Article
Food Science & Technology
Elham Alehosseini, Hoda Shahiri Tabarestani, Mohammad Saeed Kharazmi, Seid Mahdi Jafari
Summary: Chitosan nanoparticles (CSNPs) have high performance and unique properties, making them widely applicable in the food, pharmaceutical, and cosmetic sectors. This research synthesized CSNPs using the ionic gelation method and optimized the synthesis conditions. The concentration of chitosan, sodium tripolyphosphate, and the ratio between them influenced the size and zeta potential of the nanoparticles. The optimized CSNPs can be used as efficient carriers and stabilizers.
Review
Medicine, Research & Experimental
Mariana Carolina Di Santo, Cecilia Luciana D'Antoni, Ana Paula Dominguez Rubio, Agustina Alaimo, Oscar Edgardo Perez
Summary: Plant-based polyphenols are natural compounds found in fruits and vegetables, known for their nutraceutical and pharmacological activities. However, their photosensitivity, low bioavailability, rapid metabolism, and short biological half-life present major limitations for their use, which can be overcome by encapsulating polyphenols into chitosan-tripolyphosphate based nanoparticles.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Polymer Science
Shafiq Ahmad Kahdestani, Mehrnoosh Hasan Shahriari, Majid Abdouss
Summary: Chitosan, a natural polysaccharide, shows high potential for controlled drug delivery due to its unique properties like biocompatibility, drug loading capacity, and antibacterial characteristics. When prepared as nanoparticles with ionic gelation, chitosan can effectively mitigate drug release and is suitable for sustained drug release in biomedical devices.
Article
Chemistry, Applied
Natalia Cristina da Silva, Tais Teo de Barros-Alexandrino, Odilio Benedito Garrido Assis, Milena Martelli-Tosi
Summary: This study utilized chitosan solution to extract active compounds from acerola-pulp by-products and form nanoparticles loaded with total phenolic compounds for protective coatings on guavas. The nanoengineered coatings effectively delayed maturation and maintained green pigmentation.
Article
Pharmacology & Pharmacy
Akshad Balde, Soottawat Benjakul, Se-Kwon Kim, Rasool Abdul Nazeer
Summary: Modified thiolated chitosan was used to prepare nanoparticles loaded with anti-inflammatory peptide derived from marine crab body muscle. These nanoparticles showed sustained release of the peptide, improved thermal stability, and non-cytotoxic effects. They also suppressed the production of nitrite and reactive oxygen species, and demonstrated greater suppression of pro-inflammatory cytokines and efficient cellular uptake. Docking results suggested enhanced stability and inflammation suppressing activity of the nanoparticles.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Materials Science, Textiles
Fitri Khoerunnisa, Mita Nurhayati, Fitri Dara, Regita Rizki, Muhamad Nasir, Hafiz Aji Aziz, Hendrawan Hendrawan, Ng Eng Poh, Chariya Kaewsaneha, Pakorn Opaprakasit
Summary: Chitosan (CS) nanoparticles with antibacterial properties were successfully synthesized using the ionic gelation method with tripolyphosphate (TPP) as a crosslinking agent. The resulting CS-TPP nanoparticles showed significant antibacterial efficacy under optimized conditions, demonstrating their potential as valuable antibacterial agents.
FIBERS AND POLYMERS
(2021)
Article
Chemistry, Applied
Asif Mohd Itoo, Milan Paul, Balaram Ghosh, Swati Biswas
Summary: In this study, a chitosan/vitamin E conjugate was synthesized and used for the assembly of oxaliplatin micelles. The micelles showed promising therapeutic efficacy in breast cancer treatment, overcoming drug resistance and reducing nephrotoxicity.
CARBOHYDRATE POLYMERS
(2022)
Review
Multidisciplinary Sciences
Avtar Singh, Ajay Mittal, Soottawat Benjakul
Summary: Chitosan nanoparticles have been widely used in the food and biomedical industries for their biodegradability and bioactivities. Various techniques, such as ionic gelation and coating with chitosan, have been employed to produce nanoparticles with improved stability and sustained release of active compounds. The applications of chitosan nanoparticles include encapsulating agents, food additives, edible coatings, and medical uses such as wound healing and cancer treatments.
