标题
Lipid Nanoparticles for Organ-Specific mRNA Therapeutic Delivery
作者
关键词
-
出版物
Pharmaceutics
Volume 13, Issue 10, Pages 1675
出版商
MDPI AG
发表日期
2021-10-14
DOI
10.3390/pharmaceutics13101675
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Characterization of Lipid Nanoparticles Containing Ionizable Cationic Lipids Using Design-of-Experiments Approach
- (2021) Takeshi Terada et al. LANGMUIR
- A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis
- (2021) Christina Krienke et al. SCIENCE
- Membrane-destabilizing ionizable phospholipids for organ-selective mRNA delivery and CRISPR–Cas gene editing
- (2021) Shuai Liu et al. NATURE MATERIALS
- Engineered ionizable lipid nanoparticles for targeted delivery of RNA therapeutics into different types of cells in the liver
- (2021) M. Kim et al. Science Advances
- Cytosolic Delivery of Nucleic Acids: The case of Ionizable Lipid Nanoparticles
- (2021) Michele Schlich et al. Bioengineering & Translational Medicine
- Apolipoprotein E Binding Drives Structural and Compositional Rearrangement of mRNA-Containing Lipid Nanoparticles
- (2021) Federica Sebastiani et al. ACS Nano
- Non-Immunotherapy Application of LNP-mRNA: Maximizing Efficacy and Safety
- (2021) Irena Vlatkovic Biomedicines
- Deconvoluting Lipid Nanoparticle Structure for Messenger RNA Delivery
- (2020) Yulia Eygeris et al. NANO LETTERS
- Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing
- (2020) Qiang Cheng et al. Nature Nanotechnology
- Lipid nanoparticles for nucleic acid delivery: Current perspectives
- (2020) Eleni Samaridou et al. ADVANCED DRUG DELIVERY REVIEWS
- Polymeric vehicles for nucleic acid delivery
- (2020) Alexandra S. Piotrowski-Daspit et al. ADVANCED DRUG DELIVERY REVIEWS
- Lipid Nanoparticle Acts as a Potential Adjuvant for Influenza Split Vaccine without Inducing Inflammatory Responses
- (2020) Seiki Shirai et al. Vaccines
- PEG shedding-rate-dependent blood clearance of PEGylated lipid nanoparticles in mice: Faster PEG shedding attenuates anti-PEG IgM production
- (2020) Takuya Suzuki et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Theranostic dendrimer-based lipid nanoparticles containing PEGylated BODIPY dyes for tumor imaging and systemic mRNA delivery in vivo
- (2020) Hu Xiong et al. JOURNAL OF CONTROLLED RELEASE
- Specific Modified mRNA Translation System
- (2020) Ajit Magadum et al. CIRCULATION
- Engineering precision nanoparticles for drug delivery
- (2020) Michael J. Mitchell et al. NATURE REVIEWS DRUG DISCOVERY
- Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine
- (2020) Lindsey R. Baden et al. NEW ENGLAND JOURNAL OF MEDICINE
- Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine
- (2020) Fernando P. Polack et al. NEW ENGLAND JOURNAL OF MEDICINE
- Characterization of HIV-1 nucleoside-modified mRNA vaccines in rabbits and rhesus macaques
- (2019) Norbert Pardi et al. Molecular Therapy-Nucleic Acids
- Lipid Nanoparticles for Delivery of Therapeutic RNA Oligonucleotides
- (2019) Keith Henry Moss et al. MOLECULAR PHARMACEUTICS
- Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines
- (2019) Kimberly J. Hassett et al. Molecular Therapy-Nucleic Acids
- Recent Advances in Chitosan-Based Carriers for Gene Delivery
- (2019) Ye Cao et al. Marine Drugs
- Recent advances in polymeric materials for the delivery of RNA therapeutics
- (2019) David Ulkoski et al. Expert Opinion on Drug Delivery
- Endocytic Profiling of Cancer Cell Models Reveals Critical Factors Influencing LNP-Mediated mRNA Delivery and Protein Expression
- (2019) Edward J. Sayers et al. MOLECULAR THERAPY
- Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation
- (2019) Lei Miao et al. NATURE BIOTECHNOLOGY
- Pseudouridinylation of mRNA coding sequences alters translation
- (2019) Daniel E. Eyler et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells
- (2019) Marco Maugeri et al. Nature Communications
- The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs
- (2019) Akin Akinc et al. Nature Nanotechnology
- Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses
- (2018) Norbert Pardi et al. JOURNAL OF EXPERIMENTAL MEDICINE
- A modular platform for targeted RNAi therapeutics
- (2018) Ranit Kedmi et al. Nature Nanotechnology
- Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis
- (2018) David Adams et al. NEW ENGLAND JOURNAL OF MEDICINE
- Multi-antigenic human cytomegalovirus mRNA vaccines that elicit potent humoral and cell-mediated immunity
- (2018) Shinu John et al. VACCINE
- Lipid Nanoparticles Enabling Gene Therapies: From Concepts to Clinical Utility
- (2018) Jayesh A. Kulkarni et al. Nucleic Acid Therapeutics
- Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
- (2018) Freddie Bray et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Cell specific delivery of modified mRNA expressing therapeutic proteins to leukocytes
- (2018) Nuphar Veiga et al. Nature Communications
- Optimizing Cardiac Delivery of Modified mRNA
- (2017) Nishat Sultana et al. MOLECULAR THERAPY
- Efficient Targeting and Activation of Antigen-Presenting Cells In Vivo after Modified mRNA Vaccine Administration in Rhesus Macaques
- (2017) Frank Liang et al. MOLECULAR THERAPY
- Lipid Nanoparticle Systems for Enabling Gene Therapies
- (2017) Pieter R. Cullis et al. MOLECULAR THERAPY
- Preclinical and Clinical Demonstration of Immunogenicity by mRNA Vaccines against H10N8 and H7N9 Influenza Viruses
- (2017) Kapil Bahl et al. MOLECULAR THERAPY
- Boosting Intracellular Delivery of Lipid Nanoparticle-Encapsulated mRNA
- (2017) Siddharth Patel et al. NANO LETTERS
- Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination
- (2017) Norbert Pardi et al. NATURE
- Advances in the delivery of RNA therapeutics: from concept to clinical reality
- (2017) James C. Kaczmarek et al. Genome Medicine
- The acidic tumor microenvironment: a target for smart cancer nano-theranostics
- (2017) Liangzhu Feng et al. National Science Review
- PEGylation as a strategy for improving nanoparticle-based drug and gene delivery
- (2016) Jung Soo Suk et al. ADVANCED DRUG DELIVERY REVIEWS
- Non-Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co-Delivery of Cas9 mRNA and sgRNA
- (2016) Jason B. Miller et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Activatable Water-Soluble Probes Enhance Tumor Imaging by Responding to Dysregulated pH and Exhibiting High Tumor-to-Liver Fluorescence Emission Contrast
- (2016) Hu Xiong et al. BIOCONJUGATE CHEMISTRY
- Pieter Cullis’ quest for a lipid-based, fusogenic delivery system for nucleic acid therapeutics: success with siRNA so what about mRNA?
