Article
Oncology
Yiran Chen, Deliang Guo, Xinyi Li, Chang Xu, Qian Zhu
Summary: Hypertension, liver cirrhosis, higher total bilirubin levels, tumor size > 5cm, and ascites are significant predictors of spontaneous tumor rupture in hepatocellular carcinoma. Patients in the ruptured group had a higher recurrence rate and lower survival rate, but there was no difference in postoperative complications and mortality.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Shuang Li, Limin Chen
Summary: Exosomes are extracellular vesicles that play important roles in cell-to-cell communication and can be stably present in various body fluids. They have a unique double-layer saclike structure and reflect the characteristics of their host cells. Exosomes derived from hepatocellular carcinoma cells show heterogeneity in their cargo. Additionally, exosomes are capable of efficiently delivering cargoes to target cells, which significantly impact HCC progression, including tumor occurrence, development, metastasis, immune regulation, and drug resistance. Previous studies have demonstrated wide applications of exosomes in the diagnosis and treatment of HCC. This review discusses recent findings on the significant roles of exosomes in HCC, focusing on their effects and underlying mechanisms in regulating HCC progression and their potential clinical value as biomarkers and therapeutic targets.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Juil Park, Yun Soo Jeong, Yun Seok Suh, Hyo-Cheol Kim, Jin Wook Chung, Jin Woo Choi
Summary: TAE provides effective immediate hemostasis for patients with rupture of HCC and may serve as a bridge to elective surgery. However, patients with IPDM occurring within 1 year have poorer survival and require close surveillance.
FRONTIERS IN ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Wei Wang, Tao Meng, Ying Chen, Ye-Chuan Xu, Yi-Jun Zhao, Yan Zhang, Ming-Ya Yang, Zhi-Hua Zhang, Fan Huang, Hong-Chuan Zhao, Xiao-Ping Geng, Li-Xin Zhu
Summary: This study suggests that TAE plus two-stage hepatectomy may be the optimal treatment for patients with spontaneous rupture of hepatocellular carcinoma (RHCC). It also indicates that there is no difference in prognosis between ruptured and non-RHCC patients if the therapy is appropriate.
HEPATOBILIARY SURGERY AND NUTRITION
(2022)
Article
Oncology
Ao Huang, De-Zhen Guo, Yu-Peng Wang, Jia Fan, Xin-Rong Yang, Jian Zhou
Summary: The study aimed to provide treatment guidelines for spontaneously ruptured hepatocellular carcinoma (srHCC). The results showed that hepatectomy provided better prognosis than TACE for srHCC patients, and semi-elective hepatectomy and sequential hemostatic-TACE with staged hepatectomy were viable options for patients with stable and unstable hemodynamics, respectively.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Review
Medicine, General & Internal
Rebeca Escutia-Gutierrez, Ana Sandoval-Rodriguez, Adalberto Zamudio-Ojeda, Santiago Jose Guevara-Martinez, Juan Armendariz-Borunda
Summary: Nanotechnology has promising applications in the diagnosis and treatment of hepatocellular carcinoma (HCC). Nanoparticle-based contrast agents and imaging techniques enhance the sensitivity and specificity of HCC detection. Nanotechnology enables targeted drug delivery, improves therapeutic efficacy, and reduces off-target effects.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Engineering, Biomedical
Tingting Liu, Li Liu, Li Li, Jing Cai
Summary: Hepatocellular carcinoma (HCC) is a highly prevalent and deadly cancer, and there are many limitations in its surveillance, diagnosis, and treatment. In recent years, nanotechnology research has been focused on HCC, aiming to improve diagnosis accuracy and therapeutic effect.
MATERIALS TODAY BIO
(2023)
Article
Engineering, Biomedical
Shasha Shi, Huipu Li, Xi Zheng, Lin Lv, Shengtao Liao, Peng Lu, Maoxia Liu, Hongyun Zhao, Zhechuan Mei
Summary: This article introduces a visual diagnosis and treatment system based on hierarchical targeting, which improves the drug enrichment rate and treatment accuracy through biomagnetic-mediated primary targeting and antibody-mediated secondary targeting. The combination of low intensity focused ultrasound irradiation and released interferon gamma and its receptor allows for physical damage to liver cancer stem cells and the initiation of chemotherapy and immunotherapy.
