Article
Biotechnology & Applied Microbiology
Chuming Tao, Haitao Luo, Luyue Chen, Jingying Li, Xingen Zhu, Kai Huang
Summary: This study identified a nine-EMT-related lncRNA signature with prognostic value in gliomas, showing that patients in the low-risk group had longer survival and were associated with specific genetic characteristics. The findings were validated in different genomic datasets. The lncRNA-mediated ceRNA network may play a potential role in EMT progression in gliomas.
Retraction
Cell Biology
Xinggang Guo, Hongqi Xiao, Sihong Guo, Jing Li, Yuxia Wang, Jie Chen, Ge Lou
Summary: The article published on October 26, 2018, has been retracted due to flaws and inconsistencies between results presented and experimental methods described, rendering the conclusions invalid.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shuai Yang, Hui Li, Haipei Yao, Yao Zhang, Huiqian Bao, Liangjing Wu, Conghui Zhang, Min Li, Le Feng, Jingfa Zhang, Zhi Zheng, Guotong Xu, Fang Wang
Summary: The study revealed that lncRNA ERLR plays a role in TGF-beta 1-induced EMT in human RPE cells and is involved in the pathogenesis of PVR, providing new insights into the mechanism and treatment of the disease.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Oncology
Yongming Liu, Yuan Zhang, Jinxue Zhang, Jingchang Ma, Xuexue Xu, Yuling Wang, Ziqing Zhou, Dongxu Jiang, Shen Shen, Yong Ding, Yong Zhou, Ran Zhuang
Summary: Our study revealed that knockdown of HuR suppresses OS cell EMT by regulating the lncRNA XIST/AGO2 signaling pathway.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Md Zahirul Islam Khan, Helen Ka Wai Law
Summary: This study demonstrates that silencing of CASC9 leads to reduced CRC cell proliferation and migration by regulating autophagy and AKT/mTOR/EMT signaling pathways. Therefore, CASC9 plays a crucial role in carcinogenesis and may serve as a prognostic biomarker and potential therapeutic target for CRC management.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Cell Biology
Ying Su, Ziyan Tang, Feng Wang
Summary: The study investigated the regulation of LINC01592 on human RPE cells undergoing epithelial-mesenchymal transition induced by TGF-beta 1, finding that LINC01592 overexpression enhanced the process while its inhibition reduced it. This provides a novel treatment approach for proliferative vitreoretinopathy.
Article
Medicine, General & Internal
Shenglan Huang, Dan Li, Lingling Zhuang, Jian Zhang, Jianbing Wu
Summary: A novel EMT-related lncRNA risk signature, including 12 lncRNAs, has been established and identified in patients with HCC, which accurately predicts the prognosis of HCC patients and may be used to guide individualized treatment in clinical practice.
FRONTIERS IN MEDICINE
(2022)
Article
Cell Biology
Lang Xiong, Yan Sun, Jingqi Huang, Pengjuan Ma, Xiaoran Wang, Jiani Wang, Baoxin Chen, Jieping Chen, Mi Huang, Shan Huang, Yizhi Liu
Summary: This study reveals the regulatory mechanism of lncRNA H19 in lens fibrosis. The researchers found that H19 was highly expressed in lens epithelial cells but downregulated after exposure to TGF-beta 2. Silencing H19 exacerbated TGF-beta 2-induced EMT, while overexpressing H19 partially reversed EMT. In vitro and in vivo experiments confirmed the important role of H19 in maintaining lens clarity.
