Mechanisms of impaired mitochondrial homeostasis and NAD+ metabolism in a model of mitochondrial heart disease exhibiting redox active iron accumulation

The potential of the novel NAD+ supplementing agent, SNH6, as a therapeutic strategy for the treatment of Friedreich’s ataxia

(2020) Shannon Chiang et al.   PHARMACOLOGICAL RESEARCH

Identification of Frataxin as a regulator of ferroptosis

(2020) Jing Du et al.   Redox Biology

Frataxin-deficient cardiomyocytes present an altered thiol-redox state which targets actin and pyruvate dehydrogenase

(2020) Rosa Purroy et al.   Redox Biology

The Nrf2 induction prevents ferroptosis in Friedreich's Ataxia

(2020) Piergiorgio La Rosa et al.   Redox Biology

Human Fis1 regulates mitochondrial dynamics through inhibition of the fusion machinery

(2019) Rong Yu et al.   EMBO JOURNAL

Intrafibrillar and perinuclear mitochondrial heterogeneity in adult cardiac myocytes

(2019) Xiyuan Lu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Identification of novel dynamin‐related protein 1 (Drp1) GTPase inhibitors: Therapeutic potential of Drpitor1 and Drpitor1a in cancer and cardiac ischemia‐reperfusion injury

(2019) Danchen Wu et al.   FASEB JOURNAL

MiR‐144 protects the heart from hyperglycemia‐induced injury by regulating mitochondrial biogenesis and cardiomyocyte apoptosis

(2019) Lichan Tao et al.   FASEB JOURNAL

Positive regulation of human PINK1 and Parkin gene expression by nuclear respiratory factor 1

(2019) Yapeng Lu et al.   MITOCHONDRION

AMPK blunts chronic heart failure by inhibiting autophagy

(2018) Yanhui Li et al.   BIOSCIENCE REPORTS

The thiol switch C684 in Mitofusin-2 mediates redox-induced alterations of mitochondrial shape and respiration

(2018) Osamah Thaher et al.   NEUROCHEMISTRY INTERNATIONAL

Sirtuins and NAD + in the Development and Treatment of Metabolic and Cardiovascular Diseases

(2018) Alice E. Kane et al.   CIRCULATION RESEARCH

Droplet digital PCR shows the D-Loop to be an error prone locus for mitochondrial DNA copy number determination

(2018) Brian Li et al.   Scientific Reports

AMPK: a therapeutic target of heart failure—not only metabolism regulation

(2018) Xuan Li et al.   BIOSCIENCE REPORTS

The Metastasis Suppressor, NDRG1, Attenuates Oncogenic TGF-β and NF-ĸB Signaling to Enhance Membrane E-Cadherin Expression in Pancreatic Cancer Cells

(2018) Sharleen V Menezes et al.   CARCINOGENESIS

Quantifying the cellular NAD+ metabolome using a tandem liquid chromatography mass spectrometry approach

(2017) Sonia Bustamante et al.   Metabolomics

AMPKα2 Protects Against the Development of Heart Failure by Enhancing Mitophagy via PINK1 Phosphorylation

(2017) Bei Wang et al.   CIRCULATION RESEARCH

Mitochondrial fission/fusion and cardiomyopathy

(2016) Dorn GW   CURRENT OPINION IN GENETICS & DEVELOPMENT

Mitochondrial fusion and fission proteins as novel therapeutic targets for treating cardiovascular disease

(2015) Sang-Bing Ong et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Molecular mechanisms mediating mitochondrial dynamics and mitophagy and their functional roles in the cardiovascular system

(2015) Yoshiyuki Ikeda et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Pathology of Intercalated Discs in Friedreich Cardiomyopathy

(2015) R. Liane Ramirez et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

Negative transcriptional regulation of mitochondrial transcription factor A (TFAM) by nuclear TFAM

(2014) Eun Jin Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Assessment of different fixation protocols on the presence of membrane-bound vesicles in Caco-2 cells: A multidimensional view by means of correlative light and 3-D transmission electron microscopy

(2014) Gerald Shami et al.   MICRON

Metabolic Profiling of Alternative NAD Biosynthetic Routes in Mouse Tissues

(2014) Valerio Mori et al.   PLoS One

Parkin and PINK1: much more than mitophagy

(2014) Leslie A. Scarffe et al.   TRENDS IN NEUROSCIENCES

Molecular and Functional Alterations in a Mouse Cardiac Model of Friedreich Ataxia

