 mg L-1 h(-1) with a high NH4+ selectivity of 99.45 wt.%. The presence of H-2 inhibits oxidation reactions and promotes proton generation, resulting in increased NH4+ yield. This work provides a simple method to enhance mechanochemical N-2 fixation and highlights the mechanism of proton generation.
Article
Engineering, Environmental
Zheng Wang, Jia-Jia Liu, Meng-Yang Li, Guang Chen
Summary: This paper reports two metal-organic frameworks (MOFs) materials, SUST-WJ-12 and SUST-WJ-13, based on multinuclear clusters with long persistent luminescence (LPL). It is found that both materials exhibit excitation-dependent emission color-tuning and can emit bright and visible LPL for 2-3 seconds after the removal of the excitation light source. Single-crystal X-ray diffraction analysis and theoretical calculations reveal that the LPL is enhanced by the ligand center in the presence of metal clusters. These findings have important implications for applications in lighting and security systems, among others.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Chemical
Jikang Wang, Yawen Wang, Wenbo Xiong, Zixian Li, Xianggui Kong, Hong Yan, Yanjun Lin, Haohong Duan, Yufei Zhao
Summary: The treatment and recycling of heavy metal pollutants play a crucial role in restoring the ecological environment and recovering valuable resources. A novel CaCr-layered double hydroxide (LDH) was successfully synthesized by extracting toxic Cr3+ from industrial wastewater, purifying it to meet discharge standards. The CaCr-LDH demonstrated a high capacity for the mineralization of multiple heavy metal ions, offering potential applications in environmental remediation and resource recovery.
CHEMICAL ENGINEERING SCIENCE
(2023)
Article
Physics, Multidisciplinary
Li Zhu, Wei-Min Zhao, Zhen-Yu Jia, Huiping Li, Xuedong Xie, Qi-Yuan Li, Qi-Wei Wang, Li-Guo Dou, Ju-Gang Hu, Yi Zhang, Wenguang Zhu, Shun-Li Yu, Jian-Xin Li, Shao-Chun Li
Summary: Excitons in solid state are bosons generated by electron-hole pairs as the Coulomb screening is reduced. The condensation of excitons can lead to exotic physics like superfluidity and insulating state. 1T-TiSe2 in charge density wave (CDW) state is a candidate for exciton condensation, but it is still challenging to envision its excitonic effect in the two-dimensional limit applicable to future devices. In this study, we create a 2D epitaxial bilayer of 1T-TiSe2 to explore the exciton-associated effect and discover an unexpected state below the conduction band and within the CDW gap region, which is found to be in good agreement with the electron-exciton coupling through theoretical analysis. Our research provides a material platform for investigating exciton-based electronics and opto-electronics.
CHINESE PHYSICS LETTERS
(2023)
Article
Thermodynamics
Xianda Cheng, Haoran Zheng, Qian Yang, Peiying Zheng, Wei Dong
Summary: The use of surrogate method enables real-time gas path fault diagnosis of gas turbines under transient operating conditions, improving diagnosis speed while maintaining accuracy.
Article
Environmental Sciences
Mengyi Wang, Min Zhou, Qiyou Tan, Linling Yu, Chaoqian Dong, Ruyi Liang, Wei Liu, Yongfang Zhang, Minjing Li, XiuQuan Nie, Tao Jing, Weihong Chen
Summary: This study aimed to assess the associations between triazine herbicides and glycemia-related risk indicators in general adults. The results showed that triazine herbicides exposure was positively associated with abnormal glucose metabolism, and decreasing serum IgM partly mediated these associations among uninfected participants.
ENVIRONMENTAL POLLUTION
(2023)
Article
Clinical Neurology
Yuanyu Hu, Yanlei Dong, Zhongwei Yang, Junbo Qi, Xin Zhang, Guojin Hou, Yang Lv, Yun Tian
Summary: The aim of this study was to identify the incidence, clinical features, and risk factors for postoperative acute pancreatitis (PAP) after lumbar surgery. It was found that fusion of L1/2, high surgical invasiveness index, and low intraoperative mean arterial pressure were independent risk factors for PAP after surgery for lumbar degenerative disease.
EUROPEAN SPINE JOURNAL
(2023)