Review
Oncology
Kenneth C. W. Wong, David Johnson, Edwin P. Hui, Rachel C. T. Lam, Brigette B. Y. Ma, Anthony T. C. Chan
Summary: The combination of radiotherapy and immune checkpoint inhibitors has potential for improving prognosis in locally advanced and recurrent/metastatic head and neck cancers, but the clinical trials have yielded largely negative results. Further investigation is needed to explore parameters such as dose fractionation, sequencing, irradiated volume, and predictive biomarkers.
CANCER TREATMENT REVIEWS
(2022)
Article
Oncology
Xuefeng Wang, Jameel Muzaffar, Kedar Kirtane, Feifei Song, Matthew Johnson, Michael J. Schell, Jiannong Li, Sean J. Yoder, Jose R. Conejo-Garcia, Jose A. Guevara-Patino, Marcelo Bonomi, Priyanka Bhateja, James W. Rocco, Conor E. Steuer, Nabil F. Saba, Christine H. Chung
Summary: This study characterized and compared the TCR repertoire in peripheral blood mononuclear cells (PBMC) of head and neck squamous cell carcinoma (HNSCC) patients and found a correlation between TCR repertoire diversity and treatment response and clinical characteristics. The results suggest that pretreatment peripheral TCR repertoire may serve as a beneficial biomarker for immunotherapy in HNSCC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Joel Guigay, Keun-Wook Lee, Manish R. Patel, Amaury Daste, Deborah J. Wong, Sanjay Goel, Michael S. Gordon, Martin Gutierrez, Ani Balmanoukian, Christophe Le Tourneau, Alain Mita, Damien Vansteene, Ulrich Keilholz, Patrick Schoffski, Hans Juergen Grote, Dongli Zhou, Marcis Bajars, Nicolas Penel
Summary: In a study of patients with recurrent/metastatic SCCHN, avelumab demonstrated clinical activity with a low rate of severe treatment-related adverse events.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Pablo Nenclares, Lucinda Gunn, Heba Soliman, Mateo Bover, Amy Trinh, Isla Leslie, Kee Howe Wong, Alan Melcher, Kate Newbold, Chris M. Nutting, Derfel Ap Dafydd, Shreerang A. Bhide, Kevin Harrington
Summary: In patients with relapsed and/or metastatic head and neck squamous cell carcinoma (HNSCC) treated with immunotherapy, on-treatment levels of neutrophil-to-lymphocyte ratio (NLR) and fibrinogen are significantly correlated with response and survival outcomes. An on-treatment scoring system incorporating these biomarkers shows appropriate discrimination for predicting overall survival (OS) and progression-free survival (PFS).
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Oncology
Siqi Zhang, Mengge Zheng, Deheng Nie, Lili Xu, Huimin Tian, Mengmeng Wang, Wenjia Liu, Zhenbang Feng, Fujun Han
Summary: The addition of cetuximab to PD-1 inhibitors improves treatment efficacy in patients with HPV-negative HNSCC, but has less benefit in HPV-positive patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Jennifer M. Johnson, Ioannis A. Vathiotis, Larry A. Harshyne, Ayesha Ali, Voichita Bar Ad, Rita Axelrod, Emily Lorber, Joseph Curry, David M. Cognetti, Adam J. Luginbuhl, Madalina Tuluc, Scott Keith, My G. Mahoney, Athanassios Argiris
Summary: This is a phase I study on the combination treatment of nivolumab and ipilimumab for squamous cell carcinoma of the head and neck. The results show that this treatment has sufficient clinical activity to support further development. Early changes in circulating biomarkers can predict treatment outcomes as well as in-field soft tissue ulceration.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
McKenzie Crist, Benyamin Yaniv, Sarah Palackdharry, Maria A. Lehn, Mario Medvedovic, Timothy Stone, Shuchi Gulati, Vidhya Karivedu, Michael Borchers, Bethany Fuhrman, Audrey Crago, Joseph Curry, Ubaldo Martinez-Outschoorn, Vinita Takiar, Trisha M. Wise-Draper
Summary: The study demonstrates that metformin enhances the activation of peripheral NK cells and promotes NK cell-mediated cytotoxicity in HNSCC through downregulation of CXCL1.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Robert L. Ferris, William C. Spanos, Rom Leidner, Anthony Goncalves, Uwe M. Martens, Chrisann Kyi, William Sharfman, Christine H. Chung, Lot A. Devriese, Helene Gauthier, Simon Chiosea, Lazar Vujanovic, Janis M. Taube, Julie E. Stein, Jun Li, Bin Li, Tian Chen, Adam Barrows, Suzanne L. Topalian