(2013) Michael Li-Hsuan Huang et al.   AMERICAN JOURNAL OF PATHOLOGY

Mapping NAD+ metabolism in the brain of ageing Wistar rats: potential targets for influencing brain senescence

(2013) Nady Braidy et al.   BIOGERONTOLOGY

Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure

(2013) Marc Liesa et al.   Cell Metabolism

Dynamin-related protein 1 (Drp1)-mediated diastolic dysfunction in myocardial ischemia-reperfusion injury: therapeutic benefits of Drp1 inhibition to reduce mitochondrial fission

(2013) Willard W. Sharp et al.   FASEB JOURNAL

A Role for Peroxisome Proliferator-activated Receptor γ Coactivator 1 (PGC-1) in the Regulation of Cardiac Mitochondrial Phospholipid Biosynthesis

(2013) Ling Lai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure, function, and assembly of heme centers in mitochondrial respiratory complexes

(2012) Hyung J. Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial morphology, topology, and membrane interactions in skeletal muscle: a quantitative three-dimensional electron microscopy study

(2012) Martin Picard et al.   JOURNAL OF APPLIED PHYSIOLOGY

Mitochondrial division/mitophagy inhibitor (Mdivi) Ameliorates Pressure Overload Induced Heart Failure

(2012) Srikanth Givvimani et al.   PLoS One

Identification of nonferritin mitochondrial iron deposits in a mouse model of Friedreich ataxia

(2012) M. Whitnall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

PGC-1 Proteins and Heart Failure

(2012) Christian Riehle et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis

(2011) Pablo J Fernandez-Marcos et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Metformin improves cardiac function in a nondiabetic rat model of post-MI heart failure

(2011) Meimei Yin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mitochondrial Mayhem: The Mitochondrion as a Modulator of Iron Metabolism and Its Role in Disease

(2011) Michael Li-Hsuan Huang et al.   ANTIOXIDANTS & REDOX SIGNALING

PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease

(2011) Joo-Ho Shin et al.   CELL

Age Related Changes in NAD+ Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats

(2011) Nady Braidy et al.   PLoS One

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Inhibiting Mitochondrial Fission Protects the Heart Against Ischemia/Reperfusion Injury

(2010) Sang-Bing Ong et al.   CIRCULATION

Ubiquitin Proteasome-dependent Degradation of the Transcriptional Coactivator PGC-1α via the N-terminal Pathway

(2010) Julie Trausch-Azar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 is regulated by a PPARγ–SIRT1 negative feedback loop associated with senescence

(2010) Limin Han et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol

(2010) D. R. Richardson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic regulation of PGC-1α localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response

(2009) Rozalyn M. Anderson et al.   AGING CELL

Nicotinamide Phosphoribosyltransferase Regulates Cell Survival Through NAD + Synthesis in Cardiac Myocytes

(2009) Chiao-Po Hsu et al.   CIRCULATION RESEARCH

Heterogeneity of Mitochondria and Mitochondrial Function within Cells as Another Level of Mitochondrial Complexity

(2009) Andrey Kuznetsov et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Elucidation of the mechanism of mitochondrial iron loading in Friedreich's ataxia by analysis of a mouse mutant

(2009) M. L.-H. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heme Oxygenase-1 Regulates Cardiac Mitochondrial Biogenesis via Nrf2-Mediated Transcriptional Control of Nuclear Respiratory Factor-1

(2008) Claude A. Piantadosi et al.   CIRCULATION RESEARCH

SCFCdc4 acts antagonistically to the PGC-1  transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis

(2008) B. L. Olson et al.   GENES & DEVELOPMENT

Nuclear Respiratory Factor 1 Controls Myocyte Enhancer Factor 2A Transcription to Provide a Mechanism for Coordinate Expression of Respiratory Chain Subunits

(2008) Bindu Ramachandran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteomic analysis of hearts from frataxin knockout mice: Marked rearrangement of energy metabolism, a response to cellular stress and altered expression of proteins involved in cell structure, motility and metabolism

(2008) Robert Sutak et al.   PROTEOMICS