期刊
INFECTION AND DRUG RESISTANCE
卷 14, 期 -, 页码 5235-5252出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IDR.S319780
关键词
antibiotic resistance; perioperative care; surgical antibiotic prophylaxis; surgical site infection; antimicrobial stewardship
资金
- Economic and Social Research Council (ESRC)
- National Institute for Health Research ASPIRES project (Antibiotic use across Surgical Pathways: Investigating, Redesigning and Evaluating Systems)
- National Institute for Health Research, UK Department of Health [HPRU-2012-10047]
- Public Health England
The rising antimicrobial resistance poses a global crisis for healthcare, increasing the risk of surgical site infections and highlighting the need for more data and practices to optimize surgical antibiotic prophylaxis.
The increasing incidence of antimicrobial resistance (AMR) presents a global crisis to healthcare, with longstanding antimicrobial agents becoming less effective at treating and preventing infection. In the surgical setting, antibiotic prophylaxis has long been established as routine standard of care to prevent surgical site infection (SSI), which remains one of the most common hospital-acquired infections. The growing incidence of AMR increases the risk of SSI complicated with resistant bacteria, resulting in poorer surgical outcomes (prolonged hospitalisation, extended durations of antibiotic therapy, higher rates of surgical revision and mortality). Despite these increasing challenges, more data are required on approaches at the institutional and patient level to optimise surgical antibiotic prophylaxis in the era of antibiotic resistance (AR). This review provides an overview of the common resistant bacteria encountered in the surgical setting and covers wider considerations for practice to optimise surgical antibiotic prophylaxis in the perioperative setting.
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