Review
Transplantation
Anthony Bonavia, Nicholas Stiles
Summary: This study explores the impact of AKI on liver function and discusses the potential mechanisms by which AKI can cause liver dysfunction, including traditional complications of AKI and systemic inflammation. The findings have therapeutic implications for clinical medicine and highlight the importance of understanding the relationship between kidney and liver function.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Biochemistry & Molecular Biology
Yong Kwon Han, Ji Su Kim, GiBong Jang, Kwon Moo Park
Summary: Cisplatin induces lung cell damage, ciliary fragmentation, and increased oxidative stress, but these effects can be prevented by the mitochondria-specific antioxidant Mito-TEMPO.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Lei-lei Ma, Fei-juan Kong, Yuan-ji Ma, Jun-jie Guo, Shi-jun Wang, Zheng Dong, Ai-jun Sun, Yun-zeng Zou, Jun-bo Ge
Summary: Short-term nonischemic hypertrophy stimulation (TAC preconditioning) can render the heart resistant to subsequent ischemic injury, by reducing oxidative stress and increasing the expression and activity of SIRT3 protein. Regulation of the IDH2 gene also plays a crucial role in the protective mechanism.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Physiology
Peter R. Corridon
Summary: Hydrodynamic fluid delivery has potential in influencing renal function in disease models. Mitochondrial adaptation and improved microvascular perfusion can be achieved through this technique. A study found that hydrodynamic mitochondrial gene delivery can halt progressive or persistent renal function impairment in acute kidney injury (AKI), resulting in improved serum creatinine and blood urea nitrogen levels, increased urine output, and improved mitochondrial membrane potential, despite elevated histology injury score. This study identifies a promising approach to boost recovery and halt the progression of AKI at its inception.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Livia Interdonato, Ramona D'amico, Marika Cordaro, Rosalba Siracusa, Roberta Fusco, Alessio Filippo Peritore, Enrico Gugliandolo, Rosalia Crupi, Stefano Coaccioli, Tiziana Genovese, Daniela Impellizzeri, Rosanna Di Paola, Salvatore Cuzzocrea
Summary: Acute lung injury (ALI) is a common and devastating clinical disorder with a high mortality rate and no specific therapy. The aim of this study was to evaluate the protective effects of Adelmidrol (ADM) in a mice model of ALI induced by lipopolysaccharide (LPS). ADM administration reduced lung damage, airway infiltration, and oxidative stress by regulating mast cells and antioxidant enzymes. These findings suggest that ADM could be a potential candidate in the management of ALI.
Review
Food Science & Technology
Jesus Ivan Lara-Prado, Fabiola Pazos-Perez, Carlos Enrique Mendez-Landa, Dulce Paola Grajales-Garcia, Jose Alfredo Feria-Ramirez, Juan Jose Salazar-Gonzalez, Mario Cruz-Romero, Alejandro Trevino-Becerra
Summary: The mechanisms behind multi-organ dysfunction in acute kidney injury (AKI) are not fully understood, with oxidative stress and uremic toxin accumulation being major contributors. Discrepancies between animal models and human presentations exist, and inflammatory cytokines play a role in endothelial and epithelial injury.
Article
Biochemistry & Molecular Biology
Chih-Chao Yang, Pei-Hsun Sung, John Y. Chiang, Han-Tan Chai, Chih-Hung Chen, Yi-Ching Chu, Yi-Chen Li, Hon-Kan Yip
Summary: Combined tacrolimus and melatonin therapy was more effective than either single treatment in protecting the kidney from IR injury by suppressing inflammation and oxidative stress.
Review
Biochemistry & Molecular Biology
Qianying Lu, Siyu Huang, Xiangyan Meng, Jianfeng Zhang, Sifan Yu, Junfeng Li, Mingyu Shi, Haojun Fan, Yanmei Zhao
Summary: Phosgene poisoning can lead to acute respiratory distress syndrome or death, and there is currently no specific antidote for it. Further research is needed to explore treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Rong Chen, Chen Cao, Huimin Liu, Wanli Jiang, Rui Pan, He He, Ke Ding, Qingtao Meng
Summary: This study identifies macrophage Spry4 as a key regulator in sepsis-induced acute lung injury (ALI) and suggests that targeting Spry4 could be a potential therapeutic approach for ALI. Mechanistically, macrophage Spry4 deficiency alleviates ALI by activating the CaMKK2/AMPK pathway.