- (2016) Ying K. Tam et al. JOURNAL OF DRUG TARGETING
- Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy
- (2016) Lena M. Kranz et al. NATURE
- Preclinical Safety Evaluation in Rats of a Polymeric Matrix Containing an siRNA Drug Used as a Local and Prolonged Delivery System for Pancreatic Cancer Therapy
- (2016) Yuval Ramot et al. TOXICOLOGIC PATHOLOGY
- Lipid-Based Nanocarriers for RNA Delivery
- (2015) Hui Xue et al. CURRENT PHARMACEUTICAL DESIGN
- Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes
- (2015) Norbert Pardi et al. JOURNAL OF CONTROLLED RELEASE
- An Orthogonal Array Optimization of Lipid-like Nanoparticles for mRNA Delivery in Vivo
- (2015) Bin Li et al. NANO LETTERS
- Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs
- (2015) Kevin J. Kauffman et al. NANO LETTERS
- RNA degradation in antiviral immunity and autoimmunity
- (2015) Rachel E. Rigby et al. TRENDS IN IMMUNOLOGY
- RNAi therapy targeting KRAS in combination with chemotherapy for locally advanced pancreatic cancer patients
- (2015) Talia Golan et al. Oncotarget
- Delivery of Therapeutic siRNA to the Lung Endothelium via Novel Lipoplex Formulation DACC
- (2014) V Fehring et al. MOLECULAR THERAPY
- mRNA-based therapeutics — developing a new class of drugs
- (2014) Ugur Sahin et al. NATURE REVIEWS DRUG DISCOVERY
- Non-viral vectors for gene-based therapy
- (2014) Hao Yin et al. NATURE REVIEWS GENETICS
- Shielding of Lipid Nanoparticles for siRNA Delivery: Impact on Physicochemical Properties, Cytokine Induction, and Efficacy
- (2014) Varun Kumar et al. Molecular Therapy-Nucleic Acids
- Cationic lipid nanocarriers activate Toll-like receptor 2 and NLRP3 inflammasome pathways
- (2013) Caroline Lonez et al. Nanomedicine-Nanotechnology Biology and Medicine
- Anti-Epidermal Growth Factor Receptor (EGFR) Antibodies Overcome Resistance of Ovarian Cancer Cells to Targeted Therapy and Natural Cytotoxicity
- (2012) Nina Gottschalk et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo
- (2012) Yusuke Sato et al. JOURNAL OF CONTROLLED RELEASE
- Microfluidic Synthesis of Highly Potent Limit-size Lipid Nanoparticles for In Vivo Delivery of siRNA
- (2012) Nathan M Belliveau et al. Molecular Therapy-Nucleic Acids
- Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA
- (2011) Katalin Karikó et al. NUCLEIC ACIDS RESEARCH
- The systemic toxicity of positively charged lipid nanoparticles and the role of Toll-like receptor 4 in immune activation
- (2010) Ranit Kedmi et al. BIOMATERIALS
- Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms
- (2010) Akin Akinc et al. MOLECULAR THERAPY
- Rational design of cationic lipids for siRNA delivery
- (2010) Sean C Semple et al. NATURE BIOTECHNOLOGY
- Apolipoprotein E: From lipid transport to neurobiology
- (2010) Paul S. Hauser et al. PROGRESS IN LIPID RESEARCH
- Recognition of 5′ Triphosphate by RIG-I Helicase Requires Short Blunt Double-Stranded RNA as Contained in Panhandle of Negative-Strand Virus
- (2009) Martin Schlee et al. IMMUNITY
- MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice
- (2009) Thomas E. Callis et al. JOURNAL OF CLINICAL INVESTIGATION
- Activation of MDA5 Requires Higher-Order RNA Structures Generated during Virus Infection
- (2009) A. Pichlmair et al. JOURNAL OF VIROLOGY
- Apoprotein E as a lipid transport and signaling protein in the blood, liver, and artery wall
- (2008) Godfrey S. Getz et al. JOURNAL OF LIPID RESEARCH
- Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability
- (2008) Katalin Karikó et al. MOLECULAR THERAPY
- Membrane lipids: where they are and how they behave
- (2008) Gerrit van Meer et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
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