期刊
ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 7, 期 12, 页码 5363-5396出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.1c00875
关键词
graphene-based nanomaterials; biomedical applications; drug delivery carrier; tissue engineering; antibacterial activity; potential risks
资金
- National Natural Science Foundation of China [81730108]
- Key Project of Zhejiang project Ministry of Science and Technology [2021C03087]
- Key Project of Hangzhou Ministry of Science and Technology [20212013B03]
- Zhejiang Province Basic public welfare research program of China [1579 LGF20H300006]
This review provides a comprehensive summary of the history, synthesis methods, applications, risks, and strategies to reduce toxicity of graphene-based nanomaterials (GBNs) in the biomedical field, as well as analyzing the challenges to be overcome in the future.
Graphene-based nanomaterials (GBNs) have been the subject of research focus in the scientific community because of their excellent physical, chemical, electrical, mechanical, thermal, and optical properties. Several studies have been conducted on GBNs, and they have provided a detailed review and summary of various applications. However, comprehensive comments on biomedical applications and potential risks and strategies to reduce toxicity are limited. In this review, we systematically summarized the following aspects of GBNs in order to fill the gaps: (1) the history, synthesis methods, structural characteristics, and surface modification; (2) the latest advances in biomedical applications (including drug/gene delivery, biosensors, bioimaging, tissue engineering, phototherapy, and antibacterial activity); and (3) biocompatibility, potential risks (toxicity in vivo/vitro and effects on human health and the environment), and strategies to reduce toxicity. Moreover, we have analyzed the challenges to be overcome in order to enhance application of GBNs in the biomedical field.
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