Article
Chemistry, Applied
Titilope John Jayeoye, Uraiwan Sirimahachai, Thitima Rujiralai
Summary: A sensitive detection strategy for ascorbic acid using sodium alginate reduced/stabilized gold nanoparticles as the optical probe was successfully developed. This method showed good linearity for AA quantitation in vitamin C injection and fruit juice, with satisfactory accuracy and precision.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Applied
Zhao Wei, Pan Pan, Feng F. Hong, Zhangjun Cao, Ying Ji, Lin Chen
Summary: By incorporating chitosan nanoparticles into bacterial nanocellulose, a composite material with excellent antibacterial activity and biocompatibility was developed in this study. Utilizing the three-dimensional fibrillar network of BNC as a template and using the ionic gelation method, this composite approach is simple and efficient, showing great potential for widespread biomedical applications.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Physical
Samah Attia Algharib, Ali Dawood, Kaixiang Zhou, Dongmei Chen, Chao Li, Kuiyu Meng, Aoxue Zhang, Wanhe Luo, Saeed Ahmed, Lingli Huang, Shuyu Xie
Summary: This study demonstrated that by controlling the primary formulation parameters, it is possible to reproducibly control the production and characteristics of chitosan nanoparticles in the nanomaterial size range.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Pharmacology & Pharmacy
Katiuscia Vieira Jardim, Joseilma Luciana Neves Siqueira, Sonia Nair Bao, Alexandre Luis Parize
Summary: The objective of this study was to nanoencapsulate quercetin in chitosan nanoparticles and evaluate its release profile, cytotoxicity, and antioxidant activity. The chitosan nanoparticles showed good stability and high encapsulation efficiency, exhibiting significant cytotoxicity against tumor cells and superior antioxidant activity compared to free quercetin.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Nutrition & Dietetics
Anitra C. Carr, Jens Lykkesfeldt
Summary: The study examines the relationship between vitamin C dose and concentration, specifically in relation to age and smoking status. It found that while vitamin C intake was similar across age groups, older individuals had significantly lower circulating vitamin C concentrations. This effect was more pronounced in non-smokers and suggests that older individuals may be more sensitive to low vitamin C intake, possibly due to the effects of long-term smoking and increased chronic disease prevalence.
Article
Biochemistry & Molecular Biology
Nicolas Van Bavel, Travis Issler, Liping Pang, Max Anikovskiy, Elmar J. J. Prenner
Summary: Chitosan nanoparticles (CNPs) with a size range of 68-77 nm were successfully synthesized through a simple and efficient method, using low molecular weight chitosan and tripolyphosphate as crosslinker. The CNPs showed monodispersity and high yield. Different purification methods and solution conditions were investigated and found to affect the size and polydispersity of CNP formation. The smaller CNPs synthesized using homogenization and filtration exhibited good interaction with negatively charged proteins and DNA, making them suitable for the development of virus surrogates for water applications.
Article
Engineering, Chemical
Yeganeh Poureghbal, Masoud Rahimi, Mona Akbari
Summary: The study successfully produced monodisperse and spherical chitosan nanoparticles using the novel IG-NFF method, demonstrating its effectiveness in achieving highly uniform particle sizes.
CANADIAN JOURNAL OF CHEMICAL ENGINEERING
(2022)
Article
Pharmacology & Pharmacy
Bernd Gutberlet, Eduard Preis, Valeri Roschenko, Udo Bakowsky
Summary: Chronic wound infections caused by antibiotic-resistant bacteria pose a major problem for modern healthcare systems. In this study, nanofibers loaded with curcumin and indocyanine green were developed for local antimicrobial treatment. The nanofibers showed successful drug release triggered by elevated temperature, excellent antimicrobial properties against resistant bacteria, and good biocompatibility with mouse fibroblasts.
