Article
Immunology
Weizhuo Wang, Xi Zhang, Silin Jiang, Peng Xu, Kang Chen, Kai Li, Fei Wang, Xiang Le, Ke Zhang
Summary: This study aimed to construct a prognostic model based on differential gene expression between muscular and non-muscular invasive bladder cancer (BCa), and to investigate the prognosis of BCa patients. BCa patient data from GEO and TCGA databases were analyzed, and single-cell sequencing and microarray data were used to validate the differential gene expression. The prognostic model showed accuracy and validity, and S100A9 may be a better prognostic marker and therapeutic target for BCa.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xuan-Mei Piao, Chaelin You, Young Joon Byun, Ho Won Kang, Junho Noh, Jaehyun Lee, Hee Youn Lee, Kyeong Kim, Won Tae Kim, Seok Joong Yun, Sang-Cheol Lee, Kyuho Kang, Yong-June Kim
Summary: NMIBC is a common disease with high recurrence rate, which may progress to the lethal form MIBC. BUB1, a mitotic checkpoint kinase, has been identified as a potential prognostic biomarker for NMIBC by promoting cell proliferation through regulating the G2/M transition of the cell cycle. Further validation in internal and external cohorts showed its correlation with NMIBC progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Jillian Marie Walker, Padraic O'Malley, Mei He
Summary: Muscle invasive bladder cancer (MIBC) is a subtype of bladder cancer with a high risk of metastasis and death. Current diagnostic methods include urologic evaluation, CT scan, urinalysis, and cystoscopy. However, these invasive procedures carry risks and potential health concerns. Exosomes, as a novel source of biomarkers, show promise in addressing some of the limitations of urine cytology. This review provides an overview of MIBC, current urine cytology methods, the role of exosomes, and their potential as a diagnostic tool.
Article
Genetics & Heredity
Chen Huang, Chuqi Lei, Boyu Pan, Senbiao Fang, Yubao Chen, Wenfeng Cao, Liren Liu
Summary: MCM2/4/10 were significantly highly expressed in both LUAD and LUSC, and MCM2/4/6/7/8 expression levels were associated with advanced tumor stages. High expression levels of MCM1/2/3/4/5/6/7/8/10 were linked to worse OS, while high expression of MCM9 was associated with better OS in NSCLC patients. These results suggest that MCM2 and MCM4 may serve as potential prospective biomarkers for high-risk subgroups of NSCLC patients.
FRONTIERS IN GENETICS
(2021)
Article
Medicine, General & Internal
Seung-Woo Baek, Jeong-Yeon Mun, In-Hwan Jang, Gi-Eun Yang, Mi-So Jeong, Seon-Kyu Kim, Jong-Kil Nam, In-Sun Chu, Sun-Hee Leem
Summary: This study identifies the activation of Yes-associated protein 1 (YAP1) as a significant prognostic factor for bladder cancer progression and suggests its potential as a tool for immunotherapy selection.
Article
Genetics & Heredity
Dongdong Tang, Yangyang Li, Ying Tang, Haoxiang Zheng, Weihan Luo, Yuqing Li, Yingrui Li, Zhiping Wang, Song Wu
Summary: This study aims to construct an effective prediction model for the prognosis of bladder cancer based on glycometabolism-associated lncRNAs. The proposed model can divide patients into high- and low-risk groups and predict prognosis without relying on traditional clinical traits. The high-risk group demonstrates distinct immune cell infiltration conditions and gene set enriched terms and is more sensitive to certain chemotherapy drugs.
FRONTIERS IN GENETICS
(2022)
Review
Biotechnology & Applied Microbiology
Carmine Valenza, Gabriele Antonarelli, Federica Giugliano, Gaetano Aurilio, Elena Verri, Alberto Briganti, Giuseppe Curigliano, Andrea Necchi
Summary: The article provides an overview of clinical trials investigating innovative immunological and target agents in patients with BCG unresponsive and BCG naive NMIBC. Promising treatment options such as pembrolizumab, atezolizumab, oportuzumab monatox, nadofaragene firadenovec, and N-803 are emerging.
