期刊
FRONTIERS IN CHEMISTRY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fchem.2021.762248
关键词
acetylcoumarin; hydrazonoyl halides; multicomponent synthesis; ultrasonic radiation; anticancer
资金
- Princess Nourah bint Abdulrahman University [PRFA-P-42-7]
A new three-component reaction using chitosan-grafted poly(vinylpyridine) as an eco-friendly catalyst was developed for the synthesis of novel 3-heteroaryl-coumarin under ultrasonic irradiation. The process proved to be simple, efficient, and yielded compounds with promising anticancer activities, as demonstrated by the evaluation of the products against HEPG2-1.
A three-component reaction for the synthesis of novel 3-heteroaryl-coumarin utilizing acetylcoumarin synthon under ultrasonic irradiation was developed using chitosan-grafted poly(vinylpyridine) as an eco-friendly catalyst. The process is a simple, facile, efficient procedure for the preparation of compounds displaying a thiazole ring linked to coumarin moiety. Moreover, all the products were evaluated for their anticancer activities against HEPG2-1. The results revealed that three new compounds showed promising anticancer activities.
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