The applications of catalytic asymmetric halocyclization in natural product synthesis

Halocyclization of olefinic substrate enables the establishment of cyclic skeletons via intramolecular halonium-induced nucleophilic addition, which has been well utilized as a practical strategy for constructing cyclic skeletons in natural product synthesis. Recently, the renaissance and rapid evolution of organocatalysis have accelerated the development of catalytic asymmetric halocyclization. In this context, natural product synthesis powered by catalytic asymmetric halocyclization has also achieved considerable progress in recent years. In some cases, these newly developed protocols enable more concise synthetic routes for accessing enantioenriched natural products. To this end, this review summarizes the applications of catalytic asymmetric halocyclization in natural product synthesis.

Automated summary

Halocyclization of olefinic substrate has been widely used as a practical strategy for constructing cyclic skeletons in natural product synthesis. The renaissance and rapid evolution of organocatalysis have accelerated the development of catalytic asymmetric halocyclization, leading to considerable progress in the field of natural product synthesis. These new protocols enable more concise synthetic routes for accessing enantioenriched natural products in some cases.