MATERIALS TODAY BIO
(2022)
Article
Gastroenterology & Hepatology
Jae Hyun Kwon, Gi-Won Song, Shin Hwang, Ki-Hun Kim, Chul-Soo Ahn, Deok-Bog Moon, Tae-Yong Ha, Dong-Hwan Jung, Gil-Chun Park, Young-In Yoon, Ju Hyun Shim, Kyong Won Kim, Sung-Gyu Lee
Summary: Surgical outcomes in ruptured hepatocellular carcinoma (HCC) are unfavorable compared to unruptured HCC, with a high risk of peritoneal seeding (PS). However, surgical resection combined with transcatheter arterial chemoembolization can help achieve acceptable oncological outcomes.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Review
Biotechnology & Applied Microbiology
Caizheng Wang, Xiaoying Zhang, Jiahui Yu, Jiawen Bu, Xi Gu, Yue Wang, Xudong Zhu, Jie Lin
Summary: Hepatocellular carcinoma (HCC), a prevalent and highly deadly cancer, severely affects patient health. The lack of accurate targets hampers early screening and diagnosis, and decreases the effectiveness of therapies. Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, are nanometer-sized vesicles derived from lipid bilayer membranes. EVs can be secreted by different cancer cells and release diverse biomolecules, such as DNA, RNA, proteins, metabolites, and lipids, making them potential biomarkers and regulators of the tumor microenvironment. EVs are involved in intercellular communication by carrying biological information. They play a role in the oncogenesis of HCC, including proliferation, invasion, metastasis, and chemoresistance. EVs are also considered promising biomarkers and nanotherapeutic targets for HCC. This review highlights the current understanding of the interactions between EVs and HCC, and proposes potential biomarkers and nanotherapeutic strategies.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Immunology
Hao Jiang, Jian Liao, Liezhi Wang, Chong Jin, Jinggang Mo, Sheng Xiang
Summary: Axitinib, as an oral tyrosine kinase inhibitor, shows promising anti-tumoral effects in advanced hepatocellular carcinoma (HCC). It does not prolong overall survival, but improves progression free survival and time to tumor progression. Axitinib's biochemical effects in HCC may be regulated by associated genes and affected signaling cascades. More studies are needed to explore its potential in combination therapy for advanced HCC.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Surgery
Jiaxuan Xu, Jiaze Hong, Yiran Wang, Lingling Zhou, Binbin Xu, Yuexiu Si, Yujing He, Yizhou Chen
Summary: Spontaneous tumor rupture is a prognostic risk factor for hepatocellular carcinoma patients after hepatic resection, but it is not a prognostic risk factor in patients with macrovascular invasion.
FRONTIERS IN SURGERY
(2021)
Review
Biochemistry & Molecular Biology
Meijin Liu, Zhonghong Lai, Xiaoying Yuan, Qing Jin, Haibin Shen, Dingyu Rao, Defa Huang
Summary: This review explores the role of exosomes in hepatocellular carcinoma (HCC), including their involvement in cancer cell proliferation, invasion, and metastasis. Additionally, the potential applications of exosomes in HCC diagnosis and treatment are discussed, highlighting their versatility as both a diagnostic platform and drug delivery vehicle.
MOLECULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Nan Seol Kim, Hea Rim Chun, Hae Il Jung, Jin Ku Kang, Sul Ki Park, Sang Ho Bae
Summary: The article presents a case study of a 71-year-old male patient with spontaneous rupture of pyogenic liver abscess (PLA). The patient was successfully treated with surgery and had good postoperative recovery without any complications during follow-up. The importance of vigilance in diagnosing ruptured PLA is highlighted to prevent misdiagnosis and improve prognosis.
Article
Oncology
Jixue Zou, Jia Yuan, Hong Chen, Xinghao Zhou, Tongchun Xue, Rongxin Chen, Lan Zhang, Zhenggang Ren
Summary: This study developed and validated a nomogram for predicting the prognosis of patients with ruptured hepatocellular carcinoma (HCC) undergoing transarterial chemoembolization (TACE) treatment. The study identified total bilirubin (TBIL) levels and diameter of the largest tumor as independent prognostic factors for predicting overall survival (OS) in ruptured HCC. The newly developed nomogram can help evaluate the approximate survival rates based on tumor diameter and TBIL level after TACE treatment.
JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2022)
Review
Oncology
Feng Xia, Zhen Sun, Jian-Hong Wu, You Zou
Summary: The article discusses the occurrence and treatment of intussusception after gastric surgery, focusing mainly on the anastomosis sites following Billroth II and Roux-en-Y reconstruction, while also mentioning cases after bariatric surgery.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Review
Pharmacology & Pharmacy
Mingyu Zhang, Feng Xia, Suhong Xia, Wangdong Zhou, Yu Zhang, Xu Han, Kai Zhao, Lina Feng, Ruonan Dong, Dean Tian, Yan Yu, Jiazhi Liao
Summary: This article reviews the descriptive data on intestinal mucosal injury caused by various NSAIDs and discusses various factors related to NSAID-associated enteropathy. The limitations of current drug modeling are also pointed out, and the potential application prospects of chemically modified NSAIDs, dietary therapy, and natural products against intestinal mucosal injury are explored.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Feng Xia, Elijah Ndhlovu, Zhicheng Liu, Xiaoping Chen, Bixiang Zhang, Peng Zhu
Summary: This research aimed to establish an A-A scoring system based on preoperative serum AFP and ALP levels and investigate its clinical significance in patients with rHCC after hepatectomy. The results showed that the A-A score effectively predicted the prognosis of patients with ruptured hepatocellular carcinoma and had good evaluation ability in different subgroups.
