期刊
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
卷 22, 期 2, 页码 222-228出版社
SPRINGER JAPAN KK
DOI: 10.1007/s10147-016-1072-z
关键词
Alpha-bisabolol; EMT mechanism; Pancreas cancer; Adipocyte
类别
Alpha-bisabolol is a plant-derived sesquiterpene alcohol recently associated with a supposed anti-cancer action due to its ability to induce BID-related apoptosis. The molecule, which enters the cell through lipid rafts, may also interact with kisspeptin receptor 1, which has recently been associated with tumor mobility and invasiveness. This evidence suggests the possibility that alpha-bisabolol might act on the epithelial-mesenchymal transition mechanism, closely associated with the desmoplastic reaction of adipose tissue surrounding a pancreatic ductal adenocarcinoma. This review addresses the issue on the basis of the most recent reported literature in the field.
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