Article
Physiology
R. Shanmugasundaram, D. Adams, S. Ramirez, G. R. Murugesan, T. J. Applegate, S. Cunningham, A. Pokoo-Aikins, A. E. Glenn
Summary: Subclinical doses of combined FB and DON predispose broiler chickens to necrotic enteritis (NE), and the presence of FB + DON in NE-induced birds exacerbates the severity of NE. The effects include decreased body weight gain, increased feed conversion ratio, intestinal structural damage, and alterations in immune factors.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Microbiology
Candice E. C. Blue, Nima K. Emami, Mallory B. White, Staci Cantley, Rami A. Dalloul
Summary: This study evaluated the effects of a saponin-based product (Clarity Q, CQ) on necrotic enteritis (NE) and found that adding Clarity Q to broiler diets can improve performance, reduce intestinal lesions, and positively modulate the mRNA abundance of tight junction proteins and key nutrient transporters during peak NE infection.
Article
Microbiology
Liugang Kan, Fangshen Guo, Yan Liu, Van Hieu Pham, Yuming Guo, Zhong Wang
Summary: The study found that dietary supplementation of Bacillus licheniformis can significantly reduce intestinal lesion scores in broilers challenged with subclinical necrotic enteritis (SNE), modulate intestinal mucosal barrier function, activate mucosal immune responses, and regulate intestinal microbial structure. It has potential applications in the growth, immunity, and intestinal health of broilers.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Fisheries
Yong Shi, Yuanxiang Liu, Kai Xie, Jihong Dai, Ya Wang, Shouqi Xie, Yi Hu, Lei Zhong
Summary: High cottonseed meal diets have negative effects on the growth and intestinal health of aquatic animals. Sanguinarine supplementation in these diets can improve growth, enhance intestinal antioxidant ability, alleviate intestinal barrier damage, and ameliorate intestinal microbiota homeostasis.
Article
Agriculture, Dairy & Animal Science
Eunjoo Kim, Amy F. Moss, Natalie K. Morgan, Kosar Gharib-Naseri, Peter Ader, Mingan Choct
Summary: The present study investigated the effect of supplementing fibre-degrading enzymes on the severity of subclinical necrotic enteritis (NE) in broiler chickens offered wheat- or maize-based diets. The findings showed that adding fibre-degrading enzymes can alleviate the negative impact of NE on growth performance in birds, and the type of diet and enzyme supplementation affect growth performance and digesta viscosity in the birds.
Article
Immunology
Zhiyuan Lu, Lin Feng, Wei-Dan Jiang, Pei Wu, Yang Liu, Jun Jiang, Sheng-Yao Kuang, Ling Tang, Shu-Wei Li, Xiang-An Liu, Cheng-Bo Zhong, Xiao-Qiu Zhou
Summary: The study found that dietary Mannan oligosaccharides (MOS) supplementation can reduce skin lesion morbidity in grass carp challenged by pathogenic bacteria, maintain skin barrier function by improving antioxidant capacity, inhibiting cell apoptosis, and strengthening cell connections. Additionally, MOS can regulate immune barrier function by modulating the expression of immune factors and related signaling pathways.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Ning Sun, Yan Xue, Siyi Wei, Bangyuan Wu, Hesong Wang, Dong Zeng, Ying Zhao, Abdul Khalique, Kangcheng Pan, Yan Zeng, Gang Shu, Bo Jing, Xueqin Ni
Summary: This study explores the combined application of BS15 and H2 for the control of SNE in broilers. The results show that the combined application has a positive effect on growth performance, promotes intestinal development, and improves immune levels.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Veterinary Sciences
Caiyun Yu, Yichun Tong, Qiming Li, Tian Wang, Zaibin Yang
Summary: This study investigated the alleviative effects of trans-anethole on intestinal oxidative stress in subclinical necrotic enteritis infected broilers. The results showed that trans-anethole improved the growth performance and enhanced the intestinal antioxidant status of the infected broilers.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Environmental Sciences
Andong Zha, Ruiqi Tu, Ming Qi, Jing Wang, Bie Tan, Peng Liao, Chenchen Wu, Yulong Yin
