Review
Polymer Science
Payam Abasian, Sepideh Shakibi, Mohammad Saeed Maniati, Saied Nouri Khorasani, Shahla Khalili
Summary: After long-term research, science has proposed new drug delivery systems to reduce the side effects of traditional treatment methods, in order to deliver drugs to target organs with minimum side effects.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2021)
Article
Engineering, Biomedical
Carla Jimenez-Jimenez, Almudena Moreno-Borrallo, Bianca Dumontel, Miguel Manzano, Maria Vallet-Regi
Summary: Nanotechnology has revolutionized potential disease treatments, but immune clearance and poor biocompatibility limit the use of nanoparticles for drug delivery. Coating nanoparticles with cell membranes is a hypothesis to overcome rejection and enhance biocompatibility. Here, we show that coating mesoporous silica nanoparticles with membranes from preosteoblastic cells can be used for potential bone disease treatments. Our results demonstrate the cellular selectivity and migration capability of camouflaged nanocarriers, which inspire future treatments.
ACTA BIOMATERIALIA
(2023)
Article
Biotechnology & Applied Microbiology
Wei Xiong, Zhengdong Guo, Baoyan Zeng, Teng Wang, Xiaowei Zeng, Wei Cao, Daizheng Lian
Summary: This study constructed multifunctional nanoparticles for the encapsulation of dacarbazine (DTIC) and targeted therapy of malignant melanoma (MM). In vitro and in vivo experiments showed that these nanoparticles had good release properties and exhibited strong anti-tumor effects with no side effects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Sebastian J. Beckers, Alexander H. J. Staal, Christine Rosenauer, Mangala Srinivas, Katharina Landfester, Frederik R. Wurm
Summary: This study investigates the stability and transport mechanisms of a series of nanocarriers within grapevines, demonstrating their potential transport through xylem inside the plant. Two tracking methods, F-19 magnetic resonance imaging and induced coupled plasma-optical emission spectroscopy, prove the effectiveness of transporting and localizing nanocarriers inside plants, providing essential information for designing nanocarriers for agrochemical delivery in plants.
Review
Pharmacology & Pharmacy
Xin Huang, Haoyu Guo, Lutong Wang, Zhicai Zhang, Weiyue Zhang
Summary: This review discusses the ongoing research on small interfering RNA (siRNA) therapeutics for cancer treatment. The targeted delivery of siRNA to cancer cells is the main challenge for clinical applications. Cell membrane-coated nanocarriers, which combine the properties of cell membranes and nanoparticles, have advantages in siRNA delivery. Various types of cell membrane-coated nanocarriers for targeted siRNA delivery, including cancer cell membranes, platelet membranes, erythrocyte membranes, stem cell membranes, exosome membranes, and hybrid membranes, are also discussed. Overall, biomimetic cell membrane-coated nanotechnology shows promise for targeted siRNA delivery in cancer treatment.
DRUG DISCOVERY TODAY
(2023)
Review
Pharmacology & Pharmacy
Lei Zhang, Zhen Li, Xianren Ye, Zhuo Chen, Zhe-Sheng Chen
Summary: Thromboembolic diseases have been on the rise globally, leading to increased mortality, but targeting delivery strategies have advanced, holding significant promise for accurate treatment of thrombolysis.
