Article
Multidisciplinary Sciences
Ryan Tamashiro, Leah Strange, Kristin Schnackenberg, Janelle Santos, Hana Gadalla, Lisa Zhao, Eric C. Li, Emilie Hill, Brett Hill, Gurjit S. Sidhu, Mariana Kirst, Clay Walker, Gary P. Wang
Summary: Smoking accelerates the progression of periodontal disease by altering the subgingival microbiome, characterized by an increase in microbial richness and diversity in smokers compared to non-smokers. Temporal analysis revealed that the microbiome in shallow sites was less stable, while progression of periodontal disease was associated with specific taxa in the subgingival microbiome. These findings suggest that subgingival dysbiosis in smokers precedes clinical signs of periodontal disease.
SCIENTIFIC REPORTS
(2023)
Article
Microbiology
Enkhchimeg Lkhagva, Hea-Jong Chung, Jinny Hong, Wai Hong Wilson Tang, Sang-Il Lee, Seong-Tshool Hong, Seungkoo Lee
Summary: Research reveals significant variation in environmental conditions and microbial compositions along different locations of the gastrointestinal tract, with higher diversity observed in the colon and cecum compared to feces. The fecal microbiome differs from the entire microbiome of the GI tract, challenging prevailing assumptions in contemporary microbiome research.
Article
Microbiology
Scott C. Thomas, Fangxi Xu, Smruti Pushalkar, Ziyan Lin, Nirali Thakor, Mridula Vardhan, Zia Flaminio, Alireza Khodadadi-Jamayran, Rebeca Vasconcelos, Adenike Akapo, Erica Queiroz, Maria Bederoff, Malvin N. Janal, Yuqi Guo, Deanna Aguallo, Terry Gordon, Patricia M. Corby, Angela R. Kamer, Xin Li, Deepak Saxena
Summary: The use of electronic cigarettes (e-cigs) is becoming increasingly popular and is often considered a healthier alternative to traditional smoking. However, there is limited evidence on the long-term effects of e-cig use on oral health. This study found that e-cig users have a unique periodontal microbiome, which shares some similarities with both conventional smokers and nonsmokers but has more in common with cigarette smokers. This suggests that there may be a unique periodontal risk associated with e-cig use.
Review
Biochemistry & Molecular Biology
Mattia Di Stefano, Alessandro Polizzi, Simona Santonocito, Alessandra Romano, Teresa Lombardi, Gaetano Isola
Summary: The oral cavity harbors a complex microbial community, which can lead to periodontal damage. Periodontal disease is a common chronic inflammatory condition globally, with diverse clinical manifestations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Manuel Aira, Marcos Perez-Losada, Keith A. Crandall, Jorge Dominguez
Summary: Host evolutionary history and diet are important factors shaping the earthworm cast microbiome. Experimental results showed that earthworm microbiomes are species-specific and influenced by host evolutionary history and diet. Diet has a significant impact on microbiome composition, while under homogenous feeding conditions, it has a minor effect on microbiome composition, structure, and diversity.
FEMS MICROBIOLOGY ECOLOGY
(2022)
Article
Microbiology
Lijuan Cheng, Yan Gao, Qing Xia, Hui Wang, Xiuzhen Xie, Yurong Liu, Heying Shang, Yutao Diao
Summary: The study revealed that there were no significant differences in the relative abundance of vaginal microbes among women at childbearing age based on their childbearing history and menstrual cycle. However, women who were pregnant or without reproductive tract infections showed lower alpha and beta diversity in their vaginal microbiota.
Article
Microbiology
Jonathan Fenn, Christopher Taylor, Sarah Goertz, Klara M. M. Wanelik, Steve Paterson, Mike Begon, Joe Jackson, Jan Bradley
Summary: In this study, the microbiome of wild field voles was analyzed using high-throughput sequencing methods. The microbiome showed changes at different timescales, with a notable loss of species richness in the short-term and a slight increase in the medium and long-term. The dominance of Firmicutes shifted to Bacteroidetes over time. The results indicate that microbiome diversity changes can be rapid and associated with environmental changes.
