Melatonin affects hypoxia-inducible factor 1α and ameliorates delayed brain injury following subarachnoid hemorrhage via H19/miR-675/HIF1A/TLR4

Long non-coding RNA and microRNA-675/let-7a mediates the protective effect of melatonin against early brain injury after subarachnoid hemorrhage via targeting TP53 and neural growth factor

(2018) Song Yang et al.   Cell Death & Disease

Identifying Involvement of H19-miR-675-3p-IGF1R and H19-miR-200a-PDCD4 in Treating Pulmonary Hypertension with Melatonin

(2018) Ran Wang et al.   Molecular Therapy-Nucleic Acids

Melatonin-mediated mitophagy protects against early brain injury after subarachnoid hemorrhage through inhibition of NLRP3 inflammasome activation

(2017) Shenglong Cao et al.   Scientific Reports

Emerging Markers of Early Brain Injury and Delayed Cerebral Ischemia in Aneurysmal Subarachnoid Hemorrhage

(2017) Fawaz Al-Mufti et al.   World Neurosurgery

Long noncoding RNA H19 mediates melatonin inhibition of premature senescence of c-kit+cardiac progenitor cells by promoting miR-675

(2016) Benzhi Cai et al.   JOURNAL OF PINEAL RESEARCH

Effects of Toll-Like Receptor 4 Antagonists Against Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage in Mice

(2016) Fumihiro Kawakita et al.   MOLECULAR NEUROBIOLOGY

MiR675-5p Acts on HIF-1α to Sustain Hypoxic Responses: A New Therapeutic Strategy for Glioma

(2016) Alessia Lo Dico et al.   Theranostics

The non-coding RNAs of the H19-IGF2 imprinted loci: A focus on biological roles and therapeutic potential in Lung Cancer

(2015) Imad J Matouk et al.   Journal of Translational Medicine

H19-derived miR-675 contributes to bladder cancer cell proliferation by regulating p53 activation

(2015) Changkun Liu et al.   TUMOR BIOLOGY

The H19/let-7 double-negative feedback loop contributes to glucose metabolism in muscle cells

(2014) Yuan Gao et al.   NUCLEIC ACIDS RESEARCH

What is Early Brain Injury?

(2014) Hidenori Suzuki   Translational Stroke Research

The role of microglia and the TLR4 pathway in neuronal apoptosis and vasospasm after subarachnoid hemorrhage

(2013) Khalid A Hanafy   Journal of Neuroinflammation

Melatonin activates the Nrf2-ARE pathway when it protects against early brain injury in a subarachnoid hemorrhage model

(2012) Zhong Wang et al.   JOURNAL OF PINEAL RESEARCH

On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK

(2012) Annia Galano et al.   JOURNAL OF PINEAL RESEARCH

The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1r

(2012) Andrew Keniry et al.   NATURE CELL BIOLOGY

The importance of early brain injury after subarachnoid hemorrhage

(2012) Fatima A. Sehba et al.   PROGRESS IN NEUROBIOLOGY

Progesterone Administration Modulates Cortical TLR4/NF-κB Signaling Pathway after Subarachnoid Hemorrhage in Male Rats

(2011) Zhong Wang et al.   MEDIATORS OF INFLAMMATION

Oxygen Sensing, Homeostasis, and Disease

(2011) Gregg L. Semenza   NEW ENGLAND JOURNAL OF MEDICINE

Endothelial Nitric Oxide Synthase Mediates Endogenous Protection Against Subarachnoid Hemorrhage-Induced Cerebral Vasospasm

(2011) Ananth K. Vellimana et al.   STROKE

New insights into the role of fatty acids in the pathogenesis and resolution of inflammatory bowel disease

(2010) Darla R. Shores et al.   INFLAMMATORY BOWEL DISEASES

Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis

(2010) Rajnish A. Gupta et al.   NATURE

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Hypoxic stress up-regulates the expression of Toll-like receptor 4 in macrophages via hypoxia-inducible factor

(2009) So Young Kim et al.   IMMUNOLOGY

Melatonin reduces experimental subarachnoid hemorrhage-induced oxidative brain damage and neurological symptoms

(2009) Mehmet Ersahin et al.   JOURNAL OF PINEAL RESEARCH