Review
Oncology
Guangbing Xiong, Shutao Pan, Jikuan Jin, Xiaoxiang Wang, Ruizhi He, Feng Peng, Xu Li, Min Wang, Jianwei Zheng, Feng Zhu, Renyi Qin
Summary: The study provides a comprehensive review of the role of lncRNAs and miRNAs in the initiation and progression of pancreatic cancer, highlighting the crucial function of ceRNA networks in the biological processes of pancreatic cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Hao Ning, Lu Zhang, Baicheng Zhu, Xinxin Zhou, Tianyuan Zhang, Teng Ma
Summary: Breakdown of the blood-brain barrier (BBB) is an important pathological marker in the development of Alzheimer's disease. Beta-amyloid deposition disrupts tight junction proteins formed by endothelial cells, leading to increased BBB permeability. Through regulation of various genes and molecules, the TARBP2/SNHG7/miR-17-5p/NFATC3 pathway may provide insights into the changes in the BBB during the progression of Alzheimer's disease.
CELL DEATH & DISEASE
(2022)
Article
Medicine, General & Internal
Gu Xi, Xu Ziyu, Liu Yiting, Liu Zonghang, Zheng Lifeng
Summary: This study identified two novel lncRNAs (LINC00114 and UCA1) in colon cancer through bioinformatics analysis. These lncRNAs may be associated with the occurrence and development of colon cancer, with LINC00114 potentially impacting the overall survival of patients.
Article
Genetics & Heredity
Zifan Yue, Pei Mou, Sainan Chen, Fei Tong, Ruili Wei
Summary: A study investigated the lncRNA/circRNA-miRNA-mRNA network in Graves' ophthalmopathy (GO) patients, revealing significant differences in RNA expression levels compared to control patients. Through high-throughput sequencing and qPCR validation, the study identified key genes and constructed ceRNA networks. This innovative study identified two important ceRNA pathways that may impact autoimmune response and inflammation in GO patients.
FRONTIERS IN GENETICS
(2021)
Review
Engineering, Chemical
Fernanda Costa Brandao Berti, Sara Cristina Lobo-Alves, Camila de Freitas Oliveira-Tore, Amanda Salviano-Silva, Karen Brajao de Oliveira, Patricia Savio de Araujo-Souza, Jong Kook Park, Gabriel Adelman Cipolla, Danielle Malheiros
Summary: MicroRNAs regulate gene expression by binding to target mRNAs, while interacting in competitive ceRNA networks. Long noncoding RNAs play essential roles in cervical cancer, impacting cell processes by modulating miRNA sponging. This dynamic molecular interaction affects cell growth, proliferation, apoptosis, and adhesion in CC.
Article
Multidisciplinary Sciences
Lecai Xiong, Xueyu He, Le Wang, Peng Dai, Jinping Zhao, Xuefeng Zhou, Hexiao Tang
Summary: This study investigated the hypoxia-associated molecular hallmarks in LUAD, constructed prognostic models based on hypoxia-related DEGs, and explored the ceRNA network underlying the potential mechanism of poor prognosis.
SCIENTIFIC REPORTS
(2022)
Article
Biology
Li-Wei Meng, Guo-Rui Yuan, Meng-Ling Chen, Li-Sha Zheng, Wei Dou, Yu Peng, Wen-Jie Bai, Zhen-Yu Li, John Vontas, Jin-Jun Wang
Summary: The insect cuticle contributes over 40.0% to insecticide resistance, and miR-994 and CPCFC play key roles in regulating cuticle thickness and insecticide penetration.
Article
Multidisciplinary Sciences
Yongsuk Ku, Joo-Hwan Park, Ryeongeun Cho, Yongki Lee, Hyoung-Min Park, MinA Kim, Kyunghoon Hur, Soo Young Byun, Jun Liu, Young-Suk Lee, David Shum, Dong-Yeop Shin, Youngil Koh, Je-Yoel Cho, Sung-Soo Yoon, Junshik Hong, Yoosik Kim
Summary: This study uncovers the mechanism of viral mimicry and cell death triggered by decitabine through the activation of endogenous retroviruses (ERVs), highlighting the essential role of the double-stranded RNA-binding protein Staufen1 (Stau1) and providing a novel target for predicting the efficacy of DNMTis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Adriano Biasini, Baroj Abdulkarim, Stefano de Pretis, Jennifer Y. Tan, Rajika Arora, Harry Wischnewski, Rene Dreos, Mattia Pelizzola, Constance Ciaudo, Ana Claudia Marques
Summary: Translation is necessary for miRNA-dependent transcript destabilization, and coding and noncoding transcripts are differently affected by miRNAs.