Article
Chemistry, Multidisciplinary
Yasmin R. Maghraby, Rehan M. El-Shabasy, Ahmed H. Ibrahim, Hassan Mohamed El-Said Azzazy
Summary: Enzymes are crucial in various industries and are essential for the production of industrial products. Immobilized enzymes are more resistant to environmental changes and can be easily recovered/recycled compared to free enzymes. Immobilization protects enzymes from harsh conditions and enables their use in large-scale industries such as medical, food, detergent, textile, pharmaceutical, and water treatment. Different techniques, including covalent binding, encapsulation, entrapment, and adsorption, are employed for enzyme immobilization. This review discusses enzyme immobilization techniques, their industrial applications from 1992 to 2022, and the impact of the COVID-19 pandemic on global enzyme production.
Article
Chemistry, Multidisciplinary
Hassan Mohamed El-Said Azzazy, Anwar Abdelnaser, Hadeer Al Mulla, Amany M. Sawy, Samir N. Shamma, Mahmoud Elhusseiny, Salim Alwahibi, Noha Khalil Mahdy, Sherif Ashraf Fahmy
Summary: This study aims to develop and optimize blended polylactide-co-glycolide (PLGA) and poly(epsilon-caprolactone, PCL) loaded with Boswellia sacra oil (BO) for improved physicochemical properties and anti-breast cancer effects. The BO was extracted and characterized, and BO/PLGA-PCL NPs were formulated using an emulsion solvent evaporation technique. The optimized NPs exhibited a spherical morphology with the smallest size and the highest zeta potential. They could entrap and sustain release BO, resulting in enhanced apoptotic effect compared to free BO. These findings support the potential use of BO/PLGA-PCL NPs in breast cancer treatment.
Article
Biochemistry & Molecular Biology
Nada K. Sedky, Nour M. Abdel-Kader, Marwa Y. Issa, Manal M. M. Abdelhady, Samir N. Shamma, Udo Bakowsky, Sherif Ashraf Fahmy
Summary: Smart pH-responsive niosomes loaded with Oxaliplatin, Ylang ylang essential oil, or both compounds significantly improved cytotoxic activity against triple-negative breast cancer cells. The co-loaded niosomes demonstrated the lowest IC50 value and induced apoptosis effectively. This study suggests that combining natural essential oil with synthetic platinum-based drugs in pH-responsive nanovesicles is a promising approach to breast cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Polymer Science
Rana Ahmed Youness, Abdulaziz Mohsen Al-Mahallawi, Farah Haytham Mahmoud, Hind Atta, Maria Braoudaki, Sherif Ashraf Fahmy
Summary: This study aims to design and optimize chitosan-coated bilosomal formulations loaded with psoralidin (Ps-CS/BLs) with improved physicochemical properties, oral bioavailability, and boosted apoptotic and necrotic effects. The best-optimized formulation was coated with chitosan at two different concentrations, resulting in Ps-CS/BLs. The optimized Ps-CS/BLs exhibited improved particle size, zeta potential, entrapment efficiency, sustained release behavior, and mucoadhesive efficiency compared to Ps/BLs.
Review
Nanoscience & Nanotechnology
Obaydah Abd Alkader Alabrahim, Sherif Ashraf Fahmy, Hassan Mohamed El-Said Azzazy
Summary: Supramolecular nanovesicles are promising nanocarriers for drug delivery, with the ability to encapsulate hydrophilic and hydrophobic guest molecules. Cucurbit[n]urils (CBs) have been used as smart and multifunctional host macromolecules, with the potential for targeted delivery of chemotherapeutics.
ACS APPLIED NANO MATERIALS
(2023)
Review
Cell Biology
Mostafa K. Abd El-Aziz, Alyaa Dawoud, Caroline J. Kiriacos, Sherif Ashraf Fahmy, Nadia M. Hamdy, Rana A. Youness
Summary: The underlying mechanisms of hepatocellular carcinoma (HCC) are poorly understood, and the roles of long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) in HCC have been less investigated compared to coding genes and microRNAs. However, dysregulation of lncRNAs plays a significant role in HCC progression, making it an important research topic for potential diagnostic and prognostic biomarkers, as well as drug development.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Doaa Sayed Nady, Udo Bakowsky, Sherif Ashraf Fahmy
Summary: As the global population increases, the incidence of Alzheimer's disease rises. Current anti-AD drugs provide only temporary relief and face limitations in clinical applications. However, the use of nanotechnology allows for more efficient drug delivery to the brain.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Oncology
Deena Elsori, Gowhar Rashid, Nihad Ashraf Khan, Punya Sachdeva, Riya Jindal, Falak Kayenat, Bhuvi Sachdeva, Mohammad Azhar Kamal, Asaad Ma Babker, Sherif Ashraf Fahmy
Summary: This review explores the potential of carbon nanotubes (CNTs) in the treatment of Alzheimer's disease and brain tumors, highlighting their ability to cross the blood-brain barrier, target affected cells, and deliver medications effectively.