EXPERT OPINION ON BIOLOGICAL THERAPY
(2022)
Review
Oncology
Camilla De Carlo, Marina Valeri, Devin Nicole Corbitt, Miriam Cieri, Piergiuseppe Colombo
Summary: This review summarizes the recent evidence on prognostic and predictive tissue biomarkers in non-muscle invasive bladder cancer (NMIBC), highlighting the importance of histological features and molecular events in predicting recurrence and progression. The review also emphasizes the potential of immunohistochemical evaluation as a cost-effective tool for clinical practice.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Ruixia Song, Fengsen Liu, Yu Ping, Yi Zhang, Liping Wang
Summary: Immune checkpoint inhibitors (ICIs) have greatly improved the treatment outcomes for various malignancies, but only a small percentage of patients respond significantly. Accurate identification of responders and timely administration of ICIs are critical issues. Recent advancements at the intersection of oncology, immunology, biology, and computer science have provided predictive biomarkers for ICI efficacy. Non-invasive markers have been shown to have better availability and accuracy in predicting ICI efficacy compared to invasive markers.
BIOMARKER RESEARCH
(2023)
Article
Urology & Nephrology
Wei Shen Tan, Roberto Contieri, Nicolo Maria Buffi, Giovanni Lughezzani, Valentina Grajales, Mark Soloway, Paolo Casale, Rodolfo Hurle, Ashish M. Kamat
Summary: The purpose of this study was to determine whether the International Bladder Cancer Group IR-NMIBC scoring system can predict the need for delayed transurethral resection of bladder tumor in low-grade nonmuscle-invasive bladder cancer patients managed by active surveillance. The study found that the scoring system can predict the risk of subsequent transurethral resection of bladder tumor in patients on active surveillance.
JOURNAL OF UROLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Alison Schulz, Justin Loloi, Luis Pina Martina, Alexander Sankin
Summary: Bladder cancer is a challenging disease with high recurrence rates, leading to invasive surveillance methods. Non-invasive urinary tests have gained attention for early detection and to reduce unnecessary procedures; however, there is a need for improved sensitivity and specificity. Recent advancements in technology and research offer novel detection systems and biomarkers that show promise in clinical practice.
ONCOTARGETS AND THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Seon-Kyu Kim, Seong-Hwan Park, Yeong Uk Kim, Young Joon Byun, Xuan-Mei Piao, Pildu Jeong, Kyeong Kim, Hee Youn Lee, Sung Pil Seo, Ho Won Kang, Won Tae Kim, Yong-June Kim, Sang-Cheol Lee, Sung-Kwon Moon, Yung Hyun Choi, Wun-Jae Kim, Seon-Young Kim, Seok Joong Yun
Summary: A molecular signature, MSP888, has been identified for Non-muscle-invasive bladder cancer (NMIBC) that can predict heterogeneity and responses to Bacillus Calmette-Guerin (BCG) therapy. This signature includes three distinct molecular subtypes, with DP.BCG+ related to progression and response to BCG treatment, and REC.BCG+ related to recurrence and response to BCG treatment. These findings enhance understanding of NMIBC prognosis and the effectiveness of BCG therapy, potentially improving clinical practice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Hannah Slovacek, Jerry Zhuo, Jennifer M. Taylor
Summary: NMIBC is a heterogeneous malignancy with high recurrence and progression rates, necessitating uniform recommendations for diagnosis and management. Guidelines worldwide have adopted risk-stratification at diagnosis to provide evidence-based treatment and surveillance recommendations. Improved endoscopic technologies enhance NMIBC detection and decrease recurrence.
CURRENT ONCOLOGY REPORTS
(2021)
Article
Biochemistry & Molecular Biology
R. Singh, U. P. Singh, V. Agrawal, M. Garg
Summary: This study evaluated the diagnostic and prognostic significance of epithelial-to-mesenchymal transition (EMT) associated biomarkers in bladder cancer patients. The study found that altered EMT profile was associated with tumor stage, tumor type, smoking/tobacco chewing status, and patient age. It also identified these biomarkers as predictors of short-term progression-free survival and overall survival.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Multidisciplinary Sciences
Won Sik Ham, Jee Soo Park, Won Sik Jang, Young Deuk Choi, Jongchan Kim
Summary: The study suggests a correlation between larger prostate volume and worse recurrence and progression-free survival in non-muscle invasive bladder cancer.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
German Corredor, Paula Toro, Can Koyuncu, Cheng Lu, Christina Buzzy, Kaustav Bera, Pingfu Fu, Mitra Mehrad, Kim A. Ely, Mojgan Mokhtari, Kailin Yang, Deborah Chute, David J. Adelstein, Lester D. R. Thompson, Justin A. Bishop, Farhoud Faraji, Wade Thorstad, Patricia Castro, Vlad Sandulache, Shlomo A. Koyfman, James S. Lewis, Anant Madabhushi
Summary: This study investigates whether OP-TIL, a biomarker, can separate stage I HPV-associated OPSCC patients into low-risk and high-risk groups and aid in patient selection for de-escalation clinical trials.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Urology & Nephrology
Ilaha Isali, Ahmad Osama Khalifa, Subba Shankar, Stanley Dannemiller, Walter Horne, Michelle Evancho-Chapman, Phillip McClellan, Gregory T. MacLennan, Ozan Akkus, Adonis Hijaz
Summary: This study evaluates the use of sheep as a potential model for preclinical evaluation of urethral slings. The anatomical measurements and histological tissue integration in sheep show similar results to humans, suggesting the suitability of this model for biomaterial response assessment.