Article
Oncology
Feng Xia, Zhiyuan Huang, Qiao Zhang, Elijah Ndhlovu, Mingyu Zhang, Xiaoping Chen, Yifa Chen, Bixiang Zhang, Peng Zhu
Summary: Ruptured hepatocellular carcinoma (rHCC) typically has a poor prognosis. This study aimed to evaluate the impact of rHCC and the effectiveness of hepatectomy in patients with Barcelona Clinic Liver Cancer (BCLC) stage 0/A rHCC. The results showed that patients with BCLC stage 0/A rHCC treated with surgery had worse prognosis compared to patients with BCLC stage 0/A non-rHCC treated with surgery. However, the prognosis of patients with BCLC stage 0/A rHCC who underwent surgery was comparable to patients with BCLC stage B HCC who underwent surgery or TACE.
Article
Oncology
Feng Xia, Peng Zhu, Xiao-Ping Chen, Bi-Xiang Zhang, Ming-Yu Zhang
Summary: This study aimed to compare the postoperative prognosis of rHCC patients with and without cirrhosis, and found that the long-term prognosis of rHCC-NC patients was better than that of rHCC-C patients. Serum markers such as AFP and HBsAg play a role in predicting survival in rHCC patients. Additionally, factors such as tumor diameter, BCLC stage, and HCV antibodies were also associated with prognosis in the two groups of patients.
JOURNAL OF ONCOLOGY
(2022)
Article
Oncology
Feng Xia, Zhiyuan Huang, Qiao Zhang, Elijah Ndhlovu, Mingyu Zhang, Xiaoping Chen, Bixiang Zhang, Peng Zhu
Summary: This study assessed the impact of different tumor diameters on the posttreatment prognosis of BCLC stage 0/A ruptured hepatocellular carcinoma (rHCC) patients. The results showed that rHCC with a relatively small diameter can achieve a similar prognosis as non-ruptured HCC patients after aggressive treatment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Surgery
Feng Xia, Qiao Zhang, Xiaoping Chen, Bixiang Zhang, Elijah Ndhlovu, Mingyu Zhang, Peng Zhu
Summary: This study compared the overall survival of ruptured hepatocellular carcinoma patients undergoing transarterial chemoembolization (TACE) or hepatectomy. After propensity score matching, it was found that patients treated with hepatectomy had better short-term prognosis but no difference in long-term prognosis compared to those treated with TACE. Subgroup analysis showed no significant difference in survival prognosis between the two groups for patients who met the Milan criteria, but a significant difference for patients beyond the Milan criteria.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Oncology
Feng Xia, You Zou, Qiao Zhang, Jianhong Wu, Zhen Sun
Summary: This study aims to construct a model for predicting the probability of LARS occurrence after ileostomy reversal and guide preventive strategies. Three risk factors were identified, and a predictive model was constructed. This model can help screen high-risk patients and guide individualized preventive strategies.
Article
Immunology
Yuefan Wang, Biao Lei, Yonglong Pan, Chen Su, Weijian Wang, Haoquan Zhang, Feng Xia, Peng Zhu, Songqing He, Qi Cheng
Summary: ORTHOTOPIC liver transplantation is an effective treatment option, but it carries the risk of ischemia-reperfusion injury. Static cold preservation is widely used, but prolonged cold ischemia time may increase bile duct complications. Cell junctions play critical roles in maintaining homeostasis and regulating oxidative stress and inflammation, suggesting that influencing cell junctions may help reduce ischemia-reperfusion injury.
TRANSPLANTATION PROCEEDINGS
(2022)
Article
Multidisciplinary Sciences
Danyang Chen, Zhicheng Liu, Jingxuan Wang, Chen Yang, Chao Pan, Yingxin Tang, Ping Zhang, Na Liu, Gaigai Li, Yan Li, Zhuojin Wu, Feng Xia, Cuntai Zhang, Hao Nie, Zhouping Tang
Summary: This study established a multiomics-based classification of GBM and identified three subclasses with different molecular features. A robust GBM poor prognostic signature score model was developed using machine learning method, and specific drugs were identified to be effective in targeting patients with a high risk of poor prognosis. The study also suggested the potential of GBM classification and GPS score model as biomarkers for immunotherapy response.
Article
Oncology
Feng Xia, Zhiyuan Huang, Qiao Zhang, Elijah Ndhlovu, Xiaoping Chen, Bixiang Zhang, Peng Zhu
Summary: The specific effect of clinically significant portal hypertension (CSPH) on patients with early-stage HCC after surgery was examined. The study found that CSPH affects the surgical prognosis of early-stage HCC patients, with a prognosis comparable to BCLC stage B patients.
Article
Oncology
Ali Mo, Qiao Zhang, Feng Xia, Zhiyuan Huang, Shasha Peng, Wenjing Cao, Hongliang Mei, Li Ren, Yang Su, Hengyi Gao, Weiqiang Chen
Summary: Preoperative TACE is found to be effective in improving the recurrence-free survival and overall survival for patients with solitary HCC (>= 10 cm) compared to those without preoperative TACE.
Article
Gastroenterology & Hepatology
Feng Xia, Qiao Zhang, Jun Zheng, Zhiyuan Huang, Elijah Ndhlovu, Hengyi Gao
Summary: This study establishes a clinical model to predict R1 resection after hepatectomy for resectable ruptured hepatocellular carcinoma (rHCC), which can be used to better plan perioperative strategies.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)