Summary: This study aimed to evaluate the safety and efficacy of neoadjuvant anti-PD-1 therapy in high-risk resectable HPV-positive and HPV-negative HNSCC, showing that neoadjuvant nivolumab therapy was generally safe and induced pathologic regressions in HPV-positive (23.5%) and HPV-negative (5.9%) tumors.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Rom Leidner, Marka Crittenden, Kristina Young, Hong Xiao, Yaping Wu, Marcus A. Couey, Ashish A. Patel, Allen C. Cheng, Amber L. Watters, Carlo Bifulco, George Morris, Lessli Rushforth, Shorin Nemeth, Walter J. Urba, Michael Gough, R. Bryan Bell
Summary: The study demonstrated that the combination of radiation therapy with immunotherapy is safe and effective for patients with HNSCC, resulting in a high rate of pathological response and downstaging. The majority of patients in the study showed tumor pathological responses and clinical to pathological downstaging.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Oncology
Morena Fasano, Carminia Maria Della Corte, Raimondo Di Liello, Giuseppe Viscardi, Francesca Sparano, Maria Lucia Iacovino, Fernando Paragliola, Antonio Piccolo, Stefania Napolitano, Giulia Martini, Floriana Morgillo, Salvatore Cappabianca, Fortunato Ciardiello
Summary: Immunotherapy has revolutionized the treatment of Head and Neck cancer, but there is still limited understanding of its efficacy and resistance mechanisms. Cost-effectiveness analysis and effective patient selection should be encouraged. New biomarker research involving innate immunity, regulatory T lymphocytes, and the microbiome shows promise in improving treatment outcomes.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Article
Immunology
Markus Haas, Alexander Lein, Thorsten Fuereder, Julia Schnoell, Faris F. Brkic, Nicholas J. Campion, David T. Liu, Lorenz Kadletz-Wanke, Gregor Heiduschka, Bernhard J. Jank
Summary: Thyroid dysfunction is common in patients with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) treated with pembrolizumab. Low fT3 is associated with worse overall survival (OS), while immune-related hyperthyroidism is correlated with longer progression-free survival (PFS).
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Oncology
Dan P. Zandberg, Ashley V. Menk, Maria Velez, Daniel Normolle, Kristin DePeaux, Angen Liu, Robert L. Ferris, Greg M. Delgoffe
Summary: The study analyzed the effect of anti-PD-1 therapy in patients with recurrent/metastatic squamous cell carcinoma of the head and neck (HNSCC), finding that anti-PD-1 resistance is associated with changes in tumor cell metabolism, increased tumor hypoxia, and decreased CD8+ T cell numbers. Lower tumor hypoxia was associated with increased efficacy of anti-PD-1 therapy in patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Pooja Karukonda, Diana Odhiambo, Yvonne M. Mowery
Summary: Head and neck squamous cell carcinoma (HNSCC) presents treatment challenges with common TP53 dysfunction and potential therapeutic benefits of ATR inhibition in combination with other treatments.
MOLECULAR CARCINOGENESIS
(2022)
Review
Biochemistry & Molecular Biology
Juliana Runnels, Julie R. Bloom, Kristin Hsieh, Daniel R. Dickstein, Yuhao Shi, Brianna M. Jones, Eric J. Lehrer, Richard L. Bakst
Summary: Head and neck squamous cell carcinoma (HNSCC) is a prevalent and deadly disease worldwide. Immunotherapy has shown promise as a treatment option for HNSCC, and combining it with radiation therapy (RT) may enhance effectiveness. This review highlights the advantages of combining RT and immunotherapy, such as improved tumor response rates, increased survival, and reduced toxicity, while also discussing the challenges in redefining the standard of care and the need for further research.
