Article
Plant Sciences
Joel A. Mercado-Reyes, Talitha Soares Pereira, Anju Manandhar, Ian M. Rimer, Scott A. M. Mcadam
Summary: The phytohormone ABA plays a role in regulating stomata closure and desiccation tolerance pathways during drought. Some plants show a peaking-type response in ABA levels, with an initial increase followed by a decrease as drought progresses. This study found that the mechanism driving the decline in ABA levels may be conserved in embolism-resistant seed plants and is mediated by sustained conjugation of ABA and deactivation of ABA accumulation as leaf water potential becomes more negative.
PLANT CELL AND ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Marta Baczewska, Elzbieta Supruniuk, Klaudia Bojczuk, Pawel Guzik, Patrycja Milewska, Katarzyna Kononczuk, Jakub Dobroch, Adrian Chabowski, Pawel Knapp
Summary: The study aimed to assess the dominant energy substrate transport mechanism in ovarian cancer cells and predict clinical outcomes using genomic aberrations. The researchers found differential gene expression in high-grade serous carcinoma and suggested the potential use of glucose and lactate transport as therapeutic targets to impede ovarian cancer growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Physiology
Nedra Abdelli, Alison Ramser, Elizabeth S. Greene, Lesleigh Beer, Travis W. Tabler, Sara K. Orlowski, Jose Francisco Perez, David Sola-Oriol, Nicholas B. Anthony, Sami Dridi
Summary: The study revealed that heat stress affects body weight and the gene expression of nutrient transporters in the jejunum of different broiler populations, showing diverse impacts among populations.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Plant Sciences
Jayant Kulkarni, Sripati A. Sahoo, Pawel Herzyk, Vitthal T. Barvkar, Sanjukta A. Kumar, Janani Ravichandran, Areejit Samal, Anna Amtmann, Mahesh Borde, Penna Suprasanna, Ashish K. Srivastava
Summary: Sesuvium portulacastrum is a halophyte that can naturally grow in saline environments. It can tolerate high concentrations of NaCl without significant growth reduction. After salt treatment, it accumulates beneficial substances and restores transcriptional activity. The overexpression of gene SpRAB18 in soybean increases biomass and maintains growth benefits even under high salt conditions. Additionally, the development of an open-access transcriptome database SesuviumKB provides a platform for studying the functional genes of S. portulacastrum and engineering salt tolerance in crops.
PLANT CELL AND ENVIRONMENT
(2023)
Review
Plant Sciences
Simranjeet Singh, Vijay Kumar, Parul Parihar, Daljeet Singh Dhanjal, Rachana Singh, Praveen C. Ramamurthy, Ram Prasad, Joginder Singh
Summary: This article discusses the impact of stress caused by abiotic factors on plant growth and productivity, especially how drought conditions affect plants by disrupting water balance and ion homeostasis. Plants have evolved transportation systems to survive under drought stress, utilizing channels and transporters such as ABA, proteins, and carbohydrates.
PLANT CELL REPORTS
(2021)
Article
Chemistry, Medicinal
Xiao-Wei Liu, Tian-Yu Shi, Dong Gao, Cai-Yi Ma, Hao Lin, Dan Yan, Ke-Jun Deng
Summary: Diabetes mellitus is a chronic metabolic disease that disrupts blood glucose homeostasis and leads to severe complications. The development of artificial intelligence has provided a powerful tool, iPADD, for accelerating the discovery of potential antidiabetic drugs. iPADD achieved high accuracy in drug prediction by using molecular fingerprints and machine learning algorithms.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Editorial Material
Plant Sciences
Agata Daszkowska-Golec
Summary: Recent reports highlight the significant impact of long-distance abscisic acid (ABA) transport on plant growth and physiology under both non-stress and stress conditions. Understanding ABA transport may provide valuable insights for modulating plant response to climate change.
TRENDS IN PLANT SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Jincheng Shen, Jie Liu, Yongge Yuan, Luxi Chen, Junxia Ma, Xin Li, Junmin Li
Summary: Under low temperature stress, Fragaria daltoniana and F. vesca adjust their response by regulating the accumulation of ABA and the expression of transcription factors. F. daltoniana has higher levels of ABA accumulation and glucose signaling, which contribute to its stronger cold tolerance.