Summary: The study showed that dietary supplementation of MOSS had beneficial effects on ETEC-induced diarrhea in weaned piglets, increasing growth performance, reducing diarrhea incidence, and regulating intestinal microbiota composition. MOSS also decreased inflammation and oxidative stress, and improved intestinal barrier function.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Pharmacology & Pharmacy
Yongfu Wang, Jingjing Liu, Ziwei Huang, Yucui Li, Yuanyuan Liang, Chaodan Luo, Chen Ni, Jianhui Xie, Ziren Su, Jiannan Chen, Cailan Li
Summary: Coptisine has demonstrated therapeutic effects on ulcerative colitis by maintaining the integrity of the intestinal epithelial barrier, inhibiting apoptosis, and inflammatory response.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Gastroenterology & Hepatology
Sweta Ghosh, Caleb Samuel Whitley, Bodduluri Haribabu, Venkatakrishna Rao Jala
Summary: This review discusses the recent advances in understanding the role of gut microbial metabolites in regulating intestinal barrier function. While the mechanisms of action of these metabolites are still being explored, they likely impact gut barrier function through shared pathways. Utilizing beneficial microbiota and their metabolites to restore pathophysiological balance may prove to be a valuable therapeutic tool amidst advancing technology and expanding knowledge.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Nutrition & Dietetics
Aya Harasawa, Shiori Ishiyama, Kazuki Mochizuki
Summary: This study found that indigestible carbohydrates can directly strengthen tight junctions in intestinal absorptive cells and investigated the association between genes constructing tight junctions and other genes using mRNA microarray analysis. The results showed that intake of fructo-oligosaccharides could decrease the expression of CLDN2 gene, which weakens tight junctions, and increase the expression of CLDN4 gene, which strengthens tight junctions, in Caco-2 cells. It also induced the expression of inflammatory genes, including CLEC7A.
Review
Agriculture, Dairy & Animal Science
Nima K. Emami, Rami A. Dalloul
Summary: Necrotic enteritis (NE) is a significant enteric disease in commercial poultry, causing considerable economic losses. The use of antibiotic growth promoters (AGPs) has been effective in maintaining enteric health and improving production efficiency of broilers. However, with the removal of AGPs, there is a need to intensify research on alternative solutions to support gut health.
Article
Agriculture, Dairy & Animal Science
Kosar Gharib-Naseri, Sarbast K. Kheravii, Lily Li, Shu-Biao Wu
Summary: The study indicates that high doses of Amasil NA and low doses of BalanGut LS P significantly improve performance in broilers under NE challenge, while antibiotics reduce feed conversion ratio in the grower and finisher stages, with high doses of Amasil NA improving FCR in the finisher stage.
Article
Biotechnology & Applied Microbiology
Xiaomin Yu, Min Wei, Dong Yang, Xiaoli Wu, Hua Wei, Feng Xu
Summary: This study found that the probiotic Lactiplantibacillus plantarum FLPL05 significantly prolonged the lifespan of aged mice by improving the integrity of the intestinal barrier and reducing inflammation. Analysis of the intestinal microbiota showed that FLPL05 altered the composition of the microbiota, favoring intestinal health. Proteomic analysis further revealed the mechanism of action, indicating that FLPL05 protected intestinal cells by regulating the expression of tight junction proteins and apoptosis-related proteins.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Biotechnology & Applied Microbiology
Hongna Zhang, Jingbo Liu, Lei Wang, Zhenzhen Zhai
Summary: Glyphosate has been found to accelerate the horizontal transfer of conjugative plasmids carrying antibiotic resistance genes in bacteria by regulating the expression levels of related genes through the over-production of reactive oxygen and nitrogen species. This study sheds new light on the biological effects of glyphosate on antibiotic resistance genes.
Article
Environmental Sciences
Yufeng Xin, Zhenzhen Zhai, Xiaohua Qu
Summary: In this study, a Pb-resistant acetochlor-degrading bacterial strain belonging to the Serratia genus was isolated. The strain QSxin4 can efficiently degrade acetochlor and reduce its toxic effects on seed germination in the presence of high concentrations of Pb, showing potential for bioremediation of acetochlor-contaminated soil.
WATER AIR AND SOIL POLLUTION
(2021)