Article
Medicine, General & Internal
Lei Jing, Wenhui Chen, Li Zhao, Lijuan Guo, Chaoyang Liang, Jingyu Chen, Chen Wang
Summary: Acute kidney injury (AKI) is a common and serious complication following lung transplantation (LTx), and it is associated with high mortality and morbidity. This study found that AKI is related to several perioperative factors and clinical outcomes, and persistent and severe AKI are associated with decreased kidney function and reduced survival in LTx patients.
CHINESE MEDICAL JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Zhi-Wei Huang, Yannan Shi, Yuan-Yuan Zhai, Chu-Chu Du, Jiaoyuan Zhai, Run-Jie Yu, Longfa Kou, Jian Xiao, Ying-Zheng Zhao, Qing Yao
Summary: Acute kidney injury (AKI) is a common pathological process associated with high morbidity and mortality worldwide. Bilirubin, with its antioxidant, anti-inflammatory, and anti-apoptotic properties, shows promise as a therapeutic candidate for AKI. Nanotechnology-mediated therapy, particularly using hyaluronic acid-coated epsilon-polylysine-bilirubin conjugate nanoparticles (nHA/PLBR), has shown potential for targeted delivery and enhanced efficacy in protecting against renal injury induced by oxidative stress and inflammation in AKI.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Surgery
Elizabeth M. Sonnenberg, Jesse Y. Hsu, Jordana B. Cohen, Vishnu S. Potluri, Zhi Geng, Matthew H. Levine, Peter L. Abt, Peter P. Reese
Summary: This study found that kidney transplants from deceased donors with persistent acute kidney injury (AKI) did not have clinically meaningful differences in graft survival and function compared to transplants from donors without kidney injury.
Article
Multidisciplinary Sciences
Marcelo Augusto Duarte Silveira, Jose Manuel Condor Capcha, Talita Rojas Sanches, Roberto de Sousa Moreira, Margot S. Garnica, Maria Heloisa Shimizu, Andresa Berretta, Flavio Teles, Irene L. Noronha, Lucia Andrade
Summary: The study found that Brazilian green propolis has protective effects on the kidneys and lungs of rats with sepsis, improving survival rate, alleviating kidney injury, restoring renal tubular function, and reducing inflammation and cell infiltration. This discovery opens up new prospects for using Brazilian green propolis in clinical trials for treating sepsis.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Kai Lai, Congkuan Song, Minglang Gao, Yu Deng, Zilong Lu, Ning Li, Qing Geng
Summary: This study found that uridine metabolism is closely related to combating oxidative stress, and redox imbalance-mediated ferroptosis plays a key role in sepsis-induced acute lung injury (ALI). The results showed that uridine metabolism can alleviate lung injury and inflammation, and inhibit tissue iron levels and lipid peroxidation. Uridine also inhibits macrophage ferroptosis by activating the Nrf2 signaling pathway. Therefore, uridine supplementation may be a potential avenue for ameliorating sepsis-induced ALI by suppressing ferroptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Yang Zheng, Juan-Juan Cai, Xue Yang, Zi-Qiang Shao, Jing-Quan Liu, Xiang-Hong Yang, Ren-Hua Sun, Bang-Chuan Hu, Shi-Jing Mo, Lan-Juan Li
Summary: ADH1 is highly expressed in kidneys of mice with lethal endotoxemia, and its deficiency exacerbates tubular cell apoptosis by suppressing mitophagy. Kidney-specific overexpression of PINK1 and Parkin can ameliorate this condition.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Immunology
Shun-Mei Lin, A-Yeung Jang, Yong Zhi, Shuang Gao, Sangyong Lim, Jae Hyang Lim, Joon Young Song, Paul M. Sullam, Joon Haeng Rhee, Ho Seong Seo
JOURNAL OF INFECTIOUS DISEASES
(2018)
Article
Biotechnology & Applied Microbiology
Min Joo Choi, Ji Yun Noh, Hee Jin Cheong, Woo Joo Kim, Shun-Mei Lin, Yong Zhi, Jae Hyang Lim, Sangyong Lim, Ho Seong Seo, Joon Young Song