Article
Oncology
Sophie Papa, Antonella Adami, Michael Metoudi, Richard Beatson, Molly Sarah George, Daniela Achkova, Evangelia Williams, Sefina Arif, Fiona Reid, Maria Elstad, Nicholas Beckley-Hoelscher, Abdel Douri, Marc Delord, Mike Lyne, Dharshene Shivapatham, Christopher Fisher, Andrew Hope, Sakina Gooljar, Arindam Mitra, Linda Gomm, Cienne Morton, Rhonda Henley-Smith, Selvam Thavaraj, Alice Santambrogio, Cynthia Andoniadou, Sarah Allen, Victoria Gibson, Gary J. R. Cook, Ana C. Parente-Pereira, David M. Davies, Farzin Farzaneh, Anna Schurich, Teresa Guerrero-Urbano, Jean-Pierre Jeannon, James Spicer, John Maher
Summary: This study developed an autologous CD28-based chimeric antigen receptor T-cell (CAR-T) therapy named T4 immunotherapy for locally advanced/recurrent head and neck squamous cell carcinoma (HNSCC). Patient-derived T-cells were engineered to express a panErbB-specific CAR and an IL-4-responsive chimeric cytokine receptor. Intratumoral delivery was used to mitigate off-tumor toxicity. The study demonstrated the safe and effective intratumoral administration of T4 immunotherapy in advanced HNSCC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Chemistry, Multidisciplinary
Laigang Hu, Wenhao Wu, Li Gong, Hongxia Zhu, Ling Jiang, Min Hu, Daohui Lin, Kun Yang
Summary: In this study, a novel metal-organic framework (MOF) called ZJU-620(Al) was synthesized using low toxic aluminum (Al) as the metal. ZJU-620(Al) has a uniform micropore size of 8.37 +/- 0.73 angstrom and a specific surface area of 1347 m(2) g(-1). It shows excellent chemical-thermal stability and adsorption for trace BTEX.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Meteorology & Atmospheric Sciences
Xu Yuan, Kun Yang, Hui Lu, Yan Wang, Xiaogang Ma
Summary: This study clarifies the impacts of moisture transport between the lower layer and the upper layer through and over the Yarlung Tsangpo Grand Canyon (YTGC). The results show that moisture transport in the lower layer through the YTGC is critical to precipitation in the YTGC, while moisture transport in the upper layer over the YTGC is more important to precipitation in the eastern Tibetan Plateau (TP).
ATMOSPHERIC RESEARCH
(2023)
Article
Meteorology & Atmospheric Sciences
Jing Sun, Kun Yang, Hui Lu, Xu Zhou, Xin Li, Yingying Chen, Weidong Guo, Jonathon S. Wright
Summary: This study comprehensively explores the effects of soil organic matter (SOM) on the hydrothermal state of the land-atmosphere system on the eastern Tibetan Plateau. The results show that SOM can improve the simulations by reducing cold and wet biases, increasing air temperature, decreasing humidity, and reducing precipitation. Including SOM in climate models not only improves the representation of atmospheric energy and water cycles, but also enhances the simulation of frozen soil evolution with increased confidence and reliability.
JOURNAL OF HYDROMETEOROLOGY
(2023)
Article
Environmental Sciences
Jun Qin, Min He, Wei Yang, Ning Lu, Ling Yao, Hou Jiang, Jin Wu, Kun Yang, Chenghu Zhou
Summary: The Tibetan Plateau is experiencing rapid warming, leading to increased glacial melting and natural hazards. However, due to a lack of high-quality, long-term observations, there is no complete understanding of its temperature status in the past few decades. This study uses satellite and weather station data to derive long-term surface air temperatures, revealing widespread warming across the plateau, particularly in the western region. The derived warming rate is higher than other datasets, implying a severe threat to the cryosphere.
