期刊
FRONTIERS IN PHARMACOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2021.685116
关键词
vitiligo; oxidative stress; natural product; melanocytes; flavonoids; phenols; glycosides
资金
- National Natural Science Foundation of China [81804066, 82074443, 81873310]
- Xinglin Scholar Research Promotion Project of Chengdu University of TCM [QNXZ2019017, QNXZ2020003]
- Hundred Talents Program of the Hospital of Chengdu University of Traditional Chinese Medicine [20-B01, 20-Q03, 20-Q05]
Vitiligo is the most common depigmenting disorder characterized by white patches in the skin. Natural compounds such as flavonoids, phenols, glycosides and coumarins have been shown to have a protective role in melanocytes and thus can help arrest depigmentation. Several signaling pathways are implicated in these protective effects.
Vitiligo is the most common depigmenting disorder characterized by white patches in the skin. The pathogenetic origin of vitiligo revolves around autoimmune destruction of melanocytes in which, for instance, oxidative stress is responsible for melanocyte molecular, organelle dysfunction and melanocyte specific antigen exposure as well as melanocyte cell death and thus serves as an important contributor for vitiligo progression. In recent years, natural products have shown a wide range of pharmacological bioactivities against many skin diseases, and this review focuses on the effects and mechanisms of natural compounds against vitiligo models. It is showed that some natural compounds such as flavonoids, phenols, glycosides and coumarins have a protective role in melanocytes and thereby arrest the depigmentation, and, additionally, Nrf2/HO-1, MAPK, JAK/STAT, cAMP/PKA, and Wnt/beta-catenin signaling pathways were reported to be implicated in these protective effects. This review discusses the great potential of plant derived natural products as anti-vitiligo agents, as well as the future directions to explore.
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