Article
Oncology
Guiwen Ye, Peng Wang, Zhongyu Xie, Jinteng Li, Guan Zheng, Wenjie Liu, Qian Cao, Ming Li, Shuizhong Cen, Zhaofeng Li, Wenhui Yu, Yanfeng Wu, Huiyong Shen
Summary: This study identified a novel long noncoding RNA, HHAS1, that facilitates bone marrow-derived mesenchymal stem cell osteogenic differentiation, and proposed a role for the IRF2/HHAS1/miR-204-5p/RUNX2 axis in the regulation of BMSC osteogenesis.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Qin Wang, Jiena Liu, Zilong You, Yanling Yin, Lei Liu, Yujuan Kang, Siwei Li, Shipeng Ning, Hui Li, Yajie Gong, Shouping Xu, Da Pang
Summary: The study revealed that TINCR is upregulated in human breast cancer tissues and its knockdown suppresses tumorigenesis in vitro and in vivo. Mechanistically, TINCR recruits DNMT1 to the miR-503-5p locus promoter, increasing methylation and suppressing transcriptional expression of miR-503-5p. Additionally, TINCR functions as a competing endogenous RNA to upregulate EGFR expression by sponging miR-503-5p.
CELL DEATH & DISEASE
(2021)
Article
Genetics & Heredity
Yuxin Ding, Yuhong Chen, Xiaoshuang Yang, Piaopiao Xu, Jing Jing, Yujie Miao, Meiqi Mao, Jiali Xu, Xianjie Wu, Zhongfa Lu
Summary: This study investigates the mechanisms of noncoding RNAs and competitive endogenous RNA networks associated with the hair follicle cycle, and identifies new alopecia-related genes such as GSPT1. The study provides valuable insights into the regulation of the hair follicle cycle.
FRONTIERS IN GENETICS
(2022)
Article
Cell Biology
Zi Liang, Liyan Liu, Xinyi Guo, Xia Wu, Yun-Li Yu, Ziyang Yu, Xiaolong Hu, Xing Zhang, Ji Wang
Summary: This study revealed differentially expressed circRNAs in iCCA tissues, suggesting that circRNAs may play crucial roles in iCCA pathogenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Xiao-Feng Cui, Si-Lin Zhang, Wei-Ping Wang, Xiao-Wu Huang, Xiang-Jun Chen
Summary: In this study, key long noncoding RNAs (lncRNAs) involved in the competitive endogenous RNA (ceRNA) network associated with laryngeal squamous cell carcinoma (LSCC) were investigated. Through functional enrichment analysis and construction of the ceRNA regulatory network, the functions of these lncRNAs and their importance in LSCC were determined. The results were further validated by quantitative real-time polymerase chain reaction (qRT-PCR) analysis.
Article
Genetics & Heredity
Meichen Yin, Lingyun Zhai, Jianzhang Wang, Qin Yu, Tiantian Li, Xinxin Xu, Xinyue Guo, Xinqi Mao, Jianwei Zhou, Xinmei Zhang
Summary: This study focused on the potential molecular mechanism of competitive endogenous RNA (ceRNA) composed of long non coding RNAs (lncRNAs) and circular RNAs (circRNAs) related to endometriosis. Through high-throughput sequencing, the expression profile of lncRNA, circRNA, and mRNA in different endometrial tissues was analyzed, revealing differential expression in endometriosis. The study also identified key pathways and constructed networks that contributed to a better understanding of the pathogenesis of endometriosis and new target identification.
FRONTIERS IN GENETICS
(2022)
Article
Agriculture, Dairy & Animal Science
Jialu Li, Lingbin Liu, Jipan Zhang, Lei Cheng, Lingtong Ren, Yongju Zhao
Summary: The study suggests that miR-129-5p plays a key role in regulating the formation of coat color in goats by decreasing the expression of TYR. Additionally, the expression of TYR and MITF varies with age in goats of different coat colors.
ANIMAL BIOTECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Jipan Zhang, Chengchen Deng, Jialu Li, Yongju Zhao
Article
Agriculture, Dairy & Animal Science
Nanjian Luo, Wenqiang Cheng, Yumei Zhou, Bowen Gu, Zhongquan Zhao, Yongju Zhao
Summary: This study investigated the trophoblast transcriptome in early goat placental development, identifying potential functional genes and enriched signaling pathways. The RAP1 signaling pathway was found to play a central role in regulating cell proliferation, invasion, migration, and fusion of trophoblasts, providing insights into the molecular mechanisms of ruminant placentation.
Article
Agriculture, Dairy & Animal Science
Bowen Gu, Ruifan Sun, Xingqiang Fang, Jipan Zhang, Zhongquan Zhao, Deli Huang, Yuanping Zhao, Yongju Zhao
Summary: This study conducted a genome-wide association study on a Chinese indigenous goat breed, Dazu black goats, to identify the genetic variants associated with body conformation traits. A total of 53 significant single nucleotide polymorphisms and 42 candidate genes were detected. These findings have practical applications for genetic improvement and economic benefits in the goat meat industry.
Article
Agriculture, Dairy & Animal Science
Yiming Gong, Hao-Yuan Zhang, Ying Yuan, Yongmeng He, Weiyi Zhang, Yanguo Han, Risu Na, Yan Zeng, Jia Luo, Haili Yang, Yongfu Huang, Yongju Zhao, Zhongquan Zhao, E. Guang-Xin
Summary: This study confirms the genetic contribution of wild boar to the domestication process of European domestic pigs through genomic analysis and phylogenetic estimation. The findings are important for understanding the metabolic and emotional differences between European wild boar and domestic pigs.
Article
Agriculture, Dairy & Animal Science
Tingting Liu, Rui Li, Nanjian Luo, Peng Lou, Sean W. Limesand, You Yang, Yongju Zhao, Xiaochuan Chen
Summary: Low birth weight has a broad impact on neonatal survival, growth performance, and metabolic health in livestock. In this study, we evaluated the lipid and metabolic status of low birth weight goat livers and found impairments in antioxidant capacity, increased pro-inflammatory cytokines, and enhanced hepatic lipid accumulation. Understanding the intrinsic mechanisms underlying hepatic dyslipidemia in low birth weight goats is important for promoting efficiency of production and health in their later life.
Article
Agriculture, Dairy & Animal Science
Ying Yuan, Weiyi Zhang, Chengli Liu, Yongmeng He, Haoyuan Zhang, Lu Xu, Baigao Yang, Yongju Zhao, Yuehui Ma, Mingxing Chu, Zhongquan Zhao, Yongfu Huang, Yanguo Han, Yan Zeng, Hangxing Ren, Gaofu Wang, E. Guangxin
Summary: This study analyzed the genome-wide selection signatures of South African indigenous goats, African Boer goats, and Australian Boer goats, and identified 10 genes potentially responsible for reproduction, metabolism, growth, and development. The findings provide valuable insights for future genetic improvement of Boer goats.
Article
Agriculture, Dairy & Animal Science
Yongmeng He, Yongfu Huang, Shizhi Wang, Lupei Zhang, Huijiang Gao, Yongju Zhao, E. Guangxin
Summary: This study identified several variants and candidates with strong associations to coat color in Angus cattle using genome sequencing data. The MC1R variants, which result in lighter coat color, further enriched the genetic basis between DNA damage and melanin production. The study also found other potential genes and markers related to meat phenotypes. However, further investigation is needed to confirm their phenotypic causality and genetic relationships.
Article
Agriculture, Dairy & Animal Science
Bing Pan, Haoyuan Long, Ying Yuan, Haoyuan Zhang, Yangyang Peng, Dongke Zhou, Chengli Liu, Baiju Xiang, Yongfu Huang, Yongju Zhao, Zhongquan Zhao, Guangxin E
Summary: This study used genome-wide selection analysis to identify candidate regions and genes related to the body size of pigs. Key genes and molecular pathways associated with body development were discovered, providing a better understanding of the genetic basis of body size determination.
Article
Agriculture, Dairy & Animal Science
Le Zhao, Yongheng Yang, Haili Yang, Nanjian Luo, Xingchun Li, Jikang Zheng, Songjian Yang, Yongju Zhao
Summary: This study systematically collected goat uterine tissue at different stages of pregnancy and used RNA-seq to screen for genes related to embryo implantation. The differentially expressed genes and enriched signaling pathways provide valuable references for exploring the molecular mechanisms of goat embryo implantation.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Pan Wang, Nanjian Luo, Le Zhao, Yongju Zhao
Summary: This study investigated the relationship between vascular distribution and the expression and methylation patterns of major angiogenic factors in the goat caruncle during early pregnancy. The results showed that vascular density and area increased gradually, and cell proliferation rate also increased. The expression patterns of angiogenic factors changed, and the methylation levels of ANGPT2 were negatively correlated with vascular density. These findings suggest that methylation may be involved in the regulation of caruncle angiogenesis in early pregnancy in goats.
Article
Agriculture, Dairy & Animal Science
Yumei Zhou, Xingchun Li, Xinyue Zhang, Minghui Li, Nanjian Luo, Yongju Zhao
Summary: This study aimed to screen candidate housekeeping genes in Carpra hircus uterus caruncles. The stability of 22 selected genes was assessed during non-pregnant and pregnancy stages. PPIB and EIF3K were found to be the most stable reference genes and recommended for use in nonpregnant and whole stages of goat uterus caruncle tissue. This study identified suitable reference genes for gene expression studies in uterus caruncle tissues at various stages of non-pregnancy and pregnancy.
Article
Genetics & Heredity
Xingqiang Fang, Bowen Gu, Meixi Chen, Ruifan Sun, Jipan Zhang, Le Zhao, Yongju Zhao
Summary: Reproductive traits are important indicators in goat breeding. This study identified SNPs and candidate genes associated with reproductive traits in Dazu black goats, providing useful biological information for improving goat reproductive traits.
Article
Agriculture, Dairy & Animal Science
Haoyuan Zhang, Pu Yang, Chengli Liu, Yuehui Ma, Yanguo Han, Yan Zeng, Yongfu Huang, Yongju Zhao, Zhongquan Zhao, Xiaohong He, E. Guangxin
Summary: The genetic basis of the four-horn phenotype (FHP) in sheep was investigated using a genome-wide association study. The study revealed significant associations of specific genetic sequences in CHR2 and CHR16, particularly the key candidate genes HOXD1 and ADAMTS12, with the FHP phenotype. These findings contribute to our understanding of the Mendelian genetic basis of the FHP in sheep.