Article
Microbiology
Zirui Ray Xiong, Jonathan H. Sogin, Randy W. Worobo
Summary: This study utilized next-generation sequencing to analyze the microbial composition of raw honey and found that honey type significantly influenced the diversity and richness of bacterial and fungal communities. The study also identified important microbial variants that influenced the overall community.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Nutrition & Dietetics
Yuni Choi, Susan L. Hoops, Calvin J. Thoma, Abigail J. Johnson
Summary: The human gut microbiome is associated with metabolic and cardiovascular disease risk. Modifying the microbiome through diet offers a potential way to prevent microbiome-related diseases, although this potential has not been fully realized. Integrating observational human diet and microbiome data can help researchers understand the complex interactions between diet and microbiome, and improve the detection of diet-microbiome signals.
JOURNAL OF NUTRITION
(2022)
Article
Nutrition & Dietetics
Daphne M. Rodriguez, Korry J. Hintze, Giovanni Rompato, Arnaud J. Van Wettere, Robert E. Ward, Sumira Phatak, Canyon Neal, Tess Armbrust, Eliza C. Stewart, Aaron J. Thomas, Abby D. Benninghoff
Summary: Black raspberries are rich in anthocyanins with potential anti-inflammatory properties. Studies show that dietary supplementation with black raspberries can inhibit colitis and colon tumorigenesis, while also altering the composition of the gut microbiome.
Article
Ecology
Grace J. Vaziri, Maggie M. Jones, Haley A. Carr, Cassandra M. V. Nunez
Summary: Disruption of animals' microbiota can be caused by various factors, including diet changes, hormone level fluctuations, and stressors. This study investigates the effects of increased social instability on the microbiota of free-living horses. Results show that changing social groups leads to compositional differences and increased abundance of certain bacterial genera and families in the fecal microbial communities. This is the first study to demonstrate an association between acute social perturbations and the microbiota in a free-ranging mammal.
ECOLOGY AND EVOLUTION
(2023)
Review
Nutrition & Dietetics
Aleisha Bliesner, Jade Eccles-Smith, Claire Bates, Olivia Hayes, Jet Yee Ho, Catia Martins, Helen Truby, Marloes Dekker Nitert
Summary: This systematic review investigates the effect of food-based weight loss diets on microbiota outcomes in individuals who have successfully lost weight. The results show minimal changes in alpha- and beta-diversity and faecal SCFA concentrations following weight loss, while changes in relative bacterial abundance at the phylum and genus level were inconsistent. Further research is needed to understand the effect of diet-induced weight loss on the gut microbiota.
Article
Gastroenterology & Hepatology
Lama Izzat Hasan Abdel-Rahman, Xochitl C. Morgan
Summary: In this study, we conducted a meta-analysis of 13 inflammatory bowel disease studies to evaluate the reproducibility. The results showed that the heterogeneity was greater in Crohn's disease studies compared to ulcerative colitis studies, and sample type variation played a significant role in the inconsistency.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Immunology
Naoki Toyama, Daisuke Ekuni, Aya Yokoi, Daiki Fukuhara, Md Monirul Islam, Nanami Sawada, Yukiho Nakashima, Momoko Nakahara, Ichiro Sumita, Manabu Morita
Summary: This study investigated the profile and diversity of the oral microbiome in elderly Japanese individuals with different degrees of periodontitis. The results showed that the oral microbiome in the non-severe periodontitis group had lower diversity and four specific bacterial species.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Y. Kurushima, P. M. Wells, R. C. E. Bowyer, N. Zoheir, S. Doran, J. P. Richardson, D. D. Sprockett, D. A. Relman, C. J. Steves, L. Nibali
