Intranasal Delivery of MVA Vector Vaccine Induces Effective Pulmonary Immunity Against SARS-CoV-2 in Rodents

A modified vaccinia Ankara vector-based vaccine protects macaques from SARS-CoV-2 infection, immune pathology, and dysfunction in the lungs

(2021) Nanda Kishore Routhu et al.   IMMUNITY

SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies

(2021) Markus Hoffmann et al.   CELL

Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 variant of concern 202012/01 (B.1.1.7): an exploratory analysis of a randomised controlled trial

(2021) Katherine R W Emary et al.   LANCET

Sensitivity of infectious SARS-CoV-2 B.1.1.7 and B.1.351 variants to neutralizing antibodies

(2021) Delphine Planas et al.   NATURE MEDICINE

Initial report of decreased SARS-CoV-2 viral load after inoculation with the BNT162b2 vaccine

(2021) Matan Levine-Tiefenbrun et al.   NATURE MEDICINE

Effectiveness of the BNT162b2 Covid-19 Vaccine against the B.1.1.7 and B.1.351 Variants

(2021) Laith J. Abu-Raddad et al.   NEW ENGLAND JOURNAL OF MEDICINE

New SARS-CoV-2 Variants — Clinical, Public Health, and Vaccine Implications

(2021) Salim S. Abdool Karim et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy of the ChAdOx1 nCoV-19 Covid-19 Vaccine against the B.1.351 Variant

(2021) Shabir A. Madhi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vasculitis and Neutrophil Extracellular Traps in Lungs of Golden Syrian Hamsters With SARS-CoV-2

(2021) Kathrin Becker et al.   Frontiers in Immunology

Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum

(2021) Chang Liu et al.   CELL

Safety, tolerability, and immunogenicity of an aerosolised adenovirus type-5 vector-based COVID-19 vaccine (Ad5-nCoV) in adults: preliminary report of an open-label and randomised phase 1 clinical trial

(2021) Shipo Wu et al.   LANCET INFECTIOUS DISEASES

Immune responses against SARS-CoV-2 variants after heterologous and homologous ChAdOx1 nCoV-19/BNT162b2 vaccination

(2021) Joana Barros-Martins et al.   NATURE MEDICINE

Effect of Vaccination on Household Transmission of SARS-CoV-2 in England

(2021) Ross J. Harris et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immunogenicity and efficacy of the COVID-19 candidate vector vaccine MVA-SARS-2-S in preclinical vaccination

(2021) Alina Tscherne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protection of K18-hACE2 mice and ferrets against SARS-CoV-2 challenge by a single-dose mucosal immunization with a parainfluenza virus 5–based COVID-19 vaccine

(2021) Dong An et al.   Science Advances

Inhalation Delivery for the Treatment and Prevention of COVID-19 Infection

(2021) Basanth Babu Eedara et al.   Pharmaceutics

Local heroes or villains: tissue-resident memory T cells in human health and disease

(2020) S. C. Sasson et al.   Cellular & Molecular Immunology

Simulation of the clinical and pathological manifestations of Coronavirus Disease 2019 (COVID-19) in golden Syrian hamster model: implications for disease pathogenesis and transmissibility

(2020) Jasper Fuk-Woo Chan et al.   CLINICAL INFECTIOUS DISEASES

Safety and immunogenicity of a modified vaccinia virus Ankara vector vaccine candidate for Middle East respiratory syndrome: an open-label, phase 1 trial

(2020) Till Koch et al.   LANCET INFECTIOUS DISEASES

Pathogenesis and transmission of SARS-CoV-2 in golden hamsters

(2020) Sin Fun Sia et al.   NATURE

Rare driver mutations in head and neck squamous cell carcinomas converge on NOTCH signaling

(2020) Sampath K. Loganathan et al.   SCIENCE

Convergent antibody responses to SARS-CoV-2 in convalescent individuals

(2020) Davide F. Robbiani et al.   NATURE

A SARS-CoV-2 surrogate virus neutralization test based on antibody-mediated blockage of ACE2–spike protein–protein interaction

(2020) Chee Wah Tan et al.   NATURE BIOTECHNOLOGY

Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development

(2020) Masaki Imai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combating COVID-19: MVA Vector Vaccines Applied to the Respiratory Tract as Promising Approach Toward Protective Immunity in the Lung

(2020) Reinhold Förster et al.   Frontiers in Immunology

The receptor binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients

(2020) Lakshmanane Premkumar et al.   Science Immunology

A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2

(2020) Ahmed O. Hassan et al.   CELL

An adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaques

(2020) Liqiang Feng et al.   Nature Communications

Cold-Adapted Live Attenuated SARS-Cov-2 Vaccine Completely Protects Human ACE2 Transgenic Mice from SARS-Cov-2 Infection

(2020) Sang Heui Seo et al.   Vaccines

Intranasal vaccination with a lentiviral vector protects against SARS-CoV-2 in preclinical animal models

(2020) Min-Wen Ku et al.   Cell Host & Microbe

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

(2020) Merryn Voysey et al.   LANCET

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

(2020) Lindsey R. Baden et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

(2020) Fernando P. Polack et al.   NEW ENGLAND JOURNAL OF MEDICINE

Development of a multi-antigenic SARS-CoV-2 vaccine candidate using a synthetic poxvirus platform

