Article
Endocrinology & Metabolism
Yepeng Hu, Jian Yu, Xiangdi Cui, Zhe Zhang, Qianqian Li, Wenxiu Guo, Cheng Zhao, Xin Chen, Meiyao Meng, Yu Li, Mingwei Guo, Jin Qiu, Fei Shen, Dongmei Wang, Xinran Ma, Lingyan Xu, Feixia Shen, Xuejiang Gu
Summary: This study introduced a protocol of combined usage of multiple tools to accurately and efficiently measure adipocyte sizes. The research found that the combined method could quantify adipocyte sizes comparably accurately to manual measurement, but in a more efficient manner. Additionally, the recognition effect of monochrome segmentation image was better than that of color segmentation image.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Muhammad Bilal, Allah Nawaz, Tomonobu Kado, Muhammad Rahil Aslam, Yoshiko Igarashi, Ayumi Nishimura, Yoshiyuki Watanabe, Takahide Kuwano, Jianhui Liu, Hiroyuki Miwa, Takumi Era, Koichi Ikuta, Johji Imura, Kunimasa Yagi, Takashi Nakagawa, Shiho Fujisaka, Kazuyuki Tobe
Summary: The expansion of adipose tissue during obesity through the recruitment of newly generated adipocytes is metabolically healthy, particularly in the gonadal white adipose tissue of male mice receiving a high-fat diet. Contrary to previous findings, the inguinal white adipose tissue of male mice also shows a high potential for proliferation and differentiation of adipocyte progenitors, leading to hyperplasia in response to high-fat diet feeding.
MOLECULAR METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Yuelei Zhao, Xuexin Li, Ye Tian, Jindi Zhao, Wensai Yu, Lifan Zhang, Wei Wei, Jie Chen
Summary: This study found that nonivamide can induce browning of porcine adipocytes, inhibit adipogenesis and promote lipolysis, as well as up-regulate thermogenesis gene markers and mitochondrial biogenesis-related genes.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Endocrinology & Metabolism
Run Zhou Ye, Gabriel Richard, Nicolas Gevry, Andre Tchernof, Andre C. Carpentier
Summary: This paper presents a systematic review of the relationship between adipocyte hypertrophy and obesity-related glucose and lipid dysmetabolism, ectopic fat accumulation, and cardiovascular disorders, as well as the mechanistic origins of adipocyte hypertrophy. Different FCS measurement methods and their impact on research results are also discussed.
Article
Cell Biology
Hahn Nahmgoong, Yong Geun Jeon, Eun Seo Park, Yoon Ha Choi, Sang Mun Han, Jeu Park, Yul Ji, Jee Hyung Sohn, Ji Seul Han, Ye Young Kim, Injae Hwang, Yun Kyung Lee, Jin Young Huh, Sung Sik Choe, Tae Jung Oh, Sung Hee Choi, Jong Kyoung Kim, Jae Bum Kim
Summary: This study characterized adipose stem cells (ASCs) in two different types of white adipose tissues (EAT and IAT) and investigated the effects of intrinsic and tissue micro-environmental factors on ASC features. The results showed that ASC subpopulations in EAT and IAT exhibited different molecular features and adipogenic potential. Furthermore, ASCs in these two depots responded differently to obesogenic stimuli, influencing the characteristics of the adipose tissues.
Article
Endocrinology & Metabolism
Benjamin Brustolin, Nina Touly, Marine Maillefer, Lola Parisot, Elisa Di Pillo, Marc Derive, Sebastien Gibot
Summary: This study demonstrates that TREM-1 plays a significant role in obesity and its associated complications. In the mouse model of high-fat diet-induced obesity, suppressing TREM-1 reduces weight gain, insulin resistance, and inflammation in white adipose tissue and liver. Therefore, TREM-1 could be a potential therapeutic target for obesity.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Hongkai Wang, Yu Wei, Xiaoxin Hu, Jian Pan, Junlong Wu, Beihe Wang, Hailiang Zhang, Guohai Shi, Xiaohang Liu, Jinou Zhao, Yao Zhu, Dingwei Ye
Summary: This study demonstrates that the computed tomography fat attenuation index (FAI) can reflect the inflammation degree of peri-tumor adipose tissue and predict the survival outcome of renal cell carcinoma (RCC). The study also found synchronized alterations in transcriptomic features of tumor tissues and adjacent adipocytes.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shih-Yi Lin, Ya-Yu Wang, Pin-Ho Pan, Jiaan-Der Wang, Ching-Ping Yang, Wen-Ying Chen, Yu-Hsiang Kuan, Su-Lan Liao, Yu-Li Lo, Yih-Hsin Chang, Chun-Jung Chen
Summary: This study investigated the effects of DHA on obesity-related inflammation and adipose tissue browning in obese mice. The results showed that DHA improved obesity phenotypes, including insulin resistance, inflammation, and macrophage polarization in the liver and adipose tissues. Furthermore, DHA alleviated dysregulated adipokines and impaired thermogenic and browning molecules, along with ER stress and mitochondrial dysfunction.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Review
Medicine, General & Internal
Hubert Kolb
Summary: Obesity-induced inflammation of adipose tissue is initially a protective response, but may contribute to tissue damage later on. The metabolic imbalance of adipocytes in obesity leads to activation of resident immune cells, enhancing tissue protective responses. However, chronic overnutrition results in insufficient protective actions, leading to adipocyte death and cellular senescence. This can cause influx and activation of immune cells, as well as intensified matrix remodeling and angiogenesis.
Article
Endocrinology & Metabolism
Agne Kulyte, Alisha Aman, Rona J. Strawbridge, Peter Arner, Ingrid A. Dahlman
Summary: Interindividual differences in the generation of new fat cells are associated with body fat and type 2 diabetes risk. This study identified several genetic loci and candidate genes, including SPATS2L, KCTD18, RPL8, HSD17B12, and PEPD, that are potentially important in controlling fat cell numbers, body fat size, and diabetes risk.
Article
Medicine, Research & Experimental
Zhe Cheng, Xinyu Xiong, Yi Zhou, Fan Wu, Qingqing Shao, Ruolan Dong, Qiong Liu, Lingli Li, Guang Chen
Summary: The study demonstrated that 6-gingerol can alleviate obesity by regulating adipocytokines and the TLR3/IL-6/JAK1/STAT3 axis, inhibiting excessive hyperplasia and hypertrophy of adipocytes.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Natalie Theobalt, Isabel Hofmann, Sonja Fiedler, Simone Renner, Georg Dhom, Annette Feuchtinger, Axel Walch, Martin Hrabe de Angelis, Eckhard Wolf, Ruediger Wanke, Andreas Blutke
Summary: In translational obesity research, LSFM is demonstrated as an effective tool for accurate analysis of adipocyte volumes and numbers, providing valuable data for evaluating intervention efficacies.
Article
Medicine, Research & Experimental
Jessica Latorre, Francisco Ortega, Nuria Oliveras-Canellas, Ferran Comas, Aina Lluch, Aleix Gavalda-Navarro, Samantha Moron-Ros, Wifredo Ricart, Francesc Villarroya, Marta Giralt, Jose Manuel Fernandez-Real, Jose Maria Moreno-Navarrete
Summary: Lipopolysaccharide binding protein (Lbp) plays an important role in adiposity and white adipose tissue (WAT). Knockdown of adipose tissue Lbp gene in male mice can reduce body weight gain and fat accretion, and improve insulin action. Knockdown of adipose tissue Lbp gene in both male and female mice can promote WAT browning. These findings suggest that targeting adipose tissue Lbp gene could be a potential therapeutic approach in preventing obesity-associated fat accretion.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Biochemistry & Molecular Biology
Jianfang Gao, Zhongxiao Zhang, Xiaohua Dong, Jing Zhao, Zhou Peng, Ling Zhang, Zhongqing Xu, Liling Xu, Xingyun Wang, Xirong Guo
Summary: This study demonstrated the role of traumatic acid (TA) in reducing lipid accumulation and preventing obesity. It also revealed that TA activates fatty acids degradation and metabolism signaling pathways. The study identified ACSL4 as a key regulator in TA's effect on lipid accumulation.
Review
Food Science & Technology
Bo Wang, Min Du
Summary: The rising prevalence of obesity is a serious public health threat. Vitamin A promotes adipose tissue vascular development, increases the number of adipose progenitors, and stimulates the browning process in white adipocytes as well as the thermogenic activity in brown/beige adipocytes. Hence, vitamin A is a promising anti-obesity micronutrient.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Medicine, General & Internal
Henna K. Soderstrom, Jari Rasanen, Juha Saarnio, Vesa Toikkanen, Tuula Tyrvainen, Tuomo Rantanen, Antti Valtola, Pasi Ohtonen, Minna Paaaho, Arto Kokkola, Raija Kallio, Tuomo J. Karttunen, Vesa-Matti Pohjanen, Ari Ristimaki, Simo Laine, Eero Sihvo, Joonas H. Kauppila
Article
Immunology
Alzahraa Abdelwahab, Sanna Palosaari, Soha Abdelkawy Abdelwahab, Rehab Ahmed Rifaai, Nashwa Fathy El-Tahawy, Entesar Ali Saber, Tomi Nousiainen, Maarit Valkealahti, Johanna Huhtakangas, Tuomo J. Karttunen, Petri Lehenkari
Summary: Research on synovial tissue expression of Toll-like receptors (TLRs) in rheumatoid arthritis (RA) showed differences between seropositive and seronegative RA, potentially impacting disease outcomes. High expression of specific TLRs in seropositive RA may prime the synovium for reactions to citrullinated proteins and nucleic acids, which could contribute to inflammation.