Article
Ophthalmology
Sachiko Iwai, Tomoko Hasegawa, Hanako Ohashi Ikeda, Akitaka Tsujikawa
Summary: This study demonstrates that BCAAs enhance intracellular ATP production by promoting glucose uptake through translocation of glucose transporters to the plasma membrane. These findings have implications for the clinical application of BCAAs in treating retinal neurodegenerative diseases.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Plant Sciences
Wei-Jian Sun, Jiu-Cheng Zhang, Xing-Long Ji, Zi-Quan Feng, Xun Wang, Wen-Jing Huang, Chun-Xiang You, Xiao-Fei Wang, Yu-Jin Hao
Summary: The study found that the application of low nitrate can alleviate iron chlorosis symptoms in apple leaves and promote iron uptake in roots. In addition, low nitrate also increases the accumulation of citrate and abscisic acid in roots, facilitating iron transport.
PLANT CELL AND ENVIRONMENT
(2021)
Article
Chemistry, Medicinal
Keum-soo Song, Satish Balasaheb Nimse, Junghoon Kim, Shrikant Dashrath Warkad, Taisun Kim
Summary: The developed ID-Checker enables highly specific delivery of anticancer agents to cancer cells through GLUT channels, resulting in cancer cell death within a short period of time without causing damage to normal cells.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Letter
Biochemistry & Molecular Biology
Nicolas Papon, Vincent Courdavault
Summary: Salt stress interrupts the cytokinin transduction pathway by promoting the degradation of some cytokinin signaling modules, inhibiting plant growth and development under stress conditions.
Article
Multidisciplinary Sciences
Bo Xu, Yu Long, Xueying Feng, Xujun Zhu, Na Sai, Larissa Chirkova, Annette Betts, Johannes Herrmann, Everard J. Edwards, Mamoru Okamoto, Rainer Hedrich, Matthew Gilliham
Summary: The study shows that GABA production in guard cells of Arabidopsis reduces stomatal opening and transpirational water loss, thereby enhancing water use efficiency. This highlights a novel role for GABA metabolism in fine tuning plant physiology and offers new possibilities for enhancing plant stress resilience.
NATURE COMMUNICATIONS
(2021)
Article
Plant Sciences
Sofia Racca, Diana E. Gras, M. Victoria Canal, Lucia V. Ferrero, Bruno E. Rojas, Carlos M. Figueroa, Federico D. Ariel, Elina Welchen, Daniel H. Gonzalez
Summary: During seed germination, the protein cytochrome c plays an important role in respiratory metabolism and energy production. It affects the sensitivity of germination to ABA and is regulated by the transcription factor ABI4. This establishes a link between mitochondrial and hormonal functions during seed germination.
Article
Multidisciplinary Sciences
Laura Bacete, Julia Schulz, Timo Engelsdorf, Zdenka Bartosova, Lauri Vaahtera, Guqi Yan, Joachim Matthias Gerhold, Tereza Ticha, Camilla Ovstebo, Nora Gigli-Bisceglia, Svanhild Johannessen-Starheim, Jeremie Margueritat, Hannes Kollist, Thomas Dehoux, Scott A. M. McAdam, Thorsten Hamann
Summary: Plant cells have a mechanism to maintain the integrity of their cell walls, which involves adaptive responses to wall damage. The cell wall integrity sensor THESEUS1 plays a key role in regulating mechanical properties, abscisic acid production, and jasmonic acid production in response to wall damage. This mechanism coordinates changes in cell wall stiffness and turgor pressure.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Hematology
Roberta Pece, Sara Tavella, Delfina Costa, Serena Varesano, Caterina Camodeca, Doretta Cuffaro, Elisa Nuti, Armando Rossello, Massimo Alfano, Cristina D'Arrigo, Denise Galante, Jean-Louis Ravetti, Marco Gobbi, Francesca Tosetti, Alessandro Poggi, Maria Raffaella Zocchi
Summary: This study investigates the combined effect of ADAM10 inhibitors and ADC drug BtxVed on lymphoma treatment. By establishing 3D culture models, the study found that ADAM10 inhibitors enhance the anti-lymphoma effect of BtxVed and provide a reliable drug testing tool that recapitulates the LN microenvironment.
Article
Radiology, Nuclear Medicine & Medical Imaging
Victor M. Baart, Labrinus van Manen, Shadhvi S. Bhairosingh, Floris A. Vuijk, Luisa Iamele, Hugo de Jonge, Claudia Scotti, Massimo Resnati, Robert A. Cordfunke, Peter J. K. Kuppen, Andrew P. Mazar, Jacobus Burggraaf, Alexander L. Vahrmeijer, Cornelis F. M. Sier
Summary: In this study, fluorescence-guided surgery using uPAR-targeting antibody fragments resulted in earlier tumor visualization compared to the parent IgG, but at the expense of peak fluorescence intensity.