Article
Biochemistry & Molecular Biology
Ching-Chung Ko, Yao-Yu Hsieh, Pei-Ming Yang
Summary: Epithelial-to-mesenchymal transition (EMT) is a biological process that promotes cancer cell dissemination and drug resistance. This study revealed that overexpression of MIR31HG in pancreatic ductal adenocarcinoma (PDAC) patients is associated with poorer disease-free survival, as well as upregulation of genes related to TGF beta signaling and EMT. In vitro experiments further demonstrated that TGF beta induces MIR31HG expression and knockdown of MIR31HG reverses TGF beta-induced EMT phenotypes and cancer cell migration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Chengxin Li, Lewei Zheng, Gaoran Xu, Qianqian Yuan, Ziyang Di, Yalong Yang, Xingxing Dong, Jinxuan Hou, Gaosong Wu
Summary: In this study, an EMT-related lncRNA signature was constructed to predict the prognosis of breast cancer patients. A risk score signature consisting of 10 lncRNAs associated with the EMT process was developed and validated. The signature was also evaluated for its impact on drug sensitivity and tumor immune cell infiltration in breast cancer.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Oncology
Xiaoying Yang, Cheng Qin, Bangbo Zhao, Tianhao Li, Yuanyang Wang, Zeru Li, Tianyu Li, Weibin Wang
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant tumor with poor prognosis. The molecular mechanisms of pancreatic oncogenesis and malignant progression are not fully understood. Recent studies have shown that long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) play important roles in the epithelial-mesenchymal transition (EMT) process in PDAC, affecting the migration and invasion of tumor cells. These RNAs can regulate the expression of EMT-related proteins through different mechanisms, thus influencing the development of cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Toxicology
Fa-Xuan Wang, Fang-Yu Gao, Xuan Liu, Xi-Yuan Chen, Di Tian, Xue-Yan Tian, Zi-Ming Jiao, Peng-Yi Hou
Summary: Silicosis is a lung fibrotic disease caused by chronic silica exposure, and differential expression of lncRNAs is related to its development, with MRAK050699 playing a crucial role in epithelial-mesenchymal transition.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2021)
Article
Engineering, Biomedical
Zhixiong Chen, Xi Chu, Jinghong Xu
Summary: This study identified differentially expressed EMT-related lncRNAs and mRNAs in keloid tissues compared to normal tissues and interpreted their functions. The differentially expressed mRNAs were found to function in the extracellular matrix, protein binding, the positive regulation of cellular processes, the Set1C/COMPASS complex, and histone acetyltransferase activity. The lncRNA XLOC_000587 may promote cell proliferation and migration by enhancing the expression of ENAH, while AF268386 may facilitate the invasive growth of keloids by upregulating DDR2.
BIOMEDICAL ENGINEERING ONLINE
(2022)
Article
Medicine, Research & Experimental
Yan Sun, Lang Xiong, Xiaoran Wang, Liping Wang, Baoxin Chen, Jingqi Huang, Mi Huang, Jieping Chen, Jing Wu, Shan Huang, Yizhi Liu
Summary: This study demonstrated that TGF-beta 2 induces autophagy flux during EMT progression of LECs, with autophagy activation enhancing fibrogenic responses and cell migration, while autophagy inhibition alleviates EMT markers and cell migration. Additionally, modulation of Smad signaling by autophagy was observed, and ATG7-silenced LECs showed antifibrosis effect induced by TGF-beta 2. Overall, intervention/inhibition of autophagy could attenuate TGF-beta 2-induced EMT in LECs, providing insights for preventing and treating fibrotic cataracts and other fibrotic diseases.
Review
Biochemistry & Molecular Biology
Kenji Takahashi, Kenzui Taniue, Yusuke Ono, Mikihiro Fujiya, Yusuke Mizukami, Toshikatsu Okumura
Summary: ncRNAs, including small and long ncRNAs, are involved in the pathogenesis of various diseases, with some being encapsulated in extracellular vesicles and transferred to recipient cells to regulate cellular processes. Studies have uncovered the molecular mechanisms and functions of lncRNAs in PDAC, providing insights into their roles in EMT and tumor cell stemness. Dysregulated expression of lncRNAs and the potential contribution of lncRNAs and EVs in PDAC pathogenesis have been highlighted.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