Summary: Limited evidence is available on how host genetic variants affect microbiota composition. This study examines the associations between candidate host genetic variants and microbial composition in saliva and gut. The findings suggest that certain genetic variants are associated with microbial diversity and composition, and periodontal status may drive variations in the microbiota.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Microbiology
Ralf Salzer, Timo Kern, Friederike Joos, Beate Averhoff
ENVIRONMENTAL MICROBIOLOGY
(2016)
Article
Genetics & Heredity
Niels Grarup, Ida Moltke, Mette K. Andersen, Maria Dalby, Kristoffer Vitting-Seerup, Timo Kern, Yuvaraj Mahendran, Emil Jorsboe, Christina V. L. Larsen, Inger K. Dahl-Petersen, Arthur Gilly, Daniel Suveges, George Dedoussis, Eleftheria Zeggini, Oluf Pedersen, Robin Andersson, Peter Bjerregaard, Marit E. Jorgensen, Anders Albrechtsen, Torben Hansen
Article
Multidisciplinary Sciences
Tue H. Hansen, Timo Kern, Emilie G. Bak, Alireza Kashani, Kristine H. Allin, Trine Nielsen, Torben Hansen, Oluf Pedersen
SCIENTIFIC REPORTS
(2018)
Article
Microbiology
Ralf Salzer, Timo Kern, Friederike Joos, Beate Averhoff
FEMS MICROBIOLOGY LETTERS
(2014)
Article
Clinical Neurology
Anders Abildgaard, Timo Kern, Oluf Pedersen, Torben Hansen, Gregers Wegener, Sten Lund
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2019)
Article
Multidisciplinary Sciences
Tue H. Hansen, Mette T. Thomassen, Mia L. Madsen, Timo Kern, Emilie G. Bak, Alireza Kashani, Kristine H. Allin, Torben Hansen, Oluf Pedersen
SCIENTIFIC REPORTS
(2018)
Article
Endocrinology & Metabolism
Thomas Bryrup, Caecilie W. Thomsen, Timo Kern, Kristine H. Allin, Ivan Brandslund, Nikias R. Jorgensen, Henrik Vestergaard, Torben Hansen, Tue H. Hansen, Oluf Pedersen, Trine Nielsen
Article
Endocrinology & Metabolism
Timo Kern, Martin Baek Blond, Tue Haldor Hansen, Mads Rosenkilde, Jonas Salling Quist, Anne Sofie Gram, Claus Thorn Ekstrom, Torben Hansen, Bente Stallknecht
INTERNATIONAL JOURNAL OF OBESITY
(2020)
Article
Genetics & Heredity
Mette K. Andersen, Emil Jorsboe, Line Skotte, Kristian Hanghoj, Camilla H. Sandholt, Ida Moltke, Niels Grarup, Timo Kern, Yuvaraj Mahendran, Bolette Soborg, Peter Bjerregaard, Christina V. L. Larsen, Inger K. Dahl-Petersen, Hemant K. Tiwari, Bjarke Feenstra, Anders Koch, Howard W. Wiener, Scarlett E. Hopkins, Oluf Pedersen, Mads Melbye, Bert B. Boyer, Marit E. Jorgensen, Anders Albrechtsen, Torben Hansen
Article
Clinical Neurology
Anders Abildgaard, Timo Kern, Oluf Pedersen, Torben Hansen, Sten Lund, Gregers Wegener
Summary: This study found that probiotics increased the relative abundance of Bifidobacterium, Lactococcus, and Lactobacillus genera in rats fed a high-fat diet. An HFD-induced microbiota component associated with depressive-like behavior was identified, and probiotics improved this component score. Furthermore, plasma levels of 44 metabolites correlated with the depression-related microbiota component, with three metabolites showing good predictive ability for depressive-like behavior.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Anurag Singh, Davide D'Amico, Penelope A. Andreux, Gillian Dunngalvin, Timo Kern, William Blanco-Bose, Johan Auwerx, Patrick Aebischer, Chris Rinsch
Summary: This study investigates the prevalence of UA producers in a healthy population and the effectiveness of direct UA supplementation in overcoming microbiome variability. Results show that 40% of subjects converted precursor compounds into UA after consuming pomegranate juice. UA producers were characterized by higher gut microbiome diversity and a specific bacteria ratio. Direct supplementation significantly increased plasma UA levels, providing a >6-fold exposure compared to PJ.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Microbiology
Alireza Kashani, Asker Daniel Brejnrod, Chunyu Jin, Timo Kern, Andreas Nygaard Madsen, Louise Aas Holm, Georg K. Gerber, Jens-Christian Holm, Torben Hansen, Birgitte Holst, Manimozhiyan Arumugam
Meeting Abstract
Endocrinology & Metabolism
T. Nielsen, T. Bryrup, C. W. Thomsen, T. H. Hansen, T. Kern, K. H. Allin, N. R. Jorgensen, H. Vestergaard, T. Hansen, O. Pedersen