FRONTIERS IN ONCOLOGY
(2023)
Article
Pharmacology & Pharmacy
Uzma Ali, Michael Bette, Ghazala Ambreen, Shashank R. Pinnapireddy, Imran Tariq, Andre Marquardt, Boris A. Stuck, Udo Bakowsky, Robert Mandic
Summary: This study evaluates the tumor-inhibiting effect of RNAi-mediated knockdown of CRPV oncogenes, E6 and E7, using siRNA-loaded lipopolyplexes (LPPs), and validates the VX2 cells and COS-7 cell line as CRPV model systems.
Article
Pharmacology & Pharmacy
Nada K. Sedky, Kholoud K. Arafa, Manal M. M. Abdelhady, Marwa Y. Issa, Nour M. Abdel-Kader, Noha Khalil Mahdy, Fatma A. Mokhtar, Mohammad Y. Alfaifi, Sherif Ashraf Fahmy
Summary: This study developed a controlled-release nano-delivery system using nanofiber mats to prevent tumor recurrence after breast cancer surgery. The system combined platinum-based drugs with phytochemicals to enhance the anticancer activity of chemotherapy while minimizing side effects on normal cells.
Article
Pharmacology & Pharmacy
Valeri Roschenko, Abdallah M. Ayoub, Konrad Engelhardt, Jens Schaefer, Muhammad Umair Amin, Eduard Preis, Robert Mandic, Udo Bakowsky
Summary: Infection with HPV is a major risk factor for head and neck squamous cell carcinomas (HNSCCs), but photodynamic therapy (PDT) using CUR-LCNPs shows promise as an alternative treatment regardless of HPV status.
Article
Chemistry, Multidisciplinary
Sherif Ashraf Fahmy, Asmaa Ramzy, Nourhan M. El Samaloty, Nada K. Sedky, Hassan Mohamed El-Said Azzazy
Summary: This study investigated the anticancer effects of PEGylated chitosan nanoparticles co-loaded with betaine and nedaplatin on breast adenocarcinoma cells and breast cancer-bearing rats. The results showed that the PEGylated nanoparticles had high encapsulation efficiency and reduced the viability of tumor cells by releasing their contents. Among the nanoparticles, those containing both betaine and nedaplatin exhibited the strongest anticancer effect.
Article
Chemistry, Multidisciplinary
Nada K. Sedky, Maria Braoudaki, Noha Khalil Mahdy, Kenzy Amin, Iten M. Fawzy, Eleni K. Efthimiadou, Rana A. Youness, Sherif Ashraf Fahmy
Summary: Thermo-responsive liposomes (TLs) loaded with Asp (Asp/TLs) were successfully prepared and the optimal formulation was obtained through optimization of preparation variables. The optimal Asp/TLs exhibited the highest cytotoxic activity at 40 degrees Celsius, releasing Asp and inducing apoptosis and necrosis in breast cancer cells.
NANOSCALE ADVANCES
(2023)
Article
Chemistry, Multidisciplinary
Nada K. Sedky, Maria Braoudaki, Noha Khalil Mahdy, Kenzy Amin, Iten M. Fawzy, Eleni K. Efthimiadou, Rana A. Youness, Sherif Ashraf Fahmy
Summary: In this study, thermo-responsive liposomes (TLs) loaded with Asp (Asp/TLs) were prepared and optimized. The optimized Asp/TLs exhibited desirable physicochemical properties and high encapsulation efficiency. Asp/TLs showed the ability to release Asp under elevated temperatures and displayed high cytotoxic activity against invasive triple-negative breast cancer cells. The induction of apoptosis was achieved through the regulation of apoptotic gene expression.
NANOSCALE ADVANCES
(2023)