UROLOGIA INTERNATIONALIS
(2023)
Article
Virology
Nilottam Rana, Atul Kumar Singh, Mohd Shuaib, Sanjay Gupta, Mahmoud M. Habiballah, Mustfa F. Alkhanani, Shafiul Haque, Mohd Salim Reshi, Shashank Kumar
Summary: The study investigates the molecular mechanism of saquinavir resistance caused by the M46I mutation in HIV-1 protease. The results show that this mutation significantly affects the protein's structure and stability, leading to decreased van der Waals interaction and binding free energy, as well as inward flap curling and wider opening. These findings provide valuable insights for the development of inhibitors against drug-resistant HIV-1 protease.
Article
Multidisciplinary Sciences
Xiangxue Wang, Cristian Barrera, Kaustav Bera, Vidya Sankar Viswanathan, Sepideh Azarianpour-Esfahani, Can Koyuncu, Priya Velu, Michael D. Feldman, Michael Yang, Pingfu Fu, Kurt A. Schalper, Haider Mahdi, Cheng Lu, Vamsidhar Velcheti, Anant Madabhushi
Summary: This study utilizes image analysis to capture morphologic attributes and evaluates their association with survival in lung cancer and gynecological cancer patients treated with immune checkpoint inhibitors (ICIs).
Article
Oncology
Amr Mohamed, Namrata Vijayvergia, Matthew Kurian, Lisa Liu, Pingfu Fu, Satya Das
Summary: This study retrospectively analyzed the treatment outcomes of EP-NEC patients and found that dual ICPIs showed better progression-free survival and overall survival in patients with EP-NEC in the second-line setting, compared to single ICPIs or cytotoxic chemotherapy.
Article
Oncology
Sara Arabyarmohammadi, Patrick Leo, Vidya Sankar Viswanathan, Andrew Janowczyk, German Corredor, Pingfu Fu, Howard Meyerson, Leland Metheny, Anant Madabhushi
Summary: Computer-extracted morphology and texture features from chromatin patterns of myeloblasts can predict post-HCT relapse and prognosticate RFS in patients with AML/MDS.
JCO CLINICAL CANCER INFORMATICS
(2022)
Article
Medicine, General & Internal
Gourav Modanwal, Sadeer Al-Kindi, Jonathan Walker, Rohan Dhamdhere, Lei Yuan, Mengyao Ji, Cheng Lu, Pingfu Fu, Sanjay Rajagopalan, Anant Madabhushia
Summary: This study presents a deep-learning-based hepatic fat assessment (DeHFt) pipeline for segmenting and estimating liver attenuation on CT images, and investigates the association between hepatic steatosis and the severity of COVID-19 infections. The results show that DeHFt pipeline accurately assesses hepatic steatosis and reveals its association with the severity of COVID-19 infections.
Article
Hematology
Ernest R. Chan, Jasmine Lee, Howard Meyerson, Alona Merkulova, Susan Smith, Feng Lin, Jae S. Cho, Alvin H. Schmaier
Summary: Elevated neutrophil-to-lymphocyte ratio (NLR) in patients undergoing elective vascular surgery (EVS) is associated with increased mortality. We investigated the gene expression of neutrophils and lymphocytes in these patients and found that downregulation of genes related to humoral immunity and complement systems in neutrophils may contribute to the elevated NLR and increased mortality.
Article
Multidisciplinary Sciences
Mehdi Alilou, Mohammadhadi Khorrami, Prateek Prasanna, Kaustav Bera, Amit Gupta, Vidya Sankar Viswanathan, Pradnya Patil, Priya Darsini Velu, Pingfu Fu, Vamsidhar Velcheti, Anant Madabhushi
Summary: The study found that the quantitative vessel tortuosity (QVT) imaging biomarker has the potential to predict the response and survival of patients with non-small cell lung cancer (NSCLC) treated with immune checkpoint inhibitor (ICI) therapy.
Article
Biochemistry & Molecular Biology
Mohd Shuaib, Kumari Sunita Prajapati, Sanjay Gupta, Shashank Kumar
Summary: In this study, it was found that Withaferin A (WA) can exert an anticancer effect on triple-negative breast cancer cells by modulating the expression of miRNA. The results showed that WA up-regulated the expression of miR-181c-5p and down-regulated the expression of miR-1275, among other miRNAs. These miRNAs were found to affect the expression of cancer-associated genes and signaling pathways. Additionally, co-treatment of WA and miR-181c-5p mimic inhibited cell growth, induced apoptosis, and regulated the expression of genes involved in cell cycle and apoptosis.
Article
Oncology
Kelsey L. Polak, Ilaria Tamagno, Neetha Parameswaran, Jacob Smigiel, E. Ricky Chan, Xueer Yuan, Brenda Rios, Mark W. Jackson
Summary: In pancreatic ductal adenocarcinoma (PDAC), OSM induces tumor plasticity and resistance, while ZEB1 and SNAI1 do not have similar effects. Further analysis revealed that OSM-mediated stemness requires MAPK activation and sustained, feed-forward transcription of OSMR. Disrupting the OSM-OSMR-MAPK feed-forward loop may be a novel way to target the stem-like behaviors common to aggressive PDAC.
MOLECULAR CANCER RESEARCH
(2023)
Editorial Material
Oncology
Smit Brahmbhatt, Herta H. H. Chao, Shiv Verma, Sanjay Gupta
Review
Oncology
Shashank Kumar, Mohd Shuaib, Abdullah F. AlAsmari, Faleh Alqahtani, Sanjay Gupta
Summary: Guanine nucleotide-binding protein-like 3 (GNL3) and proliferation-associated protein 2G4 (PA2G4) are overexpressed in several human cancers, including prostate cancer, and could serve as prognostic biomarkers of clinical significance in prostate cancer. Prostate cancer is a common disease in males and lacks reliable biomarkers for prognosis. In this review, the function of GNL3 and PA2G4 is highlighted, and their potential as prognostic biomarkers in prostate cancer is discussed.
Article
Oncology
Cristian Barrera, German Corredor, Vidya Sankar Viswanathan, Ruiwen Ding, Paula Toro, Pingfu Fu, Christina Buzzy, Cheng Lu, Priya Velu, Philipp Zens, Sabina Berezowska, Merzu Belete, David Balli, Han Chang, Vipul Baxi, Konstantinos Syrigos, David L. Rimm, Vamsidhar Velcheti, Kurt Schalper, Eduardo Romero, Anant Madabhushi
Summary: The tumor immune composition has an impact on prognosis and treatment sensitivity in lung cancer. Effective adaptive immune responses are associated with better clinical outcomes after immune checkpoint blockers, while immunotherapy resistance can occur due to T-cell exhaustion, immunosuppressive signals, and regulatory cells. This study investigates a new computational pathology approach called PhenoTIL, which uses machine learning to analyze the spatial interactions and functional features of immune cell niches associated with tumor rejection and patient outcomes in non-small cell lung cancer (NSCLC). The study demonstrates the potential of PhenoTIL as a valuable biomarker for treatment-specific outcomes in NSCLC.
NPJ PRECISION ONCOLOGY
(2023)
Article
Oncology
Bolin Song, Kailin Yang, Vidya Sankar Viswanathan, Xiangxue Wang, Jonathan Lee, Sarah Stock, Pingfu Fu, Cheng Lu, Shlomo Koyfman, James S. Lewis, Anant Madabhushi
Summary: This study aimed to develop and validate a prognostic and predictive radiomic image signature (pRiS) using CT scans to inform survival and chemotherapy benefit in HPV-associated OPSCC. The results showed that pRiS was able to predict patient survival and determine whether chemotherapy provided additional benefit.
NPJ PRECISION ONCOLOGY
(2023)