MOLECULAR IMAGING AND BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Maristella Maggi, Claudia Scotti
Summary: This study describes for the first time the molecular structure of type II asparaginase from Escherichia coli in complex with its secondary product, L-glutamate. Analysis of the structure reveals that reduced catalytic efficiency in the presence of L-glutamine is caused by its misfitting into the enzyme-binding pocket and a local change in the catalytic center geometry. Additionally, tight interaction between the protomers in the enzyme active site limits the capability of L-glutamine to fit into the binding pocket of E. coli L-asparaginase.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Anna Sbalchiero, Yasmin Abu Hweij, Tommaso Mazza, Elisabetta Buscarini, Claudia Scotti, Fabio Pagella, Guido Manfredi, Elina Matti, Giuseppe Spinozzi, Carla Olivieri
Summary: This study demonstrates, for the first time, a founder effect for a HHT pathogenic variant in Italy. The variant, a deletion in the coding region of the ACVRL1 gene, occurred about 200 years ago and affects protein stability and glycosylation site.
MOLECULAR GENETICS & GENOMIC MEDICINE
(2022)
Article
Genetics & Heredity
Ibrahim Taha, Selena Foroni, Roberto Valli, Annalisa Frattini, Pamela Roccia, Giovanni Porta, Marco Zecca, Elena Bergami, Marco Cipolli, Francesco Pasquali, Cesare Danesino, Claudia Scotti, Antonella Minelli
Summary: A reanalysis of available WES files of SDS patients with biallelic SBDS pathogenic variants was performed, and the results were studied using next bioinformatic and protein structural analysis. Clinical attention was given to the patient focused in this study.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Mirko Magnone, Sonia Spinelli, Giulia Begani, Lucrezia Guida, Laura Sturla, Laura Emionite, Elena Zocchi
Summary: This study demonstrates that the plant hormone ABA can improve glycemic control and enhance muscle insulin sensitivity and glucose uptake in a murine model of T1D.
Article
Biology
Giovanni de Nola, Berenice Leclercq, Alexandra Mougel, Solenne Taront, Claire Simonneau, Federico Forneris, Eric Adriaenssens, Herve Drobecq, Luisa Iamele, Laurent Dubuquoy, Oleg Melnyk, Ermanno Gherardi, Hugo de Jonge, Jerome Vicogne
Summary: Hepatocyte growth factor/scatter factor (HGF/SF) and its receptor MET play important roles in embryogenesis and regeneration of epithelial organs. However, the limited stability and diffusion of native HGF/SF have led to a search for HGF/SF mimics. This study introduces K1K1, a novel MET agonist that is highly stable and displays superior biological activity compared to native HGF/SF, suggesting its potential applications in the treatment of acute and chronic liver diseases.
LIFE SCIENCE ALLIANCE
(2022)
Article
Cell Biology
Sonia Spinelli, Lucrezia Guida, Tiziana Vigliarolo, Mario Passalacqua, Giulia Begani, Mirko Magnone, Laura Sturla, Andrea Benzi, Pietro Ameri, Edoardo Lazzarini, Claudia Bearzi, Roberto Rizzi, Elena Zocchi
Summary: In this study, the role of ABA-LANCL1/2 system in cardiomyocyte protection against hypoxia mediated by NO was investigated. The results showed that ABA stimulated NO production and increased the survival of cardiomyocytes under hypoxic conditions. ABA also enhanced glucose uptake and phosphorylation of Akt, AMPK and eNOS, which are involved in cell survival and energy metabolism. Overexpression or silencing of LANCL1/2 affected the expression and phosphorylation of AMPK, Akt and eNOS, as well as the mitochondrial function and cell vitality after hypoxia/reoxygenation.
Article
Biochemistry & Molecular Biology
Isabella Guardamagna, Ombretta Iaria, Leonardo Lonati, Alice Mentana, Andrea Previtali, Virginia Ugge, Giovanni Battista Ivaldi, Marco Liotta, Paola Tabarelli de Fatis, Claudia Scotti, Greta Pessino, Maristella Maggi, Giorgio Baiocco
Summary: Colorectal cancer (CRC) has the highest incidence (38.7 per 100,000 people) and mortality (13.9 per 100,000 people) rates among colon cancers. The poor response of CRC to standard therapies is attributed to its high heterogeneity and complex genetic background. The dysregulation or depletion of the tumor suppressor p53 is involved in its transformation and ability to resist therapy, particularly in p53(null) cancer subtypes with a poor prognosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Andrea Benzi, Sonia Spinelli, Laura Sturla, Markus Heine, Alexander W. Fischer, Friedrich Koch-Nolte, Hans-Willi Mittruecker, Andreas H. Guse, Antonio De Flora, Joerg Heeren, Santina Bruzzone
Summary: This study investigates the role of CD38 in liver thermogenesis and suggests that CD38 inhibition can be a strategy to boost NAD(+) levels without negatively affecting liver functions.
