Ramelteon protects against human pulmonary microvascular endothelial cell injury induced by lipopolysaccharide (LPS) via activating nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway

Panaxydol attenuates ferroptosis against LPS-induced acute lung injury in mice by Keap1-Nrf2/HO-1 pathway

(2021) Jiucui Li et al.   Journal of Translational Medicine

Protective Effects of Pterostilbene on Lipopolysaccharide-Induced Acute Lung Injury in Mice by Inhibiting NF-κB and Activating Nrf2/HO-1 Signaling Pathways

(2021) Yong Zhang et al.   Frontiers in Pharmacology

MitoQ protects against hyperpermeability of endothelium barrier in acute lung injury via a Nrf2-dependent mechanism

(2021) Mengyuan Cen et al.   Redox Biology

Ramelteon Ameliorates LPS-Induced Hyperpermeability of the Blood-Brain Barrier (BBB) by Activating Nrf2

(2021) Yonglei Liu et al.   INFLAMMATION

Botanical formulation, TADIOS, alleviates lipopolysaccharide (LPS)-Induced acute lung injury in mice via modulation of the Nrf2-HO-1 signaling pathway

(2021) Wonwoo Lee et al.   JOURNAL OF ETHNOPHARMACOLOGY

Melatonin receptor agonist ramelteon attenuates mouse acute and chronic ischemic brain injury

(2020) Xiao-li Wu et al.   ACTA PHARMACOLOGICA SINICA

Acute Lung Injury

(2020) Nathan T. Mowery et al.   CURRENT PROBLEMS IN SURGERY

Critical role of mitochondrial oxidative stress in acid aspiration induced ALI in mice

(2020) Gayatri Puri et al.   TOXICOLOGY MECHANISMS AND METHODS

Alveolar macrophage - derived exosomes modulate severity and outcome of acute lung injury

(2020) Cong Ye et al.   Aging-US

The Melatonin Receptor Agonist Ramelteon Induces Cardioprotection that Requires MT2 Receptor Activation and Release of Reactive Oxygen Species

(2020) Martin Stroethoff et al.   CARDIOVASCULAR DRUGS AND THERAPY

Acute lung injury: The therapeutic role of Rho kinase inhibitors

(2020) Farshad Abedi et al.   PHARMACOLOGICAL RESEARCH

The Implication of Oxidative Stress and AMPK-Nrf2 Antioxidative Signaling in Pneumonia Pathogenesis

(2020) Weitong Xu et al.   Frontiers in Endocrinology

Non-GABA sleep medications, suvorexant as risk factors for falls: Case-control and case-crossover study

(2020) Yoshiki Ishibashi et al.   PLoS One

The Protective Effects of Ramelteon Against Isoflurane-Induced Insults and Inflammatory Response in Brain Microvascular Endothelial Cells

(2020) Tao Wang et al.   NEUROTOXICITY RESEARCH

Endothelial SIRT6 Is Vital to Prevent Hypertension and Associated Cardiorenal Injury Through Targeting Nkx3.2-GATA5 Signaling

(2019) Jian Guo et al.   CIRCULATION RESEARCH

Baicalin ameliorates lipopolysaccharide-induced acute lung injury in mice by suppressing oxidative stress and inflammation via the activation of the Nrf2-mediated HO-1 signaling pathway

(2019) Xiangli Meng et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Biomarkers of Acute Lung Injury The Individualized Approach: for Phenotyping, Risk Stratification and Treatment Surveillance

(2019) Daniel D. Murray et al.   Journal of Clinical Medicine

Effect of Administration of Ramelteon, a Melatonin Receptor Agonist, on the Duration of Stay in the ICU

(2018) Mitsuaki Nishikimi et al.   CRITICAL CARE MEDICINE

Ripasudil Attenuates Lipopolysaccharide (LPS)-Mediated Apoptosis and Inflammation in Pulmonary Microvascular Endothelial Cells via ROCK2/eNOS Signaling

(2018) Jianxin Yang et al.   MEDICAL SCIENCE MONITOR

Hypoxia Exacerbates Inflammatory Acute Lung Injury via the Toll-Like Receptor 4 Signaling Pathway

(2018) Gang Wu et al.   Frontiers in Immunology

Activating Mas receptor protects human pulmonary microvascular endothelial cells against LPS‐induced apoptosis via the NF‐kB p65/P53 feedback pathways

(2018) Weifeng Huang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Melatonin receptor activation provides cerebral protection after traumatic brain injury by mitigating oxidative stress and inflammation via the Nrf2 signaling pathway

(2018) Junmin Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Acute Lung Injury: A Clinical and Molecular Review

(2016) Yasmeen Butt et al.   ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism

(2016) Agnieszka Loboda et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Molecular mechanisms in lipopolysaccharide-induced pulmonary endothelial barrier dysfunction

(2015) Han Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Tumor Necrosis Factor Alpha: A Link between Neuroinflammation and Excitotoxicity

(2014) Gabriel Olmos et al.   MEDIATORS OF INFLAMMATION

Melatonin ameliorates Angiotensin II-induced vascular endothelial damage via its antioxidative properties

(2013) Tomoko Nakao et al.   JOURNAL OF PINEAL RESEARCH

Quantitative assessment of the microcirculation in healthy volunteers and in patients with septic shock*

(2012) Vanina S. Kanoore Edul et al.   CRITICAL CARE MEDICINE

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Ramelteon: a review of its therapeutic potential in sleep disorders

(2009) Seithikurippu R. Pandi-Perumal et al.   ADVANCES IN THERAPY

Acute Lung Injury Review

(2009) Kenji Tsushima et al.   INTERNAL MEDICINE

Selective activation of melatonin receptors with ramelteon improves liver function and hepatic perfusion after hemorrhagic shock in rat

(2008) Alexander M. Mathes et al.   CRITICAL CARE MEDICINE