REMOTE SENSING OF ENVIRONMENT
(2023)
Article
Environmental Sciences
Xiaoming Tao, Jiang Xu, Kun Yang, Daohui Lin
Summary: The new paradigm in wastewater treatment focuses on resource recovery, especially for non-renewable phosphorus (P). Nanomaterial-based adsorption technology, such as oxymagnesite/green rust (OMGR) nanohybrids, offers high efficiency and selectivity for P recovery from wastewater. OMGR demonstrated excellent selectivity for phosphate removal, wide pH adaptability, and a high removal capacity of 141 mg P.g-1. Phosphate-loaded OMGR also acted as a slow-release P-fertilizer, providing a green and eco-friendly approach to P resource recovery and reuse.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Computer Science, Artificial Intelligence
Fan Meng, Kunlin Yang, Yichen Yao, Zhibin Wang, Tao Song
Summary: Tropical cyclones are extreme disasters with significant impact on human beings, and forecasting their intensity has been a challenging task. Deep learning-based intensity forecasting has shown potential to outperform traditional methods, but inherent uncertainty in weather forecasting needs to be quantified for decision-making and risk assessment. This study proposes an intelligent system, PTCIF, based on deep learning to quantify uncertainty using multimodal meteorological data, the first study to assess uncertainty of tropical cyclones using a deep learning approach. Probabilistic forecasts are made for the intensity of 6-24 hours, showing comparable performance to weather forecast centers in terms of deterministic forecasts. Reliable prediction intervals and probabilistic forecasts are obtained, which are crucial for disaster warning and expected to complement operational models.
INTERNATIONAL JOURNAL OF INTELLIGENT SYSTEMS
(2023)
Article
Engineering, Environmental
Hongyuan Zheng, Zhiyi Chen, Kunde Yang, Kaiyan Xiao, Jincai Zhu, Zhiwei Gao, Zheyi Han, Yanguang Liu, Minghong Cai
Summary: Current-use Organoamine Pesticides (CUOAPs) are emerging pesticide pollutants found in Chinese Marginal Seas (CMSs), with the highest levels detected in the East China Sea. The Yangtze and Yellow rivers play a crucial role as significant terrestrial sources, leading to variations in the source, distribution, and seasonal patterns of CUOAPs. Spatial redistribution occurs through ocean current transport, resulting in significant regional disparities. CMSs may become a secondary source region for the surrounding seas.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Engineering, Environmental
Limin Duan, Huihao Jiang, Wenhao Wu, Daohui Lin, Kun Yang
Summary: Introducing crystal defects into iron-based metal-organic frameworks (Fe-MOFs) is a promising strategy to enhance Fenton-like performance. However, developing a facile and effective strategy to construct defective Fe-MOFs as highly efficient Fenton-like catalysts is still challenging. In this study, MIL-100(Fe) (Def-MIL-100 (Fe)) with missing ligand defects was synthesized by a simple heterogeneous reaction, and it exhibited significantly higher Fenton-like activity compared to the perfect MIL-100(Fe). The missing ligand defects played a key role in promoting fast H2O2 adsorption, accelerating electron transfer, and improving OH generation and utilization efficiency.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Engineering, Civil
Yanbin Lei, Tandong Yao, Yongwei Sheng, Kun Yang, Wei Yang, Shenghai Li, Jing Zhou, Yaozhi Jiang, Yifan Yu
Summary: Extreme events on the Tibetan Plateau, such as unprecedented lake expansion, have become more frequent and severe due to climate warming and moistening. This expansion, attributed to abnormally high precipitation, poses a substantial threat to regional ecosystems, infrastructure, and habitats. Therefore, it is necessary to identify threatened areas using satellite images and conduct real-time observations of lake level changes.
JOURNAL OF HYDROLOGY
(2023)
Article
Multidisciplinary Sciences
Vagner Ferreira, Bin Yong, Henry Montecino, Christopher E. E. Ndehedehe, Kurt Seitz, Hansjoerg Kutterer, Kun Yang
Summary: The availability and use of terrestrial water storage anomaly (TWSA) data from Gravity Recovery and Climate Experiment (GRACE) supports various hydrological applications. There are currently five operational TWSA products, three based on mass concentration (mascon) solutions and two based on spherical harmonic coefficients (SHCs) synthesis. This study presents a new TWSA data set based on novel processing protocols, with a spatial re-sampling of 0.25 arc-degrees from 2002 to 2022, which reliably agrees with mascon solutions. The proposed data set would be valuable for regional hydrological applications, particularly for improved assessment of regional water budgets.
Article
Medicine, General & Internal
Bing Wang, Wenzhi Gao, Kunlin Yang, Honglei Liu, Yangjun Han, Mingxin Diao, Chao Zuo, Minghua Zhang, Yingzhi Diao, Zhihua Li, Xinfei Li, Gang Wang, Peng Zhang, Chunji Wang, Chunjuan Xiao, Chen Huang, Yaming Gu, Xuesong Li
Summary: This study aimed to investigate the efficacy of balloon dilation in ureteral stricture and analyze the risk factors for its failure. A retrospective analysis of 196 patients who underwent balloon dilation was conducted, with 127 patients having complete data. The success rates of balloon dilation and balloon dilation combined with endoureterotomy for lower ureteral stricture were higher compared to other cases. Balloon circumference and multiple ureteral strictures were identified as risk factors for balloon dilation failure.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Environmental Sciences
Fang Li, Yishui Shui, Jiayao Liang, Kun Yang, Junyi Yu
Summary: By modeling the measured data of marine wireless channels and creating sea surface morphology models under multiple wind speeds, this paper calculates the radio propagation characteristics of the Pearl River estuary and estimates the path loss in the same area under different conditions using the Monte Carlo method. The simulation results show that the electric wave propagation gradually changes from the round earth loss (REL) model to the free space model with increasing wind speed. The distribution of the shadow fading varies with distance. The findings provide references for the network planning of marine communication.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Oncology
Fangyuan Zhou, You Qin, Xixi Liu, Jing Huang, Bian Wu, Zhanjie Zhang, Zhongyuan Yin, Jinsong Yang, Sheng Zhang, Ke Jiang, Kunyu Yang
Summary: This study evaluates the efficacy and safety of thoracic radiotherapy in patients with stage IV non-small-cell lung cancer (NSCLC) treated with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). The findings show that the combination of EGFR inhibitors and thoracic radiotherapy significantly improves overall survival but not progression-free survival. Therefore, preemptive thoracic radiotherapy during EGFR-TKI treatment could be considered as a competitive first-line therapeutic option with superior progression-free survival and a lower incidence of side effects.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2023)
Article
Geosciences, Multidisciplinary
Yaozhi Jiang, Kun Yang, Youcun Qi, Xu Zhou, Jie He, Hui Lu, Xin Li, Yingying Chen, Xiaodong Li, Bingrong Zhou, Ali Mamtimin, Changkun Shao, Xiaogang Ma, Jiaxin Tian, Jianhong Zhou
Summary: This study produced a high-resolution long-term precipitation dataset (TPHiPr) for the Third Pole region by merging atmospheric simulation-based ERA5_CNN and gauge observations. The dataset showed higher accuracy and better detection of precipitation extremes compared to widely used datasets. It has broad applications in meteorological, hydrological, and ecological studies.
EARTH SYSTEM SCIENCE DATA
(2023)
Article
Urology & Nephrology
Zhihua Li, Xiang Wang, Yicen Ying, Xinfei Li, Weijie Zhu, Chang Meng, Guanpeng Han, Jing Liu, Jie Wang, Yanbo Huang, Kunlin Yang, Peng Zhang, Hongjian Zhu, Hua Guan, Xuesong Li, Liqun Zhou
Summary: This study evaluated the health-related quality of life, anxiety, and depression levels in patients with ureteral stricture (US) and identified independent factors affecting these outcomes. The results showed that patients with US had poor quality of life and emotional well-being. Factors such as increased age, female gender, and higher education level were associated with worse health-related quality of life. Additionally, iatrogenic US, nephrostomy tube placement, urinary symptoms, and high levels of anxiety and depression independently predicted poorer quality of life.
WORLD JOURNAL OF UROLOGY
(2023)