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2018)
Article
Cell Biology
Myeong-Joo Kim, Ye-Ji Lee, Young-So Yoon, Jae H. Lim, Eun-Mi Park, Young H. Chong, Jihee L. Kang
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2018)
Review
Biotechnology & Applied Microbiology
Joon Young Song, Jae Hyang Lim, Sangyong Lim, Zhi Yong, Ho Seong Seo
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2018)
Article
Multidisciplinary Sciences
Suji Kim, Jung-Hwa Han, Dae-Hwan Nam, Geun-Young Kim, Jae Hyang Lim, Jae-Ryong Kim, Chang-Hoon Woo
SCIENTIFIC REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Won Ho Kim, Chi-Ho Lee, Jung-Hwa Han, Sujin Kim, Seong Yong Kim, Jae Hyang Lim, Kwon Moo Park, Duk Seop Shin, Chang-Hoon Woo
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Article
Immunology
A-Yeung Jang, Ki Bum Ahn, Yong Zhi, Hyun-Jung Ji, Jing Zhang, Seung Hyun Han, Huichen Guo, Sangyong Lim, Joon Yong Song, Jae Hyang Lim, Ho Seong Seo
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Multidisciplinary Sciences
Shuang Gao, Jong-Hyun Jung, Shun-Mei Lin, A-Yeung Jang, Yong Zhi, Ki Bum Ahn, Hyun-Jung Ji, Jae Hyang Lim, Huichen Guo, Hyon E. Choy, Sangyong Lim, Ho Seong Seo
SCIENTIFIC REPORTS
(2020)
Article
Biotechnology & Applied Microbiology
Fengjia Chen, Ho Seong Seo, Hyun Jung Ji, Eunji Yang, Jung Ah Choi, Jae Seung Yang, Manki Song, Seung Hyun Han, Sangyong Lim, Jae Hyang Lim, Ki Bum Ahn
Summary: The study investigated the immune responses of gamma radiation-inactivated influenza vaccine (RADVAX(FluA)) and found that it provided better protection against influenza virus infection in mice compared to formalin-inactivated influenza virus (FIV). RADVAX(FluA) enhanced the production of virus-specific serum IgG and alveolar mucosal IgA, effectively neutralizing HA and NA activities and blocking viral binding to cells. Furthermore, RADVAX(FluA) induced strong dendritic cell activation and higher activation of CD8(+) T cells than FIV, indicating improved immunogenicity by RADVAX(FluA).
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Immunology
Yong Zhi, Hyun Jung Ji, Huichen Guo, Jae Hyang Lim, Eui-Baek Byun, Woo Sik Kim, Ho Seong Seo
Summary: The study demonstrated that using irradiated Salmonella as transgenic vectors successfully delivered FMDV VP1 protein, stimulating high levels of VLP-specific antibodies in mice, as well as increasing the population of immune cells expressing IFN-gamma, IL-5, and IL-17A.
Article
Immunology
Hyun Jung Ji, Eui-Baek Byun, Fengjia Chen, Ki Bum Ahn, Ho Kyoung Jung, Seung Hyun Han, Jae Hyang Lim, Yongkwan Won, Ja Young Moon, Jin Hur, Ho Seong Seo
Summary: The study showed that using gamma irradiation as an inactivation method for the SG vaccine can enhance antibody levels and protective immune responses, potentially serving as a substitute for the 9R vaccine in young chickens with little to no side effects.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Yong Zhi, Hyun Jung Ji, Jong Hyun Jung, Eui Baek Byun, Woo Sik Kim, Shun Mei Lin, Sangyong Lim, A-Yeung Jang, Min Joo Choi, Ki Bum Ahn, Jae Hyang Lim, Joon Young Song, Ho Seong Seo
Summary: This study analyzed the genotypes of non-srr1/2 GBS clinical isolates collected in South Korea between 2013 and 2016. It identified unique gene clusters associated with multidrug resistance in these strains, and found that their adherence mechanisms and virulence were comparable to Srr1/2-expressing strains.
Article
Immunology
Woo Sik Kim, Yong Zhi, Huichen Guo, Eui-Baek Byun, Jae Hyang Lim, Ho Seong Seo
Article
Biochemistry & Molecular Biology
Seo Hyun Koh, Seul Gi Shin, Maria Jose Andrade, Ryun-hee Go, Seonghee Park, Chang-Hoon Woo, Jae Hyang Lim
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2017)