Review
Biochemistry & Molecular Biology
Andrea Angeletti, Maurizio Bruschi, Xuliana Kajana, Sonia Spinelli, Enrico Verrina, Francesca Lugani, Gialuca Caridi, Corrado Murtas, Giovanni Candiano, Marco Prunotto, Gian Marco Ghiggeri
Summary: Glomerulonephritis is a renal disorder caused by various pathogenic mechanisms. Understanding the details of the pathogenic cascade is crucial in limiting disease progression. The balance between tissue injury, protective systems activation, and tissue repair determines the outcome. Oxidative stress plays a role in glomerular inflammation, and the activation of antioxidant systems is important in reducing tissue damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Sonia Spinelli, Vanessa Cossu, Mario Passalacqua, Jacob B. Hansen, Lucrezia Guida, Mirko Magnone, Gianmario Sambuceti, Cecilia Marini, Laura Sturla, Elena Zocchi
Summary: The ABA/LANCL system regulates glucose uptake, mitochondrial respiration, and proton gradient dissipation in myocytes. The study aimed to investigate its role in human white and brown adipocyte thermogenesis. LANCL1/2 overexpression increases mitochondrial number, respiration rates, and transcription of thermogenic genes; while silencing LANCL1/2 reduces these effects. ABA-treated mice lacking LANCL2 but overexpressing LANCL1 also show enhanced transcription of receptors for browning hormones in brown adipose tissue. The ABA/LANCL system controls human brown and beige adipocyte thermogenesis through a signaling pathway involving AMPK, PGC-1 alpha, Sirt1, and ERR alpha.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Sonia Spinelli, Lucrezia Guida, Mario Passalacqua, Mirko Magnone, Vanessa Cossu, Gianmario Sambuceti, Cecilia Marini, Laura Sturla, Elena Zocchi
Summary: The cross-kingdom stress hormone abscisic acid (ABA) and its mammalian receptors LANCL1 and LANCL2 regulate the response of cardiomyocytes to hypoxia by activating NO generation. Overexpression of LANCL1/2 enhances eNOS activity and improves cell vitality after hypoxia/reoxygenation via the AMPK/PGC-1 alpha axis. Furthermore, the ABA/LANCL system has significant effects on mitochondrial oxidative metabolism and structural proteins in cardiomyoblasts.
Review
Biochemistry & Molecular Biology
Edoardo La Porta, Ottavia Exacoustos, Francesca Lugani, Andrea Angeletti, Decimo Silvio Chiarenza, Carolina Bigatti, Sonia Spinelli, Xhuliana Kajana, Andrea Garbarino, Maurizio Bruschi, Giovanni Candiano, Gianluca Caridi, Nicoletta Mancianti, Marta Calatroni, Daniela Verzola, Pasquale Esposito, Francesca Viazzi, Enrico Verrina, Gian Marco Ghiggeri
Summary: Plastic pollution has become a major challenge for humans, with microplastics being found ubiquitously in human tissues and fluids. Limited evidence suggests potential harmful effects of microplastics on human cells, mediated by oxidative stress, inflammation, and fibrosis. Studies on the impact of microplastics on kidneys are insufficient, but animal models have shown histological and functional alterations, as well as cytotoxicity, in kidney cells. Urgent further research is needed to analyze the potential correlation between kidney disease and exposure to microplastics in humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Liujun Chen, Lisha Li, Donghong Cui, Yiheng Huang, Haibin Tong, Haleh Zabihi, Shuxia Wang, Yadan Qi, Ted Lakowski, Lin Leng, Suixin Liu, Hong Wu, Lawrence H. Young, Richard Bucala, Dake Qi
Summary: Attenuation of adipose hormone sensitive lipase (HSL) may impair lipolysis and exacerbate obesity. Cytokine macrophage migration inhibitory factor (MIF) plays a role in regulating adipose HSL and adipocyte hypertrophy. Both intracellular and extracellular MIF have opposing effects on HSL, but extracellular action predominates to downregulate HSL and exacerbate obesity development during high-fat diet (HFD).
MOLECULAR METABOLISM
(2024)
Article
Endocrinology & Metabolism
Mengyang Tang, Yi Zhang, Rong Zhang, Yuemei Zhang, Jiangfei Zheng, Daixi Wang, Xinyu Wang, Jing Yan, Cheng Hu
Summary: This study aimed to explore the role of GPSM1 in POMC neurons and the underlying mechanisms in metabolic homeostasis. Through various molecular, biochemical, immunofluorescent, immunohistochemical analyses, and cell culture studies, the study revealed the pathophysiological role of GPSM1 in POMC neurons and its regulation of POMC neuron activity.
MOLECULAR METABOLISM
(2024)