DRUG DISCOVERY TODAY
(2021)
Review
Pharmacology & Pharmacy
Xiuru Yang, Yan Xie
Summary: Polymeric core-shell nanocarriers (PCS NCs) composed of a polymer core and at least one shell have shown great potential in selectively delivering chemotherapeutic drugs to tumor sites. They can effectively improve the delivery efficiency and therapeutic index of anticarcinogens.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Inorganic & Nuclear
Mehrab Pourmadadi, Shima Ostovar, Gustavo Ruiz-Pulido, Dilawar Hassan, Maryam Souri, Amanda-Lee Ezra Manicum, Razieh Behzadmehr, Sonia Fathi-karkan, Abbas Rahdar, Dora I. Medina, Sadanand Pandey
Summary: Cancer is a global disease that affects millions of people, and in 2023, there are projected to be 1,958,310 new cancer cases and 609,820 cancer fatalities in the United States. Epirubicin is a potential anticancer chemotherapy agent that has shown efficacy against various malignancies. Nanotechnology has been used to develop novel drug delivery systems to enhance the therapeutic efficacy of EPI and overcome its limitations.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Review
Polymer Science
Mengfan Zhu, Xunhao Wang, Yan Zhou, Mengmeng Li, Yufei Wang, Yinhan Wang, Tengfei Li, Sean Yan Song, Boxin Zhang, Kamal Hezam, Jin Zhang
Summary: Breast cancer is a common and highly malignant type of cancer, lacking efficient treatments due to off-target events occurring during drug administration. Recent progress in polymer nanocarriers shows potential in targeted delivery, utilizing stimuli-responsive materials to release drugs to specific tissues or cells. This article elucidates the mechanism and engineering methods of current targeting strategies, as well as highlights the design and applications of targeted nanocarriers derived from polymers in chemotherapy, hyperthermia, immunotherapy, and gene therapy.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Materials Science, Biomaterials
Shun Liu, Yun Zhao, Meili Shen, Yujiao Hao, Xiaodong Wu, Yixuan Yao, Yapeng Li, Qingbiao Yang
Summary: In this study, a multifunctional drug-loaded nano-delivery system with pH-responsive, CD44-targeted, and chemical-photothermal synergistic treatment was successfully prepared. This system showed excellent drug-controlled release properties in the weakly acidic microenvironment of atherosclerotic inflammation, and exhibited low cytotoxicity against RAW 264.7 cells. The combination of CuS photothermal treatment with anti-atherosclerosis chemotherapy had better effects than single treatment in vitro and in vivo, demonstrating broad application prospects in anti-atherosclerosis.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Review
Chemistry, Multidisciplinary
Gulmi Chakraborty, Minakshi Meher, Sanjay Dash, Rudra Narayan Rout, Sibananda Pradhan, Dipanjali Sahoo
Summary: In the past decade, there has been a significant increase in studies on polymeric aggregates as nanocarriers. Polymeric nanocarriers (PNCs) are unparalleled in terms of their morphology, size, functionality, and immunostability. With various characteristics such as large surface area to volume ratio, amphiphilic nano-environment, non-toxic components, chemically modifiable composition, and stimuli-dependent self-assembly, PNCs have emerged as strong candidates for therapeutic applications. This article reviews the latest research on challenges and strategies for targeted drug delivery and serves as a guide for researchers in designing site-specific nanocarriers for future applications.
Review
Pharmacology & Pharmacy
Xixi Zheng, Tianyuan Zhang, Ting Huang, Yanjun Zhou, Jianqing Gao
Summary: This review summarizes the applications of cell-derived membrane biomimetic nanocarriers in the targeted therapy of pulmonary diseases and introduces the improvements of nanocarriers to enhance therapeutic ability. It is of great significance for guiding the potential applications of cell-derived membrane biomimetic nanocarriers in the treatment of pulmonary diseases.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Physical
Yo Han Song, Ranjit De, Kang Taek Lee
Summary: Blood-brain barrier (BBB) is a crucial interface between the central nervous system (CNS) and its surroundings, allowing selective permeation of essential substances while restricting the entry of potentially harmful materials. The development of polymeric nanocarriers has shown promise in facilitating BBB permeation for the treatment of neurodegenerative diseases and brain cancers. However, the challenge of transporting drug-loaded nanomaterials across the BBB remains formidable. This concise analysis explores strategies for designing polymeric nanocarriers and discusses the impact of size, shape, surface charge, and ligand modification on BBB permeation. The review also highlights future directions for designing smart polymeric nanocarriers to enhance BBB permeation.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2023)
Review
Nanoscience & Nanotechnology
Mandana T. Manzari, Yosi Shamay, Hiroto Kiguchi, Neal Rosen, Maurizio Scaltriti, Daniel A. Heller
Summary: Precision medicine offers personalized treatment strategies for individual patients, especially in the field of cancer therapy. While there have been some clinical successes, challenges such as drug toxicities and resistance still hinder the full potential of precision medicine. Advanced drug delivery materials and approaches provide opportunities to improve therapeutic outcomes and overcome pharmacological issues in cancer treatment.
NATURE REVIEWS MATERIALS
(2021)
Article
Biotechnology & Applied Microbiology
Zhining Zhao, Xiaodan Li, Yan Wang, Cheng Liu, Guixia Ling, Peng Zhang
Summary: This study successfully enhanced the delivery and accumulation of nanomedicines in thrombus and improved the antithrombotic effect by using platelet-like biological targeting and the parallel strategy of thrombus thermal ablation and anticoagulation.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)