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Fluid Bath-Assisted 3D Printing for Biomedical Applications: From Pre- to Postprinting Stages

期刊

ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 7, 期 10, 页码 4736-4756

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.1c00910

关键词

fluid bath-assisted 3D printing; embedded 3D printing; support bath-enabled 3D printing; fluid bath materials; biomedical applications

资金

  1. University of Nevada, Reno
  2. National Key R&D Program of China [2018YFA0703000]
  3. Fundamental Research Funds for the Central Universities [DUT19ZD202]

向作者/读者索取更多资源

Fluid bath-assisted 3D printing is an innovative strategy that extrudes liquid ink materials into a fluid bath to construct complex 3D structures, broadening material selections for biomedical applications. The technology can be divided into two subcategories and includes three main manufacturing processes: preprinting, printing, and postprinting. Key technical issues include filament formation mechanisms, effects of nozzle movement, and design strategies for printing paths.
Fluid bath-assisted three-dimensional (3D) printing is an innovative 3D printing strategy that extrudes liquid ink materials into a fluid bath to form various 3D configurations. Since the support bath can provide in situ support, extruded filaments are able to freely construct complex 3D structures. Meanwhile, the supporting function of the fluid bath decreases the dependence of the ink material's cross-linkability, thus broadening the material selections for biomedical applications. Fluid bath-assisted 3D printing can be divided into two subcategories: embedded 3D printing and support bath-enabled 3D printing. This review will introduce and discuss three main manufacturing processes, or stages, for these two strategies. The stages that will be discussed include preprinting, printing, and postprinting. In the preprinting stage, representative fluid bath materials are introduced and the bath material preparation methods are also discussed. In addition, the design criteria of fluid bath materials including biocompatibility, rheological properties, physical/chemical stability, hydrophilicity/hydrophobicity, and other properties are proposed in order to guide the selection and design of future fluid bath materials. For the printing stage, some key technical issues discussed in this review include filament formation mechanisms in a fluid bath, effects of nozzle movement on printed structures, and design strategies for printing paths. In the postprinting stage, some commonly used postprinting processes are introduced. Finally, representative biomedical applications of fluid bath-assisted 3D printing, such as standalone organoids/tissues, biomedical microfluidic devices, and wearable and bionic devices, are summarized and presented.

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