Article
Pathology
Minna Nortunen, Nina Vakiparta, Katja Porvari, Juha Saarnio, Tuomo J. Karttunen, Heikki Huhta
Summary: The study evaluated the expression patterns of TLR2, TLR4, and FXR in patients with GERD, showing upregulation of TLR2 but no change in TLR4 expression in GERD; FXR expression was increased in GERD and might have a regulatory connection to TLR2.
Article
Gastroenterology & Hepatology
Minna Nortunen, Nina Vakiparta, Seppo Parkkila, Juha Saarnio, Heikki Huhta, Tuomo J. Karttunen
Summary: This study examined the immunohistochemical expression patterns of CAII, CAIX, and CAXII in the normal esophageal squamous epithelium and in patients with GERD. The findings showed increased expression of CAII, CAIX, and CAXII in patients with GERD, potentially contributing to enhanced esophageal epithelial resistance to acidic reflux.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Oncology
Olli-Pekka Koivurova, Ritva Koskela, Timo Blomster, Antti Ala-Rami, Henri Lumme, Olli Kettunen, Janne Hukkanen, Tuomo J. Karttunen, Markus Makinen, Jukka Ronkainen, Kari Syrjanen
Summary: This study evaluated the diagnostic accuracy of the new-generation GastroPanel test in detecting atrophic gastritis (AG) and Helicobacter pylori (Hp) infection, showing high precision in diagnosing these conditions in dyspeptic patients.
ANTICANCER RESEARCH
(2021)
Article
Cell Biology
Minna Nortunen, Seppo Parkkila, Juha Saarnio, Heikki Huhta, Tuomo J. Karttunen
Summary: Non-ampullary duodenal adenocarcinoma (DAC) is a rare malignancy with little information on histopathological prognostic factors. Carbonic anhydrases (CAs) are metalloenzymes associated with prognosis in various cancers. The study found low expression of CAII and comparable expression of CAIX in adenomas and adenocarcinoma, suggesting potential as biomarkers for epithelial dysplasia in the duodenum.
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
(2021)
Article
Gastroenterology & Hepatology
Heikki Huhta, Jukka Melkko, Teijo Kuopio, Tuomo J. Karttunen, Olli Helminen
Summary: This study compared the diagnostic accuracy of general and expert gastrointestinal pathologists in assessing the risk of Barrett's progression. It found that general pathologists tend to overdiagnose low-grade dysplasia (LGD), while LGD diagnosed by expert pathologists is a better predictor of disease progression.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Pathology
Olli Helminen, Jukka Melkko, Juha Saarnio, Eero Sihvo, Teijo Kuopio, Pasi Ohtonen, Joonas H. Kauppila, Tuomo J. Karttunen, Heikki Huhta
Summary: The aim of this study was to evaluate the value of p53, Ki67, and toll-like receptor 5 (TLR5) in predicting the malignant progression of Barrett's esophagus. It was found that aberrant p53 expression is associated with a high risk of malignant progression in Barrett's low-grade dysplasia. Routine staining of p53 is recommended in expert confirmed low-grade dysplasia cases.
Article
Oncology
Niko Hiltunen, Jukka Rintala, Juha P. Vayrynen, Jan Bohm, Tuomo J. Karttunen, Heikki Huhta, Olli Helminen
Summary: This study found that high MCT4 expression is associated with improved prognosis in small bowel neuroendocrine tumors (SB-NETs), while MCT1 expression is not correlated with survival.
Article
Oncology
Taneli T. Mattila, Madhura Patankar, Juha P. Vayrynen, Kai Klintrup, Jyrki Makela, Anne Tuomisto, Pentti Nieminen, Markus J. Makinen, Tuomo J. Karttunen
Summary: Anoikis refers to apoptosis induced by the loss of contact with the extracellular matrix. We have found that it is possible to quantitatively evaluate putative anoikis resistant subpopulations in colorectal carcinoma, and the abundance of these structures in lymph node metastases is associated with prognosis.
CLINICAL & EXPERIMENTAL METASTASIS
(2022)
Article
Endocrinology & Metabolism
Ville A. Palomaki, Petri Lehenkari, Sanna Merilainen, Tuomo J. Karttunen, Vesa Koivukangas
Summary: This case-control study analyzed the macrophage infiltration in subcutaneous adipose tissue after bariatric surgery or conservative treatment of obesity, and investigated whether these features could predict weight loss outcome. The study found a significant decline in crown-like structures (CLS) density after surgery, regardless of weight loss. However, surgery had no effect on the infiltration of single-cell macrophages, and the abundance of these macrophage populations before surgery did not predict weight loss or response to surgery.
Article
Oncology
Karoliina Paarnio, Juha P. Vaeyrynen, Sara A. Vaeyrynen, Tiina Kantola, Timo Karhu, Taina Tervahartiala, Kai Klintrup, Timo Sorsa, Tuula Salo, Jyrki Maekelae, Tuomo J. Karttunen
Summary: This study found that tumor necrosis is associated with low TLR4 expression in cancer cells and that low TLR4 expression correlates with a strong systemic inflammatory response. In normal mucosa, low TLR2 expression is associated with high levels of systemic inflammation.