(2020) Flavia Chiuppesi et al.   Nature Communications

Memory T Cell Dynamics in the Lung during Influenza Virus Infection

(2019) Angela Pizzolla et al.   JOURNAL OF IMMUNOLOGY

Alternate aerosol and systemic immunisation with a recombinant viral vector for tuberculosis, MVA85A: A phase I randomised controlled trial

(2019) Zita-Rose Manjaly Thomas et al.   PLOS MEDICINE

Human lung tissue resident memory T cells in health and disease

(2019) Mark E Snyder et al.   CURRENT OPINION IN IMMUNOLOGY

Interstitial-resident memory CD8+ T cells sustain frontline epithelial memory in the lung

(2019) Shiki Takamura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Application of light sheet microscopy for qualitative and quantitative analysis of bronchus-associated lymphoid tissue in mice

(2018) David Twapokera Mzinza et al.   Cellular & Molecular Immunology

Intravital mucosal imaging of CD8+ resident memory T cells shows tissue-autonomous recall responses that amplify secondary memory

(2018) Lalit K. Beura et al.   NATURE IMMUNOLOGY

A Single Dose of Modified Vaccinia Ankara expressing Ebola Virus Like Particles Protects Nonhuman Primates from Lethal Ebola Virus Challenge

(2018) Arban Domi et al.   Scientific Reports

Manifold Roles of CCR7 and Its Ligands in the Induction and Maintenance of Bronchus-Associated Lymphoid Tissue

(2018) Henrike Fleige et al.   Cell Reports

The Immune Epitope Database (IEDB): 2018 update

(2018) Randi Vita et al.   NUCLEIC ACIDS RESEARCH

Induction of Both Local Immune Response in Mice and Protection in a Rabbit Model by Intranasal Immunization with Modified Vaccinia Ankara Virus Expressing a Secreted Form of Bovine Herpesvirus 1 Glycoprotein D

(2017) María Paula Del Medico Zajac et al.   VIRAL IMMUNOLOGY

Harnessing Local Immunity for an Effective Universal Swine Influenza Vaccine

(2017) et al.   Viruses-Basel

Specific niches for lung-resident memory CD8 + T cells at the site of tissue regeneration enable CD69-independent maintenance

(2016) Shiki Takamura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Induction of mucosal immunity through systemic immunization: Phantom or reality?

(2016) Fei Su et al.   Human Vaccines & Immunotherapeutics

Protective Efficacy of Recombinant Modified Vaccinia Virus Ankara Delivering Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein

(2015) Asisa Volz et al.   JOURNAL OF VIROLOGY

An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels

(2015) B. L. Haagmans et al.   SCIENCE

Tissue-Resident Memory T Cells

(2014) Jason M. Schenkel et al.   IMMUNITY

IL-17–induced CXCL12 recruits B cells and induces follicle formation in BALT in the absence of differentiated FDCs

(2014) Henrike Fleige et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Safety and immunogenicity of a candidate tuberculosis vaccine MVA85A delivered by aerosol in BCG-vaccinated healthy adults: a phase 1, double-blind, randomised controlled trial

(2014) Iman Satti et al.   LANCET INFECTIOUS DISEASES

Evaluation of the Safety and Immunogenicity of a Candidate Tuberculosis Vaccine, MVA85A, Delivered by Aerosol to the Lungs of Macaques

(2013) A. D. White et al.   Clinical and Vaccine Immunology

Lung-resident memory CD8 T cells (TRM ) are indispensable for optimal cross-protection against pulmonary virus infection

(2013) Tao Wu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Middle East Respiratory Syndrome Coronavirus Spike Protein Delivered by Modified Vaccinia Virus Ankara Efficiently Induces Virus-Neutralizing Antibodies

(2013) F. Song et al.   JOURNAL OF VIROLOGY

Clinical development of Modified Vaccinia virus Ankara vaccines

(2013) Sarah C. Gilbert   VACCINE

Multi-Faceted Functions of Secretory IgA at Mucosal Surfaces

(2013) Blaise Corthésy   Frontiers in Immunology

Induction of BALT in the absence of IL-17

(2011) Henrike Fleige et al.   NATURE IMMUNOLOGY

Long term recall of memory CD8 T cells in mice to first and third generation smallpox vaccines

(2011) Sharone Green et al.   VACCINE

Candidate influenza vaccines based on recombinant modified vaccinia virus Ankara

(2009) Guus F Rimmelzwaan et al.   Expert Review of Vaccines

Induced bronchus-associated lymphoid tissue serves as a general priming site for T cells and is maintained by dendritic cells

(2009) Stephan Halle et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inducible Bronchus-Associated Lymphoid Tissue Elicited by a Protein Cage Nanoparticle Enhances Protection in Mice against Diverse Respiratory Viruses

(2009) James A. Wiley et al.   PLoS One

Aerosol immunization with NYVAC and MVA vectored vaccines is safe, simple, and immunogenic

(2008) M. Corbett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA